Hábitos alimentares de utentes adultos do centro de saúde de Castelo Branco

Em Portugal têm vindo a revelar-se alguns erros alimentares praticados por grande parte da população. Esses erros cometem-se por excesso de ingestão de certo tipo de alimentos que, consequentemente, levam a problemas no organismo, como é o caso da obesidade, diabetes, hipertensão arterial, entre outras doenças

Non-steroidal anti-inflammatory agents, tolmetin and sulindac, inhibit liver tryptophan 2,3-dioxygenase activity and alter brain neurotransmitter levels

Hepatic tryptophan 2,3-dioxygenase (TDO) is one of the rate-limiting enzymes in tryptophan catabolism and plays an important role in regulating the physiological flux of tryptophan into relevant metabolic pathways. In this study, we determined the effect of the non-steroidal anti-inflammatory agents, tolmetin and sulindac, on rat liver TDO activity and the subsequent changes in the hippocampal and striatal neurotransmitter levels. The amount of melatonin produced by the pineal gland was also measured using high performance liquid chromatography (HPLC). Treatment of rats with tolmetin or sulindac (5 mg/kg/bd for 5 days) significantly inhibited liver TDO activity. The results show that whilst tolmetin and sulindac increase serotonin levels in the hippocampus, these agents also significantly reduce dopamine levels in the striatum. Tolmetin, but not sulindac, increased the amount of melatonin produced by the pineal gland. The results of this study suggest that whilst tolmetin and sulindac may be beneficial for patients suffering from depression, these agents also have the potential to induce adverse effects in patients suffering with neurological disorders such as Parkinson's disease

Mauriac syndrome still exists

BACKGROUND/OBJECTIVE: Mauriac syndrome (MS) is a rare complication of type 1 diabetes mellitus (DM1). It is related to low insulin concentrations and is less common since longer-acting insulins became available. It is characterized by hepatomegaly, growth and puberty delay, and the presence of elevated transaminases and serum lipids. The aim of this study was to describe the patients from a pediatric diabetic population that fulfill the criteria of MS. MATERIALS AND METHODS: A retrospective analysis of the pediatric diabetic population with diagnostic criteria of MS currently followed at Hospital de Braga, was performed. RESULTS: From a population of 91 patients with DM1 18 years, 6 patients with the criteria for MS were identified: 5 girls, and 1 boy. The age at presentation was 13-17 years, with a minimum interval between DM1 diagnosis and MS criteria of 4 years. All the patients were prescribed intensive insulin therapy (median daily insulin dose: 0.88U/kg). All had a previous history of poor glycemic control before the diagnosis of MS with glycated hemoglobin (HbA1c) between 8.8 and 12.9%. Increase of hepatic enzymes was present in all the patients; 4 of them had associated hepatomegaly. All the girls presented puberty delay and cushingoid features. None of the patients presented short stature and 5 of them presented mixed dyslipidemia. CONCLUSIONS: Although MS is an ancient entity described in DM1, it still exists, particularly in adolescent females. Being aware of MS is of extreme importance since most of the clinical features are reversible with better glycemic control

El síndrome de Mauriac todavía existe

BACKGROUND/OBJECTIVE: Mauriac syndrome (MS) is a rare complication of type 1 diabetes mellitus (DM1). It is related to low insulin concentrations and is less common since longer-acting insulins became available. It is characterized by hepatomegaly, growth and puberty delay, and the presence of elevated transaminases and serum lipids. The aim of this study was to describe the patients from a pediatric diabetic population that fulfill the criteria of MS. MATERIALS AND METHODS: A retrospective analysis of the pediatric diabetic population with diagnostic criteria of MS currently followed at Hospital de Braga, was performed. RESULTS: From a population of 91 patients with DM1 18 years, 6 patients with the criteria for MS were identified: 5 girls, and 1 boy. The age at presentation was 13-17 years, with a minimum interval between DM1 diagnosis and MS criteria of 4 years. All the patients were prescribed intensive insulin therapy (median daily insulin dose: 0.88 U/kg). All had a previous history of poor glycemic control before the diagnosis of MS with glycated hemoglobin (HbA1c) between 8.8 and 12.9%. Increase of hepatic enzymes was present in all the patients; 4 of them had associated hepatomegaly. All the girls presented puberty delay and cushingoid features. None of the patients presented short stature and 5 of them presented mixed dyslipidemia. CONCLUSIONS: Although MS is an ancient entity described in DM1, it still exists, particularly in adolescent females. Being aware of MS is of extreme importance since most of the clinical features are reversible with better glycemic control

Detection and Quantification of Grass and Olea Airborne Pollen Allergens in Outdoor Air Samples and its Correlation with Pollen Counts

