227 research outputs found
Circuit quantum acoustodynamics with surface acoustic waves
The experimental investigation of quantum devices incorporating mechanical
resonators has opened up new frontiers in the study of quantum mechanics at a
macroscopic level. Superconducting microwave circuits have proven to be
a powerful platform for the realisation of such quantum devices, both in cavity
optomechanics, and circuit quantum electro-dynamics (QED).
While most experiments to date have involved localised nanomechanical
resonators, it has recently been shown that propagating surface acoustic waves
(SAWs) can be piezoelectrically coupled to superconducting qubits, and
confined in high-quality Fabry-Perot cavities up to microwave frequencies in
the quantum regime, indicating the possibility of realising coherent
exchange of quantum information between the two systems. Here we present
measurements of a device in which a superconducting qubit is embedded in, and
interacts with, the acoustic field of a Fabry-Perot SAW cavity on quartz,
realising a surface acoustic version of cavity quantum electrodynamics. This
quantum acoustodynamics (QAD) architecture may be used to develop new quantum
acoustic devices in which quantum information is stored in trapped on-chip
surface acoustic wavepackets, and manipulated in ways that are impossible with
purely electromagnetic signals, due to the times slower speed of
travel of the mechanical waves.Comment: 12 pages, 9 figures, 1 tabl
Oscillating bound states for a giant atom
We investigate the relaxation dynamics of a single artificial atom interacting, via multiple coupling points, with a continuum of bosonic modes (photons or phonons) in a one-dimensional waveguide. In the non-Markovian regime, where the traveling time of a photon or phonon between the coupling points is sufficiently large compared to the inverse of the bare relaxation rate of the atom, we find that a boson can be trapped and form a stable bound state. As a key discovery, we further find that a persistently oscillating bound state can appear inside the continuous spectrum of the waveguide if the number of coupling points is more than two since such a setup enables multiple bound modes to coexist. This opens up prospects for storing and manipulating quantum information in larger Hilbert spaces than available in previously known bound states
Large collective Lamb shift of two distant superconducting artificial atoms
Virtual photons can mediate interaction between atoms, resulting in an energy
shift known as a collective Lamb shift. Observing the collective Lamb shift is
challenging, since it can be obscured by radiative decay and direct atom-atom
interactions. Here, we place two superconducting qubits in a transmission line
terminated by a mirror, which suppresses decay. We measure a collective Lamb
shift reaching 0.8% of the qubit transition frequency and exceeding the
transition linewidth. We also show that the qubits can interact via the
transmission line even if one of them does not decay into it.Comment: 7+5 pages, 4+2 figure
Probing the quantum vacuum with an artificial atom in front of a mirror
Quantum fluctuations of the vacuum are both a surprising and fundamental
phenomenon of nature. Understood as virtual photons flitting in and out of
existence, they still have a very real impact, \emph{e.g.}, in the Casimir
effects and the lifetimes of atoms. Engineering vacuum fluctuations is
therefore becoming increasingly important to emerging technologies. Here, we
shape vacuum fluctuations using a "mirror", creating regions in space where
they are suppressed. As we then effectively move an artificial atom in and out
of these regions, measuring the atomic lifetime tells us the strength of the
fluctuations. The weakest fluctuation strength we observe is 0.02 quanta, a
factor of 50 below what would be expected without the mirror, demonstrating
that we can hide the atom from the vacuum
Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility.
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked FilesMultiple sclerosis (MS) is an autoimmune disease with both genetic and environmental risk factors. Recent studies indicate that childhood and adolescent obesity double the risk of MS, but this association may reflect unmeasured confounders rather than causal effects of obesity. We used separate-sample Mendelian randomization to estimate the causal effect of body mass index (BMI) on susceptibility to MS. Using data from non-Hispanic white members of the Kaiser Permanente Medical Care Plan of Northern California (KPNC) (2006-2014; 1,104 cases of MS and 10,536 controls) and a replication data set from Sweden (the Epidemiological Investigation of MS (EIMS) and the Genes and Environment in MS (GEMS) studies, 2005-2013; 5,133 MS cases and 4,718 controls), we constructed a weighted genetic risk score using 97 variants previously established to predict BMI. Results were adjusted for birth year, sex, education, smoking status, ancestry, and genetic predictors of MS. Estimates in KPNC and Swedish data sets suggested that higher genetically induced BMI predicted greater susceptibility to MS (odds ratio = 1.13, 95% confidence interval: 1.04, 1.22 for the KPNC sample; odds ratio = 1.09, 95% confidence interval: 1.03, 1.15 for the Swedish sample). Although the mechanism remains unclear, to our knowledge, these findings support a causal effect of increased BMI on susceptibility to MS for the first time, and they suggest a role for inflammatory pathways that characterize both obesity and the MS disease process.National Institute of Neurological Disorders and Stroke
