The Other January Effect: International Evidence

This paper investigates the predictive power of stock market returns in January for the subsequent eleven months' returns across 19 countries, thereby contributing to the literature on stock market seasonalities. Only two out of 19 countries' stock markets exhibit a robust Other January Eect. In light of this evidence, we conclude that the Other January Eect is not an international phenomenon.Stock market efciency, Other January Efect, Stock market anomalies

Do Individual Index Futures Investors Destabilize the Underlying Spot Market?

This paper investigates the impact of introducing index futures trading on the volatility of the underlying stock market. We exploit a unique institutional setting in which presumably uninformed individuals are the dominant trader type in the futures markets. This enables us to investigate the destabilization hypothesis more accurately than previous studies do and to provide evidence for or against the in uence of individuals trading in index futures on spot market volatility. To overcome econometric shortcomings of the existing literature we employ a Markov-switching-GARCH approach to endogenously identify distinct volatility regimes. Our empirical evidence for Poland surprisingly suggests that the introduction of index futures trading does not destabilize the spot market. This nding is robust across 3 stock market indices and is corroborated by further analysis of a control group.Individual Investors, Uninformed Trading, Stock Index Futures, Emerging Capital Markets, Stock Market Volatility, Markov-Switching-GARCH Model

ENVISIONING CATHOLICISM: POPULAR PRACTICE OF A TRADITIONAL FAITH IN THE POST-WWII US

Marian apparitions in the United States have occurred in ever-increasing numbers since World War Two, particularly in the 1980s and 1990s. These apparitions occupy a unique space in religious life, as they provide opportunities for Catholics to practice their faith outside of the Church hierarchy while still maintaining their status as faithful Catholics, often placing women in prominent positions. Although apparitions are an important part of faith for thousands of American Catholics, most Americans and Catholics are unaware of how widespread this movement is. This dissertation takes a comparative approach to examine a selection of apparition events, illuminating the pilgrimage experience in connection to historic events, such as the Cold War and Vatican II, as well as issues of race, gender, class, and consumerism. Chapter One focuses on the apparition events at Necedah, Wisconsin which began in 1949 and continued until the visionary’s death in 1984. Chapter Two offers an explanation of Vatican II, the Roman Catholic Church council in the 1960s that changed the way Catholics worshiped, but also the relationship between members and Church authorities, and the way many Catholics perceived their identity. Chapter Three addresses apparition events at a variety of sites in Ohio and Kentucky through most of the pertinent time period, with a particular emphasis on the pilgrimage experience and parachurch organizations. Chapter Four discusses apparition events at Conyers, Georgia in the 1980s and 1990s, especially the economic effects that resulted. Chapter Five examines apparition events in Phoenix and Scottsdale, Arizona, and Emmitsburg, Maryland, which demonstrate the appeal of these events across race and class. In addition to secondary sources by historians, religious scholars, anthropologists, and sociologists, the dissertation uses newspaper accounts, publications by visionaries and their associated organizations, diocesan archival material, and interviews conducted by the author with religious leaders, believers, journalists, city officials, and neighbors to explore how apparition events have attracted thousands of believers despite the lack of official approval by the Roman Catholic Church and how the areas where these events take place have been affected

Converging Perturbative Solutions of the Schroedinger Equation for a Two-Level System with a Hamiltonian Depending Periodically on Time

We study the Schroedinger equation of a class of two-level systems under the action of a periodic time-dependent external field in the situation where the energy difference 2epsilon between the free energy levels is sufficiently small with respect to the strength of the external interaction. Under suitable conditions we show that this equation has a solution in terms of converging power series expansions in epsilon. In contrast to other expansion methods, like in the Dyson expansion, the method we present is not plagued by the presence of ``secular terms''. Due to this feature we were able to prove absolute and uniform convergence of the Fourier series involved in the computation of the wave functions and to prove absolute convergence of the epsilon-expansions leading to the ``secular frequency'' and to the coefficients of the Fourier expansion of the wave function

Self‐guided clinical cases for medical students based on postmortem CT scans of cadavers

In the summer of 2009, we began full body computed tomography (CT) scanning of the pre‐embalmed cadavers in the University of Michigan Medical School (UMMS) dissection lab. We theorized that implementing web‐based, self‐guided clinical cases based on postmortem CT (PMCT) scans would result in increased student appreciation for the clinical relevance of anatomy, increased knowledge of cross‐sectional anatomy, and increased ability to identify common pathologies on CT scans. The PMCT scan of each cadaver was produced as a DICOM dataset, and then converted into a Quicktime movie file using Osirix software. Clinical cases were researched and written by the authors, and consist of at least one Quicktime movie of a PMCT scan surrounded by a novel navigation interface. To assess the value of these clinical cases we surveyed medical students at UMMS who are currently using the clinical cases in their coursework. Students felt the clinical cases increased the clinical relevance of anatomy (mean response 7.77/10), increased their confidence finding anatomical structures on CT (7.00/10), and increased their confidence recognizing common pathologies on CT (6.17/10). Students also felt these clinical cases helped them synthesize material from numerous courses into an overall picture of a given disease process (7.01/10). These results support the conclusion that our clinical cases help to show students why the anatomy they are learning is foundational to their other coursework. We would recommend the use of similar clinical cases to any medical school utilizing cadaver dissection as a primary teaching method in anatomy education. Clin. Anat. 24:655–663, 2011. © 2011 Wiley‐Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87056/1/21143_ftp.pd

The pp24 phosphoprotein of Mason-Pfizer monkey virus contributes to viral genome packaging

BACKGROUND: The Gag protein of Mason-Pfizer monkey virus, a betaretrovirus, contains a phosphoprotein that is cleaved into the Np24 protein and the phosphoprotein pp16/18 during virus maturation. Previous studies by Yasuda and Hunter (J. Virology. 1998. 72:4095–4103) have demonstrated that pp16/18 contains a viral late domain required for budding and that the Np24 protein plays a role during the virus life cycle since deletion of this N-terminal domain blocked virus replication. The function of the Np24 domain, however, is not known. RESULTS: Here we identify a region of basic residues (KKPKR) within the Np24 domain that is highly conserved among the phosphoproteins of various betaretroviruses. We show that this KKPKR motif is required for virus replication yet dispensable for procapsid assembly, membrane targeting, budding and release, particle maturation, or viral glycoprotein packaging. Additional experiments indicated that deletion of this motif reduced viral RNA packaging 6–8 fold and affected the transient association of Gag with nuclear pores. CONCLUSION: These results demonstrate that the Np24 domain plays an important role in RNA packaging and is in agreement with evidence that suggests that correct intracellular targeting of Gag to the nuclear compartment is an fundamental step in the retroviral life cycle

Serendipitous Discovery of Light-Induced \u3cem\u3e(In Situ)\u3c/em\u3e Formation of An Azo-Bridged Dimeric Sulfonated Naphthol as a Potent PTP1B Inhibito

Background Protein tyrosine phosphatases (PTPs) like dual specificity phosphatase 5 (DUSP5) and protein tyrosine phosphatase 1B (PTP1B) are drug targets for diseases that include cancer, diabetes, and vascular disorders such as hemangiomas. The PTPs are also known to be notoriously difficult targets for designing inihibitors that become viable drug leads. Therefore, the pipeline for approved drugs in this class is minimal. Furthermore, drug screening for targets like PTPs often produce false positive and false negative results. Results Studies presented herein provide important insights into: (a) how to detect such artifacts, (b) the importance of compound re-synthesis and verification, and (c) how in situ chemical reactivity of compounds, when diagnosed and characterized, can actually lead to serendipitous discovery of valuable new lead molecules. Initial docking of compounds from the National Cancer Institute (NCI), followed by experimental testing in enzyme inhibition assays, identified an inhibitor of DUSP5. Subsequent control experiments revealed that this compound demonstrated time-dependent inhibition, and also a time-dependent change in color of the inhibitor that correlated with potency of inhibition. In addition, the compound activity varied depending on vendor source. We hypothesized, and then confirmed by synthesis of the compound, that the actual inhibitor of DUSP5 was a dimeric form of the original inhibitor compound, formed upon exposure to light and oxygen. This compound has an IC50 of 36 μM for DUSP5, and is a competitive inhibitor. Testing against PTP1B, for selectivity, demonstrated the dimeric compound was actually a more potent inhibitor of PTP1B, with an IC50 of 2.1 μM. The compound, an azo-bridged dimer of sulfonated naphthol rings, resembles previously reported PTP inhibitors, but with 18-fold selectivity for PTP1B versus DUSP5. Conclusion We report the identification of a potent PTP1B inhibitor that was initially identified in a screen for DUSP5, implying common mechanism of inhibitory action for these scaffolds

