<Original Article> Clinical Study of Delapril Hydrochloride in Patients with Acute Myocardial Infarction: Effects of Early ACE Inhibition foflowing Effective Thrombofytic Coronary Recanalizati

The present study investigated the effects of a new angiotensin-converting enzyme inhibitor, delapril hydrochloride, on left ventricular dysfunction in patients with acute myocardial infarction (AMI). Ten patients admitted within 24 hr after the onset of AMI symptoms who had undergone successful thrombolytic coronary recanalization, were randomized to either the delapril group (n=5) or the control group (n=5). Groups were comparable in terms of age, gender, heart rate, blood pressure, inclusion time, infarct location and max CPK. The administration of delapril (15 mg p.o., every 12 hr) was started within 24 hr after randomization. Left ventriculography was performed immediately and 4 weeks after admission to assess global and local ventricular contractility. Both the delapril group and the control group showed significant improvement over the 4 weeks in both global ejection fraction and local impaired ventricular wall motion ""stunned"" by ischemic episode. However, the increments of both variables in the delapril group were somewhat greater. Delapril was well tolerated by all patients, and symptomatic hypotension or untoward clinical effect was not observed. There were no adverse hematological or biochemical effects detected. These results suggest that delapril could become a good candidate for a large-scale phase III clinical trial for the treatment of left ventricular dysfunction following effective thrombolytic recanalization.journal articl

Atomic structure of an Al–Co–Ni decagonal quasicrystalline surface

We have analyzed the structure and composition of the first layer of an Al_72Co_16Ni_12 tenfold surface by means of scanning tunneling microscopy (STM), ion scattering spectroscopy (ISS), and Auger electron spectroscopy (AES). High-resolution STM images reveal local structures that have decagonal symmetry in addition to the usual pentagonal symmetry of the surface. This quasicrystal surface resembles a random tiling instead of an ideal quasiperiodic tiling. After annealing at 1100 K, the total surface atomic density found by ISS is (9±1d)*10^14 cm^{−2}. The surface densities of Al and TM (transition metal, i.e., Co and Ni) are determined as (8±1)*10^14 cm^{−2} and (1.0±0.2)*10^14 cm{−2}, respectively from ISS, indicating a similar density of Al and much lower density of the TM atoms in the surface layer than in a truncated bulk. The Al surface atomic density agrees well with the number of corrugation maxima in the STM images. A model of the arrangement of the Al atoms in the top layer is presented. Scanning unneling spectroscopy (STS) is performed to study the local electronic structure. The STS spectrum at the corrugation maxima is similar to that at the corrugation minima. A few ≃0.12 nm high protrusions in the STM images are attributed to local oxide clusters due to their STS spectra different from the corrugation ma ima and through in situ STM observations during exposure to O_2 gas at 2*10^{−6} Pa at RT.journal articl

Effectiveness of Virtual Reality Playback in Public Speaking Training

In this paper, factors with positive effects in the playback of virtual reality (VR) presentation in training are discussed. To date, the effectiveness of VR public speaking training in both anxiety reduction and skills improvement has been reported. Though the playback using videotape is an effective way in original public speaking training, very few researchers focused on the effectiveness and possibility of VR playback. In this research, A VR playback system for public speaking training is proposed, and a pilot experiment is carried out, so as to figure out the effects of the virtual agent, immersion and public speaking anxiety level in VR playback.conference pape

Improved measurement of CP-violation parameters sin⁡2ϕ1 and |λ|, B meson lifetimes, and B0-B̅0 mixing parameter Δmd

journal articl

CART809401_Supplemental_Material – Supplemental material for Protein Levels and Microstructural Changes in Localized Regions of Early Cartilage Degeneration Compared with Adjacent Intact Cartilage

Supplemental material, CART809401_Supplemental_Material for Protein Levels and Microstructural Changes in Localized Regions of Early Cartilage Degeneration Compared with Adjacent Intact Cartilage by Bincy Jacob, Mia Jüllig, Martin Middleditch, Leo Payne, Neil Broom, Vijayalekshmi Sarojini and Ashvin Thambyah in CARTILAGE</p

Statistics pertaining to HPRD growth, experimental types for protein–protein interactions and a breakdown of PTMs

<p><b>Copyright information:</b></p><p>Taken from "Human protein reference database—2006 update"</p><p>Nucleic Acids Research 2005;34(Database issue):D411-D414.</p><p>Published online 28 Dec 2005</p><p>PMCID:PMC1347503.</p><p>© The Author 2006. Published by Oxford University Press. All rights reserved</p> () Growth of HPRD over the last 3 years with respect to protein entries, protein–protein interactions and PTMs. () Distribution of protein–protein interactions in HPRD based on the type of the experimental method. () Distribution of various types of PTMs in HPRD. The percentage of the respective PTM is indicated only when it is greater than or equal to 2