中国に進出する日本多国籍企業の海外赴任前研修に関する考察 －M 社を事例に

departmental bulletin pape

シアノバクテリア Synechocystis sp.PCC 6803による遊離脂肪酸高生産

学位記号番号 : 博理工乙第250号博士の専攻分野の名称 : 博士(理学) 学位授与年月日 : 令和元年9月20日textapplication/pdfthesi

Improved reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) index: an analysis of reorientation technique of the OASIS-3 dataset

Japanese Journal of Radiology. 2022, 41, P.393-400journal articl

Development and validation of a deep learning model for detection of breast cancers in mammography from multi-institutional datasets

PLoS ONE. 2022, 17 (3), e0265751journal articl

Observation of the DsJ(2317) and DsJ(2457) in B Decays

journal articl

Formation of Peer group in Which Children Enjoy Expression and Share it : Through Course Planning to Foster Children Who Enjoy Their Life (Education Practice in the Course of a Junior High Department of Tottori University school for Children with Special Needs)

departmental bulletin pape

LIE DERIVATIVES ON HOMOGENEOUS REAL HYPERSURFACES OF TYPE B IN A COMPLEX PROJECTIVE SPACE

application/pdfThe purpose of this paper is to give some characterizations of homogeneous real hypersurfaces of type B in a complex projective space P_{n}(C) in terms of Lie derivative.departmental bulletin pape

A Model for p38MAPK-Induced Astrocyte Senescence

<div><p>Experimental evidence indicates that aging leads to accumulation of senescent cells in tissues and they develop a secretory phenotype (also known as SASP, for senescence-associated secretory phenotype) that can contribute to chronic inflammation and diseases. Recent results have showed that markers of senescence in astrocytes from aged brains are increased in brains with Alzheimer’s disease. These studies strongly involved the stress kinase p38MAPK in the regulation of the secretory phenotype of astrocytes, yet the molecular mechanisms underlying the onset of senescence and SASP activation remain unclear. In this work, we propose a discrete logical model for astrocyte senescence determined by the level of DNA damage (reparable or irreparable DNA strand breaks) where the kinase p38MAPK plays a central role in the regulation of senescence and SASP. The model produces four alternative stable states: proliferation, transient cycle arrest, apoptosis and senescence (and SASP) computed from its inputs representing DNA damages. Perturbations of the model were performed through gene gain or loss of functions and compared with results concerning cultures of normal and mutant astrocytes showing agreement in most cases. Moreover, the model allows some predictions that remain to be tested experimentally.</p></div

Comparison with experiments.

Comparison with experiments.</p

Regulatory network for astrocyte fate decision.

<p>Rectangular and elliptic nodes represent Boolean and multi-valued nodes, respectively. The input nodes in dark color at the top of the network denote single (SSB) and double-strand (DSB) DNA breaks, respectively. The output nodes in white color represent the possible cell fate decisions and the internal nodes are the regulators of the outputs.</p