Epidemiology of nausea and vomiting of pregnancy: prevalence, severity, determinants, and the importance of race/ethnicity

<p>Abstract</p> <p>Background</p> <p>Studies that contributed to the epidemiology of nausea and vomiting of pregnancy have reported conflicting findings, and often failed to account for all possible co-variables necessary to evaluate the multidimensional associations. The objectives of this study were to: 1) Estimate the prevalence and the severity of nausea and vomiting of pregnancy during the 1^stand the 2^ndtrimester of pregnancy, and 2) Identify determinants of presence and severity of nausea and vomiting of pregnancy during the 1^stand 2^ndtrimesters separately, with a special emphasis on the impact of race/ethnicity.</p> <p>Methods</p> <p>A prospective study including pregnant women attending the Centre Hospitalier Universitaire (CHU) Sainte-Justine or René-Laennec clinics for their prenatal care was conducted from 2004 to 2006. Women were eligible if they were ≥ 18 years of age, and ≤ 16 weeks of gestation. Women were asked to fill out a 1^sttrimester self-administered questionnaire and were interviewed over the telephone during their 2^ndtrimester of pregnancy. Presence of nausea and vomiting of pregnancy was based on the reporting of pregnant women (yes/no); severity of symptoms was measured by the validated modified-PUQE index.</p> <p>Results</p> <p>Of the 367 women included in the study, 81.2% were Caucasians, 10.1% Blacks, 4.6% Hispanics, and 4.1% Asians. Multivariate analyses showed that race/ethnicity was significantly associated with a decreased likelihood of reporting nausea and vomiting of pregnancy (Asians vs. Caucasians OR: 0.13; 95%CI 0.02–0.73; and Blacks vs. Caucasians OR: 0.29; 95%CI 0.09–0.99).</p> <p>Conclusion</p> <p>Our study showed that race/ethnicity was associated with the reporting of nausea and vomiting of pregnancy in the 1^sttrimester of pregnancy.</p

Fat distribution in men of different waist girth, fitness level and exercise habit

Background: The risk of chronic disease is lower in obese men who are fit and active than obese men who are unfit and inactive. Methods/Objectives: Magnetic resonance imaging and spectroscopy were used to assess total and regional adipose tissue in 13 men who were slim, fit and active (the slim-fit), in 12 men who were slim, unfit and inactive (the slim-unfit), in 13 men who were fat, fit and active (the fat-fit) and in 12 men who were fat, unfit and inactive (the fat-unfit), in order to investigate the hypothesis that visceral fat and liver fat are lower in the fat-fit than the fat-unfit. Waist girth was used to distinguish slim men (less than or equal to90 cm) and fat men (greater than or equal to100 cm). Maximal oxygen consumption was used to identify fit men (above average for age) and unfit men (average or below for age). Fit men reported at least 60 min of vigorous aerobic activity per week and unfit men reported no regular moderate or vigorous activity in the last 2 years. Results: Total fat was not significantly different in the slim-fit and the slim unfit, but the proportion of internal fat was significantly lower (P<0.05) and the proportion of visceral fat was almost significantly lower (P=0.06) in the slim-fit than all other groups. Total fat was not significantly different in the fat-fit and the fat-unfit, but visceral fat and liver fat were significantly lower in the fat-fit than the fat-unfit (P<0.01). Waist girth and years of exercise explained 84% of the variance in total fat, waist girth and maximal oxygen consumption explained 70% of the variance in visceral fat, and waist girth alone explained 25% of the variance in liver fat. Conclusion: Chronic disease risk may be lower because visceral fat and liver fat are lower in men who are fat, fit and active