Effects of Implantation of Self-Assembling Peptides on Sympathetic Nerve Remodeling in Rats with Myocardial Infarction

背景恶性心律失常事件是缺血性心脏病患者死亡的主要原因。心梗后出现组织、电学及神经系统的重构，这些都是心律失常产生的基质。交感神经重构与心梗后心律失常的关系自提出后成为研究热点。交感神经重构表现为交感神经密度的增加及分布的不均一。心梗后神经重构与微环境关系密切，特别是各种神经营养因子和供神经粘附的支架。而自聚肽（Self-assemblingpeptides，SAP）作为一种很有应用前景的组织工程学材料，在细胞三维培养和神经组织的损伤修复实验中证实能显著改善微环境。本实验拟通过注射自聚肽到心梗局部，研究其植入对交感神经重构的影响，并检测自聚肽植入对心律失常的发生有无促进或改善作用。 方法SD大...Malignant arrhythmia is the main cause of death in patients with ischemic heart disease. Tissue reconstruction, Electrical remodeling and neural remodeling after myocardial infarction, is the substrate for arrhythmia. The disorder of cells and tissue is possibly due to the damage of extracellular matrix. After injected into tissue, Self Assembling Peptides (SAP) assembles into fiber network, serve...学位：医学硕士院系专业：医学院_内科学学号：2452010115328

On Sellers’ Liability for Quality warranties in International Sales of Goods

卖方的品质担保义务是国际贸易法中的一个重要问题。虽然很多国家在本国立法中都对这一义务进行了明确，但由于两大法系有关品质担保义务的理论基础不同，致使各国的规定也存在差异，所以依据各国国内法对国际货物贸易中出现的品质担保问题进行解释显然会造成法律适用的不确定性，给国际贸易的正常发展造成阻碍。为了减少国际贸易的法律障碍，促进国际贸易的发展，1980年联合国国际贸易法委员会在维也纳召开的外交会议上通过了《国际货物销售合同公约》（以下简称《公约》）。《公约》作为国际贸易领域非常重要的一部实体法，充分考虑到了国际货物贸易的特点，并且综合了两大法系的规定，对品质担保义务形成了自身一套比较完整的制度，获得很多...Seller’s liability for quality warranties is an important issue of international trade law. Although it was written in many countries’ sales contract law, but the regulation was not same due to the different of the theoretical basis between two legal systems. It will be uncertain if the problem of quality warranties, arisen in international cargo trade, was interpreted according to domestic law of...学位：法律硕士院系专业：法学院法律系_法律硕士(JM)学号：X20040812

Study on the Regulation of Affiliated Enterprise Bankruptcy

本文的研究对象是关联企业破产时关联企业利益关系人的利益平衡，文章在梳理美国、德国、我国台湾地区及我国大陆地区规制关联企业破产的相关法律规范的基础上，结合理论前沿和我国关联企业破产的实际问题，对我国关联企业破产制度的完善提出合理建议。 本文除引言和结语外，共分为分五章： 第一章概述关联企业及其破产。第一节介绍了关联企业的定义及其特征。第二节对关联企业破产进行了界定，分析了关联企业破产的种类及特征。 第二章梳理域外对关联企业破产的规制。第一节阐述美国用来规制关联企业破产、实现相关利益者利益平衡的三大制度——“揭开公司面纱”制度、“衡平居次”原则、“实质合并”规则。第二节阐述德国用来规制关联企...The object of this paper is the balance of the stakeholders’ interests when affiliated enterprise goes bankrupt. This paper will comb the relevant laws and regulations about affiliated enterprise bankruptcy of the United States, Germany, Taiwan and mainland of China. Then we will put forward reasonable suggestions on improving Chinese system of affiliated enterprise bankruptcy combining the front ...学位：法律硕士院系专业：法学院_法律硕士(JM)学号：X200912008

Effect of phenanthrene and 3-methylcholanthrene exposure on reproductive functions of Sebastiscus marmoratus

     本实验以我国沿海常见的鱼类褐菖鲉（Sebastiscusmarmoratus）为主要研究对象，在生态条件下，在环境污染的浓度范围内，通过多环芳烃菲和3-甲基胆蒽（0.06、0.6、6μg/L）的长期慢性暴露实验，对生殖功能相关的生理生化指标进行观察测定，以分析两者对鱼类生殖机能的影响及作用机理，同时分析低环数PAHs和高环数PAHs在鱼类生殖机能毒性作用中的不同作用和机制。      1.Phe和3MC的代谢。Phe暴露50d后，除雄性低浓度组肝脏的GST活性显著升高外，其他各组肝脏...       This study was conducted to investigate the chronic effects of phenanthrene（Phe） and 3-methylcholanthrene（3MC） at environmental levels (0.06, 0.6, 6μg/L) on the reproductive function in an oceanic fish, Sebastiscus marmoratus. Some index on reporoductive function were assayed to examine the possible mechanism of the toxic effect. The different mechanism of low-...学位：理学硕士院系专业：生命科学学院生物学系_动物学学号：2005130198

实时操作系统中任务间通信的一种方法

在实时操作系统中任务间通信是影响系统性能的1 个关键因素. 当前多数的实时内核中所提 供的邮箱机制在一对多的任务间通信中效率不高, 实时性不强. 针对实时内核这个缺点引入固定消息 邮箱机制的通信方法. 这种方法的优点是: 占用内存少, 实时性强. 将固定消息邮箱机制与传统的邮箱 机制配合使用可以极大的提高任务间通信的效率.哈尔滨工业大学跨学科交叉性研究基金资助, 课题代号:HITMD. 2001. 01

化学信息学网络考试系统的构建

在WindowsNT 4 .0服务器建立化学信息学的Access试题数据库 ,使用ASP编写网络考试系统 ,供学生在Internet上使用浏览器进行在线考试。该系统安全可靠、应用范围广 ,是发展远程教育的重要工具

Clinical Research of Kangshi Kangxian Recipe Treating on Hepatic Fibrosis of Chronic Hepatitis B

目的观察康氏抗纤方治疗慢性乙型肝炎肝纤维化的临床疗效,探讨其对肝组织N-花生四烯酸氨基乙醇(; arachidonoylethanolamine,AEA) 、2-花生四烯酸甘油( 2-arachidonoylglycerol,2-AG); 、大麻素受体1( cannabinoid receptor 1,CBR1) mRNA、大麻素受体2( cannabinoid receptor; 1,CBR2); mRNA含量变化的影响。方法将110例慢性乙型肝炎肝纤维化患者按随机数字表法分为治疗组和对照组,每组55例。治疗组予中药康氏抗纤方联合恩替卡韦分; 散片治疗,对照组用恩替卡韦分散片单药治疗,两组均治疗48周。判定两组临床疗效,检测血清ALT水平,HBV; DNA、HBsAg、HBsAb定量,肝组织病理、肝硬度变化,肝组织AEA、 2-AG含量和CBR1、CBR2; mRNA表达水平。结果与对照组比较,治疗组的临床总有效率、HBsAg阴转率、肝组织纤维化分期疗效有效率均高于对照组(chi~2 =; 4.453,4.152,6.364,均P < 0.05); 。与本组治疗前比较,治疗后两组患者肝纤维化瞬时弹性测定值、AEA、2-AG含量及CBR1、CBR2 mRNA表达均降低(均P <; 0.05),且治疗组降低更明显(均P < 0.05); 。肝组织病理显示:治疗后治疗组肝小叶结构基本完整,肝细胞轻度水样变性,汇管区纤维组织无增生,局部少量淋巴细胞浸润,炎症及纤维化较对照组明显改善。; 结论康氏抗纤方具有提高慢性乙型肝炎肝纤维化患者的临床总有效率、HBsAg阴转率、肝组织纤维化分期疗效有效率,其作用机制可能与调节内源性大麻素系统; 有关。Objective To observe the clinical effect of Kangshi Kangxian Decoction (; KSKXD) in treating on patients of hepatic fibrosis of chronic hepatitis; B ( CHB),and to explore the mechanisms of KSKXD by regulating the; contents of arachidonoylethanolamine ( AEA),2-arachidonoylglycerol (; 2-AG),cannabinoid receptor 1 ( CBR1 mRNA) and cannabinoid receptor 2 (; CBR2 mRNA) in the liver tissue. Methods Totally 110 patients with; hepatic fibrosis of CHB were assigned to the treatment group and the; control group according to random digit table,55 cases in each group.; The treatment group was treated with Chinese herb KSKXD combined with; Entecavir,and the control group was treated with Entecavir. Both of the; two groups were treated for 48 weeks. The clinical efficacy of the two; groups was determined. The serum ALT levels,HBV DNA, HBsAg and HBsAb; quantification,liver pathological changes,liver stiffness; changes,contents of AEA and 2-AG,mRNA expression of CBR1 and CBR2 in the; liver tissue were detected. Results The total effective rate,HBsAg; negative conversion rate,hepatic fibrosis staging and curative effect; rate of the treatment group were higher than those of the control group; (chi~2 = 4.453,4.152,6.364,allP <0.05). After treatment,the; instantaneous elasticity of liver fibrosis,the contents of AEA and; 2-AG,the mRNA expressions of CBR1 and CBR2 in the liver tissue in the; two groups were decreased compared to those of the same group before; treatment (P < 0.05),and the treatment group had better effect than that; of the control group (P < 0.05). The pathological changes in the; treatment group after treatment indicated the liver lobules; integrity,mild hydropic degeneration of liver cells,periportal fibrous; tissue hyperplasia,local small lymphocytic infiltration,which fibrosis; and inflammation were better than those of the control group.; Conclusions KSKXD was effective in the treatment of hepatic fibrosis of; CHB, which improved total effective rate,HBsAg seroconversion rate and; liver fibrosis stage efficiency. And its mechanism maybe related to the; regulation of the endocannabinoid system.国家自然科学基金资助项目; 福建省科技计划引导性项目; 厦门市科技惠民项目; 福建中医药大学临床专项校管课题基

