Do criminal sanctions deter insider trading?

Many developed markets have taken what appears to be a tough stance on illegal insider trading through the use of criminal sanctions. Although criminal sanctions represent a much greater penalty than civil sanctions, the higher burden of proof required makes their enforceability weaker. This trade-off between severity and enforceability makes the impact of criminal sanctions ambiguous. In this paper, we empirically examine this issue by studying the deterrence of insider trading following the introduction of criminal sanctions in a developed market. Significant changes in sanction regimes are rare, especially when criminal sanctions are introduced without other changes. In February 2008, New Zealand introduced criminal sanctions for insider trading. This change of law offers a unique setting in which to examine the deterrence effect of criminalization. Using measures for the cost of trading, degree of information asymmetry, and probability of informed trading, we find that the enactment of this law led to a worsening in these measures. These findings suggest that the weaker enforceability of criminalization outweighs the associated increased severity of the penalties

Susceptibility of Leishmania major to Veronica persica Poir. extracts - In vitro and in vivo assays

Leishmania major is an intracellular parasite generally responsible for cutaneous leishmaniasis (CL), one of the most encountered skin diseases especially in Pakistan, Iran, Iraq, and Saudi Arabia. Current treatment options are not ideal, due to unwanted side effects and increasing resistance and availability is often limited in developing countries. Medicinal plants continue to attract attention because of their beneficial effects in the prevention or/and accelerating the healing process of various diseases. In this study, in vitro and in vivo susceptibility of L. major to Veronica persica Poir. extract, a medicinal plant with many applications, has been evaluated. Antileishmanial activity of plant extract was investigated both on cultured L. major promastigotes and in mice challenged with L. major. Animals were divided into three groups including control (without any treatment), test (treated with plant extract) and glucantime (the reference drug) treated groups. After treatments, skin lesion sizes and body weights of animals were checked during 4 weeks. The potential of the plant extract in decreasing the number of parasites in spleen cells of animals as well as inducing the nitric oxide (NO) production by macrophage cells was also investigated. In vitro tests showed that the plant extract was able to reduce the survival time of promastigotes in a concentration-dependent manner. In vivo experiments also revealed a significant influence of V. persica extracts on accelerating the healing process as well as reducing the overall disease burden in animal model by inducing NO production in macrophage cells. Our findings indicated the promising potential of V. persica extract as an ideal candidate in the treatment of CL caused by L. major

In vitro and in vivo assessment of free radical scavenging and antioxidant activities of Veronica persica Poir

With the appearance of new disorders along with inability of some conventional therapies for the treatment of diseases without any side effects, the discovery of safe and efficient therapeutic agents is of utmost importance in the medical area. In this context, medicinal plants as promising therapeutic candidates can provide a reliable and efficient profile. Since free radicals are at the center of various disorder pathways, reducing their production or complete removal of these chemical species could be advantageous for prevention and treatment of many diseases. In this experiment, free radical scavenging and antioxidant activities of Veronica persica Poir., a known medicinal plant, were evaluated using in vitro and in vivo assays. Chemical characterization results showed a high phenolic content in the V. persica methanol extract. In addition, in vitro assays including DPPH radical-scavenging assay, nitric oxide-scavenging activity assay, hydrogen peroxide scavenging test and bleomycin-dependent DNA damage test revealed significant antioxidant power and radical scavenging capacity of this plant. In accordance, in vivo experiments showed inhibitory effects of the methanol extract on lipid peroxidation, a main cause of cell damage. Our findings revealed the promising potential of this plant in reducing free radicals through different pathways. Moreover, our data suggested a correlation between the high phenolic content of the V. persica extract and its free radical scavenging and antioxidant activities

Pullulan gum production from low-quality fig syrup using Aureobasidium pullulans

Pullulan is an important polysaccharide with several potential applications in food science, pharmaceutical and cosmetic industries, but high costs of pullulan production are the main limitation for commercial utilization. Therefore, a cost-effective process for pullulan production was developed using fig syrup as an exclusive nutrient source. In particular, the feasibility of using low quality fig syrup as a supplemental substrate for pullulan gum production by Aureobasidium pullulans was investigated. Fermentation was carried out over a range of fig syrup and sucrose degrees Brix (5-15%). Maximum pullulan gum production was observed after 96h using 12.5% fig syrup, yielding approximately14.06 g/L. This value of pullulan production (14.06 g/L) was higher than the amount of pullulan produced using sucrose as substrate (5.01 g/L). In conclusion, fig syrup was an effective substrate for pullulan production by Aureobasidium pullulans, and, therefore, this byproduct deserves attention for the cost-effective and environmentally friendly pullulan production

Early Detection of Breast Cancer Using Machine Learning Techniques

Cancer is the second cause of death in the world. 8.8 million patients died due to cancer in 2015. Breast cancer is the leading cause of death among women. Several types of research have been done on early detection of breast cancer to start treatment and increase the chance of survival. Most of the studies concentrated on mammogram images. However, mammogram images sometimes have a risk of false detection that may endanger the patient’s health. It is vital to find alternative methods which are easier to implement and work with different data sets, cheaper and safer, that can produce a more reliable prediction. This paper proposes a hybrid model combined of several Machine Learning (ML) algorithms including Support Vector Machine (SVM), Artificial Neural Network (ANN), K-Nearest Neighbor (KNN), Decision Tree (DT) for effective breast cancer detection. This study also discusses the datasets used for breast cancer detection and diagnosis. The proposed model can be used with different data types such as image, blood, etc

Efecto de la aplicación foliar de selenio y zinc para aumentar los rendimientos cuantitativos y cualitativos de colza en diferentes fechas de siembra

