Effects of Chinese Medicine of Fuyang Detoxification on Cellular Immune Function in Breast Cancer Undergoing Neoadjuvant Chemotherapy

目的研究与分析中药扶阳清毒治疗对乳腺癌新辅助化疗患者细胞免疫功能的具体影响。方法方便选取该院自2014年3月—2017年3月收治的乳腺癌初治患者68例,按照随机数字表法将其随机分为单一治疗组与联合治疗组,每组34例,予以单一治疗组患者单纯新辅助化疗治疗,予以联合治疗组患者新辅助化疗联合中药扶阳清毒法治疗,另选取该院同一时期收治的乳腺纤维瘤患者34例患者做为对照组,对单一治疗组及联合治疗组两组患者治疗前后细胞免疫功能变化进行观察与对比。结果单一治疗组患者与联合治疗患者组两组治疗前的CD3、CD4、CD8及NK细胞数量与对照组患者相比差异有统计学意义（P〈0.05）;治疗后,单一治疗组患者CD3、CD4、CD8及NK细胞数量分别为（46.62±8.67）、（34.16±6.68）、（29.32±6.41）、（31.05±5.35）,与治疗前相比差异有统计学意义（P〈0.05）;治疗后,联合治疗组患者CD3、CD4、CD8、CD4/CD8值及NK细胞数量分别为（49.18±8.87）、（36.51±6.65）、（27.54±7.50）、（1.31±0.65）、（32.53±5.44）,与治疗前相比具有一定变化,但对比结果差异无统计学意义（P〉0.05）。结论对于接受新辅助化疗出现细胞免疫功能下降患者行中药扶阳清毒法联合治疗可明显改善其细胞免疫功能,中药扶阳清毒治疗可对乳腺癌患者细胞免疫功能的改善起到积极作用。Objective This paper tries to study and analyze the specific effects of Chinese medicine ＂Fuyang detoxification＂on cellular immune function in breast cancer patients undergoing neoadjuvant chemotherapy. Methods 68 patients with breast cancer in this hospital from March 2014 to March 2017 were selected and randomly divided into the single treatment group and the combined treatment group, with 34 patients in each group, the patients in the treatment group adopted single Danchunxin adjuvant chemotherapy treatment, the combined group was treated with neoadjuvant chemotherapy detoxification combined with traditional Chinese medicine Fuyangqing, another 34 mammary fibroma patients in this hospital during the same period were selected as the control group. The changes of cellular immune function were observed and compared before and after a single treatment group and combined treatment between the two groups. Results CD3, CD4, CD8 and NK cells in the treatment group and combined treatment group before treatment were（46.62 ±8.67）,（34.16 ±6.68）、（29.32 ±6.41）,（31.05±5.35）, significant different from those before treatment（P0.05）; after treatment, a single treatment of patients with CD3, CD4, CD8 and the number of NK cells were（49.18±8.87）,（36.51±6.65）,（27.54±7.50）,（1.31±0.65）,（32.53±5.44）, but the result was not statistically significant（P〉0.05）. Conclusion Neoadjuvant chemotherapy for the cell immune function decline in patients with traditional Chinese medicine Fuyangqing combined therapy can significantly improve the cellular immune function, Chinese medicine treatment can help Fuyang detoxification on immune cells in patients with breast cancer plays a positive role in improving the function

扶阳健脾法在晚期胃癌治疗中的应用观察及对患者生活质量的影响

目的探讨中药扶阳健脾法在晚期胃癌治疗中的应用价值及对患者生活质量的影响。方法方便选取该院120例晚期胃癌患者(2015年1月—2017年6月间收治)进行观察研究,按随机数表法将患者分组:常规组(n=60)、干预组(n=60),常规组进行常规化疗,干预组进行健脾扶正汤配合化疗,总结两种治疗方案对患者疗效及预后的影响。结果干预组治疗后中医证候积分(12.5±1.4)分明显低于常规组(14.1±1.2)分,KPS评分(81.3±2.1)分、CD4+(40.3±3.8)%、CD3+(60.2±6.8)%、生活质量评分(70.5±6.8)分明显高于常规组(75.2±2.3)分、(35.2±4.3)%、(56.2±5.6)%、(62.2±6.2)分(t=10.328,P=0.000;t=20.544,P=0.000;t=9.187,P=0.000;t=5.533,P=0.000;t=10.370,P=0.000)。干预组患者不良反应发生率1.67%明显低于常规组13.33%(χ2=5.886,P=0.015)。干预组1年生存率96.67%明显高于常规组80.00%(χ2=8.086,P=0.004)。结论在晚期胃癌治疗中应用中药扶阳健脾法治疗可提升患者治疗效果,改善患者免疫功能及生活质量

The Vibration analysis and the design of vibration Reduction for Baoli Forklift Truck

凯傲集团（由Linde，Baoli，OM，STill）旗下F系列一款BaoLi叉车由于市场销售不错，在外观和性价比上有很大的市场优势，Linde叉车想在此车型上研发出一款自己品牌的车来满足国内市场，但在研发测试中发现这款车振动没有满足林德品牌的性能要求，所以需要找到振动原因，设计出减振方案。同时在车架外型已经定型，不能做很大的更改，同时研发时间紧迫和进度要求快速，需要快速简洁的减振方案。林德品牌的叉车一直以来很关注叉车的振动，关心驾驶员的安全和操作舒适度，基于保障叉车的安全性和可靠性、避免它在正常情况下发生共振的现象进而使叉车驾驶舒适度得以提升，这篇文章进一步探讨了该款叉车架构的动态特点，在架...KION group (by Linde, Baoli, OM, STill) under a BaoLi F series forklift as the market is good, have great market advantage in appearance and price, Linde forklift want to models developed a own brand cars to meet the domestic market, but in the R & D found in testing the car vibration does not meet the performance requirements of Linde brand, so it is necessary to find the cause of vibration, damp...学位：工程硕士院系专业：信息科学与技术学院_控制工程学号：X201022302

Finance Analysis Based on F Electric Power Grid Company Strategy

F省地处台湾海峡西岸的东南沿海，其电力工业至今已有近百年历史，F省电网公司系国家电网公司属下全资子公司，现承担F省全省九地市的供电任务，该公司前身为F省电力工业局，于2003年电力工业体制改革“厂网分开”后正式组建为F省电网有限公司。 本文充分利用所掌握的内部资料，通过对F省电网公司的财务报表进行战略财务分析，我们发现F电网公司既存在有利于公司战略发展的有利优势和机会，也在主客观方面存在不利于公司战略的威胁和各种急需改进和克服的不利因素。有利于战略发展的方面主要有：（1）采取了适度超前建设战略，电网较之以前更加坚强。（2）全面推进农电股改，大大提升了省内电力市场占有率；（3）强化资金集中管理...F Province is the coastland that located at Southeast of China and western side of the Taiwan Strait, the electric power industry has nearly a hundred years of history. F Power Grid Co. is the wholly owned subsidiary under the State Grid Corporation of China, and now F Power Grid Co. assuming power supply for the whole province that cover nine cities. The company was formerly known as F Electric P...学位：工商管理硕士院系专业：管理学院工商管理教育中心（MBA中心）_工商管理硕士(MBA)学号：X20041547

新时期的广场音乐文化建设探究

当下城市广场文化越来越流行,深受人们的喜爱,成为都市休闲生活中不可缺少的活动。本文主要对新时期广场音乐文化的建设进行深入探究,并提出几点设想,希望对城市精神文明建设提供一定的指导

未成年人犯罪之文化因素初探

未成年人犯罪的预防和矫正,必须建立在对未成年人犯罪原因的准确把握的基础之上。当前未成年人犯罪日趋严重是由多种因素造成的,文化是其中之一。不良文化毒害未成年人的身心,极易诱发青少年犯罪。在各种犯罪文化中,尤以暴力文化、色情文化、不良网络文化的影响最为突出

Commentary on Assessment Methods for Performances of Comprehensive Environmental Rehabilitation

在总结各地环境综合整治情况的基础上,将环境综合整治绩效评价的方法归总为指标法和投入效益分析法。前者通过制定全面的参照系,有利于政府综合整治工作的横向与纵向的比较;后者则用更为直观的货币值衡量综合整治的收益,通过与费用比较得出环境综合整治的绩效值。Based on summarizing situations of comprehensive environmental rehabilitation all over the country,two main methods to evaluate performance of comprehensive environmental rehabilitation were generalized,including index method and input-benefit analysis method. The former method was propitious to comparing performance in longitudinal and latitudinal way by establishing comprehensive frame of indexes. The latter used more obvious monetary value to weigh benefit of comprehensive rehabilitation by comparing with its cost to acquire the value of comprehensive environmental rehabilitation

基于双MCU通信的改进型燃烧控制器

针对当前国内设计的燃烧器安全性不高的缺点,本文设计了一种基于双MCu通信的改进型强制通风燃气燃烧控制器,以优化燃烧器的电控系统,增强燃烧器安全性。本设计以两片PIC16f886单片机作为主控芯片,通过串行共享EEPrOM进行双机通信以增强安全性,并采用了其他保障系统安全稳定运行的设计,其中使用电容降压电路为整个程控器供电,通过倍压整流电路控制继电器的工作电源,多级三极管驱动继电器来控制外部设备,实现了燃烧器的点火、燃烧、熄火保护、诊断和报警等功能。本设计经过实际测试、验证,实现预期功能

Antitumor effect of hydroxy camptothecin-loaded amphiphilic block copolymer nanoparticles

目的研究羟基喜树碱双嵌段共聚物纳米粒（MePEG．PLGA．HCPT．NPs）的抗肿瘤作用。方法选择人肝癌细胞株Bel-7402为体外模型，采用MTT法观察体外肝癌细胞的生长和增殖抑制情况，评价MePEG-PLGA-HCPT-NPs对肝癌细胞的毒性作用；采用激光共聚焦荧光显微镜技术观察其对肝癌细胞摄取药物的影响；采用小鼠H22肝癌细胞实体瘤模型进行体内抑瘤实验观察荷瘤动物的生长情况，测定肿瘤生长抑制率。结果MePEG—PLGA-HCPT．NPs能抑制肝癌细胞的生长增殖，且随羟基喜树碱浓度的升高而增强；激光共聚焦荧光照片显示载药纳米粒能有效地被Bel．7402细胞摄取；MePEG-PLGA-HCPT-NPs对小鼠的H22实体瘤生长具有明显的抑制作用，低、中、高剂量组的生长抑瘤率分别为37．62％、50．31％和70．25％，与对照组相比差异均有统计学意义（P〈0．05）。结论MePEG-PLGA-HCPT-NPs具有较强的体外、体内抗肿瘤作用。与羟基喜树碱注射剂相比，MePEG-PLGA-HCPT-NPs的抑瘤率更高，且与剂量有关，并对肿瘤生长的抑制更为持久。AIM To study the antitumor effect of hydroxy camptothecin（HCPT）-loaded amphiphilic block copolymer nanoparticles（MePEG-PLGA-HCPT-NPs）. METHODS The human hepatoma cell lines Bel-7402 in vitro were selected as model, the cell growth and viability inhibited by MePEG-PLGA-HCPT-NPs were observed and the antitumor cytotoxicity was evaluated by MTT assay. Cellular uptake of HCPT was observed by Confocal fluores- cence microscopy（CLSM）. Hepatocellular carcinoma cell H22 was subcutaneously injected into mice and MePEG- PLGA-HCPT-NPs was administered to the tumor-bearing mice. The growth of tumor was measured, and the inhibi- tory rate of tumor growth was calculated. RESULTS Hepatoma cell growth and viability were inhibited by Me- PEG-PLGA-HCPT-NPs, the inhibition was enhanced with increasing concentrations. CLSM photos indicated that MePEG-PLGA-HCPT nanoparticles enhanced the intracellular uptake of HCPT in Bel-7402 ceils. Marked inhibitory effect of MePEG-PLGA-HCPT-NPs on the transplanted hepatocellular carcinoma H22 was observed in the tumor- bearing mice. The inhibitory rates were 37.62% , 50.31% and 70.25% in the groups treated with low, medium and high dosage of MePEG-PLGA-HCPT-NPs, respectively （P 〈 0. 05 vs control group）. CONCLUSION Me- PEG-PLGA-HCPT-NPs has marked inhibitory effects on tumor growth in vitro and in vivo. The inhibitory effect of MePEG-PLGA-HCPT-NPs is obvious and dose-dependent and higher than that of HCPT injection.福建省医学创新课题项目（编号2014-CXB-35）;厦门市科技计划指导性项目（编号3502220159001