Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions

Background: Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). Methods: The study includes 213 ICU patients with clinical criteria of sepsis and septic shock. 77 donors served as controls. Plasma levels of PTX-3, procalcitonin (PCT) and interleukin-6 were measured on day 1, 3 and 8. Results: PTX-3 correlated with higher lactate levels as well as with APACHE II and SOFA scores (p = 0.0001). PTX-3 levels of patients with sepsis or septic shock were consistently significantly higher than in the control group (p ≤ 0.001). Plasma levels were able to discriminate sepsis and septic shock significantly on day 1, 3 and 8 (range of AUC 0.73–0.92, p = 0.0001). Uniform cut-off levels were defined at ≥5 ng/ml for at least sepsis, ≥9 ng/ml for septic shock (p = 0.0001). Conclusion: PTX-3 reveals diagnostic value for sepsis and septic shock during the first week of intensive care treatment, comparable to interleukin-6 according to latest Sepsis-3 definitions. Trial registration: NCT01535534. Registered 14.02.201

Mapping and Assessment of forest Ecosystem and Their Services. Applications and guidance for decision making in the framework of MAES

The aim of this report is to illustrate by means of a series of case studies the implementation of mapping and assessment of forest ecosystem services in different contexts and geographical levels. Methodological aspects, data issues, approaches, limitations, gaps and further steps for improvement are analysed for providing good practices and decision making guidance. The EU initiative on Mapping and Assessment of Ecosystems and their Services (MAES), with the support of all Member States, contributes to improve the knowledge on ecosytem services. MAES is one of the building-block initiatives supporting the EU Biodiversity Strategy to 2000

Mapping and assessment of forest ecosystems and their services - Applications and guidance for decision making in the framework of MAES

The aim of this report is to illustrate by means of a series of case studies the implementation of mapping and assessment of forest ecosystem services in different contexts and geographical levels. Methodological aspects, data issues, approaches, limitations, gaps and further steps for improvement are analysed for providing good practices and decision making guidance. The EU initiative on Mapping and Assessment of the state of Ecosystems and their Services (MAES), with the support of all Member States, contributes to improve the knowledge on ecosystem services. MAES is one of the building-block initiatives supporting the EU Biodiversity Strategy to 2020.JRC.H.3-Forest Resources and Climat

Democratic Education: A Theoretical Review (2006–2017)

This theoretical review examines how democratic education is conceptualized within educational scholarship. Three hundred and seventy-seven articles published in English language peer-reviewed journals between 2006 and 2017 are discursively analyzed. Democratic education functions as a privileged nodal point of different political discourses. Two discourses against (elitist and neoliberal) and six discourses pro democratic education (liberal, deliberative, multiculturalist, participatory, critical, and agonistic) construct its meaning. It is argued that the different versions of democratic education respond to various (a) ontological and epistemological assumptions, (b) normative approaches to democracy, and (c) conceptions of the relationship between education and politics. For educational policy, the review provides a critique of elitist and neoliberal policies and support for participatory decision making across discourses. Recommendations for educational practice are made by identifying pedagogies across democratic education scholarship as well as specific pedagogies for each discourse

Water quality improvements from afforestation in an agricultural catchment in Denmark illustrated with the INCA model

Intensive agricultural land use across Europe has altered nitrogen (N) budget of catchments substantially, causing widespread N pollution of freshwater. Although the N cycle in forests has changed due to increased N deposition, most forest soil waters in Europe have low nitrate concentrations. The protective function of forests on water quality has led to increasing interest in the planting of new forests on arable land as a measure to protect valuable or sensitive freshwater resources. The paper illustrates the effects of afforestation on water and N cycling using the Integrated Nitrogen Catchment (INCA) model. The model was calibrated on the Horndrup catchment in the eastern part of Jutland, Denmark, which is dominated by agricultural land use but also covered by 18% of forest land. The dynamics of nitrate concentrations in the stream water were simulated successfully by INCA over a three-year period. The simulation of the dynamics of nitrate concentrations in the soil water is closely linked to the simulation of the hydrological dynamics and especially to the rainfall. The best fit was achieved for both arable and forest land during the wettest year of the study period. The model was then used to simulate the effect of afforestation of a catchment dominated by agriculture on N fluxes with seepage and runoff. Scenarios of whole catchment conversion to forest were run, based on observations of evapotranspiration and N deposition from other Danish sites. The simulated conversion to mature forest reduced runoff by 30–45% and reduced the nitrate concentrations in the soil water by 50–70%. The simulated effect of afforestation on N leaching was an almost direct reflection of the change in the N input: substantial changes in the plant demand and soil N dynamics over the afforestation period were not simulated. To simulate the N dynamics over longer time-scales, appropriate for the study of afforestation, it is suggested that the INCA model be run with transient scenarios and linked to more detailed plant and soil models.</p> <p style='line-height: 20px;'><b>Keywords: </b>afforestation, arable land, forest hydrology, INCA, modelling, nitrogen, nitrate leachin

Water quality improvements from afforestation in an agricultural catchment in Denmark illustrated with the INCA model

International audienceIntensive agricultural land use across Europe has altered nitrogen (N) budget of catchments substantially, causing widespread N pollution of freshwater. Although the N cycle in forests has changed due to increased N deposition, most forest soil waters in Europe have low nitrate concentrations. The protective function of forests on water quality has led to increasing interest in the planting of new forests on arable land as a measure to protect valuable or sensitive freshwater resources. The paper illustrates the effects of afforestation on water and N cycling using the Integrated Nitrogen Catchment (INCA) model. The model was calibrated on the Horndrup catchment in the eastern part of Jutland, Denmark, which is dominated by agricultural land use but also covered by 18% of forest land. The dynamics of nitrate concentrations in the stream water were simulated successfully by INCA over a three-year period. The simulation of the dynamics of nitrate concentrations in the soil water is closely linked to the simulation of the hydrological dynamics and especially to the rainfall. The best fit was achieved for both arable and forest land during the wettest year of the study period. The model was then used to simulate the effect of afforestation of a catchment dominated by agriculture on N fluxes with seepage and runoff. Scenarios of whole catchment conversion to forest were run, based on observations of evapotranspiration and N deposition from other Danish sites. The simulated conversion to mature forest reduced runoff by 30?45% and reduced the nitrate concentrations in the soil water by 50?70%. The simulated effect of afforestation on N leaching was an almost direct reflection of the change in the N input: substantial changes in the plant demand and soil N dynamics over the afforestation period were not simulated. To simulate the N dynamics over longer time-scales, appropriate for the study of afforestation, it is suggested that the INCA model be run with transient scenarios and linked to more detailed plant and soil models. Keywords: afforestation, arable land, forest hydrology, INCA, modelling, nitrogen, nitrate leachin