Studies on Factors of Nasal Absorption of Hirudin

目的:探讨蛋白多肽类中药水蛭素的经鼻吸收特性及其影响因素。方法:用离体蟾蜍上颚黏膜模型,评价水蛭素的鼻纤毛毒性; 采用Valia-Chien水平扩散池实验与在体大鼠鼻腔灌流实验,观察水蛭素鼻腔给药的吸收特性以及药物浓度、pH值等因素对吸收的影响。结果:Valia-Chien水平扩散池实验和在体大鼠鼻腔灌流实验显示水蛭素能够透过鼻黏膜吸收; 介质pH值、药物浓度等因素均能影响水蛭素的吸收,但水蛭素的浓度与渗透系数、吸收速度间线性关系不明显,水蛭素浓度为0.6mg.mL-1时,鼻黏膜吸收较好。结论:水蛭素对离体蟾蜍上颚黏膜纤毛影响较小,并且能透过鼻黏膜吸收; 药物的浓度和介质的pH值对鼻黏膜的吸收均有影响

一种亚微米压电柔性微动系统设计及性能分析

为获得精密直线运动输出，设计一种压电柔性微驱动系统，系统由压电致动器及柔性微动机构组成，在压电致动器驱动下系统具有亚微米级定位精度。基于柔性铰链导向、传动原理，设计了一种精密柔性微动机构，在此基础上提出了压电柔性微驱动系统设计方案。采用有限元法对系统进行了运动学分析、强度分析、动态分析，分析结果显示，系统具有定位精度高（最大定位误差为0.24 μm）、强度性能好、动态性能优良等优势。研究对微驱动系统研究及应用具有一定的参考价值

The Study on Carbon Nanotube-loaded Pt Catalysts for Proton Exchange Membrane Fuel Cells

　采用原位化学还原法制备碳纳米管载铂(Pt/CNTs)和碳粉载铂(Pt/C)催化剂,经透射电镜分析和X射线衍射分析,然后制成电极,组装成质子交换膜燃料电池并进行性能测试。实验结果表明,所制备的两种催化剂,铂粒径均较小(4nm左右),而Pt/CNTs表现出比Pt/C优越的催化性能。Carbon nanotube_supported_platinum (Pt/CNTs) and carbon_supported_platinum (Pt/C) catalysts were synthesized by in_situ chemical reduction. They were analyzed using TEM and XRD, then made into electrodes to be part of assemable PEMFC for the performence tests. The resulted show that Pt clusters in both catalysts are of small particle size (about 4nm), and Pt/CNTs exhibits a higher catalytic activity than Pt/C.作者联系地址：北京交通大学理学院,中国矿业大学化工学院,北京交通大学理学院,北京交通大学理学院,北京交通大学理学院 北京100044 ,江苏徐州221008 ,北京100044 ,北京100044 ,北京100044Author's Address: 1. College of Science, Northern Jiaotong University, Beijing 100044, China; 2. School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221008, Chin

制备型高效液相色谱法制备和厚朴酚与厚朴酚

目的:厚朴中酚类化合物进行分离制备与定性。方法:厚朴提取物经硅胶柱层析得到淡黄色油状单体化合物,以及和厚朴酚与厚朴酚混合物,将混合物再进行HPLC制备色谱分离,以甲醇-水-冰醋酸(80∶20∶0.10,V/V/V)为流动相,收集相应馏分浓缩至干。结果:该法所得产品用面积归一化法与外标法定量,纯度大于98%,核磁共振确定结构,与文献数据基本一致。结论:本法简便快捷,可获得高纯度的和厚朴酚与厚朴

Effects of volatie oil of Fineleaf schizonepeta herb and Divaricate saposhnikovia root on proinflammatory cytokine expression and regulation

目的：研究荆防挥发油对炎症相关因子表达和调节的影响。方法：用OA和LPS2次打击，建立2次打击急性肺损伤（ALI）模型。荆防挥发油（45．19μL·kg^-1）对大鼠ALI模型支气管上皮细胞间黏附分子CD54，肺组织核因子-κB（NF—κB）p65、支气管上皮细胞中NF—κB p65 mRNA的组织化学观察及统计。结果：荆防挥发油能明显抑制CD54的表达、NF—κB p65的活化及阻止NF—κB p65 mRNA的转录增加。结论：荆防挥发油抑制CD54的表达，减少p65蛋白的合成可能是其抗炎的分子机制之一

一种照明成像共光路显微成像系统

本发明提出了一种照明成像共光路显微成像系统，包括光源、显微物镜组件、照明聚光片以及分光片，显微物镜组件和分光片位于同一光轴上，光源和照明聚光镜、分光片位于同一光轴上，光源与显微物镜组件呈垂直设置。本发明的照明成像共光路显微成像系统，采用照明和成像共光路设计的方式，可以避免在物面附近设置辅助照明部件，从而使得显微镜可以工作与狭小空间

Direct mass measurements of neutron-rich ~(86)Kr projectile fragments and the persistence of neutron magic number N=32 in Sc isotopes

<span style="color: rgb(51, 51, 51); font-family: arial, helvetica, sans-serif; font-size: 13px; line-height: 22px; background-color: rgb(248, 248, 248);">In this paper, we present direct mass measurements of neutron-rich Kr-86 projectile fragments conducted at the HIRFL-CSR facility in Lanzhou by employing the Isochronous Mass Spectrometry (IMS) method. The new mass excesses of 52-54SC nuclides are determined to be -40492(82), -38928(114), -34654(540) keV, which show a significant increase of binding energy compared to the reported ones in the Atomic Mass Evaluation 2012 (AME12). In particular, Sc-53 and Sc-64 are more bound by 0.8 MeV and 1.0 MeV, respectively. The behavior of the two neutron separation energy with neutron numbers indicates a strong sub-shell closure at neutron number N=32 in Sc isotopes.</span

Shell Evolution Study for New Magic Number N =32 via Isochronous Mass Spectrometry

<span style="color: rgb(51, 51, 51); font-family: arial, helvetica, sans-serif; font-size: 13px; line-height: 22px; background-color: rgb(248, 248, 248);">Recent results and progress of mass measurements of neutron-rich nuclei utilizing Isochronous Mass Spectrometry (IMS) based on the HIRFL-CSR complex at Lanzhou are reported. The nuclei of interest were produced through projectile fragmentation of primary 86Kr ions at a realistic energy of 460.65 MeV/u. After in-flight separation by the fragment separator RIBLL2, the fragments were injected and stored in the experimental storage ring CSRe, and their masses were determined from measurements of their revolution times. The re-determined masses were compared and evaluated with other mass measurements, and the impact of these evaluated masses on the shell evolution study is discussed.</span