109 research outputs found
Measure-Based Inconsistency-Tolerant Maintenance of Database Integrity
[EN] To maintain integrity, constraint violations should be prevented or repaired. However, it may not be feasible to avoid inconsistency, or to repair all violations at once. Based on an abstract concept of violation measures, updates and repairs can be checked for keeping inconsistency bounded, such that integrity violations are guaranteed to never get out of control. This measure-based approach goes beyond conventional methods that are not meant to be applied in the presence of inconsistency. It also generalizes recently introduced concepts of inconsistency-tolerant integrity maintenance.Partially supported by FEDER and the Spanish grants TIN2009-14460-C03 and TIN2010-17139Decker, H. (2013). Measure-Based Inconsistency-Tolerant Maintenance of Database Integrity. Lecture Notes in Computer Science. 7693:149-173. https://doi.org/10.1007/978-3-642-36008-4_7S1491737693Abiteboul, S., Hull, R., Vianu, V.: Foundations of Databases. Addison-Wesley (1995)Abiteboul, S., Vianu, V.: A transaction-based approach to relational database specification. JACM 36(4), 758–789 (1989)Afrati, F., Kolaitis, P.: Repair checking in inconsistent databases: algorithms and complexity. In: 12th ICDT, pp. 31–41. ACM Press (2009)Arenas, M., Bertossi, L., Chomicki, J.: Consistent query answers in inconsistent databases. In: PODS 1999, pp. 68–79. ACM Press (1999)Arieli, O., Denecker, M., Bruynooghe, M.: Distance semantics for database repair. Ann. Math. Artif. Intell. 50, 389–415 (2007)Arni-Bloch, N., Ralyté, J., Léonard, M.: Service–Driven Information Systems Evolution: Handling Integrity Constraints Consistency. In: Persson, A., Stirna, J. (eds.) PoEM 2009. LNBIP, vol. 39, pp. 191–206. Springer, Heidelberg (2009)Bauer, H.: Maß- und Integrationstheorie, 2. Auflage. De Gruyter (1992)Besnard, P., Hunter, A.: Quasi-Classical Logic: Non-Trivializable Classical Reasoning from Inconsistent Information. In: Froidevaux, C., Kohlas, J. (eds.) ECSQARU 1995. LNCS, vol. 946, pp. 44–51. Springer, Heidelberg (1995)Bohanon, P., Fan, W., Flaster, M., Rastogi, R.: A Cost-Based Model and Effective Heuristic for Repairing Constraints by Value Modification. In: Proc. SIGMOD 2005, pp. 143–154. ACM Press (2005)Ceri, S., Cochrane, R., Widom, J.: Practical Applications of Triggers and Constraints: Success and Lingering Issues. In: Proc. 26th VLDB, pp. 254–262. Morgan Kaufmann (2000)Chakravarthy, U., Grant, J., Minker, J.: Logic-based Approach to Semantic Query Optimization. Transactions on Database Systems 15(2), 162–207 (1990)Chomicki, J.: Consistent Query Answering: Five Easy Pieces. In: Schwentick, T., Suciu, D. (eds.) ICDT 2007. LNCS, vol. 4353, pp. 1–17. Springer, Heidelberg (2006)Christiansen, H., Martinenghi, D.: On simplification of database integrity constraints. Fundamenta Informaticae 71(4), 371–417 (2006)Clark, K.: Negation as Failure. In: Gallaire, H., Minker, J. (eds.) Logic and Data Bases, pp. 293–322. Plenum Press (1978)Curino, C., Moon, H., Deutsch, A., Zaniolo, C.: Update Rewriting and Integrity Constraint Maintenance in a Schema Evolution Support System: PRISM++. PVLDB 4, 117–128 (2010)Dawson, J.: The compactness of first-order logic: From Gödel to Lindström. History and Philosophy of Logic 14(1), 15–37 (1993)Decker, H.: The Range Form of Databases and Queries or: How to Avoid Floundering. In: Proc. 5th ÖGAI. Informatik-Fachberichte, vol. 208, pp. 114–123. Springer (1989)Decker, H.: Drawing Updates From Derivations. In: Kanellakis, P.C., Abiteboul, S. (eds.) ICDT 1990. LNCS, vol. 470, pp. 437–451. Springer, Heidelberg (1990)Decker, H.: Extending Inconsistency-Tolerant Integrity Checking by Semantic Query Optimization. In: Bhowmick, S.S., Küng, J., Wagner, R. (eds.) DEXA 2008. LNCS, vol. 5181, pp. 89–96. Springer, Heidelberg (2008)Decker, H.: Answers That Have Integrity. In: Schewe, K.