34 research outputs found
Comparative structural profiling of trichome specialized metabolites in tomato (Solanum lycopersicum) and S. habrochaites: acylsugar profiles revealed by UHPLC/MS and NMR
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An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model
No full text10.1126/scitranslmed.3008517Science Translational Medicine6232
Dependence of negative-mode electrospray ionization response factors on mobile phase composition and molecular structure for newly-authenticated neutral acylsucrose metabolites
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Determination of tobacco-specific N-nitrosamines by capillary gas chromatography/selected ion monitoring mass spectrometry
No full textPreserving toxicologic activity during chromatographic fractionation of bioactive complex mixtures
No full textSynthesis and Metabolic Studies of Host-Directed Inhibitors for Antiviral Therapy
No full textTargeting host cell factors required for virus replication provides
an alternative to targeting pathogen components and represents a promising
approach to develop broad-spectrum antiviral therapeutics. High-throughput
screening (HTS) identified two classes of inhibitors (<b>2</b> and <b>3</b>) with broad-spectrum antiviral activity against
ortho- and paramyxoviruses including influenza A virus (IAV), measles
virus (MeV), respiratory syncytial virus (RSV), and human parainfluenza
virus type 3 (HPIV3). Hit-to-lead optimization delivered inhibitor <b>28a</b>, with EC<sub>50</sub> values of 0.88 and 0.81 μM
against IAV strain WSN and MeV strain Edmonston, respectively. It
was also found that compound <b>28a</b> delivers good stability
in human liver S9 fractions with a half-life of 165 min. These data
establish <b>28a</b> as a promising lead for antiviral therapy
through a host-directed mechanism
