Effects of Chinese Medicine of Fuyang Detoxification on Cellular Immune Function in Breast Cancer Undergoing Neoadjuvant Chemotherapy

目的研究与分析中药扶阳清毒治疗对乳腺癌新辅助化疗患者细胞免疫功能的具体影响。方法方便选取该院自2014年3月—2017年3月收治的乳腺癌初治患者68例,按照随机数字表法将其随机分为单一治疗组与联合治疗组,每组34例,予以单一治疗组患者单纯新辅助化疗治疗,予以联合治疗组患者新辅助化疗联合中药扶阳清毒法治疗,另选取该院同一时期收治的乳腺纤维瘤患者34例患者做为对照组,对单一治疗组及联合治疗组两组患者治疗前后细胞免疫功能变化进行观察与对比。结果单一治疗组患者与联合治疗患者组两组治疗前的CD3、CD4、CD8及NK细胞数量与对照组患者相比差异有统计学意义（P〈0.05）;治疗后,单一治疗组患者CD3、CD4、CD8及NK细胞数量分别为（46.62±8.67）、（34.16±6.68）、（29.32±6.41）、（31.05±5.35）,与治疗前相比差异有统计学意义（P〈0.05）;治疗后,联合治疗组患者CD3、CD4、CD8、CD4/CD8值及NK细胞数量分别为（49.18±8.87）、（36.51±6.65）、（27.54±7.50）、（1.31±0.65）、（32.53±5.44）,与治疗前相比具有一定变化,但对比结果差异无统计学意义（P〉0.05）。结论对于接受新辅助化疗出现细胞免疫功能下降患者行中药扶阳清毒法联合治疗可明显改善其细胞免疫功能,中药扶阳清毒治疗可对乳腺癌患者细胞免疫功能的改善起到积极作用。Objective This paper tries to study and analyze the specific effects of Chinese medicine ＂Fuyang detoxification＂on cellular immune function in breast cancer patients undergoing neoadjuvant chemotherapy. Methods 68 patients with breast cancer in this hospital from March 2014 to March 2017 were selected and randomly divided into the single treatment group and the combined treatment group, with 34 patients in each group, the patients in the treatment group adopted single Danchunxin adjuvant chemotherapy treatment, the combined group was treated with neoadjuvant chemotherapy detoxification combined with traditional Chinese medicine Fuyangqing, another 34 mammary fibroma patients in this hospital during the same period were selected as the control group. The changes of cellular immune function were observed and compared before and after a single treatment group and combined treatment between the two groups. Results CD3, CD4, CD8 and NK cells in the treatment group and combined treatment group before treatment were（46.62 ±8.67）,（34.16 ±6.68）、（29.32 ±6.41）,（31.05±5.35）, significant different from those before treatment（P0.05）; after treatment, a single treatment of patients with CD3, CD4, CD8 and the number of NK cells were（49.18±8.87）,（36.51±6.65）,（27.54±7.50）,（1.31±0.65）,（32.53±5.44）, but the result was not statistically significant（P〉0.05）. Conclusion Neoadjuvant chemotherapy for the cell immune function decline in patients with traditional Chinese medicine Fuyangqing combined therapy can significantly improve the cellular immune function, Chinese medicine treatment can help Fuyang detoxification on immune cells in patients with breast cancer plays a positive role in improving the function

扶阳健脾法在晚期胃癌治疗中的应用观察及对患者生活质量的影响

目的探讨中药扶阳健脾法在晚期胃癌治疗中的应用价值及对患者生活质量的影响。方法方便选取该院120例晚期胃癌患者(2015年1月—2017年6月间收治)进行观察研究,按随机数表法将患者分组:常规组(n=60)、干预组(n=60),常规组进行常规化疗,干预组进行健脾扶正汤配合化疗,总结两种治疗方案对患者疗效及预后的影响。结果干预组治疗后中医证候积分(12.5±1.4)分明显低于常规组(14.1±1.2)分,KPS评分(81.3±2.1)分、CD4+(40.3±3.8)%、CD3+(60.2±6.8)%、生活质量评分(70.5±6.8)分明显高于常规组(75.2±2.3)分、(35.2±4.3)%、(56.2±5.6)%、(62.2±6.2)分(t=10.328,P=0.000;t=20.544,P=0.000;t=9.187,P=0.000;t=5.533,P=0.000;t=10.370,P=0.000)。干预组患者不良反应发生率1.67%明显低于常规组13.33%(χ2=5.886,P=0.015)。干预组1年生存率96.67%明显高于常规组80.00%(χ2=8.086,P=0.004)。结论在晚期胃癌治疗中应用中药扶阳健脾法治疗可提升患者治疗效果,改善患者免疫功能及生活质量

Research on the development strategy of DeVilbiss Medical China Ltd.

企业发展战略决定企业长久发展的方向，企业的战略与企业发展的方向选择需要结合市场客观规律并遵循法律法规，以科学务实的思想观指导下确定正确的战略，对于企业的发展与成长是非常重要的；相反，战略性的偏差对于企业是重大损失，更是诸多努力付之一炬。企业的发展战略对企业来说至关重要，它是企业所有研发与市场行动的指向，是企业生存与发展的核心问题，是解决的是企业竞争致胜的关键问题。因此，企业家如何制定科学有效、符合规律、富有竞争力的成长路线和发展战略是企业长久发展的一个重要内容。 本文运用了理论联系实际的研究方法，以德百世医疗中国有限公司为研究对象，对德百世医疗中国有限公司发展战略进行了深入研究。全文共分六章...Enterprise strategy determines the direction of enterprise, picked the right direction, with the wrong direction, efforts were in vain. For a ship without a sail boat, the winds are contrary to any direction, so the marketing strategy is crucial to the enterprise, it is our guide to action, direction, the answer is the major issues issues of right and wrong, solve the problems of enterprise compet...学位：工商管理硕士院系专业：管理学院高级经理教育中心（EMBA项目）_高级管理人员工商管理硕士(EMBA)学号：X201115624

A financial performance evaluation and analysis of Globe Union and Seagull

作为第一个国内上市的台资卫浴企业成霖股份，近几年亏损连连、举步为艰。如何进行有效的财务业绩评估与决策，成为中国的卫浴公司面临的重要问题。本文研究及分析了成霖股份与海鸥卫浴从2007年至2011年的财务报表，从三维分析、盈利能力分析、资产运营效率分析、负债管理能力分析、现金创造能力分析、成长能力分析、风险分析、创值能力分析等8个方面来探讨影响成霖股份和海鸥卫浴的财务业绩的因素与指标，为卫浴企业调整负债政策、股利政策、营运资本管理政策、和投资政策，提供了借鉴作用。 本文首先介绍了卫浴行业目前的市场格局以及行业发展趋势，同时介绍了成霖股份与海鸥卫浴的发展历程、经营模式以及股权结构。 然后，以成霖...The first domestic Taiwan-funded plumbing enterprises Globe Union, in recent years, has severe continued loss, are struggling with the profit. How to carry on the financial performance evaluation and decision-making effectively, become the forthcoming important problem of the plumbing corporation in China. the paper has analyzed and researched the financial statements of Globe Union and Seagull ...学位：工商管理硕士院系专业：管理学院_工商管理硕士(MBA)学号：1792010115095

A financial performance evaluation and analysis of Globe Union and Seagull

作为第一个国内上市的台资卫浴企业成霖股份，近几年亏损连连、举步为艰。如何进行有效的财务业绩评估与决策，成为中国的卫浴公司面临的重要问题。本文研究及分析了成霖股份与海鸥卫浴从2007年至2011年的财务报表，从三维分析、盈利能力分析、资产运营效率分析、负债管理能力分析、现金创造能力分析、成长能力分析、风险分析、创值能力分析等8个方面来探讨影响成霖股份和海鸥卫浴的财务业绩的因素与指标，为卫浴企业调整负债政策、股利政策、营运资本管理政策、和投资政策，提供了借鉴作用。 本文首先介绍了卫浴行业目前的市场格局以及行业发展趋势，同时介绍了成霖股份与海鸥卫浴的发展历程、经营模式以及股权结构。 然后，以成霖...The first domestic Taiwan-funded plumbing enterprises Globe Union, in recent years, has severe continued loss, are struggling with the profit. How to carry on the financial performance evaluation and decision-making effectively, become the forthcoming important problem of the plumbing corporation in China. the paper has analyzed and researched the financial statements of Globe Union and Seagull ...学位：工商管理硕士院系专业：管理学院_工商管理硕士(MBA)学号：1792010115095

基于模态应变能的绣花机机架结构动力修改

大型绣花机的工作部件集中在一个无支撑约束的大跨度横梁上,机架整体结构的刚度提升对横梁基频提升的贡献较小,现有的机架设计通过在横梁上增加桥接子结构以提升机架整体固有频率;桥接子结构的多少和在横梁上的位置成为提高固有频率的关键因素,其模态应变能的分布反应了该模态下的刚度状况。文中对工作频率附近的模态应变能进行加权综合作为灵敏度参数,确定桥接结构的位置并讨论桥接结构个数对整体结构固有频率的影响;所提出的方法能为桥接结构的位置与个数设计提供理论依据,实现整体结构固有频率最大效率的提升

中成药用药咨询调查分析

目的调查我院中成药咨询情况,为我院中成药合理使用提供参考。方法统计我院用药咨询记录中中成药使用的情况,并根据咨询的相关内容进行分析讨论。结果中成药的用药咨询占咨询总量的34%,咨询者以18~44岁为主;中成药和西药联合使用最多的是内科;使用的中成药主要是袪湿剂和妇科用药;咨询的内容以药物的用法用量为主。结论加强门诊中成药用药咨询有利于提高药物治疗效果,提高患者用药的依从性,保证用药安全有效

Antitumor effect of hydroxy camptothecin-loaded amphiphilic block copolymer nanoparticles

