The SHARC framework:utilizing personal dropbox accounts to provide a scalable solution to the storage and sharing of community generated locative media

The emergence of personal cloud storage services provides a new paradigm for storing and sharing data. In this paper we present the design of the SHARC framework and in particular focus on the utilization of personal Dropbox accounts to provide a scalable solution to the storage and sharing of community generated locative media relating to a community's Cultural Heritage. In addition to scalability issues, the utilization of personal Dropbox storage also supports 'sense of ownership' (relating to community media) which has arisen as an important requirement during our on-going 'research-in-the-wild' working with the rural village community of Wray and involving public display deployments to support the display and sharing of community photos and stories. While the framework presented here is currently being tested with a particular place-based community (Wray), it has been designed to provide a general solution that should support other place-based communities

New WHO Violence Prevention Information System, an interactive knowledge platform of scientific findings on violence.

Scientific information on violence can be difficult to compile and understand. It is scattered across websites, databases, technical reports and academic journals, and rarely addresses all types of violence. In response, in October 2017 WHO released the Violence Prevention Information System or Violence Info, an online interactive collection of scientific information about the prevalence, consequences, risk factors and preventability of all forms of interpersonal violence. It covers homicide, child maltreatment, youth violence, intimate partner violence, elder abuse and sexual violence

Noncoding RNAs and Duchenne muscular dystrophy

Noncoding RNAs (ncRNAs) such as miRNAs and long noncoding RNAs modulate gene transcription in response to environmental stressors and other stimuli. A role for ncRNAs in muscle pathologies has been demonstrated and further evidence suggests that ncRNAs also play a role in Duchenne muscular dystrophy (DMD). Studies investigating the differential expression of miRNAs in biological fluids between DMD patients and models of dystrophin deficiency (the MDX mouse model, canine models of DMD) and controls have been published, as these have a role in fibrosis. Long noncoding RNAs are differentially expressed in DMD patients and may, in part, have a mechanism of action via targeting of miRNAs. Although many of these recent findings need to be confirmed, ncRNAs may prove to be useful as potential biomarkers of disease. However, their use as therapeutic targets in DMD remains unclear

Flight range, fuel load and the impact of climate change on the journeys of migrant birds

Collection of biometric data was supported by the Natural Environment Research Council (NE/I028068/1) to JAT and the USUK Fulbright Commission and the Oxford Clarendon Fund to C.S. This research was funded by a Durham University Seedcorn grant to SGW. Production of the underlying SDMs was funded by a National Environment Research Council training grant (NE/J500215/1).Climate change is predicted to increase migration distances for many migratory species, but the physiological and temporal implications of longer migratory journeys have not been explored. Here, we combine information about species' flight range potential and migratory refuelling requirements to simulate the number of stopovers required and the duration of current migratory journeys for 77 bird species breeding in Europe. Using tracking data, we show that our estimates accord with recorded journey times and stopovers for most species. We then combine projections of altered migratory distances under climate change with models of avian flight to predict future migratory journeys. We find that 37% of migratory journeys undertaken by long-distance migrants will necessitate an additional stopover in future. These greater distances and the increased number of stops will substantially increase overall journey durations of many long-distance migratory species, a factor not currently considered in climate impact studies.Publisher PDFPeer reviewe

Violence Info methodology

The Violence Prevention Information System (Violence Info) aims to improve access to scientific information about all types of interpersonal violence, including findings on prevalence rates, risk factors, consequences, and prevention and response strategies, through creating a data repository and displaying the information in a user-friendly format on a website. This document details the methodology used to develop the Violence Info data repository and website

Did hybridization save the Norfolk Island boobook owl Ninox novaeseelandiae undulata?

The population of the Norfolk Island boobook owl Ninox novaeseelandiae undulata, a nocturnal bird restricted to the Australian territory of Norfolk Island, was reduced to a single female in 1986. Deliberate introduction of two males of its nearest relative, the New Zealand boobook N. n. novaeseelandiae, as a conservation intervention has allowed the taxon to persist on Norfolk Island, albeit in hybrid form. Although declared Extinct in 2000, a re-examination of this unique situation has concluded there is a strong argument that the taxon should be categorized as Critically Endangered because, on average, approximately half the nuclear genome of the original taxon and all the mitochondrial DNA is conserved in all living owls on the island. This thus represents a special case in which the taxon can be considered to be extant, in hybrid form, even though no pure-bred individuals survive. More generally, we suggest that, in exceptional cases, hybridization may not be a threat to highly threatened species and that guidelines are needed to determine when to consider hybrid populations as extant forms of the original taxon, and when to declare extinction through hybridization

Employment mobility in high-technology agglomerations: the cases of Oxfordshire and Cambridgeshire

This paper examines labour market behaviour of the highly skilled in high-tech local economies, taking the UK examples of Oxfordshire and Cambridgeshire as case studies. It reports on data from a survey of members of three scientific institutes to compare rates of employee mobility in the two locations and considers the likely explanations and implications of those patterns

The impact of adverse childhood experiences on health service use across the life course using a retrospective cohort study

Objectives: The lifelong health impacts of adverse childhood experiences are increasingly being identified, including earlier and more frequent development of non-communicable disease. Our aim was to examine whether adverse childhood experiences are related to increased use of primary, emergency and in-patient care and at what ages such impact is apparent. Methods: Household surveys were undertaken in 2015 with 7414 adults resident in Wales and England using random probability stratified sampling (age range 18–69 years). Nine adverse childhood experiences (covering childhood abuse and household stressors) and three types of health care use in the last 12 months were assessed: number of general practice (GP) visits, emergency department (ED) attendances and nights spent in hospital. Results: Levels of use increased with increasing numbers of adverse childhood experiences experienced. Compared to those with no adverse childhood experiences, odds ( 95% CIs) of frequent GP use ( 6 visits), any ED attendance or any overnight hospital stay were 2.34 (1.88–2.92), 2.32 (1.90–2.83) and 2.67 (2.06–3.47) in those with 4 adverse childhood experiences. Differences were independent of socio-economic measures of deprivation and other demographics. Higher health care use in those with 4 adverse childhood experiences (compared with no adverse childhood experiences) was evident at 18–29 years of age and continued through to 50–59 years. Demographically adjusted means for ED attendance rose from 12.2% of 18-29 year olds with no adverse childhood experiences to 28.8% of those with 4 adverse childhood experiences. At 60–69 years, only overnight hospital stay was significant (9.8% vs. 25.0%). Conclusions: Along with the acute impacts of adverse childhood experiences on child health, a life course perspective provides a compelling case for investing in safe and nurturing childhoods. Disproportionate health expenditure in later life might be reduced through childhood interventions to prevent adverse childhood experiences

James A. Butchart to Dr. Silver, 28 November 1960

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