The sowing date is an important factor for expanding the cultivated area of rapeseed and affects seed yield, oil content, and fatty acid compounds. Micronutrient elements play an important role in improving the vegetative and reproductive growth of the plant, especially under conditions of biological and environmental stresses. A two-year experiment (2014-2016) was performed to study the response of rapeseed genotypes to foliar application of micronutrients on different sowing dates. The treatments were arranged as a factorial-split plot in a randomized complete block design with three replicates. Three sowing dates of 7 (well-timed sowing date), 17, and 27 (delayed sowing dates) October and two levels of foliar application with pure water (control), selenium (1.5%), zinc (1.5%), and selenium+zinc (1.5%) were factorial in the main plots and five genotypes of SW102, Ahmadi, GKH2624, GK-Gabriella, and Okapi were randomized in the subplots (a total of 30 treatments). Seed yield, oil yield and content, oleic acid, and linoleic acid were reduced when rapeseeds were cultivated on 17 and 27 October, while the contents in palmitic, linolenic, and erucic acids, and glucosinolate increased (p < 0.01). a selenium+zinc treatment improved seed yield, oil content and yield (p < 0.01). The oil quality increased due to increased contents of oleic and linoleic acids under the selenium+zinc treatment (p < 0.01). The GK-Gabriella and GKH2624 genotypes are recommended to be sown on well-timed (7 October) and delayed sowing dates (17 and 27 October) and treated with selenium+zinc due to the higher oil yield, linoleic and oleic acids.La fecha de siembra es un factor importante para expandir el área cultivada de colza que afecta el rendimiento de la semilla, el contenido de aceite y la composición en ácidos grasos. Los micronutrientes juegan un papel importante en la mejora del crecimiento vegetativo y reproductivo de la planta, especialmente en condiciones de estrés biológico y ambiental. Se realizó un experimento de dos años (2014-2016) para estudiar la respuesta de los genotipos de colza a la aplicación foliar de micronutrientes en diferentes fechas de siembra. Los tratamientos se organizaron como una parcela dividida factorial en un diseño de bloques completos al azar con tres repeticiones. Tres fechas de siembra del 7 (fecha de siembra en el momento oportuno), 17 y 27 (fechas de siembra retrasadas) de octubre y dos niveles de aplicación foliar con agua pura (control), selenio (1,5%), zinc (1,5%) y selenio + zinc (1.5%) fueron factoriales en las parcelas principales y cinco genotipos de SW102, Ahmadi, GKH2624, GK-Gabriella y Okapi fueron aleatorizados en las subparcelas (un total de 30 tratamientos). El rendimiento de semilla, el contenido y rendimiento de aceite, los ácidos grasos oleico y linoleico se redujeron cuando se cultivaron semillas de colza los días 17 y 27 de octubre, mientras que los contenidos de los ácidos grasos palmítico, linolénico y erúcico y glucosinolato aumentaron (p <0,01). El tratamiento con selenio + zinc mejoró el rendimiento de semillas, el contenido de aceite y el rendimiento (p <0,01). La calidad del aceite aumentó debido al mayor contenido de ácidos oleico y linoleico bajo tratamiento con selenio + zinc (p <0.01). Se recomiendan los genotipos GK-Gabriella y GKH2624 sembrados en fechas oportunas (7 de octubre) y tardía (17 y 27 de octubre) y tratados con selenio + zinc, respectivamente, debido al mayor rendimiento de aceite y contenido de los ácidos linoleico y oleico

Possible co-existence of local itinerancy and global localization in a quasi-one-dimensional conductor

In the chain compound PrBa$_2$Cu$_4$O$_8$ localization appears simultaneously with a dimensional crossover in the electronic ground state when the scattering rate in the chains exceeds the hopping rate between the chains. Here we report the discovery of a large, transverse magnetoresistance in PrBa$_2$Cu$_4$O$_8$ in the localized regime. This result suggests a novel form of localization whereby electrons retain their metallic (quasi-one-dimensional) character over a microscopic length scale despite the fact that macroscopically, they exhibit localized (one-dimensional) behavior.Comment: 4 pages, 4 Figure

Antioxidants: Positive or Negative Actors?

The term "antioxidant" is one of the most confusing definitions in biological/medical sciences. In chemistry, "antioxidant" is simply conceived "a compound that removes reactive species, mainly those oxygen-derived", while in a cell context, the conceptual definition of an antioxidant is poorly understood. Indeed, non-clinically recommended antioxidants are often consumed in large amounts by the global population, based on the belief that cancer, inflammation and degenerative diseases are triggered by high oxygen levels (or reactive oxygen species) and that through blocking reactive species production, organic unbalances/disorders can be prevented and/or even treated. The popularity of these chemicals arises in part from the widespread public mistrust of allopathic medicine. In fact, reactive oxygen species play a dual role in dealing with different disorders, since they may contribute to disease onset and/or progression but may also play a key role in disease prevention. Further, the ability of the most commonly used supplements, such as vitamins C, E, selenium, and herbal supplements to decrease pathologic reactive oxygen species is not clearly established. Hence, the present review aims to provide a nuanced understanding of where current knowledge is and where it should go.Antoni Sureda acknowledges the support of Institute of Health Carlos III (Project CIBEROBNCB12/03/30038). Natália Martins thank to Portuguese Foundation for Science and Technology (FCT–Portugal) for the Strategic project ref. UID/BIM/04293/2013 and “NORTE2020-Programa Operacional Regional do Norte” (NORTE-01-0145-FEDER-000012)