Detection and Quantification of Grass and Olea Airborne Pollen Allergens in Outdoor Air Samples and its Correlation with Pollen Counts R Ferro1*, R Ribeiro1*, MR Martins1,2, AT Caldeira1,3, E Caeiro6, CM Antunes1,5 & R Brandão2,4 and the HIALINE working group7 1Dep. of Chemistry, University of Evora, Portugal; 2Mediterranean Inst. Crop and Environment Sciences, Univ.Evora, Portugal; 3Centro Química, University of Évora, Portugal; 4Dep. Biology, University of Evora; 5Center for NeuroSciences and Cell Biology-University of Coimbra, Portugal; 6Soc.Portuguesa Alergol.Imunologia Clínica , Portugal 7 M. Thibaudon, France, M. Smith, United Kingdom, C. Galan, Spain R. Albertini, Italy, L. Grewling, Poland, G. Reese, Germany, A. Rantio-Lehtimäki, Finland, S. Jäger and U. Berger, Austria, M. Sofiev, Finland, I. Sauliene, Lithuania, L. Cecchi, Italy Presenting author: [email protected] tel: +351 266760889 Introduction: Allergic respiratory diseases broken out after an exposure to airborne pollen, as asthma and allergic rhinitis, are deeply increasing and they represent one of the major public health problems nowadays, affecting about 40% of European population. In Portugal, grass and Olea europaea pollen are certainly one of the main sources of athmospheric aeroallergens and as such, one of the main causes of respiratory allergy. For these reasons, it is useful the development of new strategies for prevention and treatment of these pathologies. The execution of aerobiological analysis including pollen calendars and/or immunoassays for the detection and quantification of allergens which could forecast the allergenic potential of the athmosphere are quite relevant since they would contribute to develop prevention measures of allergic respiratory diseases. The aim of this study was to evaluate the putative correlation between the concentration of some of the major allergens of and with their pollen counts. Methodology: On a meteorological platform at the town center of Evora (south Portugal), ambient air was sampled at 800L/min with a Chemvol high-volume cascade impactor equipped with stages PM>10µm, 10 µm>PM>2.5µm. The polyurethane impacting substrate was extracted with 0.1M NH4HCO3, pH8.1, supplemented with 0.1% BSA. The major pollen allergens from grass Phleum p 5 and olive Ole e 1 were determined with allergen specific ELISA´s. Airborne pollen of and Olea europaea simultaneously monitored with a Burkard Seven Day Recording Volumetric Spore Trap* , between the 30th of April and the 8th of July of 2009. Both samplers were placed side-by-side with air input at the same level. Results: During the pollen season of 2009, high values of grass pollen were recorded between May 2th and June 1 th. It was also observed that the air content of Phl p5 or Ole e1 aeroallergens were directly correlated with airborne pollen counts of Poaceae and Oleaceae, respectively. Conclusions: These results suggest that the directly quantification of aeroallergens may contribute, together with pollen counts of air samples, to define the allergic risk with higher precision. Acknowledgments: This study is integrated in the european project HIALINE (Executive Agency for Health and Consumers under grant agreement No 2008 11 07

A case of pediatric paraparesis secondary to an idiopathic acute transverse myelitis

Introduction: Acute transverse myelitis (ATM) refers to a frequently idiopathic, segmental spinal cord inflammation. It is a rare condition, in particular in children, and not previously reported in a family retinitis pigmentosa (RP) clinical setting. Case Report: An 11-year-old previously healthy girl, with a family history of RP, presented with a subacute flaccid paraparesis, with bilateral, up to the fourth dorsal level, mixed sensory hypoesthesia and autonomic dysfunction. Brain and spinal cord magnetic resonance imaging (MRI) showed an extensive, T2-hyperintense, non-contrast enhancing lesion from the second to fifth dorsal levels. Cerebrospinal fluid (CSF) and lab studies were normal, as the ophthalmologic observation. Treated with high-dose corticosteroids and intensive physical therapy,a significant recovery could be seen. Conclusion:Early pharmacological and physical treatment is fundamental and may indeed change the prognosis of this disease ATM. The family history of RP, although probably incidental, brings nevertheless the issue of a possible etiological contribution, or pathologic common pathways

Processos de mudança no campo da sustentabilidade empresarial e as contribuições dos detentores de capital : um estudo de caso em uma empresa do setor têxtil

Factors with a negative impact on the environment, such as the excessive use of natural resources or global warming, are the basis for adopting more sustainable and environmentally friendly measures. A process of change that does not allow anyone to be left out, neither people nor companies, and that has gained relevance as the latter have come to realize that adopting the path of sustainability could translate into added value. The textile sector,from which reports of efforts in this direction come to us, is an example of this, so, within the scope of an analysis and reflection around the main concepts of sustainability, we will seek to understand the role and contributions of the holders of capital for sustainability. This study explores the role of capital holders in promoting sustainability in business through an exploratory case study conducted at Sourcetextile, a company operating in the textile sector. The results found indicate that Sourcetextile presents a sustainable behavior, based on the three pillars of sustainability, and that this is due to the social and environmental concerns of entrepreneurs, which creates a kind of permanent tension between economic and environmental objectives. and social, without which the company would only be concerned with economic objectives.Resumo: Fatores com impacto negativo no meio ambiente, como o uso excessivo de recursos naturais ou o aquecimento global, estão na base da adoção de medidas mais sustentáveis e amigas ambiente. Um processo de mudança que não permite deixar ninguém de fora, nem pessoas nem empresas, e que foi ganhando relevância à medida que estas últimas foram percebendo que adotar o caminho da sustentabilidade se poderia traduzir em valor acrescentado. O setor têxtil, de onde nos chegam relatos de esforços nesse sentido, é disso exemplo, pelo que, no âmbito de uma análise e reflexão em torno dos principais conceitos da sustentabilidade, vamos procurar perceber o papel e contributos dos detentores do capital para a sustentabilidade empresarial com recurso a um estudo de caso exploratório na Sour cetextile, empresa que opera no setor têxtil. Os resultados encontrados indicam que a Sourcetextile apresenta uma conduta sustentável, com base nos três pilares da sustentabilidade, e que isto se deve às preocupações sociais e ambientais dos empresários, que vai criando como que uma espécie de tensão permanente entre os objetivos económicos e os ambientais e sociais, sem a qual a empresa apenas se preocuparia com os objetivos económicos.info:eu-repo/semantics/publishedVersio