Multistage Inverse Modeling Method and Its Application in Gelatin Solution Production Process

针对一类串联型工业大系统,提出了多阶段逆模型建模方法:将串联大系统分为若干个阶段,以产品质量指标作为过程设计的起点,用逆向推理的方法,建立各个阶段的逆模型;根据产品质量指标的要求,直接求出各个阶段的控制变量设定值。将该方法应用于胶液生成过程的软测量建模,采用多阶段建模方法和整体建模方法分别建立了基于bP神经网络的胶液生成过程逆模型,并从误差平方和MSE和命中率等方面对两种建模方法的建模精度进行了比较。结果表明,多阶段建模方法可以获得更高的建模精度;同时,具有更大的灵活性;而且逆模型方法可以根据质量指标求出控制变量设定值,更便于实际应用。Aiming at a class of serially connected industrial system,a novel multistage inverse modeling method was presented.The large-scale system is divided into several stages.Using specified product qualities as a starting point for process design.By backward reasoning the required process conditions and the control variable set points of all stages for processing system were found.The inverse models of gelatin solution production process were established based on the BP neural network by using multistage modeling method and whole stage modeling method,and modeling accuracy comparison were made from error and hit rates.The simulation results indicate the model based on the proposed method has smaller error and higher hit rates.Meanwhile,the break down of the sub models increases the flexibility of model development and reduces the effort to change the model when the sub models change.And the required process conditions and the control variable set points of all stages for processing system were found according to specified product qualities.Thus,it is easy to be really applied.This method has been successfully applied on improving the gelatin solution production process and product quality control.厦门市科技计划项目(3502Z20083028);国家自然科学基金项目(50843059);福建省教育厅科技项目(JA08218