目的研究羟基喜树碱双嵌段共聚物纳米粒（MePEG．PLGA．HCPT．NPs）的抗肿瘤作用。方法选择人肝癌细胞株Bel-7402为体外模型，采用MTT法观察体外肝癌细胞的生长和增殖抑制情况，评价MePEG-PLGA-HCPT-NPs对肝癌细胞的毒性作用；采用激光共聚焦荧光显微镜技术观察其对肝癌细胞摄取药物的影响；采用小鼠H22肝癌细胞实体瘤模型进行体内抑瘤实验观察荷瘤动物的生长情况，测定肿瘤生长抑制率。结果MePEG—PLGA-HCPT．NPs能抑制肝癌细胞的生长增殖，且随羟基喜树碱浓度的升高而增强；激光共聚焦荧光照片显示载药纳米粒能有效地被Bel．7402细胞摄取；MePEG-PLGA-HCPT-NPs对小鼠的H22实体瘤生长具有明显的抑制作用，低、中、高剂量组的生长抑瘤率分别为37．62％、50．31％和70．25％，与对照组相比差异均有统计学意义（P〈0．05）。结论MePEG-PLGA-HCPT-NPs具有较强的体外、体内抗肿瘤作用。与羟基喜树碱注射剂相比，MePEG-PLGA-HCPT-NPs的抑瘤率更高，且与剂量有关，并对肿瘤生长的抑制更为持久。AIM To study the antitumor effect of hydroxy camptothecin（HCPT）-loaded amphiphilic block copolymer nanoparticles（MePEG-PLGA-HCPT-NPs）. METHODS The human hepatoma cell lines Bel-7402 in vitro were selected as model, the cell growth and viability inhibited by MePEG-PLGA-HCPT-NPs were observed and the antitumor cytotoxicity was evaluated by MTT assay. Cellular uptake of HCPT was observed by Confocal fluores- cence microscopy（CLSM）. Hepatocellular carcinoma cell H22 was subcutaneously injected into mice and MePEG- PLGA-HCPT-NPs was administered to the tumor-bearing mice. The growth of tumor was measured, and the inhibi- tory rate of tumor growth was calculated. RESULTS Hepatoma cell growth and viability were inhibited by Me- PEG-PLGA-HCPT-NPs, the inhibition was enhanced with increasing concentrations. CLSM photos indicated that MePEG-PLGA-HCPT nanoparticles enhanced the intracellular uptake of HCPT in Bel-7402 ceils. Marked inhibitory effect of MePEG-PLGA-HCPT-NPs on the transplanted hepatocellular carcinoma H22 was observed in the tumor- bearing mice. The inhibitory rates were 37.62% , 50.31% and 70.25% in the groups treated with low, medium and high dosage of MePEG-PLGA-HCPT-NPs, respectively （P 〈 0. 05 vs control group）. CONCLUSION Me- PEG-PLGA-HCPT-NPs has marked inhibitory effects on tumor growth in vitro and in vivo. The inhibitory effect of MePEG-PLGA-HCPT-NPs is obvious and dose-dependent and higher than that of HCPT injection.福建省医学创新课题项目（编号2014-CXB-35）;厦门市科技计划指导性项目（编号3502220159001

Effect of Fluoroethylene Carbonate Additive on the Performance of Lithium Ion Battery

在1MOl·l-1lIPf6/碳酸乙烯酯(EC)+碳酸二甲酯(dMC)+碳酸甲乙酯(EMC)(EC、dMC、EMC体积比为1∶1∶1)电解液中加入体积比为2%的添加剂氟代碳酸乙烯酯(fEC),用循环伏安法(CV)、扫描电镜(SEM)、能量散射光谱(EdS)、电化学阻抗谱(EIS)等方法,研究了fEC对锂离子电池性能及石墨化中间相碳微球(MCMb)电极/电解液界面性质的影响.结果表明,体积比2%fEC的添加可以抑制部分电解液溶剂的分解,在MCMb电极表面形成一层性能优良的固体电解液相界面(SEI)膜,降低了电池的阻抗,明显提高了电池的比容量和循环稳定性.Fluoroethylene carbonate (FEC) with a volume ratio of 2% was added to the electrolyte containing 1 mol· L-1 LiPF6 in ethylene carbonate (EC), dimethyl carbonate (DMC), and methyl ethyl carbonate (EMC) (1∶1∶1 by volume).The effects of FEC on lithium ion battery performance and on the mesocarbon microbead (MCMB) electrode/electrolyte interphase were studied by cyclic voltammetry (CV), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and electrochemical impedance spectroscopy (EIS).The results indicated that the application of a 2% (volume ratio) of FEC suppressed electrolyte decomposition and caused the formation of an excellent solid electrolyte interphase (SEI) film on the MCMB electrode.The battery resistance decreased while the specific capacity and cyclic stability of the battery increased.国家基础研究重大项目计划(2007CB209702)资

新型荧光液池的设计及其在凋亡细胞核酸检测中的应用

设计并制作了可容纳塑料离心管的新型荧光液池。该液池适用的样品体积变化范围宽（10－50μL），可用于大批量样品分析，对生物和临床样品的测定尤为合适。该液池用于凋亡细胞核酸样品的检测，取得了满意的结果