MS-B-107A - Summa de casibus conscientiae

Schreiber: Johannes then KoerAufnahme nach: Die mittelalterlichen Handschriften der Signaturengruppe B in der ULB Düsseldorf. - Handschriftencensus RheinlandKurzaufnahme einer Handschrift61 MS-B-107

MS-B-107C - Summa de casibus conscientiae

Schreiber: Johannes Custodis de Assindia (Essendia)Aufnahme nach: Die mittelalterlichen Handschriften der Signaturengruppe B in der ULB Düsseldorf. - Handschriftencensus RheinlandKurzaufnahme einer Handschrift61 MS-B-107

MS-B-107B - Summa de casibus conscientiae

Aufnahme nach: Die mittelalterlichen Handschriften der Signaturengruppe B in der ULB Düsseldorf. - Handschriftencensus RheinlandKurzaufnahme einer Handschrift61 MS-B-107

Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone

The generation of pyramidal neurons in the mammalian neocortex has been attributed to proliferating progenitor cells within the ventricular zone (VZ). Recently, the subventricular zone (SVZ) has been recognized as a possible source of migratory neurons in brain slice preparations, but the relevance of these observations for the developing neocortex in vivo remains to be defined. Here, we demonstrate that a subset of progenitor cells within the SVZ of the mouse neocortex can be molecularly defined by Cre recombinase expression under control of the NEX/Math2 locus, a neuronal basic helix-loop-helix gene that by itself is dispensable for cortical development. NEX-positive progenitors are generated by VZ cells, move into the SVZ, and undergo multiple asymmetrical and symmetrical cell divisions that produce a fraction of the neurons in the upper cortical layers. Our data suggest that NEX-positive progenitors within the SVZ are committed to a glutamatergic neuronal fate and have evolved to expand the number of cortical output neurons that is characteristic for the mammalian forebrain