心脏直视手术同期射频消融迷宫术治疗心房纤颤

[目的]探讨外科直视射频消融治疗心房颤动的方法及疗效.[方法]回顾性分析25例接受心脏直视手术患者,同期用单极冲洗式射频消融行改良迷宫术治疗心房纤颤（atrial fibrillation,AF）.[结果]术毕转为窦性心律（sinus rhythm,SR）18例,结性心律5例,2例仍为AF,无Ⅲ°房室传导阻滞和死亡.随访3～25个月后,20例为SR（总有效率80%,其中有2例经电转复律）,2例为房扑,3例房颤,左房比术前明显缩小.射频消融时间短和心功能Ⅳ级,为术后3月AF复发的危险因素.[结论]单极冲洗式射频消融治疗心房纤颤是一种简易、安全、有效的方法

同期颈动脉内膜剥除及冠脉搭桥联合手术

【目的】探讨以颈动脉内膜剥除及冠状动脉搭桥联合手术同期治疗冠状动脉狭窄合并颈动脉狭窄的疗效,手术适应症及手术原 则。【方法】自 1999 年3 月至 2001 年 12 月期间,共有 5例患者接受了联合手术,其中男性 3 例,女性 2例,年龄为 65 ～ 71 岁(平均 68. 8 岁)。 冠状动脉造影显示 5 例患者均有严重的冠状动脉3 支血管病变, 3 例合并有50%以上的左主干狭窄。颈动脉造影显示4 例为70%以上的颈内 动脉狭窄, 1 例为 99% 的颈总动脉狭窄。手术在同期全身麻醉下进行,先完成颈动脉内膜剥除,再施行冠状动脉搭桥术。【结果】无 1 例手术 死亡,术后未发现脑部并发症。随访 1～ 17 个月,平均 14. 4 个月,有 1 例患者手术后 40天死于消化道大出血, 4 例恢复良好,生活质量明显提 高。【结论】颈动脉内膜剥除及冠状动脉搭桥联合手术方法简便易行,经济安全,可减少脑部并发症,免除病人再次手术的痛苦,是一种有效的 治疗方法,手术在同期麻醉下进行,在施行冠状动脉搭桥之前先完成颈动脉内膜剥除术。对有易发因素的患者,应做术前颈动脉筛选

原位心脏移植（7例报告）

【目的】总结7例心脏移植经验，探讨心脏移植的近远期疗效。【方法】1998年10月至2005年4月施行7例原位心脏移植，7例均为心肌病，其中5例为扩张型，2例为限制型，手术方法采用标准法4例、双腔静脉法3例，供心平均冷缺血时间为（167．4±22．1）min，术后定期行心内膜活检，使用四联免疫抑制剂。【结果】第1例存活5d，死于低心排及主动脉内球囊反搏（IABP）的并发症，第4例存活18月，死于中一重度的急、慢性并存的排斥反应，余5例至今存活，至今存活时间分别为6年9个月、5年6个月、1年7个月、10个月、3个月。【结论】心脏移植是治疗终末期心脏病的有效手段，处理好术后并发症，密切监测和处理排斥反应，能取得良好的近远期疗效，长期生存病例需特别注意慢性排斥反应的发生

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies