Study on the Optical-thermal Response of Nasopharyngeal Tissue

【中文文摘】利用生物传热理论模型Pennes方程对Ar+激光辐照下生物组织的温度分布进行模拟研究;实验测定了离体猪鼻咽组织在Ar+激光(λ=488.0nm和514.5nm)辐照下不同位置的温度分布,重点研究了辐照功率密度和波长对组织中温度分布的影响。理论和实验结果表明:组织中的温度分布与组织不同深部位置、激光波长以及激光辐照功率密度有关;实验获得波长488nm和514.5nm的Ar+激光分别辐照鼻咽组织时安全光剂量分别为1.85W/cm2和1.72W/cm2。 【英文文摘】The temperature distribution in nasopharynx tissue induced under the irradiation of rgon ion laser emitting at the wavelength of 488.0 nm and 514.5 nm were simulated by Pennes bioheat transfer equation.Furthermore,the dependence of measuring position,irradiation time and irradiation energy density,as well as wavelength on the temperature distribution was studied in detail.Simulation results and experimental results show that the temperature distributions in the porcine nasopharynx tissue were significantly...国家自然科学基金资助项目(60178022);; 福建省自然科学基金重大资助项目(2002F008)

Study on the Optical-thermal Response of Nasopharyngeal Tissue

【中文文摘】利用生物传热理论模型Pennes方程对Ar+激光辐照下生物组织的温度分布进行模拟研究;实验测定了离体猪鼻咽组织在Ar+激光(λ=488.0nm和514.5nm)辐照下不同位置的温度分布,重点研究了辐照功率密度和波长对组织中温度分布的影响。理论和实验结果表明:组织中的温度分布与组织不同深部位置、激光波长以及激光辐照功率密度有关;实验获得波长488nm和514.5nm的Ar+激光分别辐照鼻咽组织时安全光剂量分别为1.85W/cm2和1.72W/cm2。 【英文文摘】The temperature distribution in nasopharynx tissue induced under the irradiation of rgon ion laser emitting at the wavelength of 488.0 nm and 514.5 nm were simulated by Pennes bioheat transfer equation.Furthermore,the dependence of measuring position,irradiation time and irradiation energy density,as well as wavelength on the temperature distribution was studied in detail.Simulation results and experimental results show that the temperature distributions in the porcine nasopharynx tissue were significantly...国家自然科学基金资助项目(60178022);; 福建省自然科学基金重大资助项目(2002F008)

LD端面泵浦固体激光谐振腔的研究

为了对激光谐振腔体进行优化设计,采用ABCD光学传输矩阵理论,计算得到具有普适性的三镜折叠腔内高斯模式束腰的解析解.对一典型平平热透镜腔进行计算分析,结果表明:在针对其进行优化设计的泵浦范围内,腔体稳定性很好,激光光斑半径基本不随泵浦功率变化而波动.实验中以808nm尾纤输出的激光二极管端面泵浦Nd:YAG晶体产生连续1064nm激光,激光输出结果与理论模型值能够较好地相符

海洋储碳机制及区域碳氮硫循环耦合对全球变化的响应

海洋作为地球表面最大的活跃碳库,其碳收支在很大程度上决定了全球气候变化的走向.然而,海洋碳循环是一个多时空尺度的过程,相关的碳收支估算存在很大的; 不确定性,其控制过程与机理更是一个颇具挑战性的难题(胡敦欣等, 2015),特别是海洋储碳机制,是研究全球变化及应对的核心内容之一.国家重点研发计划专项全球变化及应对项

NMR Studies on Interactions between Diperoxovanadate and N-Substituted Picolinamide

为了探讨有机配体上取代基团对反应平衡的影响,在模拟生理条件下(0.15mol/LNaCl溶液),应用多核(1H,13C和51V)多维(COSY和DOSY)NMR以及变温技术等谱学方法研究双过氧钒配合物[OV(O2)2(D2O)]-/[OV(O2)2(HOD)]-与N-取代皮考啉酰胺的相互作用.它们反应性从强到弱的顺序为:N-甲基-皮考啉酰胺≈N-(2-羟乙基)-皮考啉酰胺>N-乙基-皮考啉酰胺>N-丙基-皮考啉酰胺,这说明了皮考啉酰胺N上取代基的电子效应影响反应.竞争配位导致一系列新的7配位的过氧钒物种生成,而利用上述谱学方法则有助于揭示此类相互作用体系的反应过程和配位机制.To understand the substituting effects of organic ligands on the reaction equilibrium, the interac- tions between diperoxovanadate complex [OV(O2)2(D2O)]-/[OV(O2)2(HOD)]- and a series of N-substituted picolinamide ligands in solution were explored using multinuclear (1H, 13C, and 51V) magnetic resonance, COSY, DOSY, and variable temperature NMR in 0.15 mol/L NaCl ionic medium for mimicking the physio- logical conditions. The order of reactive capability of the picolinamide-like ligands with [OV(O2)2(D2O)]-/ [OV(O2)2(HOD)]? is as follows: N-methylpicolinamide ≈ N-(2-hydroxyethyl)picolinamide > N-ethyl- picolinamide>N-propylpicolinamide. The substituting group influences the reactivity by an electron effect. Competitive coordination interactions result in a series of new seven-coordinated peroxovanadate species [OV(O2)2L]-(L=N-substituted picolinamide).973子课题(No.2003CB716005);; 国家自然科学基金(No.20772027);; 湖南省自然科学基金(No.06JJ30004);; 中国博士后科学基金(No.20070410805);; 卫生部(福建省)卫生教育联合攻关计划(No.3502Z20051027);; 厦门市重大疾病攻关研究基金(No.Wkj2005-2-019);; 固体表面物理化学国家重点实验室开放基金;; 湖南科技大学博士基金(No.E-55107)资助项目

NMR Studies on Interactions between Diperoxovanadate Complex and 3-Substituted Pyridines

为探讨有机配体上取代基团对反应平衡的影响,在模拟生理条件下(0.15mol/LNaCl溶液),应用多核(1H、13C和51V)多维(DOSY)以及变温NMR技术研究双过氧钒配合物[OV(O2)2(D2O)]-/[OV(O2)2(HOD)]-(简写为dpV)与3-取代吡啶的相互作用,并首次报道了一些物种的NMR化学位移.dpV与有机配体的反应性从强到弱的顺序为:吡啶>烟酸根>烟酸甲酰胺≈烟酸甲酯,这说明吡啶环上取代基影响反应平衡.竞争配位导致一系列新的6配位的过氧钒物种生成.密度泛函计算结果合理地解释了实验结果,并表明溶剂化效应在反应中起重要作用.To understand the substituting group effects of organic ligands on the reaction equilibrium, the interactions between a diperoxovanadate complex [OV(O2)2(D2O)]-/[OV(O2)2(HOD)]- (abbr. dpV) and a series of 3-substituted pyridines in solution were explored using multinuclear (1H, 13C, and 51V) magnetic resonance, DOSY, and variable temperature NMR in 0.15 mol/L NaCl ionic medium for mimicking the physiological condition. Some direct NMR data were given for the first time. The reactivity among the 3-substituted pyridines towards dpV takes the order of pyridine>nicotinate>N-methyl nicotinamide≈ methyl nicotinate. The competitive coordination results in the formation of a series of new six-coordinated peroxovanadate species [OV(O2)2L]n- (L=3-substituted pyridines, n=1 or 2). The results of density func-tional calculations provided a reasonable explanation of the relative reactivity of the 3-substituted pyridines. Solvation effects play an important role in these reactions.国家自然科学基金(Nos.20772027,20803020);; 973子课题(No.2003CB716005);; 湖南省自然科学基金(No.06JJ30004);; 中国博士后科学基金(No.20070410805);; 湖南省教育厅青年项目(No.06B028);; 固体表面物理化学国家重点实验室资助项目;; 湖南科技大学博士基金(No.E-55107)资助项

NMR and Theoretical Study on Interactions between Diperoxovanadate Complex and Substituted Pyridines

为探讨有机配体上取代基团对反应平衡的影响,在模拟生理条件下(0.15mol/L NaCl溶液),应用多核(1H,13C和51V)多维(DOSY)以及变温NMR技术研究双过氧钒配合物[OV(O2)2(D2O)]-/[OV(O2)2(HOD)]-(简写为bpV)与取代吡啶的相互作用.bpV与有机配体的反应性从强到弱的顺序为:皮考林酸根>异烟酸根>异烟酸甲酯>皮考林甲酯,这说明吡啶环上同一位置上的不同取代基团和同一取代基团在不同位置上都影响反应平衡,竞争配位导致一系列新的6配位(配体为异烟酸根和异烟酸甲酯)或7配位(配体为皮考林酸根和皮考林甲酯)的过氧钒物种[OV(O2)2L]n-(L=取代吡啶,n=1或2)生成,密度泛函计算结果较合理地解释了实验结果,并表明溶剂化在反应中起重要作用.To understand the substitution group effects of organic ligands on the reaction equilibrium,the interactions between diperoxovanadate complex [OV(O2)2(D2O)]-/[OV(O2)2(HOD)]-(abbr. bpV) and a series of substituted pyridines were explored using multinuclear(1H,13C,and 51V) magnetic resonance,DOSY,and variable temperature NMR in 0.15 mol/L NaCl ionic medium for mimicking the physiological condition. The reactivity order among the substituted pyridines and bpV is picolinate>isonicotinate> methyl isonicotinate>methyl picolinate. The competitive coordination results in the formation of a series of new six-coordinated(isonicotinate and methyl isonicotinate) or seven-coordinated(picolinate and methyl picolinate) peroxovanadate species [OV(O2)2L]n-(L=substituted pyridines,n=1 or 2). Both the different substitution groups at the same position and the same groups at the different substitution position affect these reactions. The results of density functional calculations provide someway a reasonable explanation for the relative reactivity of the substituted pyridines. Solvation effects play an important role in these reactions.国家自然科学基金(Nos.20772027,20803020);; 973子课题(No.2003CB716005);; 湖南省自然科学基金(No.06JJ30004);; 中国博士后科学基金(No.20070410805);; 湖南省教育厅青年项目(No.06B028);; 固体表面物理化学国家重点实验室资助项目;; 湖南科技大学博士基金(No.E-55107)资助项目

NMR Studies on Interactions between Diperoxovanadate and Imidazole-like Ligands

为探讨咪唑环上取代基团对反应平衡的影响,在模拟生理条件(0.15 mol·L~(-1)NaCl溶液)下,应用多核(~1H、~(13)C和~(51)V)、扩散排序谱(DOSY)以及变温NMR等谱学技术研究双过氧钒配合物NH_4[OV(O_2)_2{2-(2'-Pyri-dine)- [midazole}]·4H_2O(简写为bpV(Imi-Py))和咪唑类配体(咪唑、2-甲基-咪唑、4-甲基-咪唑和组氨酸)的相互作用,其从强到弱的顺序为咪唑≈4-甲基-咪唑>2-甲基-咪唑>组氨酸.研究结果表明,咪唑环上取代基团空间位阻对反应平衡产生较大影响,同时竞争配位的结果导致新的6配位过氧物种[OV(O_2)_2L]~-(L为咪唑类配体)的生成,当配体为4-甲基-咪唑和组氨酸时,生成的则是一对异构体.To understand the substituting effects of imidazole ring on the reaction equilibrium,the interactions between diperoxovanadate complex NH_4[OV(O_2)_2{2-(2'-Pyridine)-Imidazole}]·4H_2O (abbr.bpV(Imi-Py)) and a series of imidazole-like ligands (imidazole,2-methyl-imidazole,4-methyl-imidazole,and histidine) in solution were explored using multinuclear (~1H,~(13)C,and ~(51)V) magnetic resonance,diffusion ordered spectroscopy (DOSY),and variable temperature NMR in 0.15 mol·L~(-1) NaCl ionic medium for mimicking the physiological conditions.The experimental results indicated that the activities of bpV(Imi-Py) and organic ligands were as follows:imidazole≈4-methyl-imidazole>2-methyl- imidazole>histidine.The stedc effect of the organic ligands affects the reaction equilibrium.At the same time,new six- coordinated peroxovanadate species [OV(O_2)_2L]-(L=imidazole-like ligands) were formed due to the competitive coordination between 2-(2'-pyridyl)-imidazole and the imidazole-like ligands.When the ligand was 4-methyl- imidazole or histidine,a pair of isomers was formed.国家自然科学基金(20772027);; 973子课题(2003CB716005);; 湖南省自然科学基金(06JJ30004);; 中国博士后科学基金(20070410805);; 湖南省教育厅青年项目(068028);; 卫生部(福建省)卫生教育联合攻关计划(3502220051027);; 厦门市重大疾病攻关研究基金(Wkj2005-2-019);; 固体表面物理化学国家重点实验室开放基金和湖南科技大学博士基金(E55107)资

NMR Studies on Interactions between Diperoxovanadate and 1-Ethyl-1H-Imidazole

为探讨过氧钒配合物中有机配体对反应平衡的影响,在模拟生理条件下(0.15MOl·l-1nACl溶液),应用多核(1H、13C和51V)多维(COSy和HSQC)核磁共振(nMr)以及变温技术等谱学方法研究双过氧钒配合物[OV(O2)2l]-(l=d2O或HOd,与之配位的过氧钒物种简写为bPV)和[OV(O2)2ll′]n{-n=1-2,ll′=3-羟基-皮考啉酸根(3-OH-PIC),2-(2′-吡啶)-咪唑(Py-IM),1,10-邻菲啰啉(PHEn),与它们配位的含钒物种分别简写为bPV(3-OH-PIC)、bPV(Py-IM)和bPV(PHEn)}与n-乙基咪唑(n-ET-IM)的相互作用.实验结果表明,n-ET-IM与4种双过氧钒配合物反应性从强到弱的顺序为bPV>bPV(3-OH-PIC)>bPV(Py-IM)>bPV(PHEn).研究表明,金属中心上配体的配位能力、空间位阻和分子量等因素都对反应平衡产生较大的影响,同时竞争配位的结果导致新的6配位过氧物种[OV(O2)2(n-ET-IM)]-的生成.利用上述谱学方法有助于揭示此类相互作用体系的反应过程和配位方式.To understand the effects of organic ligands on the reaction equilibrium, interactions between a series of diperoxovanadate complexes [OV(O2)2L]- (L=D2O or HOD, the corresponding peroxovanadate species (bpV)) and [OV (O2)2LL′]n-{n=1-2; LL′ =3-hydroxyl-picolinate (3-OH-pic), 2-(2′-pyridine)-imidazole (py-im), 1,10-phenanthroline (phen), the corresponding peroxovanadate species bpV(3-OH-pic), bpV(py-im), and bpV(phen)}and 1-ethyl-1H-imidazole (N- Et-im) in solution were explored using multinuclear (1H, 13C, and 51V) magnetic resonance, COSY (correlated spectroscopy), HSQC (heteronuclear single quantum coherence) and variable temperature nuclear magnetic responance (NMR) using 0.15 mol·L-1 NaCl ionic medium to mimic physiological conditions.Experimental results indicated that the reactivity of these four complexes with 1-ethyl-1H-imidazole decreased as follows: bpV>bpV(3-OH-pic)>bpV(py-im)> bpV(phen).The coordinating ability, the steric effect, and the molecular weight of these organic ligands affected the reaction equilibrium.A new six-coordinated peroxovanadate species [OV(O2)2(N-Et-im)]- was formed because of competitive coordination.国家自然科学基金(20772027;20803020);中国博士后科学基金(20070410805);卫生部科学研究基金-福建省卫生教育联合攻关计划(WKJ2008-2-036);厦门市重大疾病攻关研究基金(3502Z20051027)资助项目---