13 research outputs found

    [μ„œν‰] κ΅­μ œμ •μΉ˜μ™€ μœ μ—”λ‚œλ―Όμ΅œκ³ λŒ€ν‘œμ‚¬λ¬΄μ†Œ(UNHCR)

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    1. Alexander Betts, Gil Loescher and James Milner. The United Nations High Commissioner for Refugees(UNHCR): The Politics and Practice of Refugee Protection. (New York: Routledge, 2012). 2. Alexander Betts and Gil Loescher (Eds.). Refugees in International Relations. (NewYork: Oxford University Press, 2011).μ‹œλ¦¬μ•„μ—μ„œ μ‹œμž‘λœ λ‚œλ―Όμœ„κΈ°λ‘œ 인해 λ‚œλ―Όμ— λŒ€ν•œ μ „μ„Έκ³„μ˜ 관심이 κ·Έ μ–΄λŠ λ•Œλ³΄λ‹€ μ¦λŒ€λ˜μ—ˆμ§€λ§Œ κ·Έ 해결책은 μš”μ›ν•˜κΈ°λ§Œ ν•˜λ‹€. 2015λ…„ 말을 κΈ°μ€€μœΌλ‘œ μ „μ„Έκ³„μ μœΌλ‘œ 2,100만 λͺ…μ˜ λ‚œλ―Όμ„ ν¬ν•¨ν•˜μ—¬ 6,500만 λͺ… μ΄μƒμ˜ 인ꡬ가 λ°•ν•΄, λΆ„μŸ, μΈκΆŒμΉ¨ν•΄λ₯Ό ν”Όν•΄ 자ꡭ λ˜λŠ” κ³ ν–₯을 λ– λ‚˜ 타지λ₯Ό λ– λŒλ©° κ΅­μ œμ‚¬νšŒμ˜ 보호λ₯Ό ν•„μš”λ‘œ ν•˜κ³  μžˆλ‹€. 이런 μƒν™©μ—μ„œ 반기문 μœ μ—” 사무총μž₯의 λ’€λ₯Ό 이어 μœ μ—”λ‚œλ―Όμ΅œκ³ λŒ€ν‘œμ‚¬λ¬΄μ†Œ(United Nations High Commissioner for Refugees, μ΄ν•˜ UNHCR) λŒ€ν‘œ μΆœμ‹ μ˜ κ΅¬ν‹°ν—€μ¦ˆκ°€ μœ μ—” 사무총μž₯으둜 μ„ μΆœλ˜λ©΄μ„œ λ‚œλ―Όλ¬Έμ œμ˜ 해결을 μœ„ν•œ κ΅­μ œλ‚œλ―Όλ ˆμ§μ˜ μ‹€μ§ˆμ  변화와 λ°œμ „μ„ κΈ°λŒ€ν•˜κ²Œ λ§Œλ“€κ³  μžˆλ‹€. 2005λ…„λΆ€ν„° 2015λ…„κΉŒμ§€ 10λ…„ λ™μ•ˆ UNHCR의 λŒ€ν‘œλ₯Ό μ—­μž„ν•œ κ΅¬ν‹°ν—€μ¦ˆλŠ” κ²©λ³€ν•˜λŠ” λ‚œλ―Όμœ„κΈ°λ“€ μ†μ—μ„œ μ„±κ³΅μ μœΌλ‘œ 리더십을 λ°œνœ˜ν•΄ 온 κ²ƒμœΌλ‘œ 평가받고 μžˆλ‹€

    HIF μ „μ‚¬μΈμžκ°€ κ°ˆμƒ‰ μ§€λ°©μ—μ„œ 열생산에 λ―ΈμΉ˜λŠ” 영ν–₯

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    ν•™μœ„λ…Όλ¬Έ (석사)-- μ„œμšΈλŒ€ν•™κ΅ λŒ€ν•™μ› : μžμ—°κ³Όν•™λŒ€ν•™ 생λͺ…κ³Όν•™λΆ€, 2018. 2. κΉ€μž¬λ²”.Systemic energy imbalance between energy intake and expenditure lies at the center of obesity pandemic. Brown adipocyte plays an important role in increasing energy expenditure by generating heat. Hypoxia-inducible factor (HIF) regulates the expression of glucose transporter 1 and several glycolytic enzymes, however its role in brown adipose tissues has not been elucidated, yet. There are two major isoforms of HIF in adipocytes, HIF1Ξ± and HIF2Ξ±. Here, I studied the mechanism of how HIF1Ξ± regulates cold-induced thermogenesis in brown adipocytes. HIF1Ξ± expression was increased in brown adipose tissue after cold exposure. Moreover, Ξ² adrenergic receptor agonist treatment increased HIF1Ξ± expression in brown adipocytes in vitro. HIF1Ξ± knockdown decreased isoproterenol- induced UCP1 expression. On the other hand, I found that HIF2Ξ± is involved in brown pre-adipocyte differentiation. These results suggest that HIF1Ξ± and HIF2Ξ± can modulate adaptive thermogenesis in brown adipose tissue.1. INTRODUCTION 1 2. MATERIAL AND METHODS 4 2.1 Animals and treatment 4 2.2 Induction of differentiation of brown adipocyte cell line and 3T3-L1 4 2.3 Transfection with small interfering RNA 5 2.4 Isolation of total RNA and quantitative RT-PCR analysis 6 2.5 Western blot analysis 6 2.6 Statistical analysis 7 3. RESULTS 9 3.1 HIF1Ξ± is induced by beta adrenergic receptor stimulation in brown adipocytes 9 3.2 Increased HIF1Ξ± expression by isoproterenol treatment is not due to increased UCP1 activity 14 3.3 HIF1Ξ± increases UCP1 expression upon Ξ² adrenergic stimulation 14 3.4 HIF2Ξ± expression increases during brown adipocytes differentiation but does not affect thermogenic gene expression in mature brown adipocytes 25 4. DISCUSSION 28 5. REFERENCES 33 6. ABSTRACT IN KOREAN 39Maste

    μΆ©λ‚¨κΈ°ν›„μ •λ³΄λΈŒλ¦¬ν•‘ 26호-μ§€μžμ²΄ κΈ°ν›„λ³€ν™” λŒ€μ‘ μ’…ν•©κ³„νš 수립 및 이행평가체계 μ†Œκ°œ

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    - κ΅­κ°€μ˜ μ‹ κΈ°ν›„μ²΄μ œ λŒ€μ‘μ„ μœ„ν•œ 제1μ°¨ κΈ°ν›„λ³€ν™”λŒ€μ‘ κΈ°λ³Έκ³„νš 및 2030 κΈ°λ³Έ λ‘œλ“œλ§΅ 수립이 μ™„λ£Œλ¨μ— 따라 νŒŒλ¦¬ν˜‘μ •μ— λ”°λ₯Έ 감좕 참여·이행점검 등을 ν¬κ΄„ν•˜λŠ” κΈ°ν›„λ³€ν™” λŒ€μ‘ 체제개편과 체계적인 이행평가 κΈ°μ€€λ§ˆλ ¨ μš”κ΅¬λ¨- μ €νƒ„μ†Œ 녹색성μž₯ 기본법 제38μ‘°, 제40쑰에 κ·Όκ±°ν•œ κΈ°ν›„λ³€ν™” λŒ€μ‘ μ’…ν•©κ³„νšμ˜ 수립과 뢀문별, 단계별 μ˜¨μ‹€κ°€μŠ€ 감좕 이행 μ’…ν•©μ κ²€Β·ν™˜λ₯˜ ν•„μš”μ— 따라 μ§€μžμ²΄ κΈ°ν›„λ³€ν™” λŒ€μ‘ μ’…ν•©κ³„νš 및 이행평가체계λ₯Ό μ†Œκ°œν•¨1. μ§€μžμ²΄ κΈ°ν›„λ³€ν™” λŒ€μ‘ μ’…ν•©κ³„νš(μ˜¨μ‹€κ°€μŠ€ 감좕) 수립 ν•„μš” 2. 좩청남도 κΈ°ν›„λ³€ν™” λŒ€μ‘ μ’…ν•©κ³„νš 수립 ν˜„ν™© 3. μ‹œμ‚¬μ  및 μ •μ±…μ œμ–Έ 4. 첨뢀 1 : κΈ°ν›„λ³€ν™” λŒ€μ‘ μ’…ν•©κ³„νš 이행평가체계 μ†Œκ°œ 5. 첨뢀 2 : 2030λ…„ κ΅­κ°€ μ˜¨μ‹€κ°€μŠ€ 감좕λͺ©ν‘œ(κ΄€κ³„λΆ€μ²˜ 합동, 2016

    제8호 - μΆ©λ‚¨μ„œν•΄μ•ˆκΈ°ν›„ν™˜κ²½μ—°κ΅¬μ†Œ μ†Œμ‹μ§€ 제8호

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    01 이슈곡감-κΈ°ν›„λ³€ν™”λŒ€μ‘μ—°κ΅¬μ„Όν„° μ±…μž„μ—°κ΅¬μ› 이상신 02 μ—°κ΅¬μ†Œ μ†Œμ‹ 03 μ£Όμš” μˆ˜ν–‰μ—°κ΅¬ μ†Œκ°œ01 이슈곡감-κΈ°ν›„λ³€ν™”λŒ€μ‘μ—°κ΅¬μ„Όν„° μ±…μž„μ—°κ΅¬μ› 이상신 02 μ—°κ΅¬μ†Œ μ†Œμ‹ 03 μ£Όμš” μˆ˜ν–‰μ—°κ΅¬ μ†Œ

    μ μ •κΈ°μˆ  ꡐ윑 ꡐ재 및 맀뉴얼 자료의 μ „μžμ±…(E-Book) μ›ΉνŽ˜μ΄μ§€ ꡬ좕 κ³΅κ°œΒ·λ³΄κΈ‰ 및 ν™•μ‚°

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    μΆ”μ§„κ²½κ³Όλ³΄κ³ μ„œ1μž₯ μ„œ λ‘  2μž₯ μ μ •κΈ°μˆ κ΄€λ ¨ μœ μ‚¬μ‚¬λ‘€ 3μž₯ μ μ •κΈ°μˆ  개발결과 4μž₯ μ μ •κΈ°μˆ  ν™œμš©λ°©μ•ˆκ³Ό κ°œμ„ λ°©

    μΆ©λ‚¨κΈ°ν›„μ •λ³΄λΈŒλ¦¬ν•‘ 24호-μ‹œ.κ΅° κΈ°ν›„λ³€ν™” μ μ‘λŒ€μ±… μ„ΈλΆ€μ‹œν–‰κ³„νš 이행평가체계와 좩청남도 μ μš©λ°©μ•ˆ

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    λ²•μ •κ³„νšμΈ μ§€μžμ²΄ κΈ°ν›„λ³€ν™” μ μ‘λŒ€μ±… μ„ΈλΆ€μ‹œν–‰κ³„νš(5κ°œλ…„) μ‹œν–‰μ˜ 적정성, μ μ ˆμ„±, 연도별 이행사항 λ“± 좔진사항에 λŒ€ν•œ 쒅합적 관리체계 ꡬ좕이 μ‹œκΈ‰ν•¨μ— 따라 μ‹œΒ·κ΅° κΈ°ν›„λ³€ν™” μ μ‘λŒ€μ±… μ„ΈλΆ€μ‹œν–‰κ³„νš 이행평가체계와 좩청남도 μ μš©λ°©μ•ˆμ„ μ œμ‹œν•¨1. μ§€μžμ²΄ κΈ°ν›„λ³€ν™” μ μ‘λŒ€μ±… μ„ΈλΆ€μ‹œν–‰κ³„νš 이행평가 ν•„μš” 2. 좩청남도 κΈ°ν›„λ³€ν™” μ μ‘λŒ€μ±… μ„ΈλΆ€μ‹œν–‰κ³„νš 이행평가 ν˜„ν™© 3. μ΄ν–‰ν‰κ°€μ˜ 좩청남도 μ μš©μ— λŒ€ν•œ μ •μ±…μ œμ–Έ 4. 첨뢀 : μ§€μžμ²΄ 이행평가 절차 및 λ°©

