The Use of Telemetry Monitoring Among General Medicine Patients

Objective: To determine why and when general medicine non-ICU patients are upgraded from a non-telemetry level of care to telemetry monitoring at Thomas Jefferson University Hospital (TJUH). Comparison of the reasons for initiation of continuous ECG monitoring with the AHA and ACC guidelines would provide a greater understanding of the applicability of these recommendations to non-ICU general medicine patients. This information can provide guidance to identify areas of intervention to decrease inappropriate and/or overutilization of telemetry. The ultimate goal is to identify general medicine patients who are likely to benefit from continuous ECG monitoring, without negatively affecting clinical outcomes for those who do not receive cardiac monitoring.https://jdc.jefferson.edu/patientsafetyposters/1025/thumbnail.jp

Revisiting the bulge-halo conspiracy I: Dependence on galaxy properties and halo mass

We carry out a systematic investigation of the total mass density profile of massive (Mstar>2e11 Msun) early-type galaxies and its dependence on galactic properties and host halo mass with the aid of a variety of lensing/dynamical data and large mock galaxy catalogs. The latter are produced via semi-empirical models that, by design, are based on just a few basic input assumptions. Galaxies, with measured stellar masses, effective radii and S\'{e}rsic indices, are assigned, via abundance matching relations, host dark matter halos characterized by a typical LCDM profile. Our main results are as follows: (i) In line with observational evidence, our semi-empirical models naturally predict that the total, mass-weighted density slope at the effective radius gamma' is not universal, steepening for more compact and/or massive galaxies, but flattening with increasing host halo mass. (ii) Models characterized by a Salpeter or variable initial mass function and uncontracted dark matter profiles are in good agreement with the data, while a Chabrier initial mass function and/or adiabatic contractions/expansions of the dark matter halos are highly disfavored. (iii) Currently available data on the mass density profiles of very massive galaxies (Mstar>1e12 Msun), with Mhalo>3e14 Msun, favor instead models with a stellar profile flatter than a S\'{e}rsic one in the very inner regions (r<3-5 kpc), and a cored NFW or Einasto dark matter profile with median halo concentration a factor of ~2 or <1.3, respectively, higher than those typically predicted by N-body numerical simulations.Comment: 23 pages, 10 figures, 3 Appendices (with an extra 7 figures). ApJ, accepted. Main results in Figures 3, 5, 6,

Effects of nanoparticles on murine macrophages

Metallic nanoparticles are more and more widely used in an increasing number of applications. Consequently, they are more and more present in the environment, and the risk that they may represent for human health must be evaluated. This requires to increase our knowledge of the cellular responses to nanoparticles. In this context, macrophages appear as an attractive system. They play a major role in eliminating foreign matter, e.g. pathogens or infectious agents, by phagocytosis and inflammatory responses, and are thus highly likely to react to nanoparticles. We have decided to study their responses to nanoparticles by a combination of classical and wide-scope approaches such as proteomics. The long term goal of this study is the better understanding of the responses of macrophages to nanoparticles, and thus to help to assess their possible impact on human health. We chose as a model system bone marrow-derived macrophages and studied the effect of commonly used nanoparticles such as TiO2 and Cu. Classical responses of macrophage were characterized and proteomic approaches based on 2D gels of whole cell extracts were used. Preliminary proteomic data resulting from whole cell extracts showed different effects for TiO2-NPs and Cu-NPs. Modifications of the expression of several proteins involved in different pathways such as, for example, signal transduction, endosome-lysosome pathway, Krebs cycle, oxidative stress response have been underscored. These first results validate our proteomics approach and open a new wide field of investigation for NPs impact on macrophagesComment: Nanosafe2010: International Conference on Safe Production and Use of Nanomaterials 16-18 November 2010, Grenoble, France, Grenoble : France (2010

The Halo Mass of Optically Luminous Quasars at z ,F≈ ,F1-2 Measured via Gravitational Deflection of the Cosmic Microwave Background

© 2019. The American Astronomical Society. All rights reserved.We measure the average deflection of cosmic microwave background photons by quasars at 〈Z〉= 1.7. Our sample is selected from the Sloan Digital Sky Survey to cover the redshift range 0.9 ≤z≤2.2 with absolute i-band magnitudes of M i ≤-24 (K-corrected to z = 2). A stack of nearly 200,000 targets reveals an 8δ detection of Planck's estimate of the lensing convergence toward the quasars. We fit the signal with a model comprising a Navarro-Frenk-White density profile and a two-halo term accounting for correlated large-scale structure, which dominates the observed signal. The best-fitting model is described by an average halo mass log 10 (M h h -1 M)12.6 ±0.2 = and linear bias b=2.7±0.3 at 〈Z 〉= 1.7, in excellent agreement with clustering studies. We also report a hint, at a 90% confidence level, of a correlation between the convergence amplitude and luminosity, indicating that quasars brighter than Mi≲ -26 reside in halos of typical mass M h ≈ 10 13 h -1 M, scaling roughly as M h ∞ L opt 3/4 at M i ≲-24 mag, in good agreement with physically motivated quasar demography models. Although we acknowledge that this luminosity dependence is a marginal result, the observed Mh-L opt relationship could be interpreted as a reflection of the cutoff in the distribution of black hole accretion rates toward high Eddington ratios: the weak trend of Mh with Lopt observed at low luminosity becomes stronger for the most powerful quasars, which tend to be accreting close to the Eddington limit.Peer reviewedFinal Accepted Versio

