Is Quantum Gravity a Chern-Simons Theory?

We propose a model of quantum gravity in arbitrary dimensions defined in terms of the BV quantization of a supersymmetric, infinite dimensional matrix model. This gives an (AKSZ-type) Chern-Simons theory with gauge algebra the space of observables of a quantum mechanical Hilbert space H. The model is motivated by previous attempts to formulate gravity in terms of non-commutative, phase space, field theories as well as the Fefferman-Graham curved analog of Dirac spaces for conformally invariant wave equations. The field equations are flat connection conditions amounting to zero curvature and parallel conditions on operators acting on H. This matrix-type model may give a better defined setting for a quantum gravity path integral. We demonstrate that its underlying physics is a summation over Hamiltonians labeled by a conformal class of metrics and thus a sum over causal structures. This gives in turn a model summing over fluctuating metrics plus a tower of additional modes-we speculate that these could yield improved UV behavior.Comment: 22 pages, LaTeX, 3 figures, references added, version to appear in PR

Quantum Gravity and Causal Structures: Second Quantization of Conformal Dirac Algebras

It is postulated that quantum gravity is a sum over causal structures coupled to matter via scale evolution. Quantized causal structures can be described by studying simple matrix models where matrices are replaced by an algebra of quantum mechanical observables. In particular, previous studies constructed quantum gravity models by quantizing the moduli of Laplace, weight and defining-function operators on Fefferman-Graham ambient spaces. The algebra of these operators underlies conformal geometries. We extend those results to include fermions by taking an osp(1|2) "Dirac square root" of these algebras. The theory is a simple, Grassmann, two-matrix model. Its quantum action is a Chern-Simons theory whose differential is a first-quantized, quantum mechanical BRST operator. The theory is a basic ingredient for building fundamental theories of physical observables.Comment: 4 pages, LaTe

On Braggarts and Gossips: Why Consumers Generate Positive but Transmit Negative Word-of-Mouth

Past research has presented conflicting evidence as to whether consumers are more likely to share positive or negative word-of-mouth. We offer a novel theoretical perspective to reconcile this conflict by comparing the generation of word-of-mouth (i.e., consumers sharing information about their own experiences) to the transmission of word-of-mouth (i.e., consumers passing-on information about experiences they heard occurred to others). We suggest that the self-enhancement motive leads consumers to generate positive word-of-mouth, but also to transmit negative word-of-mouth. Evidence for self-enhancement motives playing out in a unique fashion at word-of-mouth generation and transmission is presented across a series of four experiments

Worldline approach to noncommutative field theory

The study of the heat-trace expansion in noncommutative field theory has shown the existence of Moyal nonlocal Seeley-DeWitt coefficients which are related to the UV/IR mixing and manifest, in some cases, the non-renormalizability of the theory. We show that these models can be studied in a worldline approach implemented in phase space and arrive to a master formula for the $n$-point contribution to the heat-trace expansion. This formulation could be useful in understanding some open problems in this area, as the heat-trace expansion for the noncommutative torus or the introduction of renormalizing terms in the action, as well as for generalizations to other nonlocal operators.Comment: 19 pages, version

U(N|M) quantum mechanics on Kaehler manifolds

We study the extended supersymmetric quantum mechanics, with supercharges transforming in the fundamental representation of U(N|M), as realized in certain one-dimensional nonlinear sigma models with Kaehler manifolds as target space. We discuss the symmetry algebra characterizing these models and, using operatorial methods, compute the heat kernel in the limit of short propagation time. These models are relevant for studying the quantum properties of a certain class of higher spin field equations in first quantization.Comment: 21 pages, a reference adde

Gravity, Two Times, Tractors, Weyl Invariance and Six Dimensional Quantum Mechanics

Fefferman and Graham showed some time ago that four dimensional conformal geometries could be analyzed in terms of six dimensional, ambient, Riemannian geometries admitting a closed homothety. Recently it was shown how conformal geometry provides a description of physics manifestly invariant under local choices of unit systems. Strikingly, Einstein's equations are then equivalent to the existence of a parallel scale tractor (a six component vector subject to a certain first order covariant constancy condition at every point in four dimensional spacetime). These results suggest a six dimensional description of four dimensional physics, a viewpoint promulgated by the two times physics program of Bars. The Fefferman--Graham construction relies on a triplet of operators corresponding, respectively to a curved six dimensional light cone, the dilation generator and the Laplacian. These form an sp(2) algebra which Bars employs as a first class algebra of constraints in a six-dimensional gauge theory. In this article four dimensional gravity is recast in terms of six dimensional quantum mechanics by melding the two times and tractor approaches. This "parent" formulation of gravity is built from an infinite set of six dimensional fields. Successively integrating out these fields yields various novel descriptions of gravity including a new four dimensional one built from a scalar doublet, a tractor vector multiplet and a conformal class of metrics.Comment: 27 pages, LaTe

