What Factors contributed to Republic Airways filing for Bankruptcy?

This research will review the financial perspective of the company to determine how it arrived at its current position, and to determine what steps the airline should take next, so that in the near future it can deliver on its promise of restoring its financial position in the long run. As some background information, Republic Airways (RJET) is a regional airline. It operates through contracts under major carriers such as United, Delta and American Airlines. The Indianapolis based airline reached an agreement with its pilot union that was eight years in the making. The agreement’s purpose was to influence and encourage young pilots to work for Republic Airways in order to move up in ranks to the legacy airliners. Unfortunately, with the Federal Government increasing the number of flight hours from 250 to 1500 for incoming first officers, the company is still 300 pilots short of its hiring goal, leaving several jets unused creating more substantial losses for the company. Unable to follow its contractual obligations while making profits through the years, the company filed for Chapter 11 Bankruptcy on February 25, 2016. Republic Airways cited that pilot shortage and plunging revenues due to its aircraft groundings was the main causes of the bankruptcy. Republic hopes that it can renegotiate its contracts with major carriers and improve its financial position. While the company’s filling was surprising to most, it was not expected

Biblical Principles on Responsible Parenthood in a World Challenged by Uncertainty

In the increasingly uncertain world in which we find ourselves, parenthood brings difficulties and responsibilities. The scriptures provide sound advice on theprinciples that might direct decisions before parenthood is entertained. Theseinclude considerations encompassing the physical, mental, social, and spiritualdomains. Are we able to provide the guidance and support necessary in theenvironment we find ourselves? In making these decisions, alternativeinterpretations are suggested regarding the instruction to “fill” the earth and tohave “dominion” over it. An overarching instruction given in scripture is for thehuman family to reason analytically and creatively. This encompasses all aspectsof human endeavor

Bilateral Brachial Plexus Home Going Catheters After Digital Amputation for Patient With Upper Extremity Digital Gangrene

Peripheral nerve catheter placement is used to control surgical pain. Performing bilateral brachial plexus block with catheters is not frequently performed; and in our case sending patient home with bilateral brachial plexus catheters has not been reported up to our knowledge. Our patient is a 57 years old male patient presented with bilateral upper extremity digital gangrene on digits 2 through 4 on both sides with no thumb involvement. The plan was to do the surgery under sequential axillary blocks. On the day of surgery a right axillary brachial plexus block was performed under ultrasound guidance using 20 ml of 0.75% ropivacaine. Patient was taken to the OR and the right fingers amputation was carried out under mild sedation without problems. Left axillary brachial plexus block was then done as the surgeon was closing the right side, two hours after the first block was performed. The left axillary block was done also under ultrasound using 20 ml of 2% mepivacaine. The brachial plexus blocks were performed in a sequential manner. Surgery was unremarkable, and patient was transferred to post anesthetic care unit in stable condition. Over that first postoperative night, the patient complained of severe pain at the surgical sites with minimal pain relief with parentral opioids. We placed bilateral brachial plexus catheters (right axillary and left infra-clavicular brachial plexus catheters). Ropivacaine 0.2% infusion was started at 7 ml per hour basal rate only with no boluses on each side. The patient was discharged home with the catheters in place after receiving the appropriate education. On discharge both catheters were connected to a single ON-Q (I-flow Corporation, Lake Forest, CA) ball pump with a 750 ml reservoir using a Y connection and were set to deliver a fixed rate of 7 ml for each catheter. The brachial plexus catheters were removed by the patient on day 5 after surgery without any difficulty. Patient's postoperative course was otherwise unremarkable. We concluded that home going catheters are very effective in pain control postoperatively and they shorten the period of hospital stay

Precipitation regime change in Western North America: The role of Atmospheric Rivers.

Daily precipitation in California has been projected to become less frequent even as precipitation extremes intensify, leading to uncertainty in the overall response to climate warming. Precipitation extremes are historically associated with Atmospheric Rivers (ARs). Sixteen global climate models are evaluated for realism in modeled historical AR behavior and contribution of the resulting daily precipitation to annual total precipitation over Western North America. The five most realistic models display consistent changes in future AR behavior, constraining the spread of the full ensemble. They, moreover, project increasing year-to-year variability of total annual precipitation, particularly over California, where change in total annual precipitation is not projected with confidence. Focusing on three representative river basins along the West Coast, we show that, while the decrease in precipitation frequency is mostly due to non-AR events, the increase in heavy and extreme precipitation is almost entirely due to ARs. This research demonstrates that examining meteorological causes of precipitation regime change can lead to better and more nuanced understanding of climate projections. It highlights the critical role of future changes in ARs to Western water resources, especially over California

Oxidative Leaching Kinetics of Vanadium from Egyptian Boiler Ash under Acidic Oxidizing Conditions

Processing of Egyptian boiler ash in sulphuric acid solution using hydrogen peroxide as oxidant has been investigated. The results showed that leaching temperature, hydrogen peroxide, sulphuric acid concentration, leaching time, liquid-to-solid ratio and agitation speed, have significant effect; optimum process operating parameters were established as follows: temperature: 9

Efficacy of Mcl-1 Inhibitors in Multiple Myeloma Cells Resistant to Bortezomib

Multiple myeloma (MM) is a type of cancer that affects plasma B cells. Patients with MM often experience frequent relapses and can develop resistance to drugs. As a medical researcher, it is important to understand the role of Mcl-1 in preventing intrinsic apoptosis and drug resistance. Mcl-1 belongs to the anti-apoptotic subgroup of Bcl-2 family proteins and plays a crucial role in these processes. Mcl-1 plays a crucial role in driving disease progression and contributing to drug resistance in MM. It has been observed that there is an increased expression of Mcl-1 in 52% of patients with MM during diagnosis, which further rises to 81% during relapse. Thus, researchers are investigating the potential of Mcl-1 inhibitors as a viable treatment option for patients with MM, particularly those who have not responded to previous therapies. Proteasome inhibitor Bortezomib (BTZ) is commonly prescribed as the initial treatment for MM, but unfortunately, patients eventually develop resistance to it. For this study, we created cells that are resistant to BTZ in order to explore the potential mechanisms behind the development of resistance. These cells have been treated with BTZ over a period of 6 months. Regrettably, there are currently no Mcl-1 inhibitors that have been approved by the FDA. However, there are several agents, such as S63845, AZ5991, and VU661013, that are currently undergoing clinical trials. Interestingly, Mcl-1 inhibitors demonstrated effectiveness against sensitive cells but showed a decrease in efficacy against BTZ resistant cells. Our research indicates that cells resistant to BTZ require a higher concentration of Mcl-1 inhibitors in order to undergo cell death. This suggests that these resistant cells may possess a compensatory mechanism that stabilizes the Mcl-1 protein and alters the effectiveness of Mcl-1 inhibitors in treatment. It is worth noting that the anti-apoptotic Bcl-2 protein exhibits heightened expression in resistant cells, even when inhibitors are present. This observation may provide valuable insights into a potential resistance mechanism and calls for further investigation into the compensatory mechanisms that play a crucial role in drug resistance