Map-aided navigation for emergency searches

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this recordReal-time positioning of emergency personnel has been an active research topic for many years. However, studies on how to improve navigation accuracy by using prior information on the idiosyncratic motion characteristics of firefighters are scarce. This paper presents an algorithm for generating pseudo observations of position and orientation based on standard search patterns used by firefighters. The iterative closest point algorithm is used to compare walking trajectories estimated from inertial odometry with search patterns generated from digital maps. The resulting fitting errors are then used to integrate the pseudo observations into a map-aided navigation filter. Specifically, we present a sequential Monte Carlo solution where the pattern comparison is used to both update particle weights and create new particle samples. Experimental results involving professional firefighters demonstrate that the proposed pseudo observations can achieve a stable localization error of about one meter, and offer increased robustness in the presence of map errors

N-tert-Butanesulfinyl imines in the asymmetric synthesis of nitrogen-containing heterocycles

The synthesis of nitrogen-containing heterocycles, including natural alkaloids and other compounds presenting different types of biological activities have proved to be successful employing chiral sulfinyl imines derived from tert-butanesulfinamide. These imines are versatile chiral auxiliaries and have been extensively used as eletrophiles in a wide range of reactions. The electron-withdrawing sulfinyl group facilitates the nucleophilic addition of organometallic compounds to the iminic carbon with high diastereoisomeric excess and the free amines obtained after an easy removal of the tert-butanesulfinyl group can be transformed into enantioenriched nitrogen-containing heterocycles. The goal of this review is to the highlight enantioselective syntheses of heterocycles involving the use of chiral N-tert-butanesulfinyl imines as reaction intermediates, including the synthesis of several natural products. The synthesis of nitrogen-containing heterocycles in which the nitrogen atom is not provided by the chiral imine will not be considered in this review. The sections are organized according to the size of the heterocycles. The present work will comprehensively cover the most pertinent contributions to this research area from 2012 to 2020. We regret in advance that some contributions are excluded in order to maintain a concise format.We thank the continuous financial support from the Spanish Ministerio de Economía y Competitividad (MINECO; project CTQ2014-53695-P, CTQ2014-51912-REDC, CTQ2016-81797-REDC, CTQ2017-85093-P), Ministerio de Ciencia, Innovación y Universidades (RED2018-102387-T, PID2019-107268GB-100), FEDER, the Generalitat Valenciana (PROMETEOII/2014/017), and the University of Alicante (VIGROB-068). We are also grateful for the financial support from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Discrete-time quantum walk dispersion control through long-range correlations

We investigate the evolution dynamics of inhomogeneous discrete-time one-dimensional quantum walks displaying long-range correlations in both space and time. The associated quantum coin operators are built to exhibit a random inhomogeneity distribution of long-range correlations embedded in the time evolution protocol through a fractional Brownian motion with spectrum following a power-law behavior, $S(k)\sim 1/k^{\nu}$. The power-law correlated disorder encoded in the phases of the quantum coin is shown to give rise to a wide variety of spreading patterns of the qubit states, from localized to subdiffusive, diffusive, and superdiffusive (including ballistic) behavior, depending on the relative strength of the parameters driving the correlation degree. Dispersion control is then possible in one-dimensional discrete-time quantum walks by suitably tunning the long-range correlation properties assigned to the inhomogeneous quantum coin operator

Discretização de modelos hidrológicos de grande escala: grade regular x mini-bacias.

O emprego de modelos hidrológicos distribuídos (MHD) de grande escala para diversos propósitos é tema de pesquisa bastante relevante atualmente, principalmente para avaliação de impactos potenciais de cenários de variabilidade climática ou de mudança de uso da terra sobre os recursos hídricos. A etapa inicial da aplicação de MHD é a subdivisão ou discretização da bacia em elementos menores e o estabelecimento da rede de drenagem que os conecta. Devido à falta de conhecimento e às facilidades propiciadas por ferramentas automáticas, aspectos importantes dessa etapa são muitas vezes negligenciados pelos usuários. Este artigo discute os principais métodos de discretização, com foco principal na grade regular e mini-bacias. Tomando a bacia do rio Ji-Paraná (RO) como estudo de caso, são apresentadas vantagens e limitações de cada método. Os resultados evidenciaram que, enquanto o uso de grade regular uniformiza o tamanho dos elementos, a dificuldade em definir as direções de fluxo e os trechos de rio para propagação do escoamento permanece como principal desvantagem, a despeito de metodologias propostas mais recentemente. A abordagem em mini-bacias supera tais limitações, mas causa o inconveniente de ter que lidar com enorme variação de área superficial e comprimentos de trecho de rio entre os elementos

Exploring alternative symmetry breaking mechanisms at the LHC with 7, 8 and 10 TeV total energy

In view of the annnouncement that in 2012 the LHC will run at 8 TeV, we study the possibility of detecting signals of alternative mechanisms of ElectroWeak Symmetry Breaking, described phenomenologically by unitarized models, at energies lower than 14 TeV. A complete calculation with six fermions in the final state is performed using the PHANTOM event generator. Our results indicate that at 8 TeV some of the scenarios with TeV scale resonances are likely to be identified while models with no resonances or with very heavy ones will be inaccessible, unless the available luminosity will be much higher than expected

Enantioselective Synthesis, DFT Calculations, and Preliminary Antineoplastic Activity of Dibenzo 1-Azaspiro[4.5]decanes on Drug-Resistant Leukemias

The addition of 2-bromobenzylmagnesium bromide to chiral N-tert-butanesulfinyl imines derived from tetralone-type ketones proceeds with high levels of diastereocontrol. The resulting sulfinamide derivatives were transformed into dibenzoazaspiro compounds after a palladium-catalyzed intramolecular N-arylation. DFT calculations have been performed to rationalize the stereochemical course of the reaction. Similar results have been obtained considering either diethyl ether or toluene as a solvent, in both cases in an excellent agreement with experimental findings. NCI topological calculations have also been used to evidence crucial noncovalent interactions. In addition, the azaspiro compounds reduced the viability of chronic myeloid leukemia cells in the micromolar range. Notably, both the halogen-substituted (R)- and (S)-8g and -8h as well as (R)-8j were at least two times more effective on a multidrug-resistant derivative than on the parental cell line, exerting a collateral sensitivity effect.We acknowledge the continued financial support from the Spanish Ministerio de Economía y Competitividad (MINECO; project CTQ2014-53695-P, CTQ2014-51912-REDC, CTQ2016-81797-REDC, CTQ2016-76155-R, CTQ2017-85093-P), FEDER, the Generalitat Valenciana (PROMETEOII/2014/017), and the University of Alicante. We thankfully acknowledge the resources from the supercomputers “Memento” and “Cierzo” and technical expertise and assistance provided by BIFI-ZCAM (Universidad de Zaragoza, Spain). We also thank Prof. Vivian M. Rumjanek for providing FEPS cells and Prof. Adriano D. Andricopulo for the preliminary cytotoxicity screening. This study was also financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001