Local Unit Invariance, Back-Reacting Tractors and the Cosmological Constant Problem

When physics is expressed in a way that is independent of local choices of unit systems, Riemannian geometry is replaced by conformal geometry. Moreover masses become geometric, appearing as Weyl weights of tractors (conformal multiplets of fields necessary to keep local unit invariance manifest). The relationship between these weights and masses is through the scalar curvature. As a consequence mass terms are spacetime dependent for off-shell gravitational backgrounds, but happily constant for physical, Einstein manifolds. Unfortunately this introduces a naturalness problem because the scalar curvature is proportional to the cosmological constant. By writing down tractor stress tensors (multiplets built from the standard stress tensor and its first and second derivatives), we show how back-reaction solves this naturalness problem. We also show that classical back-reaction generates an interesting potential for scalar fields. We speculate that a proper description of how physical systems couple to scale, could improve our understanding of naturalness problems caused by the disparity between the particle physics and observed, cosmological constants. We further give some ideas how an ambient description of tractor calculus could lead to a Ricci-flat/CFT correspondence which generalizes the AdS side of Maldacena's duality to a Ricci-flat space of one higher dimension.Comment: 20 pages, 2 figure

Galileons as Wess-Zumino Terms

We show that the galileons can be thought of as Wess-Zumino terms for the spontaneous breaking of space-time symmetries. Wess-Zumino terms are terms which are not captured by the coset construction for phenomenological Lagrangians with broken symmetries. Rather they are, in d space-time dimensions, d-form potentials for (d+1)-forms which are non-trivial co-cycles in Lie algebra cohomology of the full symmetry group relative to the unbroken symmetry group. We introduce the galileon algebras and construct the non-trivial (d+1)-form co-cycles, showing that the presence of galileons and multi-galileons in all dimensions is counted by the dimensions of particular Lie algebra cohomology groups. We also discuss the DBI and conformal galileons from this point of view, showing that they are not Wess-Zumino terms, with one exception in each case.Comment: 49 pages. v2 minor changes, version appearing in JHE

First order parent formulation for generic gauge field theories

We show how a generic gauge field theory described by a BRST differential can systematically be reformulated as a first order parent system whose spacetime part is determined by the de Rham differential. In the spirit of Vasiliev's unfolded approach, this is done by extending the original space of fields so as to include their derivatives as new independent fields together with associated form fields. Through the inclusion of the antifield dependent part of the BRST differential, the parent formulation can be used both for on and off-shell formulations. For diffeomorphism invariant models, the parent formulation can be reformulated as an AKSZ-type sigma model. Several examples, such as the relativistic particle, parametrized theories, Yang-Mills theory, general relativity and the two dimensional sigma model are worked out in details.Comment: 36 pages, additional sections and minor correction

Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative

Background: The European NCI compounds programme, a joint initiative of the EORTC Research Branch, Cancer Research Campaign and the US National Cancer Institute, was initiated in 1993. The objective was to help the NCI in reducing the backlog of in vivo testing of potential anticancer compounds, synthesised in Europe that emerged from the NCI in vitro 60-cell screen. Methods: Over a period of more than twenty years the EORTC—Cancer Research Campaign panel reviewed ~2000 compounds of which 95 were selected for further evaluation. Selected compounds were stepwise developed with clear go/no go decision points using a pharmacologically directed programme. Results: This approach eliminated quickly compounds with unsuitable pharmacological properties. A few compounds went into Phase I clinical evaluation. The lessons learned and many of the principles outlined in the paper can easily be applied to current and future drug discovery and development programmes. Conclusions: Changes in the review panel, restrictions regarding numbers and types of compounds tested in the NCI in vitro screen and the appearance of targeted agents led to the discontinuation of the European NCI programme in 2017 and its transformation into an academic platform of excellence for anticancer drug discovery and development within the EORTC-PAMM group. This group remains open for advice and collaboration with interested parties in the field of cancer pharmacology