三圆弧谐波齿轮传动齿廓设计

基于谐波齿轮传动共轭精确求解方法，提出三圆弧谐波齿轮传动齿廓设计方法，并研究了三圆弧柔轮齿廓参数对谐波传动共轭区间的影响。研究结果表明，三圆弧谐波齿轮传动较双圆弧谐波齿轮传动具有更宽的共轭区间和更小的共轭间隔区间；减少凸齿廓圆弧半径有利于增加谐波传动共轭区间，但不利于减少共轭间隔区间；减少中间圆弧半径、夹角δ1和δ2既利于增加谐波传动共轭区间，也利于减少共轭间隔区间；凹齿廓圆弧半径对实际共轭区间影响很小。合理选择柔轮齿廓参数可有效减少共轭间隔区间，增加共轭区，减少尖点啮合，增加齿间共轭接触，从而提高谐波齿轮传动精度和扭转刚度

双圆弧谐波齿轮传动柔轮齿廓参数对侧隙的影响

在谐波齿轮传动中,空载啮合侧隙对其传动性能有显著影响。基于谐波传动共轭精确求解方法,研究了谐波齿轮传动共轭区间、刚轮理论共轭齿廓和侧隙随柔轮齿廓参数的变化规律。研究结果表明,柔轮齿廓参数对啮合共轭区间、刚轮理论共轭齿廓和侧隙具有决定性作用。减少凸齿廓圆弧半径有利于增加啮合共轭区间,但不利于减小侧隙;凹齿廓圆弧半径对共轭区间影响不明显,对侧隙影响较大;减小公切线倾角有利于增加共轭区间,也有利于减小侧隙值和改善侧隙分布;凸齿廓、凹齿廓圆弧半径对刚轮齿廓参数影响明显,公切线倾角对刚轮齿廓参数几乎无影响。合理选择柔轮齿廓参数能够获得更大的共轭区和更均匀的侧隙分布,从而提高承载能力和传动性能

Assessing in vivo toxicity of graphene materials: current methods and future outlook

<span lang="EN-US" style="font-family: &quot;Calibri&quot;,&quot;sans-serif&quot;; font-size: 10.5pt; mso-bidi-font-size: 11.0pt; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: 宋体; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: &quot;Times New Roman&quot;; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA;"><font color="#000000">Graphene, a novel 2D carbon nanomaterial with unique properties, has attracted massive attention. Evaluating its toxicity is of great significance due to its potential applications in many fields, especially in biomedicine. In this review, the toxicity of graphene-based nanomaterials (GNMs) and related mechanisms at the molecular and cellular level, various approaches to evaluation of the in vivo toxicity of GNMs and major factors defining their toxicity will be discussed and summarized. This review will allow better understanding of the in vitro and in vivo toxicity of GNMs, which, we believe, may facilitate design and fabrication of novel, biocompatible and efficient GNM-based systems for biomedical applications.</font></span

一种羟基磷灰石-纳米金刚石复合粉末的制备方法及其产品

本发明公开了一种羟基磷灰石-纳米金刚石复合粉末的制备方法及其产品，将纳米金刚石超声分散于去离子水中，得到纳米金刚石分散液；将硝酸钙加入纳米金刚石分散液中搅拌均匀得到混合溶液，首先向混合溶液中滴入氨水调节pH值为11～14，再搅拌滴加磷酸氢二铵溶液使硝酸钙反应完全，同时滴加氨水维持pH值恒定，滴加完成后经持续搅拌、熟化，再经后处理，得到所述的羟基磷灰石-纳米金刚石纳米复合粉末。本方法反应条件温和、简单易控、对设备要求低、便于工业化生产。制得的羟基磷灰石-纳米金刚石纳米复合粉末中纳米金刚石表面包覆的羟基磷灰石的粒径与形貌可控，纳米金刚石与羟基磷灰石结合良好，能有效改善纳米金刚石的分散性和稳定性

Ultrasmall Graphene Oxide Supported Gold Nanoparticles as Adjuvants Improve Humoral and Cellular Immunity in Mice

Adjuvants play an important role in vaccines. Alum and MF59 are two dominant kinds of adjuvants used in humans. Both of them, however, have limited capacity to generate the cellular immune response required for vaccines against cancers and viral diseases. It is desirable to develop new and efficient adjuvants with the aim of improving the cellular immune response against the antigen. Here, the feasibility and efficiency of ultrasmall graphene oxide supported gold nanoparticles (usGO-Au) as a new immune adjuvant to improve immune responses are explored. usGO-Au is obtained from reduction of chloroauric acid using usGO and then decorated with ovalbumin (OVA, a model antigen) through physical adsorption to construct usGO-Au@OVA. As the results show, the as-synthesized usGO-Au@OVA can efficiently stimulate RAW264.7 cells to secrete tumor necrosis factor- (TNF-), a mediator for cellular immune response. In vivo studies demonstrate that usGO-Au@OVA can also promote robust OVA specific antibody response, CD8(+) T cells proliferation, and different cytokines secretion. The results indicate that using usGO-Au as an adjuvant can stimulate potent humoral and cellular immune responses against antigens, which may promote better understanding of cellular immune response and facilitate potential applications for cancer and viral vaccines.&nbsp

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies