表面闭合优先发生情况下入水动力学建模与分析

本文研究了三维细长弹体以固定速度垂直入水问题,研究范围被限制在表面闭合优先于深闭合发生情况下的空气腔形成阶段。我们建立了弹体发射实验装置,通过高速相机拍摄了入水过程的时序图像。我们还在开源流体力学平台OpenFOAM~?上开发了基于压力的可压缩多相求解器,用于开展入水流场特性数值模拟研究,采用数值计算得到的空泡形态与实验结果吻合良好。本文讨论了在不同佛汝德数工况下,弹体阻力系数、压力分布、空腔轮廓和流动特性随着无量纲时间的变化规律。分析结果表明,阻力系数在接触水面的瞬间发生突变达到峰值,随后快速下降并达到一个相对稳定的值,空腔入口处和弹体的肩部存在着明显的低压,随着气体侵入的减少和空气腔体积的增大,泡内的整体压力不断降低

AHPN衍生物的合成及其与RARγ的结合活性研究

目的本实验以6-{3’-(1-金刚烷基)-4’-羟基苯基}-2-萘甲酸(AHPN)母核为结构基础,设计、合成一系列AHPN衍生物,并对这些衍生物做初步的活性筛选,期望找到活性显著的衍生物。方法以对溴苯酚和1-金刚烷醇为原料经取代、缩合、氧化、还原等反应合成AHPN衍生物,经过1H-NMR、13C-NMR、HR-MS表征,并利用Biacore技术检测衍生物与蛋白质之间的结合能力。结果衍生物7c、6c、6e、6h显示出了显著优于先导化合物AHPN与视黄酸核受体γ(RARγ)的结合能力,亚磷酸二甲酯基与氮杂环的引入提高了该类化合物的活性。结论该类AHPN衍生物与RARγ结合能力显著,有进一步研究的价值。扬州市邗江区科技计划项目资助;;福建省基金项目资助(2014Y0044);;国家海洋局第三海洋研究所基本科研业务费专项资金资助项目(海三科2016044

Musical Expertise Has Minimal Impact on Dual Task Performance

Studies investigating effect of practice on dual task performance have yielded conflicting findings, thus supporting different theoretical accounts about the organisation of attentional resources when tasks are performed simultaneously. Because practice has been proven to reduce the demand of attention for the trained task, the impact of long-lasting training on one task is an ideal way to better understand the mechanisms underlying dual task decline in performance. Our study compared performance during dual task execution in expert musicians compared to controls with little if any musical experience. Participants performed a music recognition task and a visuo-spatial task separately (single task) or simultaneously (dual task). Both groups showed a significant but similar performance decline during dual tasks. In addition, the two groups showed a similar decline of dual task performance during encoding and retrieval of the musical information, mainly attributed to a decline in sensitivity. Our results suggest that attention during dual tasks is similarly distributed by expert and non-experts. These findings are in line with previous studies showing a lack of sensitivity to difficulty and lack of practice effect during dual tasks, supporting the idea that different tasks may rely on different and not-sharable attentional resources

卷积神经网络模型在儿科疾病预测中的应用

目的:针对儿童看病需求量大导致的儿科诊疗服务效率和准确率偏低等问题,利用自然语言处理和深度学习技术,从儿科历史病历数据中自动\"学习\"专家医生诊断模式,形成智能辅助诊断模型,从而对新的儿科病历数据输出疾病诊断决策。结果:基于深度卷积神经网络的七分类疾病智能诊断模型的正确率为84.26%,F1-score为84.33%,基本达到可投入实际应用的级别。结论:智能诊断决策作为预诊信息提供给医生进行确诊参考,对提升医生诊断速度效果明显。国家自然科学基金面上项目(编号:71571056);;福建省自然科学基金面上项目(编号:2012J01274)~

Expression of the proliferation signaling pathway on the gastric mucosa cells in rats with acute gastric mucosa injury treated by acupuncture

目的:研究针刺对急性胃黏膜损伤大鼠胃黏膜细胞增殖相关信号分子表达的影响。方法:大鼠随机分为空白组、模型组、胃经穴组和对照点组,采用乙醇灌胃法制作胃黏膜损伤大鼠模型,肉眼下观察大鼠胃黏膜损伤指数,酶联免疫吸附测定法(ElISA法)检测丝裂原激活的蛋白激酶1(MAPk1)、磷酸化细胞外信号调节激酶(PErk2)、磷酸肌醇3激酶(PI3k)、蛋白激酶b(Pkb/AkT)、丝氨酸/苏氨酸蛋白激酶(PAk)的表达。结果:与模型组比较,胃经穴组和对照点组大鼠胃溃疡指数值均显著降低(P<0.05),胃经穴组大鼠胃黏膜细胞MAPk1、PErk2、PI3k、AkT、PAk表达显著升高(P<0.05);与对照点组比较,胃经穴组大鼠胃溃疡指数和胃黏膜细胞MAPk1、PErk2、PI3k、AkT、PAk表达均显著升高(P<0.05)。结论:针刺可促进胃黏膜损伤修复,降低胃黏膜细胞增殖相关信号分子表达。Objective: To study the expression of the proliferation signaling pathway on the gastric mucosa cells in rats with acute gastric mucosa injury treated by acupuncture.Methods: Rats were randomly divided into normal group, model group, stomach meridian group and control point group.The acute gastric mucosa injury model was established by the method of ethanol intragastric administration.The gastric mucosal injury indexes in rats were observed, the expression of the mitogenactivated protein kinase 1(MAPK1), phospho-extracelluar signal-regulated kinase2(pERK2), phosphoinositide3-kinase(PI3K), protein kinase B(PKB/Akt) and protein activated kinase(PAK) in gastric mucosal cell were tested with ELISA method.Results: Compared with model group, the gastric mucosa damage index in rats of stomach meridian and control point group were decreased(P<0.05), and the expression of the MAPK1, pERK2, PI3 K, Akt and PAK in gastric mucosa cells in stomach meridian group rats were decreased signfiicantly(P<0.05).Compared with control point group, the expression of the MAPK1, pERK2, PI3 K, Akt, PAK and gastric mucosa damage index in gastric mucosa cells in stomach meridian group rats were increased signfiicantly(P<0.05).Conclusion: The acupuncture could promote the gastric mucosa injury repair and decrease the expression of the proliferation signaling molecular in gastric mucosa cells.国家自然科学基金(No.30960484;No.81260556)~

艾灸预处理对胃黏膜细胞调控作用的研究进展

本文介绍了近年来艾灸疗法对胃黏膜损伤的预保护作用的实验研究进展,主要讨论了艾灸调控胃黏膜细胞增殖与凋亡相关信号通路对胃黏膜损伤的预保护作用,并在此基上提出目前艾灸在预防胃黏膜损伤相关疾病研究中存在的问题与展望

谷氨酸受体拮抗剂可通过调节脑源性神经营养因子水平改善强迫症模型小鼠的刻板行为

目的在RU24969强迫症（OCD）小鼠模型中探究NMDA受体拮抗剂氟乙基美金刚（FENM）能否改善强迫样行为及探索其潜在机制。方法将32只小鼠随机分成Saline组（n=8），RU24969组（n=8），RU+FENM组（n=8），FENM组（n=8），根据不同组别分别给予FENM或等量生理盐水进行预处理，30 min后再予RU24969或等量生理盐水进行造模。造模后1 h进行行为学测试，测试结束后取血清检测脑源性神经营养因子（BDNF）的水平。于尾静脉注射伊文思蓝，并检测脑组织中染料的含量，评估该模型血脑屏障是否受损。结果FENM治疗能够显著改善RU24969模型小鼠的重复刻板绕圈行为（F=39.850， P＜0.001）并缓解其持续运动（F=50.200， P＜0.001），此外能够显著提高RU24969强迫模型小鼠血清BDNF的水平（F=18.930， P＜0.001）。结论NMDA受体拮抗剂FENM可能通过调节BDNF的水平从而缓解强迫症小鼠的刻板行为，发挥抗强迫疗效，且RU24969该模型以及FENM治疗对血脑屏障未产生显著影响

御寒暖胃膏穴位贴敷对胃癌前病变大鼠胃黏膜的影响

目的:研究御寒暖胃膏贴敷胃经穴对慢性萎缩性胃炎癌前病变大鼠胃黏膜的影响,探讨御寒暖胃膏贴敷胃经穴对慢性萎缩性胃炎癌前病变大鼠胃黏膜损伤修复的作用机制。方法:大鼠随机分为正常组、模型组、御寒暖胃膏贴敷胃经穴组、御寒暖胃膏贴敷对照点组、药物对照组,采用综合干预方法复制慢性萎缩性胃炎癌前病变大鼠模型,肉眼下观察大鼠胃黏膜损伤指数,光镜下观察胃黏膜组织的病理变化,彩色多普勒观察胃黏膜的血流量。结果:与模型组比较,御寒暖胃膏贴敷胃经穴组和药物对照组大鼠胃黏膜损伤指数值均显著降低(P0.05),胃黏膜组织的病理损伤未得到明显修复,胃黏膜血流量未见显著升高(P>0.05)。结论:御寒暖胃膏贴敷胃经穴可以促进慢性萎缩性胃炎癌前病变大鼠胃黏膜损伤的修复,增加胃黏膜的血流量,并且存在经脉-脏腑特异相关性。深圳市科技研发资金项目(JCYJ20130401105615482

Suunnittelunohjaus metallilasirakenteiden hankinnassa

Tässä opinnäytetyössä käsitellään suunnittelunohjausta rakennuskohteiden julkisivuihin asennettavien metallilasirakenteiden hankinnassa. Työn tilaajana toimi NCC Suomi Oy. Metallilasirakenteiden lisääntyvä ostovolyymi rakennushankkeissa tarvitsee kriittistä tarkastelua rakenteiden ominaisuuksien lisääntyessä ja monimutkaistuessa. Asiaa tutkittiin yhdessä metallilasitoimittajien kanssa. Tavoitteena oli selvittää lasirakenteiden suurimmat kustannustekijät. Tutkimus suoritettiin kvalitatiivisena tutkimuksena. Syvähaastattelujen kohteena olivat NCC Suomi Oy:n yhteistyöyritysten edustajat, jotka vastaavat metallilasirakenteiden myynnistä yrityksessä. Kvalitatiivisen tutkimuksen lisäksi opinnäytetyön teoria-osiossa hyödynnettiin metallilasirakenteisiin liittyviä ohjeistuksia, määräyksiä ja muita tutkimuksia. Työn tuloksena selvitettiin metallilasirakenteiden merkittävimpiä kustannustekijöitä. Metallilasirakenteiden profiilien materiaali, lasien ruutukoko, lasin ominaisuudet sekä rakenteen värisävy vaikuttavat merkittävästi valmiin rakennustuotteen hintaan. Optimoimalla näitä ominaisuuksia rakennusliike pystyy tuottamaan kokonaisedullisen rakenneratkaisun tilaajan, suunnittelijoiden sekä metallilasitoimittajien kanssa yhteistyössä.This thesis discusses the design management of metal glass structures installed in building facades. The increasing purchase volume of metal glass structures in construction projects needs critical examination with the structures and their properties becoming more complex. The examiner's task was to investigate the matter together with metal glass suppliers with the aim to find out the major cost factors for metal glass structures. The study was conducted as a qualitative research. The interviewees were representatives of the partner companies of NCC Suomi Oy who are responsible for the sale of metal glass structures. In addition to the qualitative research, the theory section contains information relating to studies about the topic as well as guidelines and regulations for the use of the metal in glass structures. The examination resulted in finding out the most important cost factors of metal glass structures. The material of the profiles, the size of the glass panel, characteristics of the glass and the color tone of the structure significantly affect the cost of the finished metal glass structure. By optimizing these properties of the structural solution, construction companies will be able to produce affordable solutions in cooperation with the client, designers and as well with metal glass suppliers

利用‘树皮’进行大气污染历史监测的新采样方法(英文)

The concentrations of lead and cadmium in the tree bark from Sanming and Xiamen, Fujian province, China were determined by atomic fluorescence spectrometry and inductively coupled plasma mass spectrometry. The results obtained in the outer tree bark and tree bark pocket could reflect the degree of present and historical air pollution at different sampling locations. Tree bark and tree bark pocket should be expected to be as a useful biomonitor of present and historical condition of air pollution