The Willed Body Donor Interview project: Medical student and donor expectations

The Anatomical Donations Program at the University of Michigan Medical School (UMMS) has begun a multiphase project wherein interviews of donors will be recorded and later shown to medical students who participate in the anatomical dissection course. The first phase of this project included surveys of both current UMMS medical students and donors concerning their perceptions of such a program. A five‐question survey administered via Qualtrics software was electronically mailed to all current medical students at UMMS, and a survey was mailed to registered and potential donors requesting information from the UMMS on anatomical donations. A total of 224 medical student responses (response rate 33%) and 54 donor responses (response rate 27%) were received. Seventy‐four percent of students and 81% of donors reported they would participate in this program if it existed. Students and donors supported the implementation of this program for varying reasons, though many felt strongly they would not want to participate in a donor interview program. These qualitative results support those of previous studies that show a majority of students desire a closer personal relationship with the donor, and these are the first results to be reported on donor perceptions of a donor interview program. Although many students and donors are in favor of instituting this program, others feel strongly that such an experience could be traumatic. The causes of these differing reactions need to be further explored, and the opinions of those who object to this study will be respected by maintaining voluntary participation in future phases of this study. Anat Sci Educ 6: 90–100. © 2012 American Association of Anatomists.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97164/1/1326_ftp.pd

Maschenmeßgeräte - Selektionsversuche - Knotenlose Netze -Fangübergabe auf See

Aus einem Bericht über die Internationale Vergleichsfischerei bei Spitzbergen im August 195

The Impact of Stressful Life Events on Excessive Alcohol Consumption in the French Population: Findings from the GAZEL Cohort Study

Background: Major life changes may play a causative role in health through lifestyle factors, such as alcohol. The objective was to examine the impact of stressful life events on heavy alcohol consumption among French adults. Methods: Trajectories of excessive alcohol consumption in 20,625 employees of the French national gas and electricity company for up to 5 years before and 5 years after an event, with annual measurements from 1992. We used repeated measures analysis of time series data indexed to events, employing generalized estimating equations. Results: For women, excessive alcohol use increased before important purchase (p = 0.021), children leaving home (p<0.001), and death of loved ones (p = 0.03), and decreased before widowhood (p = 0.015); in the year straddling the event, increased consumption was observed for important purchase (p = 0.018) and retirement (p = 0.002); at the time of the event, consumption decreased for marriage (p = 0.002), divorce, widowhood, and death of loved one (all p<0.001), and increased for retirement (p = 0.035). For men, heavy alcohol consumption increased in the years up to and surrounding the death of loved ones, retirement, and important purchase (all p<0.001), and decreased after (all p<0.001, except death of loved one: p = 0.006); at the time of the event, consumption decreased for all events except for children leaving home and retirement, where we observed an increase (all p<0.001). For women and men, heavy alcohol consumption decreased prior to marriage and divorce and increased after (all p<0.001, except for women and marriage: p = 0.01). Conclusion: Stressful life events promote healthy and unhealthy alcohol consumption. Certain events impact alcohol intake temporarily while others have longer-term implications. Research should disentangle women's and men's distinct perceptions of events over time