Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo

The TGF-beta-related molecule Nodal plays an essential and conserved role in left-right patterning of the vertebrate embryo. Previous reports have shown that the zebrafish and mouse Cerberus-related proteins Charon and Cerberus-like-2 (Cerl-2), respectively, act in the node region to prevent the Nodal signal from crossing to the right side, whereas chick Cerberus (cCer) has an unclear function in the left-side mesoderm. In this study, we investigate the transcriptional regulation and function of cCer in left-right development. By analyzing the enhancer activity of cCer 5' genomic sequences in electroporated chick embryos, we identified a cCer left-side enhancer that contains two FoxH1 and one SMAD binding site. We show that these Nodal-responsive elements are necessary and sufficient for the activation of transcription in the left-side mesoderm. In transgenic mouse embryos, cCer regulatory sequences behave as in chick embryos, suggesting that the cis-regulatory sequences of Cerberus-related genes have diverged during vertebrate evolution. Moreover, our findings from cCer overexpression and knockdown experiments indicate that cCer is a negative-feedback regulator of Nodal asymmetric signaling. We propose that cCer and mouse Cerl-2 have evolved distinct regulatory mechanisms but retained a conserved function in left-right development, which is to restrict Nodal activity to the left side of the embryo.info:eu-repo/semantics/publishedVersio

Tunable asymmetric magnetoimpedance effect in ferromagnetic NiFe/Cu/Co films

We investigate the magnetization dynamics through the magnetoimpedance effect in ferromagnetic NiFe/Cu/Co films. We observe that the magnetoimpedance response is dependent on the thickness of the non-magnetic Cu spacer material, a fact associated to the kind of the magnetic interaction between the ferromagnetic layers. Thus, we present an experimental study on asymmetric magnetoimpedance in ferromagnetic films with biphase magnetic behavior and explore the possibility of tuning the linear region of the magnetoimpedance curves around zero magnetic field by varying the thickness of the non-magnetic spacer material, and probe current frequency. We discuss the experimental magnetoimpedance results in terms of the different mechanisms governing the magnetization dynamics at distinct frequency ranges, quasi-static magnetic properties, thickness of the non-magnetic spacer material, and the kind of the magnetic interaction between the ferromagnetic layers. The results place ferromagnetic films with biphase magnetic behavior exhibiting asymmetric magnetoimpedance effect as a very attractive candidate for application as probe element in the development of auto-biased linear magnetic field sensors.Comment: 5 figure

Spreading gossip in social networks

We study a simple model of information propagation in social networks, where two quantities are introduced: the spread factor, which measures the average maximal fraction of neighbors of a given node that interchange information among each other, and the spreading time needed for the information to reach such fraction of nodes. When the information refers to a particular node at which both quantities are measured, the model can be taken as a model for gossip propagation. In this context, we apply the model to real empirical networks of social acquaintances and compare the underlying spreading dynamics with different types of scale-free and small-world networks. We find that the number of friendship connections strongly influences the probability of being gossiped. Finally, we discuss how the spread factor is able to be applied to other situations.Comment: 10 pages, 16 figures, Revtex; Virt.J. of Biol. Phys., Oct.1 200

Impacto potencial das mudanças climáticas sobre as doenças da mandioca no Brasil.

Doenças causadas por fungos e oomicetos; Doenças causadas por bactérias; Doenças causadas por vírus

Multipartite entanglement sudden death and birth in randomized hypergraph states

We introduce and analyze the entanglement properties of randomized hypergraph states, as an extended notion of the randomization procedure in the quantum logic gates for the usual graph states, recently proposed in the literature. The probabilities of applying imperfect generalized controlled-$Z$ gates simulate the noisy operations over the qubits. We obtain entanglement measures as negativity, concurrence, and genuine multiparticle negativity, and show that entanglement exhibits a non-monotonic behavior in terms of the randomness parameters, which is a consequence of the non-uniformity of the associated hypergraphs, reinforcing the claim that the entanglement of randomized graph states is monotonic since they are related to $2$-uniform hypergraphs. Moreover, we observed the phenomena of entanglement sudden death and entanglement sudden birth in RH states. This work comes to unveil a connection between the non-uniformity of hypergraphs and loss of entanglement.Comment: 6 pages, 5 figures. Submitted for publication. Comments are welcom