Translation and validation of the Fatigue Severity Scale, Pittsburgh Sleep Quality Index and Modified Health Assessment Questionnaire into the Maltese language, in a cohort of Maltese Systemic Lupus Erythematosus patients

PURPOSE: The assessment of fatigue, sleep quality and functional disability requires the use of validated instruments such as the Fatigue Severity Scale (FSS), the Pittsburgh Sleep Quality Index (PSQI) and the Modified Health Assessment Questionnaire (mHAQ) respectively. The aim of this study was to translate and validate these instruments into the Maltese Language. METHOD: Forward translation from the original English version into Maltese was carried out by two translators. The two versions were compiled to produce a preliminary initial Maltese translation. This was translated back into English by two other translators. This led to the development of the pre-final version of the Maltese translation, which was pilot-tested in 20 bilingual patients with systemic lupus erythematosus. RESULTS: Psychometric testing revealed good reliability of the Maltese translation of the three questionnaires. Cronbach’s alpha of the Maltese versions of the FSS, PSQI and mHAQ were 0.877, 0.859 and 0.897 respectively, showing good internal consistency. Validity of the Maltese version of the FSS was shown, since it had a significant positive correlation with visual analogue scale for fatigue (r=0.809, p<0.001). CONCLUSION: The Maltese translations were thus finalised, and could be used for clinical assessment or research purposes.peer-reviewe

Physics opportunities with future proton accelerators at CERN

We analyze the physics opportunities that would be made possible by upgrades of CERN's proton accelerator complex. These include the new physics possible with luminosity or energy upgrades of the LHC, options for a possible future neutrino complex at CERN, and opportunities in other physics including rare kaon decays, other fixed-target experiments, nuclear physics and antiproton physics, among other possibilities. We stress the importance of inputs from initial LHC running and planned neutrino experiments, and summarize the principal detector R&D issues.Comment: 39 page, word document, full resolution version available from http://cern.ch/pofpa/POFPA-arXive.pd

Using switching multiple models for the automatic detection of spindles

Sleep EEG data is characterised by various events that allow for the identification of the different sleep stages. Stage 2 in particular is characterised by two morphologically distinct waveforms, specifically spindles and K-complexes. Manual scoring of these events is time consuming and risks being subjectively interpreted; hence there is the need of robust automatic detection techniques. Various approaches have been adopted in the literature, ranging from period-amplitude analysis, to spectral analysis and autoregressive modelling. Most of the adopted techniques follow an episodic approach where the goal is to identify whether an epoch of EEG data contains an event, such as a spindle, or otherwise. The disadvantage of this approach is that it requires the data to be segmented into epochs, risking that an event falls at an epoch boundary, and it has low temporal resolution. This work proposes the use of an autoregressive switching multiple model for the automatic segmentation and labelling of Stage 2 sleep EEG data characterised by spindles and K-complexes. When this modelling technique was used to identify spindles from background EEG, quantitative results based on a sample by sample basis gave a sensitivity score between 72.39% to 87.51%, depending to which scorer performance was compared. This score corresponds to a specificity that ranges between 78.89% and 90.55% and which increases to a range between 75.52% and 94.64% when performance is measured on an event basis instead [1]. This performance compares well with other spindle detection techniques published in the literature [2,3]. The advantage of the proposed technique is that it allows for the continuous segmentation of EEG data, it offers a unified framework to detect multiple events with little training data, and it can also be extended to a semi-supervised approach. The latter, which has also been applied to Stage 2 sleep EEG data, can identify new states in real time, providing a solution that not only replaces the time consuming manual scoring process but it may also provide the clinician with new insights on the data that is being analysed.peer-reviewe

Methylation status of the Runx2 p2 promoter in a family with ectopic maxillary canines

Genetic factors contribute to the aetiology of the ectopic canine (EC) (OMIM 189490), the inheritance pattern being autosomal dominant with variable expression and incomplete penetrance. However there is also evidence for an epigenetic component. The Runx2 gene is intimately involved in the mechanism of tooth eruption. It controls differentiation and maturation of osteoblasts and is expressed in the dental follicle and alveolar bone at all stages of development [2,3]. Mutations of this gene result in delayed and ectopic eruption of teeth. There is a large CpG island spanning its proximal promoter, first exon and part of the first intron. Similarities between the inheritance patterns of EC and other methylation disorders raises the hypothesis that differential methylation of the Runx2 promoter may contribute to EC. This study investigates the methylation status of the Runx2 P2 promoter in ectopic canine subjects and unaffected controls. There was no evidence of differential methylation between the groups.peer-reviewe

“They labeled me ignorant” : narratives of Maltese youth with dyslexia on national examinations

Examinations have a significant impact on well-being as they provide qualifications for entry into further education and employment. Research suggests that students with dyslexia experience greater challenges than their counterparts. This article explored the views of eight students with dyslexia, the challenges they face, and what they believe could make national examinations “fairer.” The Maltese educational system has a Secondary Education Certificate (SEC) at the end of compulsory education (16 years) and Matriculation (MATSEC) for postsecondary schooling (18 years). Narrative interviews and a thematic approach using discourse analysis presented participants’ voices in prose and strophes. Narratives evidence difficulties and abilities. Students criticized the unnecessary examination stress and anxiety caused by misunderstanding and lack of knowledge about dyslexia. Youth referred to “fairness” of examinations, which they equated with “sameness.” They believe that examinations could be fairer by being given compensatory measures without compromising the examinations’ objectives.peer-reviewe

Teacher education matters : transforming lives…Transforming schools

This study narrates the views of six students with a profile of dyslexia regarding examinations. Following current trends in educational research, the study tried to give voice to the students themselves. In-depth interviews were carried out to find out what the students thought about examinations, the challenges they faced and how they thought examinations could be made Jairer.' Results reported in this chapter suggest that dyslexic students experience real challenges when sitting for examinations due to their dyslexic profile; the time constraints of examinations and the stress and anxiety caused by their perceived inability to achieve at par with their peers. The students believed that these challenges hindered their performance in examinations. At the same time they hoped for a 'fairer' examinations system based on their involvement in the decision-making process that took into consideration their individual needs and we/I-being.peer-reviewe

The nonlinear electromigration of analytes into confined spaces

We consider the problem of electromigration of a sample ion (analyte) within a uniform background electrolyte when the confining channel undergoes a sudden contraction. One example of such a situation arises in microfluidics in the electrokinetic injection of the analyte into a micro-capillary from a reservoir of much larger size. Here the sample concentration propagates as a wave driven by the electric field. The dynamics is governed by the Nerst-Planck-Poisson system of equations for ionic transport.A reduced one dimensional nonlinear equation describing the evolution of the sample concentration is derived.We integrate this equation numerically to obtain the evolution of the wave shape and determine how the the injected mass depends on the sample concentration in the reservoir.It is shown that due to the nonlinear coupling of the ionic concentrations and the electric field, the concentration of the injected sample could be substantially less than the concentration of the sample in the reservoir.Comment: 14 pages, 5 Figures, 1 Appendi

English reading comprehension assessment in Malta : an evaluation of the use of the Neale analysis of reading ability

English literacy assessments in Malta are mainly based on tests standardised among English speaking populations. Such practice raises questions as to its suitability within the Maltese bilingual context. This study explores the implications of such practice by evaluating the performance of Maltese students on a widely used test, namely the Neale Analysis of Reading Comprehension – Revised (NARA II). The test was individually administered to a total of 224 students, representing developmental processes through three age-groups between 7-14 years, and two different home language backgrounds also reflected in two different types of school, State and Independent. Analysis of variance and correlations were used to highlight differences between the scores of the three age-groups and the two types of school and home background. The results indicate that comprehension levels improved sequentially with age; however, the norms derived from a monolingual English population do not represent appropriately the varying bilingual contexts of Maltese students. Moreover, particular discrepancies in the participants’ scores on the three subscales of the test – namely Reading Comprehension, Reading Accuracy and Reading Rate raise questions about the profile of competencies in English reading comprehension that are being acquired by Maltese students.peer-reviewe

Developmental variation in predictors of reading comprehension amongst Maltese students

This study examined cognitive and language skills that are predictive of reading comprehension in Maltese in typically developing students of different ages. A structured random sample of three different grade groups of Maltese state school students, aged between 9 and 12 years participated in this study. This sample was representative of the population. They were administered a Maltese Reading Comprehension test together with three word-level tests (Non-Word Reading, Digit Span, and Rapid Naming), and three understanding-level tests (Jumbled Sentences, Listening Comprehension, and Ravens Progressive Matrices). Statistical analyses indicated that Reading Comprehension scores were primarily related to scores on listening comprehension and syntactic awareness (Jumbled Sentences). However, the youngest students showed greater influence of word-level processes on reading comprehension in contrast to their older peers.peer-reviewe

The role of memory in distinguishing risky decisions from experience and description

People’s risk preferences differ for choices based on described probabilities versus those based on information learned through experience. For decisions from description, people are typically more risk averse for gains than for losses. In contrast, for decisions from experience, people are sometimes more risk seeking for gains than losses, especially for choices with the possibility of extreme outcomes (big wins or big losses), which are systematically overweighed in memory. Using a within-subject design, this study evaluated whether this memory bias plays a role in the differences in risky choice between description and experience. As in previous studies, people were more risk seeking for losses than for gains in description but showed the opposite pattern in experience. People also more readily remembered the extreme outcomes and judged them as having occurred more frequently. These memory biases correlated with risk preferences in decisions from experience but not in decisions from description. These results suggest that systematic memory biases may be responsible for some of the differences in risk preference across description and experience