927 research outputs found
Cyclooxygenase-2 expression inhibits trophic withdrawal apoptosis in nerve growth factor-differentiated PC12 cells
A multi-detector array for high energy nuclear e+e- pair spectrosocopy
A multi-detector array has been constructed for the simultaneous measurement
of energy- and angular correlation of electron-positron pairs produced in
internal pair conversion (IPC) of nuclear transitions up to 18 MeV. The
response functions of the individual detectors have been measured with
mono-energetic beams of electrons. Experimental results obtained with 1.6 MeV
protons on targets containing B and F show clear IPC over a wide
angular range. A comparison with GEANT simulations demonstrates that angular
correlations of pairs of transitions in the energy range between 6 and
18 MeV can be determined with sufficient resolution and efficiency to search
for deviations from IPC due to the creation and subsequent decay into
of a hypothetical short-lived neutral boson.Comment: 20 pages, 8 figure
Influence of damping on the excitation of the double giant resonance
We study the effect of the spreading widths on the excitation probabilities
of the double giant dipole resonance. We solve the coupled-channels equations
for the excitation of the giant dipole resonance and the double giant dipole
resonance. Taking Pb+Pb collisions as example, we study the resulting effect on
the excitation amplitudes, and cross sections as a function of the width of the
states and of the bombarding energy.Comment: 8 pages, 3 figures, corrected typo
The HADES Tracking System
The tracking system of the dielectron spectrometer HADES at GSI Darmstadt is
formed out of 24 low-mass, trapezoidal multi-layer drift chambers providing in
total about 30 square meter of active area. Low multiple scattering in the in
total four planes of drift chambers before and after the magnetic field is
ensured by using helium-based gas mixtures and aluminum cathode and field
wires. First in-beam performance results are contrasted with expectations from
simulations. Emphasis is placed on the energy loss information, exploring its
relevance regarding track recognition.Comment: 6 pages, 4 figures, presented at the 10th Vienna Conference on
Instrumentation, Vienna, February 2004, to be published in NIM A (special
issue
On the two first excited K=0 bands in U-238 and Pu-240
EO-enhanced spectra of conversion electrons taken after (alpha,alpha) and (alpha,2n) reactions and after projectile Coulomb excitation improve our knowledge about first and second excited bands in U-238 and Pu-240 built on O-2(+) and O-3(+) states which lie anomalously close together. The two bands are of different structure.</p
Applications of Nanopore sequencing in precision cancer medicine
Oxford Nanopore Technologies sequencing, also referred to as Nanopore sequencing, stands at the forefront of a revolution in clinical genetics, offering the potential for rapid, long read, and real‐time DNA and RNA sequencing. This technology is currently making sequencing more accessible and affordable. In this comprehensive review, we explore its potential regarding precision cancer diagnostics and treatment. We encompass a critical analysis of clinical cases where Nanopore sequencing was successfully applied to identify point mutations, splice variants, gene fusions, epigenetic modifications, non‐coding RNAs, and other pivotal biomarkers that defined subsequent treatment strategies. Additionally, we address the challenges of clinical applications of Nanopore sequencing and discuss the current efforts to overcome them
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