    제6호 - μΆ©λ‚¨μ„œν•΄μ•ˆκΈ°ν›„ν™˜κ²½μ—°κ΅¬μ†Œ μ†Œμ‹μ§€ 제6호

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    μ‚°λ¦ΌΒ·ν•˜μ²œ(λ§ˆμ„)Β·λ°”λ‹€μ˜ 관계λ₯Ό μ€‘μ‹œν•œ μƒˆλ‘œμš΄ 관리 μ •μ±… μ œμ•ˆ 산림은 μˆ˜μ›ν™•λ³΄ 및 μ΄μ‚°ν™”νƒ„μ†Œ ν‘μˆ˜Β·κ³ μ • λ“± λ‹€μ–‘ν•œ κΈ°λŠ₯을 가지고 μžˆλ‹€. λ˜ν•œ, ν•˜μ²œ(λ§ˆμ„) 및 μ—°μ•ˆμ—­μ— λΆ„ν¬ν•˜λŠ” 산림에 λŒ€ν•΄μ„œλŠ” μ˜›λ‚ λΆ€ν„° μ—°μ•ˆ μƒνƒœκ³„μ— 긍정적인 영ν–₯을 μ£Όκ³  μžˆλ‹€κ³  생각해 μ™”μ§€λ§Œ μˆ˜μ—­ 주변에 μ‘°μ„±λœ 산림이 μ—°μ•ˆ μƒνƒœκ³„μ— λ―ΈμΉ˜λŠ” ꡬ체적인 영ν–₯에 λŒ€ν•΄μ„œλŠ” 체계적이고 λͺ…ν™•ν•˜κ²Œ μ •λ¦½λ˜μ–΄ μžˆμ§€λŠ” μ•Šλ‹€. ν•œνŽΈ ν•˜μ²œ(λ§ˆμ„)μ—μ„œλŠ” ν™œλ°œν•œ 인간 ν™œλ™μœΌλ‘œ 인해 μ†ŒλΉ„ 및 μƒμ‚°λ˜λŠ” λ¬Όμ§ˆμ–‘μ΄ λ§Žμ•„ ν•˜μ²œ(λ§ˆμ„) 특히 λ„μ‹œλ‘œλΆ€ν„° λ°”λ‹€λ‘œ μœ μž…λ˜λŠ” λ¬Όμ§ˆμ–‘μ΄ 점점 더 μ¦κ°€ν•˜κ³  μžˆλ‹€. μ΄λŸ¬ν•œ λ¬Όμ§ˆλ“€μ€ 일방적으둜 μ—°μ•ˆ ν•΄μ—­μœΌλ‘œ μœ μž…λ˜κ³  μžˆμ–΄ κ·Έ 영ν–₯에 λŒ€ν•΄μ„œλ„ λ§Žμ€ λ¬Έμ œμ λ“€μ΄ μ œμ‹œλ˜κ³  μžˆλŠ” 싀정이닀. -이후 μƒλž΅01 이슈곡감 02 μ—°κ΅¬μ†Œ μ†Œμ‹ 03 μ£Όμš” μˆ˜ν–‰μ—°κ΅¬ μ†Œκ°œ 04 행사 및 ꡐ
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