The designation of manual-folding transferring implement

针对手术活动中运送病人的环节,从最大限度地减轻病人痛苦的角度出发,结合目前医院的实际要求,基于应用机械工程学原理提出手摇式可折叠移动过床器的设计概念。本过床器采用差速千斤顶,平行四杆机构以及可折叠床架三个基本核心结构具有易操作,安全性高,占用空间少的优点。本过床器具有一定的实际应用价值。Give a summarization and manifestation to the contemporary utilization of implements that are aimed to transfer patients.Meanwhile,indicated the problems that are existed in those implements.Bring out the layout of the manual-folding transferring implement,which consist of three mechanical instructions as two differential elevators,a four-bars parallel instruction and a basic folding instruction,depending on all of which the manual-folding transferring implement can be used to transfer patients in the iatrical institutions.Furthermore,this mechanical implement has been very testified by a series of theory in mechanics such as the theory of strength and the theory of rigidity

2型糖尿病高密度脂蛋白影响血管内皮细胞代谢网络的分子机制研究

2型糖尿病(T2dM)作为代谢性疾病,严重威胁着人体健康。血管病变是T2dM的重要并发症,是T2dM致残和致死的首要原因。高密度脂蛋白(Hdl)及其主要成分载脂蛋白A-I对血管内皮具有多重保护功能,与T2dM血管病变风险呈负相关,但在T2dM状态下这种保护功能受损。T2dM Hdl保护功能受损影响血管内皮细胞代谢,可能导致血管并发症,其分子机制不明。在本研究中,我们基于nMr的代谢组学技术,通过提取临床T2dM患者及非糖尿病患者Hdl,作用于人脐静脉内皮

福建石斑鱼产业发展形势分析

石斑鱼是重要的海水养殖鱼类,福建省的石斑鱼全产业链产值超50亿元,2017年养殖产量占全国总产量的22.10%。笔者在石斑鱼产业发展调研过程中发现石斑鱼产业仍面临育苗水平不高,养殖病害较严重的挑战,建议实施种业创新、建设示范基地、拓展精深加工及培育特色品牌,推进产业转型升级

Electric-field-induced selective catalysis of single-molecule reaction

随着单分子电学检测技术的迅速发展，分子电子学的研究不再局限于分子电子学器件的构筑及其电学性质的测量，而且扩展到单分子尺度化学反应过程的探索。然而目前相关的研究仍然局限于理论计算方面，在单分子尺度上实时监测和调控化学反应的活性和选择性是化学领域的长期目标和挑战。针对这一挑战，洪文晶教授课题组与程俊教授课题组合作，自主研发了精密科学仪器，将单个有机分子定向连接在两个末端尺寸为原子级的电极之间，解决了化学反应中分子取向控制的问题.理论计算结果证实了定向电场可以有效地稳定化学反应的过渡态，从而降低反应能垒。该研究工作在化学化工学院洪文晶教授、程俊教授、能源材料化学协同创新中心（iChEM）刘俊扬副研究员的共同指导下完成，由硕士研究生黄晓艳、iChEM博士研究生唐淳、博士研究生李洁琼以及兰州大学的陈力川博士作为共同第一作者，化学化工学院师佳副教授、陈招斌高级工程师、夏海平教授和田中群教授，萨本栋微纳研究院杨扬副教授、环境与生态学院白敏冬教授以及兰州大学张浩力教授参与了研究工作的讨论并给予指导，博士后乐家波、博士研究生郑珏婷、张佩（已毕业）、李瑞豪、李晓慧也参与了研究工作。Oriented external electric fields (OEEFs) offer a unique chance to tune catalytic selectivity by orienting the alignment of the electric field along the axis of the activated bond for a specific chemical reaction; however, they remain a key experimental challenge. Here, we experimentally and theoretically investigated the OEEF-induced selective catalysis in a two-step cascade reaction of the Diels-Alder addition followed by an aromatization process. Characterized by the mechanically controllable break junction (MCBJ) technique in the nanogap and confirmed by nuclear magnetic resonance (NMR) in bottles, OEEFs are found to selectively catalyze the aromatization reaction by one order of magnitude owing to the alignment of the electric field on the reaction axis. Meanwhile, the Diels-Alder reaction remained unchanged since its reaction axis is orthogonal to the electric fields. This orientation-selective catalytic effect of OEEFs reveals that chemical reactions can be selectively manipulated through the elegant alignment between the electric fields and the reaction axis.This work was supported by the National Key R&D Program of China (2017YFA0204902), the National Natural Science Foundation of China (21722305, 21703188, 21673195, 21621091, 51733004, 51525303, and 91745103), the China Postdoctoral Science Foundation (2017M622060), and the Young Thousand Talents Project of China. 该工作得到国家自然科学基金委（21722305、21703188、21673195、51733004、51525303、91745103），国家重点研发计划课题（2017YFA0204902），中国博士后面上基金（2017M622060）的资助，以及固体表面物理化学国家重点实验室、醇醚酯化工清洁生产国家工程实验室、能源材料化学协同创新中心的支持

