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Studies on Factors of Nasal Absorption of Hirudin
Authors
石森林.
葛卫红
+3 more
郭建友
陈立兵
韩玉环
Publication date
1 January 2008
Publisher
Abstract
目的:探讨蛋白多肽类中药水蛭素的经鼻吸收特性及其影响因素。方法:用离体蟾蜍上颚黏膜模型,评价水蛭素的鼻纤毛毒性; 采用Valia-Chien水平扩散池实验与在体大鼠鼻腔灌流实验,观察水蛭素鼻腔给药的吸收特性以及药物浓度、pH值等因素对吸收的影响。结果:Valia-Chien水平扩散池实验和在体大鼠鼻腔灌流实验显示水蛭素能够透过鼻黏膜吸收; 介质pH值、药物浓度等因素均能影响水蛭素的吸收,但水蛭素的浓度与渗透系数、吸收速度间线性关系不明显,水蛭素浓度为0.6mg.mL-1时,鼻黏膜吸收较好。结论:水蛭素对离体蟾蜍上颚黏膜纤毛影响较小,并且能透过鼻黏膜吸收; 药物的浓度和介质的pH值对鼻黏膜的吸收均有影响
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Institute of Psychology,Chinese Academy Of Sciences
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oai:ir.psych.ac.cn:311026/3917
Last time updated on 08/08/2019
Institutional Repository of Institute of Psychology, Chinese Academy of Sciences
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:ir.psych.ac.cn:311026/3916
Last time updated on 25/07/2018