9 research outputs found
Busulphan is active against neuroblastoma and medulloblastoma xenografts in athymic mice at clinically achievable plasma drug concentrations
High-dose busulphan-containing chemotherapy regimens have shown high response rates in children with relapsed or refractory neuroblastoma, Ewing's sarcoma and medulloblastoma. However, the anti-tumour activity of busulfan as a single agent remains to be defined, and this was evaluated in athymic mice bearing advanced stage subcutaneous paediatric solid tumour xenografts. Because busulphan is highly insoluble in water, the use of several vehicles for enteral and parenteral administration was first investigated in terms of pharmacokinetics and toxicity. The highest bioavailability was obtained with busulphan in DMSO administered i.p. When busulphan was suspended in carboxymethylcellulose and given orally or i.p., the bioavailability was poor. Then, in the therapeutic experiments, busulphan in DMSO was administered i.p. on days 0 and 4. At the maximum tolerated total dose (50 mg kg−1), busulphan induced a significant tumour growth delay, ranging from 12 to 34 days in the three neuroblastomas evaluated and in one out of three medulloblastomas. At a dose level above the maximum tolerated dose, busulphan induced complete and partial tumour regressions. Busulphan was inactive in a peripheral primitive neuroectodermal tumour (PNET) xenograft. When busulphan pharmacokinetics in mice and humans were considered, the estimated systemic exposure at the therapeutically active dose in mice (113 μg h ml−1) was close to the mean total systemic exposure in children receiving high-dose busulphan (102.4 μg h ml−1). In conclusion, busulphan displayed a significant anti-tumour activity in neuroblastoma and medulloblastoma xenografts at plasma drug concentrations which can be achieved clinically in children receiving high-dose busulphan-containing regimens. 1999 Cancer Research Campaig
Out of Asia: Understanding the nexus between technology usage and research productivity in Japan, Singapore, and Taiwan
Journal and conference publications are well-known measures of scientific and academic research productivity. Prior research on scientific productivity that studies dimensions such as research culture, technological support, and researcher collaboration focuses on Western world contexts. Asian countries, such as Japan, Singapore, and Taiwan have received attention recently for the quality of their educational institutions, which have increasingly emphasized research productivity. With a large number of established and funded public universities, these countries show a strong potential for future scientific research. Consequently, it is crucial to understand the factors that influence the research productivity of scholars in these countries. In this paper the focus is specifically on the research productivity of students and faculty members in three countries: Singapore, Taiwan, and Japan. We investigate an important factor that influences research productivity: technology usage, which we conceptualize as the summation of mobile phone and computer usage. In addition, we analyze the relationship between technology usage and international collaboration. © 2013 Elsevier Ltd. All rights reserved