-D., Thalheim, B. (eds.) SDKB 2010. LNCS, vol. 6834, pp. 54–72. Springer, Heidelberg (2011)Decker, H.: Causes of the Violation of Integrity Constraints for Supporting the Quality of Databases. In: Murgante, B., Gervasi, O., Iglesias, A., Taniar, D., Apduhan, B.O. (eds.) ICCSA 2011, Part V. LNCS, vol. 6786, pp. 283–292. Springer, Heidelberg (2011)Decker, H.: Inconsistency-tolerant Integrity Checking based on Inconsistency Metrics. In: König, A., Dengel, A., Hinkelmann, K., Kise, K., Howlett, R.J., Jain, L.C. (eds.) KES 2011, Part II. LNCS, vol. 6882, pp. 548–558. Springer, Heidelberg (2011)Decker, H.: Partial Repairs that Tolerate Inconsistency. In: Eder, J., Bielikova, M., Tjoa, A.M. (eds.) ADBIS 2011. LNCS, vol. 6909, pp. 389–400. Springer, Heidelberg (2011)Decker, H.: Consistent Explanations of Answers to Queries in Inconsistent Knowledge Bases. In: Roth-Berghofer, T., Tintarev, N., Leake, D. (eds.) Explanation-aware Computing, Proc. IJCAI 2011 Workshop ExaCt 2011, pp. 71–80 (2011), http://exact2011.workshop.hm/index.phpDecker, H., Martinenghi, D.: Classifying integrity checking methods with regard to inconsistency tolerance. In: Proc. PPDP 2008, pp. 195–204. ACM Press (2008)Decker, H., Martinenghi, D.: Modeling, Measuring and Monitoring the Quality of Information. In: Heuser, C.A., Pernul, G. (eds.) ER 2009. LNCS, vol. 5833, pp. 212–221. Springer, Heidelberg (2009)Decker, H., Martinenghi, D.: Inconsistency-tolerant Integrity Checking. IEEE TKDE 23(2), 218–234 (2011)Decker, H., Muñoz-EscoÃ, F.D.: Revisiting and Improving a Result on Integrity Preservation by Concurrent Transactions. In: Meersman, R., Dillon, T., Herrero, P. (eds.) OTM 2010 Workshops. LNCS, vol. 6428, pp. 297–306. Springer, Heidelberg (2010)Dung, P., Kowalski, R., Toni, F.: Dialectic Proof Procedures for Assumption-based Admissible Argumentation. Artificial Intelligence 170(2), 114–159 (2006)Ebbinghaus, H.-D., Flum, J.: Finite Model Theory, 2nd edn. Springer (2006)Embury, S., Brandt, S., Robinson, J., Sutherland, I., Bisby, F., Gray, A., Jones, A., White, R.: Adapting integrity enforcement techniques for data reconciliation. Information Systems 26, 657–689 (2001)Enderton, H.: A Mathematical Introduction to Logic, 2nd edn. Academic Press (2001)Eiter, T., Fink, M., Greco, G., Lembo, D.: Repair localization for query answering from inconsistent databases. ACM TODS 33(2), article 10 (2008)Furfaro, F., Greco, S., Molinaro, C.: A three-valued semantics for querying and repairing inconsistent databases. Ann. Math. Artif. Intell. 51(2-4), 167–193 (2007)Grant, J., Hunter, A.: Measuring the Good and the Bad in Inconsistent Information. In: Proc. 22nd IJCAI, pp. 2632–2637 (2011)Greco, G., Greco, S., Zumpano, E.: A logical framework for querying and repairing inconsistent databases. IEEE TKDE 15(6), 1389–1408 (2003)Guessoum, A., Lloyd, J.: Updating knowledge bases. New Generation Computing 8(1), 71–89 (1990)Guessoum, A., Lloyd, J.: Updating knowledge bases II. New Generation Computing 10(1), 73–100 (1991)Gupta, A., Sagiv, Y., Ullman, J., Widom, J.: Constraint checking with partial information. In: Proc. PODS 1994, pp. 45–55. ACM Press (1994)Hunter, A.: Measuring Inconsistency in Knowledge via Quasi-Classical Models. In: Proc. 18th AAAI &14th IAAI, pp. 68–73 (2002)Hunter, A., Konieczny, S.: Approaches to Measuring Inconsistent Information. In: Bertossi, L., Hunter, A., Schaub, T. (eds.) Inconsistency Tolerance. LNCS, vol. 3300, pp. 191–236. Springer, Heidelberg (2005)Hunter, A., Konieczny, S.: Measuring inconsistency through minimal inconsistent sets. In: Brewka, G., Lang, J. (eds.) Principles of Knowledge Representation and Reasoning (Proc. 11th KR), pp. 358–366. AAAI Press (2008)Hunter, A., Konieczny, S.: On the measure of conflicts: Shapley Inconsistency Values. Artificial Intelligence 174, 1007–1026 (2010)Kakas, A., Mancarella, P.: Database updates through abduction. In: Proc. 16th VLDB, pp. 650–661. Morgan Kaufmann (1990)Kakas, A., Kowalski, R., Toni, F.: The role of Abduction in Logic Programming. In: Gabbay, D., Hogger, C., Robinson, J.A. (eds.) Handbook of Logic in Artificial Intelligence and Logic Programming, vol. 5, pp. 235–324. Oxford University Press (1998)Lee, S.Y., Ling, T.W.: Further improvements on integrity constraint checking for stratifiable deductive databases. In: Proc. VLDB 1996, pp. 495–505. Morgan Kaufmann (1996)Lehrer, K.: Relevant Deduction and Minimally Inconsistent Sets. Journal of Philosophy 3(2,3), 153–165 (1973)Mu, K., Liu, W., Jin, Z., Bell, D.: A Syntax-based Approach to Measuring the Degree of Inconsistency for Belief Bases. J. Approx. Reasoning 52(7), 978–999 (2011)Lloyd, J., Sonenberg, L., Topor, R.: Integrity constraint checking in stratified databases. J. Logic Programming 4(4), 331–343 (1987)Lozinskii, E.: Resolving contradictions: A plausible semantics for inconsistent systems. J. Automated Reasoning 12(1), 1–31 (1994)Ma, Y., Qi, G., Hitzler, P.: Computing inconsistency measure based on paraconsistent semantics. J. Logic Computation 21(6), 1257–1281 (2011)Martinenghi, D., Christiansen, H.: Transaction Management with Integrity Checking. In: Andersen, K.V., Debenham, J., Wagner, R. (eds.) DEXA 2005. LNCS, vol. 3588, pp. 606–615. Springer, Heidelberg (2005)Martinenghi, D., Christiansen, H., Decker, H.: Integrity Checking and Maintenance in Relational and Deductive Databases and Beyond. In: Ma, Z. (ed.) Intelligent Databases: Technologies and Applications, pp. 238–285. IGI Global (2006)Martinez, M.V., Pugliese, A., Simari, G.I., Subrahmanian, V.S., Prade, H.: How Dirty Is Your Relational Database? An Axiomatic Approach. In: Mellouli, K. (ed.) ECSQARU 2007. LNCS (LNAI), vol. 4724, pp. 103–114. Springer, Heidelberg (2007)Meyer, J., Wieringa, R. (eds.): Deontic Logic in Computer Science. Wiley (1994)Nicolas, J.M.: Logic for improving integrity checking in relational data bases. Acta Informatica 18, 227–253 (1982)Plexousakis, D., Mylopoulos, J.: Accommodating Integrity Constraints During Database Design. In: Apers, P.M.G., Bouzeghoub, M., Gardarin, G. (eds.) EDBT 1996. LNCS, vol. 1057, pp. 495–513. Springer, Heidelberg (1996)Rahm, E., Do, H.: Data Cleaning: Problems and Current Approaches. Data Engineering Bulletin 23(4), 3–13 (2000)Sadri, F., Kowalski, R.: A theorem-proving approach to database integrity. In: Minker, J. (ed.) Foundations of Deductive Databases and Logic Programming, pp. 313–362. Morgan Kaufmann (1988)Thimm, M.: Measuring Inconsistency in Probabilistic Knowledge Bases. In: Proc. 25th UAI, pp. 530–537. AUAI Press (2009)Vardi, M.: On the integrity of databases with incomplete information. In: Proc. 5th PODS, pp. 252–266. ACM Press (1986)Wijsen, J.: Database repairing using updates. ACM Trans. Database Syst. 30(3), 722–768 (2005
Elevated Expression of Stromal Palladin Predicts Poor Clinical Outcome in Renal Cell Carcinoma
The role that stromal renal cell carcinoma (RCC) plays in support of tumor progression is unclear. Here we sought to determine the predictive value on patient survival of several markers of stromal activation and the feasibility of a fibroblast-derived extracellular matrix (ECM) based three-dimensional (3D) culture stemming from clinical specimens to recapitulate stromal behavior in vitro. The clinical relevance of selected stromal markers was assessed using a well annotated tumor microarray where stromal-marker levels of expression were evaluated and compared to patient outcomes. Also, an in vitro 3D system derived from fibroblasts harvested from patient matched normal kidney, primary RCC and metastatic tumors was employed to evaluate levels and localizations of known stromal markers such as the actin binding proteins palladin, alpha-smooth muscle actin (α-SMA), fibronectin and its spliced form EDA. Results suggested that RCCs exhibiting high levels of stromal palladin correlate with a poor prognosis, as demonstrated by overall survival time. Conversely, cases of RCCs where stroma presents low levels of palladin expression indicate increased survival times and, hence, better outcomes. Fibroblast-derived 3D cultures, which facilitate the categorization of stromal RCCs into discrete progressive stromal stages, also show increased levels of expression and stress fiber localization of α-SMA and palladin, as well as topographical organization of fibronectin and its splice variant EDA. These observations are concordant with expression levels of these markers in vivo. The study proposes that palladin constitutes a useful marker of poor prognosis in non-metastatic RCCs, while in vitro 3D cultures accurately represent the specific patient's tumor-associated stromal compartment. Our observations support the belief that stromal palladin assessments have clinical relevance thus validating the use of these 3D cultures to study both progressive RCC-associated stroma and stroma-dependent mechanisms affecting tumorigenesis. The clinical value of assessing RCC stromal activation merits further study
Efficient Targeting of Head and Neck Squamous Cell Carcinoma by Systemic Administration of a Dual uPA and MMP-Activated Engineered Anthrax Toxin
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Although considerable progress has been made in elucidating the etiology of the disease, the prognosis for individuals diagnosed with HNSCC remains poor, underscoring the need for development of additional treatment modalities. HNSCC is characterized by the upregulation of a large number of proteolytic enzymes, including urokinase plasminogen activator (uPA) and an assortment of matrix metalloproteinases (MMPs) that may be expressed by tumor cells, by tumor-supporting stromal cells or by both. Here we explored the use of an intercomplementing anthrax toxin that requires combined cell surface uPA and MMP activities for cellular intoxication and specifically targets the ERK/MAPK pathway for the treatment of HNSCC. We found that this toxin displayed strong systemic anti-tumor activity towards a variety of xenografted human HNSCC cell lines by inducing apoptotic and necrotic tumor cell death, and by impairing tumor cell proliferation and angiogenesis. Interestingly, the human HNSCC cell lines were insensitive to the intercomplementing toxin when cultured ex vivo, suggesting that either the toxin targets the tumor-supporting stromal cell compartment or that the tumor cell requirement for ERK/MAPK signaling differs in vivo and ex vivo. This intercomplementing toxin warrants further investigation as an anti-HNSCC agent
Tamoxifen induces pleiotrophic changes in mammary stroma resulting in extracellular matrix that suppresses transformed phenotypes
Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer
We thank the patients who participated in this study; Professor Gerry Thomas and the Imperial College Healthcare NHS Trust, Human Biomaterials Resource Centre (Tissue Bank); Professor Clare M Isacke (Institute of Cancer Research, London) for Endo180 antibodies; Dr Richard Harvey (Department of Medical Oncology, Imperial College Healthcare NHS Trust) for CA 15-3 antigen measurement. The Division of Cancer at Imperial College London, Imperial College Healthcare NHS Trust is an Experimental Cancer Medicine Centre (ECMC) supported by funds from Cancer Research UK and the Department of Health (C37/A7283) and forms part of Imperial Cancer Research UK Centre (C42671/A12196). CP is recipient of a CRUK Clinician Scientist award. JW is The Flow Foundation Professor of Oncology at Imperial College London. MPC and GK were supported by donations from Tony and Rita Gallagher and Imperial College NHS Healthcare Trust Special Trustees (to JW and JS). MPC was funded by The Rosetrees Trust (Grant JS16/M59; to JW and JS). A-VF was funded by Fundação para a Ciência e Tecnologia fellowship (project supervisor: JS) and Imperial College NHS Healthcare Special Trustees (to JW and JS). MR-T was funded by the Association of International Cancer Research (Grant 08-0803 to JS)
Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces
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