中国海及邻近区域碳库与通量综合分析

中国海总面积约470万平方公里,纵跨热带、亚热带、温带、北温带等多个气候带.其中,南海北依\"世界第三极\"青藏高原、南邻\"全球气候引擎\"西太平洋暖池,东海拥有全球最宽的陆架之一,跨陆架物质运输显著,黄海是冷暖流交汇区域,渤海则是受人类活动高度影响的内湾浅海.中国海内有长江、黄河、珠江等大河输入,外邻全球两大西边界流之一的黑潮.这些鲜明的特色赋予了中国海碳储库和通量研究的典型代表意义.文章从不同海区（渤海、黄海、东海、南海）、不同界面（陆-海、海-气、水柱-沉积物、边缘海-大洋等）,以及不同生态系统（红树林、盐沼湿地、海草床、海藻养殖、珊瑚礁、水柱生态系统等）多层面对海洋碳库与通量进行了较系统地综合分析,初步估算了各个碳库的储量与不同碳库间的通量.就海气通量而言,渤海向大气中释放CO2约0.22Tg Ca-1,黄海吸收CO2约1.15Tg Ca-1,东海吸收CO2约6.92～23.30Tg Ca-1,南海释放CO2约13.86～33.60Tg Ca-1.如果仅考虑海-气界面的CO2交换,中国海总体上是大气CO2的\"源\",净释放量约6.01～9.33Tg Ca-1.这主要是由于河流输入以及邻近大洋输入所致.河流输入渤黄海、东海、南海的溶解无机碳（DIC）分别为5.04、14.60和40.14Tg Ca-1,而邻近大洋输入DIC更是高达144.81Tg Ca-1,远超中国海向大气释放的碳量.渤海、黄海、东海、南海的沉积有机碳通量分别为2.00、3.60、7.40、7.49Tg Ca-1.东海和南海向邻近大洋输送有机碳通量分别为15.25～36.70和43.39Tg Ca-1.就生态系统而言,中国沿海红树林、盐沼湿地、海草床有机碳埋藏通量为0.36Tg Ca-1,海草床溶解有机碳（DOC）输出通量为0.59Tg Ca-1;中国近海海藻养殖移出碳通量0.68Tg Ca-1,沉积和DOC释放通量分别为0.14和0.82Tg Ca-1.总计,中国海有机碳年输出通量为81.72～103.17Tg Ca-1.中国海的有机碳输出以DOC形式为主,东海向邻近大洋输出的DOC通量约15.00～35.00Tg Ca-1,南海输出约31.39Tg Ca-1.综上,尽管从海-气通量看中国海是大气CO2的\"源\",但考虑了河流、大洋输入、沉积输出以及微型生物碳泵（DOC转化输出）作用后,中国海是重要的储碳区.需要指出的是,文章数据是基于中国海各海区碳循环研究报道,鉴于不同研究方法上的差异,所得数据难免有一定的误差范围,亟待将来统一方法标准下的更多深入研究和分析.国家重点研发计划项目(编号:2016YFA0601400);;国家自然科学基金项目(批准号:91751207、91428308、41722603、41606153、41422603);;中央高校基础研究项目(编号:20720170107);;中海油项目(编号:CNOOC-KJ125FZDXM00TJ001-2014、CNOOCKJ125FZDXM00ZJ001-2014)资

Imposex of Thais clavigera and Cantharus cecillei in the coastal waters of Xiamen

海产腹足类性畸变以其对有机锡的敏感性、特异性和不可逆性而成为海洋有机锡污染的理想指示种。调查研究了厦门海域岩相海岸带疣荔枝螺(THAIS ClAVIgErA)和甲虫螺(CAnTHAruS CECIllEI)的性畸变情况,通过生物学指标IOI(性畸变率)、rPSI(相对阴茎发展指数)、VdSI(输精管发展指数)及SrI(性比指数)综合评价其性畸变发展程度,间接指示厦门周边海域的有机锡污染程度。研究结果发现,在采集疣荔枝螺的17个站点中有5个站点种群性畸变率为100%,其中宝珠屿种群性畸变程度最为严重,VdSI达4,采集甲虫螺的4个站点的种群性畸变率均为100%。性畸变程度较严重的种群普遍集中于厦门西港,并且表现出由港内到港外逐渐减轻的趋势,而白城、会展中心和大嶝岛等位于开阔的厦门东海域的种群性畸变程度最轻,与往年厦门西海域有机锡污染监测数据相比一致,体现出性畸变程度与有机锡污染程度及海港码头远近之间的相互关系。The degree of imposex,i.e.the imposition of male characteristics onto females,in neogastropods can be used as a sensitive and accurate biomarker to evaluate organotin contamination in coastal marine environment.Now,the imposex status in females of Thais clavigera and Cantharus cecillei in 17 sites was investigated to evaluate the organotin contamination along Xiamen Bay during 2006 and 2007.The four indices including incidence of imposex(IOI),relative penis size index(RPSI),vas deferens sequences index(VDSI) and sex ratio index(SRI) were used comprehensively to assess the imposex status in order to ascertain the extent of organotin bioavailability in Xiamen Bay.Based on this research,T.clavigera in 5 sites and C.cecillei in all survey sites exhibited the IOI of 100%.At Bao ZhuYu Islet,the imposex level was the most serious with maximum VDSI value of 4.In general,the imposex level decreased from the inner to the outer of Xiamen Western Harbour,and the populations in the open Xiamen Eastern Waters including Bai Cheng,Convention and Exhibiton Center and Dadeng Island showed a lower imposex level.These results were accordant with the concentrations of organotins in 2005.The imposex degree also increased with increasing organotin contamination and decreasing distance from shipping facilities.国家自然科学基金资助项目(40476048);厦门大学近海海洋环境科学国家重点实验室开放基金资助项目;厦门大学新世纪优秀人才计划基金资助项