Application of the three-dimensional visualization and 3D printing technology for the preoperative evaluation of retroperitoneal tumors

目的探讨三维重建及3D打印技术在腹膜后肿瘤术前评估中的应用价值。方法回顾性分析2011年3月至2015年9月厦门大学附属成功医院收治的50例腹膜; 后肿瘤病人的临床资料,应用人体器官三维建模软件将病人的CT二维图像重建成三维可视化图像,使用人体器官模型3D打印设备,用两色热塑性塑料打印实物模; 型,通过观察肿瘤与腹腔器官、腹部大血管之间的关系进行术前评估并制定手术方案。实施手术,术中比较重建结果与实际的区别。结果50例病人均成功完成三维; 重建,其中10例病人完成3D打印,三维重建结果及3D打印模型能够立体、清晰和实物化的显示肿瘤解剖学位置及与周围器官、血管的毗邻关系,与术中实际情; 况大致相符。50例病人均顺利施行手术,术中无死亡。结论三维重建及3D打印技术能够对腹膜后肿瘤术前进行精准评估,对指导手术具有一定的应用价值。Objective To explore the application value of three dimensional; visualization and 3D printing technology in the preoperative evaluation; of retroperitoneal tumors. Methods March 2011 to September 2015,the; clinical data of 50 cases of retroperitoneal tumor patients in Xiamen; University Affiliated successful hospital were retrospectively analyzed.; Xiamen strong science and technology R & D human organ 3D modeling; software will reconstruct 2D CT image visualization into a; three-dimensional visualization image,and then it can print physical; model with the company's XMQB-I human organ model 3D printing equipment; and white thermoplastic. At last,preoperative evaluation and surgical; plan can be made through the relationship between the tumor,organs in; abdominal cavity,and abdominal vascular. During the surgery,make a; comparison between the visualization results with the actual condition.; Results 50 cases of patients were successfully completed the; three-dimensional visualization,including 10 cases of patients; completed. Three-dimensional visualization and 3D printing model can; three-dimensionally,clearly show the adjacent relationship between the; anatomical tumour location and surrounding organs and blood; vessels,broadly in line with the actual surgery. 50 surgeries were; successfully performed,no death during perioperative period. Conclusion; Three dimensional visualization and 3D printing technology can make an; accurate preoperative evaluation of retroperitoneal tumors,which has a; certain application value for guiding surgery.国家自然科学基

结肠癌伴孤立巨大肝转移切除术一例

患者男,72岁,因“反复中上腹胀痛不适1月余“入院;既往有乙肝病史,无高血压、糖尿病、心脏病等病史,无手术史。入院查CT示:左肝巨大占位,约22.1 CMx11.3 CM,与胃小弯粘连(图1);门静脉右支无显示(图2),左结肠壁增厚,考虑结肠癌肝转移可能。肿瘤标记物检查示:CEA 54.52μg/l,CA19-9 120.10 u/Ml,AfP正常,血常规、血液生化分析未见国家自然科学基金资助项目(81272246、81101502、61271336、61327001

Application of a three-dimensional visualization technology for precise before retroperitoneal tumor surgery(Report of 15 cases)

目的探讨三维可视化技术在腹膜后肿瘤术前评估中的应用价值。方法回顾性分析2011年3月至2013年12月厦门大学附属成功医院收治的15例腹膜后肿瘤病人的临床资料,应用三维可视化技术将病人术前二维CT图像进行三维可视化重建,通过观察肿瘤与腹腔脏器、腹部大血管之间的关系及测量肿瘤体积、手术模拟进行术前评估。对实施手术的病人,比较重建结果与实际手术的区别,对模拟切除肿瘤体积与实际切除肿瘤体积进行相关性分析。结果 15例病人三维可视化重建后图像清晰立体地显示肿瘤组织、腹腔实质脏器、腹腔大血管的解剖结构及毗邻关系,12例评估后行腹膜后肿瘤切除术,三维重建肿瘤的解剖关系与术中大致相符。12例手术病人术前模拟切除肿瘤体积(1117.50±690.35)M l,实际切除肿瘤体积(1189.92±737.74)M l,两者比较差异无统计学意义(T=0.25,P>0.05),具有相关性(r=0.81,P0.05).The actual liver resection volume was positively correlated with the predicted liver resection volume(r=0.81, P<0.05).Conclusions The three-dimensional visualization technology has acertain degree of clinical value in the precise before retroperitoneal tumor surgery.国家自然科学基金资助(No.81272246;81101502;61271336;61327001

PKCα由线粒体向细胞核转运与胃癌细胞凋亡诱导密切相关

PKC在细胞生长、分化、凋亡和信号转导调节中具有重要作用.通过激光扫描共聚焦显微镜证实:在胃癌BGC-823细胞中,一部分PKCα定位于线粒体,一部分定位在胞浆,细胞经TPA处理后,位于线粒体和胞浆的PKCα向细胞核转运;Western blot检测则发现PKCα蛋白表达水平在TPA处理前后没有发生变化.此外,应用凋亡诱导剂和特异性PKC抑制剂的实验结果进一步证实:胃癌细胞内PKCα由线粒体和胞浆向细胞核转运与细胞凋亡的诱导密切相关.提示PKCα在细胞内的定向转运可能是与细胞凋亡过程相关联的重要事件之一.国家自然科学基金（批准号:39880015,30170477）;国家杰出青年科学基金（批准号:39825502）资助项

Effects of Relaxation and Imagery Training on the Emotional and Physical Function

408例接受放化疗的癌症病人随机进入干预组和对照组。干预组的病人接受放松和意念想象训练。采用情绪和生活质量问卷,分别对两组患者进行两次测查(治疗前和治疗后)。干预组患者治疗后各项情绪、功能、症状指标和总体生活质量比对照组改善明显; 放疗或化疗后干预组病人的各项指标都可以回复到治疗前的状态,而情绪和总体生活质量显著好于治疗前

Effects of Relaxation and Imagery Training on the Emotional and Physical Function

408例接受放化疗的癌症病人随机进入干预组和对照组。干预组的病人接受放松和意念想象训练。采用情绪和生活质量问卷,分别对两组患者进行两次测查(治疗前和治疗后)。干预组患者治疗后各项情绪、功能、症状指标和总体生活质量比对照组改善明显; 放疗或化疗后干预组病人的各项指标都可以回复到治疗前的状态,而情绪和总体生活质量显著好于治疗前