IDA型固定化镍离子金属螯合亲和膜色谱对人血清白蛋白的分离纯化

采用自制的固定化镍离子亚氨二乙酸（ＩＤＡ）型复合纤维素金属螯合膜色谱对药用人血清白蛋白的进一步纯化进行了研究，考察了ＰＨ对ＨＡＳ吸附效果的影响，经一步纯化，商品药用ＨＳＡ中的许多杂蛋白可被除去，经毛细管电泳分析，纯度与Ｓｉｇｍａ的电泳纯ＨＳＡ相当，回收率可达８５％以上。纯化蛋白液中的镍离子经过自制的Ｎ，Ｎ，Ｎ′－三羧甲基乙二胺（ＴＥＤ）型螯合柱处理后可较好地除去

疏水膜色谱法对生物大分子的快速纯化

首次采用自制的分别键合了辛基，丁基，苯基及聚乙二醇－４０００的４种常用疏水基团的纤维素疏水膜色谱柱，以键合了辛基，苯基的Ｓｅｐｈａｒｏｓｅ ＣＬ－４Ｂ凝胶柱为对照，考察了疏水膜色谱柱对牛血清白蛋白（ＢＳＡ）的动态吸附容量及流速对吸附容量的影响

新型Protein A免疫吸附膜柱在血液净化中初步应用

Protein A免疫吸附膜柱足够的吸附容量和可靠的安全性能是决定其能否在临床应用的重要指标．以健康狗为对象，模拟临床免疫吸附过程，建立了一套体外连续的免疫吸附治疗路线；考察了Protein A免疫吸附膜柱的安全性能；同时也考察了其对实际病人血浆中致病因子的去除能力．实验表明，Protein A免疫吸附膜柱不仅具有良好的安全性能，对致病因子也有一定的去除能力，有望在实际临床中应用

新型Protein A免疫吸附膜柱在血液净化中初步应用

Protein A免疫吸附膜柱足够的吸附容量和可靠的安全性能是决定其能否在临床应用的重要指标．以健康狗为对象，模拟临床免疫吸附过程，建立了一套体外连续的免疫吸附治疗路线；考察了Protein A免疫吸附膜柱的安全性能；同时也考察了其对实际病人血浆中致病因子的去除能力．实验表明，Protein A免疫吸附膜柱不仅具有良好的安全性能，对致病因子也有一定的去除能力，有望在实际临床中应用

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies