Endaural tympanoplasty without flap : a report on 34 cases

The most carefully planned and executed operation on the ear is a failure as far as the patient is concerned if the cavity collects debris and discharges for months and years afterwards. According to Mawson (1967), twenty-five per cent of radical mastoid cavities fail to heal, remain infected and discharge persistently after operation. Of 428 tympanoplasties done by Portmann (1963) between 1959 and 1962, only 75 per cent achieved perfectly dry cavities.peer-reviewe

Loss of AND-34/BCAR3 Expression in Mice Results in Rupture of the Adult Lens

PURPOSE. AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor dependence. We sought to establish the effects of the loss of AND-34 expression in a mammalian organism. METHODS. AND-34−/− mice were generated by homologous recombination. Histopathology, in situ hybridization, and western blotting were performed on murine tissues. RESULTS. Western analyses confirmed total loss of expression in AND-34−/− splenic lymphocytes. Mice lacking AND-34 are fertile and have normal longevity. While AND-34 is widely expressed in wild type mice, histologic analysis of multiple organs in AND-34−/− mice is unremarkable and analyses of lymphocyte development show no overt changes. A small percentage of AND-34−/− mice show distinctive small white eye lesions resulting from the migration of ruptured cortical lens tissue into the anterior chamber. Following initial vacuolization and liquefaction of the lens cortex first observed at postnatal day three, posterior lens rupture occurs in all AND-34−/− mice, beginning as early as three weeks and seen in all mice at three months. Western blot analysis and in situ hybridization confirmed the presence of AND-34 RNA and protein in lens epithelial cells, particularly at the lens equator. Prior data link AND-34 expression to the activation of Akt signaling. While Akt Ser 473 phosphorylation was readily detectable in AND-34+/+ lens epithelial cells, it was markedly reduced in the AND-34−/− lens epithelium. Basal levels of p130Cas phosphorylation were higher in AND-34+/+ than in AND-34−/− lens epithelium. CONCLUSIONS. These results demonstrate the loss of AND-34 dysregulates focal adhesion complex signaling in lens epithelial cells and suggest that AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens.National Institutes of Health (RO1 CA114094); Logica Foundatio

A Radio Perspective on the Wet Merger Remnant NGC 34

We present VLA observations of the neutral hydrogen and radio continuum of NGC 34 (= NGC 17 = Mrk 938). This object is an ideal candidate to study the fate of gas in mergers, since, as shown by an optical study done by Schweizer & Seitzer (2007), it is a gas-rich ("wet") merger remnant of two disk galaxies of unequal mass hosting a strong central starburst and a weak AGN. We detect HI emission from both tidal tails and from nearby galaxies, suggesting that NGC 34 is actually part of a gas-rich group and might have recently interacted with one of its companions. The kinematics of the gas suggests this remnant is forming an outer disk of neutral hydrogen from the gas of the northern tail. We also detect broad HI absorption (514 +/- 21 km/s wide) at both negative and positive velocities with respect to the systemic velocity. This absorption could be explained by the motions of the tidal tails or by the presence of a circumnuclear disk. In addition, we present radio-continuum images that show both nuclear (62.4 +/- 0.3 mJy) and extra-nuclear emission (26.5 +/- 3.0 mJy). The extra-nuclear component is very diffuse and in the shape of two radio lobes, spanning 390 kpc overall. This emission could be a signature of an AGN that has turned off, or it could originate from a starburst-driven superwind. We discuss the possible scenarios that explain our observations, and what they tell us about the location of the gas and the future evolution of NGC 34.Comment: 29 pages, 12 figures, 2 tables. Accepted for publication in the Astronomical Journal. Figs. 1, 2 & 6 degraded to reduce file size

A 3-mode, Variable Velocity Jet Model for HH 34

Variable ejection velocity jet models can qualitatively explain the appearance of successive working surfaces in Herbig-Haro (HH) jets. This paper presents an attempt to explore which features of the HH-34 jet can indeed be reproduced by such a model. From previously published data on this object, we find evidence for the existence of a 3-mode ejection velocity variability, and then explore the implications of such a variability. From simple, analytic considerations it is possible to show that the longer period modes produce a modulation on the shorter period modes, resulting in the formation of ``trains'' of multiple knots. The knots observed close to the source of HH-34 could correspond to such a structure. Finally, a numerical simulation with the ejection velocity variability deduced from the HH-34 data is computed. This numerical simulation shows a quite remarkable resemblance with the observed properties of the HH-34 jet.Comment: 28 pages LaTex, 10 postscript figure

B2 0902+34: A Collapsing Protogiant Elliptical Galaxy at z=3.4

We have used the visible integral-field replicable unit spectrograph prototype (VIRUS-P), a new integral field spectrograph, to study the spatially and spectrally resolved Lyman-alpha emission line structure in the radio galaxy B2 0902+34 at z=3.4. We observe a halo of Lyman-alpha emission with a velocity dispersion of 250 km/s extending to a radius of 50 kpc. A second feature is revealed in a spatially resolved region where the line profile shows blueshifted structure. This may be viewed as either HI absorption at -450 km/s or secondary emission at -900 km/s from the primary peak. Our new data, in combination with the 21 cm absorption, suggest two important and unexplained discrepancies. First, nowhere in the line profiles of the Lyman-alpha halo is the 21 cm absorber population evident. Second, the 21 cm absorption redshift is higher than the Lyman-alpha emission redshift. In an effort to explain these two traits, we have undertaken the first three dimensional Monte Carlo simulations of resonant scattering in radio galaxies. Though simple, the model produces the features in the Lyman-alpha data and predicts the 21 cm properties. To reach agreement between this model and the data, global infall of the HI is strictly necessary. The amount of gas necessary to match the model and data is surprisingly high, >= 10E12 solar masses, an order of magnitude larger than the stellar mass. The collapsing structure and large gas mass lead us to interpret B2 0902+34 as a protogiant elliptical galaxy.Comment: 30 pages, 8 figures, 4 tables, accepted in Ap

A near-infrared study of the star forming region RCW 34

We report the results of a near-infrared imaging study of a $7.8 \times 7.8$ arcmin$^2$ region centered on the 6.7 GHz methanol maser associated with the RCW 34 star forming region using the 1.4m IRSF telescope at Sutherland. A total of 1283 objects were detected simultaneously in J, H, and K for an exposure time of 10800 seconds. The J-H, H-K two-colour diagram revealed a strong concentration of more than 700 objects with colours similar to what is expected of reddened classical T Tauri stars. The distribution of the objects on the K {\it vs} J-K colour-magnitude diagram is also suggestive that a significant fraction of the 1283 objects is lower mass pre-main sequence stars. We also present the luminosity function for the subset of about 700 pre-main sequence stars and show that it suggests ongoing star formation activity for about $10^7$ years. An examination of the spatial distribution of the pre-main sequence stars shows that the fainter (older) part of the population is more dispersed over the observed region and the brighter (younger) subset is more concentrated around the position of the O8.5V star. This suggests that the physical effects of the O8.5V star and the two early B-type stars on the remainder of the cloud out of which they formed, could have played a role in the onset of the more recent episode of star formation in RCW 34.Comment: Accepted for publication in The Astronomical Journa