Avaliação do efeito fertilizante de um composto.

Comunicação da qual só está disponível o resumo.O presente trabalho foi desenvolvido na Escola Superior Agrária e teve como principal objetivo efetuar a validação de um composto como matéria fertilizante. O composto foi obtido pela compostagem dos seguintes resíduos de origem orgânica: lamas de depuração urbanas provenientes de ETAR e estruturante, que consiste essencialmente de casca de pinho e madeira triturada (serrim). Para concretizar este objetivo realizaram-se os seguintes trabalhos experimentais: 1- Caracterização analítica do composto; 2- Ensaio de germinação, com a finalidade de demonstrar que o composto, após incorporação no solo, não afeta negativamente a germinação das sementes (1) ; 3- Ensaio em vasos, com um solo representativo das condições edáficas em Portugal e utilizando como cultura uma espécie forrageira (azevém, Lolium spp.). Este ensaio teve com o objetivo avaliar o efeito fertilizante do composto sobre as propriedades do solo e sobre a produção e qualidade da cultura. Verificou-se que o composto está conforme os valores exigidos pelo Decreto-Lei nº103/2015 de 15 de junho (2) para a colocação no mercado de matérias fertilizantes do Grupo 5- Corretivos orgânicos, Classe II podendo ser utilizado em agricultura. Os resultados obtidos nos ensaios permitem concluir que o composto não apresentou efeitos de fitotoxicidade sobre a germinação das sementes e apresentou um efeito positivo no teor de matéria orgânica do solo, possuindo assim características de matéria fertilizante como corretivo orgânico. A produção da cultura, quer de matéria verde quer de matéria seca, foi semelhante entre as modalidades com aplicação de composto e com adubação mineral. A utilização de composto apesar de não veicular quantidades significativas de P revela ter um efeito positivo na fitodisponibilidade em fósforo do solo. Da aplicação do composto não resultou uma acumulação de micronutrientes e metais pesados (Cu, Zn, Mn, Pb, Cd, Cr e Ni), quer no solo quer nas plantas. Este ensaio demonstrou, que a dose 10 t ha-1 de composto complementado com cerca de 50 kg de azoto mineral permitiu ultrapassar os efeitos negativos da imobilização de azoto, e simultaneamente demonstrou um efeito positivo quer no teor de matéria orgânica do solo, quer na disponibilização de N e P originando uma mais adequada nutrição da cultura. Esta modalidade conduziu a uma poupança de 68% na utilização exclusiva de azoto mineral.info:eu-repo/semantics/publishedVersio

Recurrent Gastrointestinal Bleeding from Dieulafoy's Lesions in a Patient with Type 1 von Willebrand Disease: A Rare Association

Von Willebrand disease (vWD) is the most prevalent hereditary bleeding disorder, affecting 0.6-1.3% of the population. While gastrointestinal bleeding from angiodysplasia is a well-known complication of vWD, the same is not true for Dieulafoy's lesions (DLs). We report the case of a 21-year-old black male with type 1 vWD and 2 previous hospital admissions for severe anemia with no visible blood loss. In both episodes, DLs were identified and treated endoscopically, one in the stomach and another in the duodenum. The patient presented to the emergency department in September 2016 with dizziness, fatigue, and again no visible blood loss. He was hemodynamically stable, and laboratory workup showed a hemoglobin level of 3.4 g/dL. After transfusion of packed red blood cells, intravenous iron, and von Willebrand factor/factor VIII concentrate infusions, the patient underwent upper endoscopy and colonoscopy, which were normal. Small-bowel capsule endoscopy showed dark blood and a fresh clot in the proximal jejunum. At this site, push enteroscopy identified a pulsatile vessel with an overlying minimal mucosal defect, consistent with a DL, type 2b of the Yano-Yamamoto classification, which was successfully treated with adrenaline and 2 hemoclips. The patient remains stable after 18 months of follow-up, with a hemoglobin level of 13.2 g/dL. This is a case of recurrent severe occult gastrointestinal bleeding from multiple DL in a young patient with vWD who is otherwise healthy. Three other cases of DL bleeding in the setting of vWD have been reported in the literature, suggesting a possible association between these 2 entities.info:eu-repo/semantics/publishedVersio