微丝细胞骨架参与植物重力感知和响应的机制研究

重力是重要的地球环境因素之一,在长期的进化中植物形成了特有的重力感知和响应机制调控着植物发育和形态建成;如根的向地性生长和地上部背地性直立生长,从而保障了植物可以有效地利用营养、水分和光能。已有较多的研究结果表明,微丝细胞骨架在植物响应重力变化中起到重要作用;但是由于以往研究中所用的微丝抑制剂、研究材料、器官的不同,至今还没有明确的有关微丝细胞骨架如何参与植物重力响应的精细机制。根据"淀粉体-平衡石"假说,植物感重细胞(如根尖小柱细胞和茎内皮层细胞)内淀粉体在感知重力变化发生沉降,可迅速将物理信号转化为生物化学信号。由于感重细胞内存在着复杂的亚细胞结构(如细胞骨架,内膜系统等)造成了淀粉体运动复杂性。我们首次应用流体力学微流变方法分析了拟南芥根尖中央小柱细胞内淀粉体的运动特性,发现在重力刺激(旋转90度)下野生型感重细胞内的淀粉体运动具有明显的"牢笼-逃逸(cageescape)"和协同运动的力学效应。在ARP2/3微丝相关蛋白复合体突变体(dis1-1,dis2-1)的中央小柱细胞中,由于淀粉体被异常形成的粗微丝束所束缚和分离,缺少明显的淀粉体"牢笼-逃逸"和协同运动;而微丝解聚剂(Latrunculin B)预处理可以显著地打破微丝突变体中存在的淀粉体运动的"牢笼"效应。我们进一步的研究结果还表明,ARP3/DIS1亚基不仅参与感重细胞内重力感知,还参与了作为重要的重力信号生长素在胞间的极性运输;在dis1-1突变体中,多个生长素运输载体PIN家族蛋白(PIN2,PIN3,PIN7)胞内运转的发生异常,影响了生长素在根上、下两侧细胞内不对称分布的迅速建立,造成根的向地弯曲生长延迟。此研究结果揭示了微丝细胞骨架在植物重力感知、信号传递中的功能,对于进一步揭示植物发育和形态建成的调控机制,以及改良作物株型、抗倒伏等农艺性状提供了新的研究方法和理论依据(Zheng et al.,2015,Molecular Plant;Zou et al.,2016,JXB

离子液体中微波促进制备5-羟甲基糠醛

The platform chemical 5-hydroxymethylfurfural (HMF), a hexose dehydration product, is an important bio-based chemical intermediate[1]. It can be further transformed into other chemicals such as 2,5-disubstituted furan derivatives and levulinic acid, which are considered as potential sustainable substitutes for building blocks derived from petrochemicals in the production of plastics and fine chemicals[2]. However, challenges remain to attain HMF from hexoses in a selective and cost-effective way[3]. In this study, we would like to report our results on HMF production using ionic liquids as solvents. Dialkylimidazolium halide ionic liquids were used as reaction media for dehydration of fructose into 5-hydroxymethylfurfural (HMF) under conventional oil-bath heating and microwave-assisted heating, respectively. It was found that the catalyst-free reaction in ionic liquids under oil-bath heating proceeded slowly. In the presence of various strong protonic acids and acidic ionic liquids, the reaction rate was substantially enhanced and the yields of HMF reached above 90%. In this case, however, side reactions were also induced by excessive catalyst. Meanwhile, water amount affect both dehydration rate and HMF yield significantly. By N2 blowing, water formed in the dehydration process could be removed instantaneously, thus higher HMF yield could be achieved. On the other hand, weak protonic acids and some organic acids, namely phosphoric acid, acetic acid and citric acid exhibited low catalytic activity. In the second part of this paper, microwave-assisted dehydration of fructose in ionic liquid was investigated. Under microwave irradiation, outstanding dehydration activity was obtained, fructose could be converted to HMF within 5 min in high selectivity with no other additive. More significantly, HMF yield of ca. 57%-97% could be obtained from high concentration fructose (50-1200 wt%) in ionic liquid under catalyst-free condition. For example, even a syrup made with 12.0 g of fructose in 1.0 g of C4mimCl, HMF yield up to 57% could be obtained within 4.8 min at 400 W irradiation. Our effort on HMF production in ionic liquids might pave a new path from carbohydrates to non-petrochemicals and biofuels

甲状腺功能亢进相关颅内静脉窦血栓形成1例报道 Cerebral Venous Sinus Thrombosis Associated with Hyperthyroidism: A Case Report

甲状腺功能亢进作为一种可能影响血液凝固的内分泌疾病，与颅内静脉窦血栓形成的关联在临床上并不常见。本文报道1例21岁男性甲状腺功能亢进并发颅内静脉窦血栓形成患者的诊治过程。患者在接受包括甲巯咪唑、抗凝治疗在内的综合治疗后头痛等症状得到明显缓解，特别是经历了血管内介入取栓这一关键性治疗步骤。本病例强调了对甲状腺功能亢进患者进行全面评估的重要性，同时也提示了在特定情况下介入性治疗的潜在价值。未来更广泛的研究将有助于制定这些并发症的管理和预防措施。 Abstract: Hyperthyroidism, as an endocrine disease that may affect blood coagulation, is not commonly associated with cerebral venous sinus thrombosis in clinical practice. This paper reports the diagnosis and treatment process of a 21-year-old male patient with hyperthyroidism complicated by cerebral venous sinus thrombosis. Following comprehensive treatment, including thiamazole and anticoagulation therapy, the patient experienced significant relief from symptoms such as headaches, particularly after undergoing the crucial treatment step of endovascular interventional thrombectomy. This case emphasizes the importance of a thorough assessment of patients with hyperthyroidism and also suggests the potential value of interventional treatment in specific circumstances. Future broader research will contribute to clarifying the management and preventive measures for such complications

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel