The model of local identity in the private provincial newspaper "Kazak"

The author studies historical experiment of the private provincial newspaper of the beginning of the 20th century on creation of bilateral communication at the expense of letters in edition, and as a result, activization of processes of self-identification of local population considered.В статье рассматривается исторический опыт частной провинциальной газеты начала XX века по созданию двусторонней коммуникации за счет писем в редакцию и, как следствие, активизации процессов самоидентификации местного населения

In Vitro Cytotoxicity of CdSe/ZnS Quantum Dots and Their Interaction with Biological Systems

Semiconductor nanocrystals (quantum dots, QDs) have a wide range of potential application in multiplexed tissue and cell imaging, and for in vivo molecular diagnostics and therapy. Therefore studying of the toxicity of QDs and their influence on various cellular processes in vitro is necessary to understand their interaction with living systems.; The paper presents the results of studies on the evaluation of CdSe/ZnS QD cytotoxicity, as well as the results of studying their interaction with freshly prepared human monocytes in vitro. Keywords: Quantum dots, semiconductor nanocrystals, cytotoxicity, in vitro models, monocytes

Broadband forward scattering from dielectric cubic nanoantenna in lossless media

Dielectric photonics platform provides unique possibilities to control light scattering via utilizing high-index dielectric nanoantennas with peculiar optical signatures. Despite the intensively growing field of all-dielectric nanophotonics, it is still unclear how surrounding media affect scattering properties of a nanoantenna with complex multipole response. Here, we report on light scattering by a silicon cubic nanoparticle embedded in lossless media, supporting optical resonant response. We show that significant changes in the scattering process are governed by the electro-magnetic multipole resonances, which experience spectral red-shift and broadening over the whole visible and near-infrared spectra as the indices of media increase. Most interestingly, the considered nanoantenna exhibits the broadband forward scattering in the visible and near-infrared spectral ranges due to the Kerker-effect in high-index media. The revealed effect of broadband forward scattering is essential for highly demanding applications in which the influence of the media is crucial such as health-care, e.g., sensing, treatment efficiency monitoring, and diagnostics. In addition, the insights from this study are expected to pave the way toward engineering the nanophotonic systems including but not limited to Huygens-metasurfaces in media within a single framework

Evolution of multipole moments in silicon nanocylinder while varying the refractive index of surrounding medium

Here we use multipole decomposition approach to study optical properties of a silicon nanocylinder in different lossless media. We show that resonant peaks of multipole moments experience red shift, smoothing and broadening. Worth noting that electric multipoles experience bigger red shift than their magnetic counterparts. Our results can be applied to design optical devices within a single framework. © 2020 IOP Publishing Ltd

Cytotoxicity of Polyelectrolyte Microcapsules Encoded with Semiconductor Nanocrystals

Polyelectrolyte microcapsules are promising carriers of drugs and diagnostic agents for designing targeted and controlled delivery systems design. The use of quantum dots (QDs) as fluorescent labels in bioimaging is a promising approach to bioimaging tool development. The potential toxicity of QDs makes their applicability as fluorescent labels in vivo questionable. Therefore, the cytotoxicity of polyelectrolyte microcapsules encoded with semiconductor nanocrystals has been investigated. Keywords: Polyelectrolyte microcapsules, semiconductor nanocrystals, cytotoxicity, theranostic agents

Selective staining and eradication of cancer cells by protein-carrying DARPin-functionalized liposomes

Since their discovery, liposomes have been widely employed in biomedical research. These nano-size spherical vesicles consisting one or few phospholipid bilayers surrounding an aqueous core are capable of carrying a wide variety of bioactive compounds, including drugs, peptides, nucleic acids, proteins and others. Despite considerable success achieved in synthesis of liposome constructs containing bioactive compounds, preparation of ligand-targeted liposomes comprising large quantities of encapsulated proteins that are capable of affecting pathological cells still remains a big challenge. Here we described a novel method for preparation of small (80\u201390 nm in diameter) unilamellar liposomes containing very large quantities (thousands of protein molecules per liposome) of heme-containing cytochrome c, highly fluorescent mCherry and highly toxic PE40 (Pseudomonas aeruginosa Exotoxin A domain). Efficient encapsulation of the proteins was achieved through electrostatic interaction between positively charged proteins (at pH lower than pI) and negatively charged liposome membrane. The proteoliposomes containing large quantities of mCherry or PE40 and functionalized with designed ankyrin repeat protein (DARPin)_9-29, which targets human epidermal growth factor receptor 2 (HER2) were shown to specifically stain and kill in sub-nanomolar concentrations HER2-positive cells, overexpressing HER2, respectively. Specific staining and eradication of the receptor-positive cells demonstrated here makes the DARPin-functionalized liposomes carrying large quantities of fluorescent and/or toxic proteins a promising candidate for tumor detection and therapy

Polarization Switching Between Electric and Magnetic Quasi-Trapped Modes in Bianisotropic All-Dielectric Metasurfaces

A general strategy for the realization of electric and magnetic quasi-trapped modes located at the same spectral position is presented. This strategy's application makes it possible to design metasurfaces allowing switching between the electric and magnetic quasi-trapped modes by changing the polarization of the incident light wave. The developed strategy is based on two stages: the application of the dipole approximation for determining the conditions required for the implementation of trapped modes at certain spectral positions and the creation of the energy channels for their excitation by introducing a weak bianisotropy in nanoparticles. Since excitation of trapped modes results in a concentration of electric and magnetic energies in the metasurface plane, the polarization switching provides possibilities to change and control the localization and distribution of optical energy at the sub-wavelength scale. A practical method for spectral tuning of quasi-trapped modes in metasurfaces composed of nanoparticles with a preselected shape is demonstrated. As an example, the optical properties of a metasurface composed of silicon triangular prisms are analyzed and discussed