Relationship between pulmonary blood flow and volume following lung resection using dynamic perfusion digital radiography

Background: Surgical intervention for lung resection can cause ventilation-perfusion mismatches and affect gas exchange; however, minimally invasive assessment of blood flow is difficult. This study aimed to evaluate changes in pulmonary blood flow after radical lung cancer surgery using a minimally invasive dynamic digital chest radiography system. Methods: We evaluated 64 patients who underwent radical lobectomies. Postoperative changes in pulmonary blood flow, assessed using dynamic chest radiography-based blood flow ratios (BFRs), were compared with the temporal evolution of both functional lung volumes (FLVs) and estimated lung weight (ELW) derived from computed tomography (CT) volumetry. Results: FLVs on the affected side gradually recovered over time from the lowest value observed 3 months after surgery in all procedures. BFRs on the affected side also showed a gradual recovery from the lowest value 1 month after surgery, except for left upper lobectomies (LULs). In LULs, FLVs and ELWs increased proportionally up to 3 months after surgery, with lung volumes continuing to increase thereafter. The recovery of BFRs differed depending on the resected lobe. Conclusions: A relationship between pulmonary blood flow and FLV was observed in the postoperative period. Despite varying compensatory responses depending on the surgical procedure, FLV recovery coincided with increased pulmonary blood flow.journal articl

Biofortification techniques to improve food security

PRIFPRI4; CRP4; B Promoting healthy food systems; B Promoting healthy food systemsHarvestPlus; A4NHCGIAR Research Program on Agriculture for Nutrition and Health (A4NH

Iron beans in Rwanda: Crop development and delivery experience

HarvestPlus and its partners have successfully developed and delivered iron bean varieties to more than one million farming households in Rwanda, DRC, and Uganda to help combat the adverse health effects of iron deficiency widespread in these countries. Focusing primarily on Rwanda, this chapter summarizes the country, nutritional and consumer background, crop development, release, and delivery of iron bean varieties and synthesizes lessons learned and future challenges.PRIFPRI3; CRP4; Rwanda SSPHarvestPlus; A4NHCGIAR Research Program on Agriculture for Nutrition and Health (A4NH

Availability, production, and consumption of crops biofortified by plant breeding: Current evidence and future potential

PRIFPRI3; ISI; HarvestPlusA4NH; HarvestPlusCGIAR Research Program on Agriculture for Nutrition and Health (A4NH

Progress update: Crop development of biofortified staple food crops under HarvestPlus

PRIFPRI3; CRP4HarvestPlus; A4NHCGIAR Research Program on Agriculture for Nutrition and Health (A4NH

Biochemistry

vii, 611 p.

内部化理論から検証した地熱発電事業の方向性 : 地熱タービン分野における世界トップシェア企業を中心に

departmental bulletin pape

パラダイムシフト期における企業の事業戦略 : 太陽光発電事業のシリコン系とペロブスカイト化合物系素材に着目して

departmental bulletin pape

Myostatin expression in lung cancer induces sarcopenia and promotes cancer progression

Objectives: Many studies have demonstrated that sarcopenia among lung cancer predicts poor prognosis due to cancer progression. However, the cytokines that link sarcopenia and lung cancer progression remain unidentified. This study aimed to investigate whether lung cancer producing myostatin, which induces skeletal muscle atrophy, leads to sarcopenia and promotes cancer progression in patients with resected lung cancer. Methods: Tumor tissues were obtained from 148 patients who underwent curative resection for lung cancer. Tumor cells were stained with myostatin and tumor-associated macrophages (TAM) in the tumor microenvironment were stained with CD68. We assessed the association between myostatin expression and the clinicopathological features. Results: High myostatin expression in lung cancer was significantly associated with low skeletal muscle mass. The 5-year overall survival and relapse-free survival were significantly worse among patients with high myostatin expression than those with low expression. A multivariate analysis showed that TAM count was positively correlated with high myostatin expression. Conclusion: Sarcopenia may be induced by myostatin secreted by lung cancer cells. Moreover, myostatin may promote TAM migration into the tumor microenvironment, leading to advance lung cancer. As a result, patients with high myostatin expression had poor prognosis.journal articl