Optimal trapping wavelengths of Cs2_2 molecules in an optical lattice

The present paper aims at finding optimal parameters for trapping of Cs$_2$ molecules in optical lattices, with the perspective of creating a quantum degenerate gas of ground-state molecules. We have calculated dynamic polarizabilities of Cs$_2$ molecules subject to an oscillating electric field, using accurate potential curves and electronic transition dipole moments. We show that for some particular wavelengths of the optical lattice, called "magic wavelengths", the polarizability of the ground-state molecules is equal to the one of a Feshbach molecule. As the creation of the sample of ground-state molecules relies on an adiabatic population transfer from weakly-bound molecules created on a Feshbach resonance, such a coincidence ensures that both the initial and final states are favorably trapped by the lattice light, allowing optimized transfer in agreement with the experimental observation

Charges and fluxes in Maxwell theory on compact manifolds with boundary

We investigate the charges and fluxes that can occur in higher-order Abelian gauge theories defined on compact space-time manifolds with boundary. The boundary is necessary to supply a destination to the electric lines of force emanating from brane sources, thus allowing non-zero net electric charges, but it also introduces new types of electric and magnetic flux. The resulting structure of currents, charges, and fluxes is studied and expressed in the language of relative homology and de Rham cohomology and the corresponding abelian groups. These can be organised in terms of a pair of exact sequences related by the Poincar\'e-Lefschetz isomorphism and by a weaker flip symmetry exchanging the ends of the sequences. It is shown how all this structure is brought into play by the imposition of the appropriately generalised Maxwell's equations. The requirement that these equations be integrable restricts the world-volume of a permitted brane (assumed closed) to be homologous to a cycle on the boundary of space-time. All electric charges and magnetic fluxes are quantised and satisfy the Dirac quantisation condition. But through some boundary cycles there may be unquantised electric fluxes associated with quantised magnetic fluxes and so dyonic in nature.Comment: 28 pages, plain Te

Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1

DNA double-strand breaks (DSBs) are repaired by nonhomologous end joining (NHEJ) or homologous recombination (HR). The C terminal binding protein–interacting protein (CtIP) is phosphorylated in G2 by cyclin-dependent kinases to initiate resection and promote HR. CtIP also exerts functions during NHEJ, although the mechanism phosphorylating CtIP in G1 is unknown. In this paper, we identify Plk3 (Polo-like kinase 3) as a novel DSB response factor that phosphorylates CtIP in G1 in a damage-inducible manner and impacts on various cellular processes in G1. First, Plk3 and CtIP enhance the formation of ionizing radiation-induced translocations; second, they promote large-scale genomic deletions from restriction enzyme-induced DSBs; third, they are required for resection and repair of complex DSBs; and finally, they regulate alternative NHEJ processes in Ku−/− mutants. We show that mutating CtIP at S327 or T847 to nonphosphorylatable alanine phenocopies Plk3 or CtIP loss. Plk3 binds to CtIP phosphorylated at S327 via its Polo box domains, which is necessary for robust damage-induced CtIP phosphorylation at S327 and subsequent CtIP phosphorylation at T847

Unraveling the Complexity of Critical Consciousness, Political Efficacy, and Political Action Among Marginalized Adolescents

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141719/1/cdev12446.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141719/2/cdev12446_am.pd

An Industry-University Response to Global Competition

In 1998, representatives of New Mexico\u27s chile pepper industry approached New Mexico State University\u27s College of Agriculture and Home Economics for help in gaining the edge on new global competition. The result was the New Mexico Chile Task Force, which brought together industry, university, and government partners to apply the most up-to-date knowledge and technology to industry problems. Key to the task force\u27s success is the search conference format used in the initial strategic planning phase. This method, pioneered by Emery and Trist in the 1960s, brought together parties with divergent opinions and empowered them to develop strategies to manage change

An Industry-University Response to Global Competition

In 1998, representatives of New Mexico\u27s chile pepper industry approached New Mexico State University\u27s College of Agriculture and Home Economics for help in gaining the edge on new global competition. The result was the New Mexico Chile Task Force, which brought together industry, university, and government partners to apply the most up-to-date knowledge and technology to industry problems. Key to the task force\u27s success is the search conference format used in the initial strategic planning phase. This method, pioneered by Emery and Trist in the 1960s, brought together parties with divergent opinions and empowered them to develop strategies to manage change