National Institute of Allergy and Infectious Diseases
Robert Wood Johnson Foundation
Wayne and Gladys Valley Foundation
Ellison Medical Foundation
AFA Foundation
Knut and Alice Wallenberg Foundation
Swedish Brain Foundation
Margareta af Ugglas Foundation
European Union Seventh Framework Programme NEURINOX
Swedish Medical Research Council
Swedish Research Council for Health, Working Life, and Welfare
Biogen Inc
Merck Serono
Teva Neuroscience
Sanofi
Novartis
Bayer Schering Pharma
Swedish Research Council
Swedish Childhood Diabetes Foundation
Neurologiskt Handikappades Riksforbund Foundation
Genzyme
Merck
Bioge
Association of Genetic Markers with CSF Oligoclonal Bands in Multiple Sclerosis Patients
Objective:to explore the association between genetic markers and Oligoclonal Bands (OCB) in the Cerebro Spinal Fluid (CSF) of Italian Multiple Sclerosis patients.Methods:We genotyped 1115 Italian patients for HLA-DRB1*15 and HLA-A*02. In a subset of 925 patients we tested association with 52 non-HLA SNPs associated with MS susceptibility and we calculated a weighted Genetic Risk Score. Finally, we performed a Genome Wide Association Study (GWAS) with OCB status on a subset of 562 patients. The best associated SNPs of the Italian GWAS were replicated in silico in Scandinavian and Belgian populations, and meta-analyzed.Results:HLA-DRB1*15 is associated with OCB+: p = 0.03, Odds Ratio (OR) = 1.6, 95% Confidence Limits (CL) = 1.1-2.4. None of the 52 non-HLA MS susceptibility loci was associated with OCB, except one SNP (rs2546890) near IL12B gene (OR: 1.45; 1.09-1.92). The weighted Genetic Risk Score mean was significantly (p = 0.0008) higher in OCB+ (7.668) than in OCB- (7.412) patients. After meta-analysis on the three datasets (Italian, Scandinavian and Belgian) for the best associated signals resulted from the Italian GWAS, the strongest signal was a SNP (rs9320598) on chromosome 6q (p = 9.4Ă—10-7) outside the HLA region (65 Mb).Discussion:genetic factors predispose to the development of OCB
Deep strong light-matter coupling in plasmonic nanoparticle crystals
In the regime of deep strong light–matter coupling, the coupling strength exceeds the transition energies of the material, fundamentally changing its properties; for example, the ground state of the system contains virtual photons and the internal electromagnetic field gets redistributed by photon self-interaction. So far, no electronic excitation of a material has shown such strong coupling to free-space photons. Here we show that three-dimensional crystals of plasmonic nanoparticles can realize deep strong coupling under ambient conditions, if the particles are ten times larger than the interparticle gaps. The experimental Rabi frequencies (1.9 to 3.3 electronvolts) of face-centred cubic crystals of gold nanoparticles with diameters between 25 and 60 nanometres exceed their plasmon energy by up to 180 per cent. We show that the continuum of photons and plasmons hybridizes into polaritons that violate the rotating-wave approximation. The coupling leads to a breakdown of the Purcell effect—the increase of radiative damping through light–matter coupling—and increases the radiative polariton lifetime. The results indicate that metallic and semiconducting nanoparticles can be used as building blocks for an entire class of materials with extreme light–matter interaction, which will find application in nonlinear optics, the search for cooperative effects and ground states, polariton chemistry and quantum technology
Genome-Wide Association Study Identifies Risk Loci for Cluster Headache
OBJECTIVE: To identify susceptibility loci for cluster headache and obtain insights into relevant disease pathways. METHODS: We carried out a genome-wide association study, where 852 UK and 591 Swedish cluster headache cases were compared with 5,614 and 1,134 controls, respectively. Following quality control and imputation, single variant association testing was conducted using a logistic mixed model, for each cohort. The two cohorts were subsequently combined in a merged analysis. Downstream analyses, such as gene-set enrichment, functional variant annotation, prediction and pathway analyses, were performed. RESULTS: Initial independent analysis identified two replicable cluster headache susceptibility loci on chromosome 2. A merged analysis identified an additional locus on chromosome 1 and confirmed a locus significant in the UK analysis on chromosome 6, which overlaps with a previously known migraine locus. The lead single nucleotide polymorphisms were rs113658130 (p = 1.92 x 10-17 , OR [95%CI] = 1.51 [1.37-1.66]) and rs4519530 (p = 6.98 x 10-17 , OR = 1.47 [1.34-1.61]) on chromosome 2, rs12121134 on chromosome 1 (p = 1.66 x 10-8 , OR = 1.36 [1.22-1.52]) and rs11153082 (p = 1.85 x 10-8 , OR = 1.30 [1.19-1.42]) on chromosome 6. Downstream analyses implicated immunological processes in the pathogenesis of cluster headache. INTERPRETATION: We identified and replicated several genome-wide-significant associations supporting a genetic predisposition in cluster headache in a genome-wide association study involving 1,443 cases. Replication in larger independent cohorts combined with comprehensive phenotyping, in relation to e.g. treatment response and cluster headache subtypes, could provide unprecedented insights into genotype-phenotype correlations and the pathophysiological pathways underlying cluster headache
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