前列腺移行带腺体定量分析

目的通过定量分析良性前列腺增生(BPH)患者前列腺和成人正常前列腺移行带腺体各成分含量及相关组织学形态的变化,探讨良性前列腺增生症治疗方案的选择。方法用计算机图像分析系统对经HE染色的40例良性前列腺增生症患者手术切除的前列腺和10例成人正常前列腺移行带组织标本进行形态学定量分析,分别测定腺体、腺腔、上皮的平均面积及上皮细胞高度。结果(1)正常前列腺和BPH前列腺移行带上皮细胞高度分别为(24.87±4.53)μm和(19.06±5.49)μm(P0.05)。结论BPH前列腺组织主要以基质成分增生为主;BPH的治疗应以α受体阻滞剂和手术治疗为主

Artificial local magnetic field inhomogeneity enhances T2 relaxivity

磁性探针作为分子影像技术中的磁共振成像（MRI）造影剂在医学诊断中发挥着重要作用。为满足实际诊断中的准确性和精确性要求，科研工作者们长期致力于发展高性能的MRI造影剂以降低高剂量的使用带来的潜在风险。该文章指出了探针聚集体中局域磁场不均匀性是影响T2弛豫效能的关键因素。该文章首次利用磁场不均匀性因素阐明了单个探针和它们聚集体的MRI造影剂之间的相互关系，将可能成为弥补探针聚集体的造影剂理论的空白，并为发展新型高效的MRI造影剂提供重要参考。 该论文共同第一作者为博士后周子健和博士生田蕊，通讯作者为陈小元教授和聂立铭博士，部分工作得到我校物理学系王瑞方教授和化学化工学院高锦豪教授的支持。【Abstract】Clustering of magnetic nanoparticles (MNPs) is perhaps the most effective, yet intriguing strategy to enhance T2 relaxivity in magnetic resonance imaging (MRI). However, the underlying mechanism is still not fully understood and the attempts to generalize the classic outersphere theory from single particles to clusters have been found to be inadequate. Here we show that clustering of MNPs enhances local field inhomogeneity due to reduced field symmetry, which can be further elevated by artificially involving iron oxide NPs with heterogeneous geometries in terms of size and shape. The r2 values of iron oxide clusters and Landau–Lifshitz–Gilbert simulations confirmed our hypothesis, indicating that solving magnetic field inhomogeneity may become a powerful way to build correlation between magnetization and T2 relaxivity of MNPs, especially magnetic clusters. This study provides a simple yet distinct mechanism to interpret T2 relaxivity of MNPs, which is crucial to the design of high-performance MRI contrast agents.This work was supported by the National Science Foundation of China (81571744 and 81601489), the National Basic Research Program of China (863 Program 2015AA020502), the Fundamental Research Funds for the Central Universities (20720170065), the Science Foundation of Fujian Province (No. 2014Y2004), and by the Intramural Research Program (IRP), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH). 研究工作得到了国家自然科学基金委、国家高技术研究发展计划863项目、福建省重大研发平台项目和美国NIH Intramural Research Program的资助

Artificial local magnetic field inhomogeneity enhances T2 relaxivity

磁性探针作为分子影像技术中的磁共振成像（MRI）造影剂在医学诊断中发挥着重要作用。为满足实际诊断中的准确性和精确性要求，科研工作者们长期致力于发展高性能的MRI造影剂以降低高剂量的使用带来的潜在风险。该文章指出了探针聚集体中局域磁场不均匀性是影响T2弛豫效能的关键因素。该文章首次利用磁场不均匀性因素阐明了单个探针和它们聚集体的MRI造影剂之间的相互关系，将可能成为弥补探针聚集体的造影剂理论的空白，并为发展新型高效的MRI造影剂提供重要参考。 该论文共同第一作者为博士后周子健和博士生田蕊，通讯作者为陈小元教授和聂立铭博士，部分工作得到我校物理学系王瑞方教授和化学化工学院高锦豪教授的支持。【Abstract】Clustering of magnetic nanoparticles (MNPs) is perhaps the most effective, yet intriguing strategy to enhance T2 relaxivity in magnetic resonance imaging (MRI). However, the underlying mechanism is still not fully understood and the attempts to generalize the classic outersphere theory from single particles to clusters have been found to be inadequate. Here we show that clustering of MNPs enhances local field inhomogeneity due to reduced field symmetry, which can be further elevated by artificially involving iron oxide NPs with heterogeneous geometries in terms of size and shape. The r2 values of iron oxide clusters and Landau–Lifshitz–Gilbert simulations confirmed our hypothesis, indicating that solving magnetic field inhomogeneity may become a powerful way to build correlation between magnetization and T2 relaxivity of MNPs, especially magnetic clusters. This study provides a simple yet distinct mechanism to interpret T2 relaxivity of MNPs, which is crucial to the design of high-performance MRI contrast agents.This work was supported by the National Science Foundation of China (81571744 and 81601489), the National Basic Research Program of China (863 Program 2015AA020502), the Fundamental Research Funds for the Central Universities (20720170065), the Science Foundation of Fujian Province (No. 2014Y2004), and by the Intramural Research Program (IRP), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH). 研究工作得到了国家自然科学基金委、国家高技术研究发展计划863项目、福建省重大研发平台项目和美国NIH Intramural Research Program的资助

GlueVaR失真风险度量下的最优再保险（英文）

受到文献[1]和文献[2]的启发,本文从保险人的角度,研究了GlueVaR失真风险度量下的最优再保险问题.假设保险标的的损失为X,保险人为分散风险签订了以索赔总额为计算基础的分保合同.按合同,分保人承担的风险为f(X),保险人承担剩下的风险X-f(X).此外基于期望保费原则,保险人需支付分保人再保险费(1+ρ)E[f(X)](其中ρ为安全负载系数).采用文献[2]中的技术方法,我们得出此时最优转移损失函数是一类增凸函数.从而可知最优再保险策略为停止损失再保险.supported in part by the National Natural Science Foundation of China(Grant Nos.11401498；11601097)；the Fundamental Research Funds for the Central Universities of China(Grant No.20720140525)

薄层SOS薄膜材料外延生长及其器件应用(英文)

亚微米CMOS/SOS器件发展对高质量的100--200纳米厚度的薄层SOS薄膜提出了更高的要求。实验证实：采用CVD方法生长的原生SOS薄膜的晶体质量可以通过固相外延工艺得到明显改进。该工艺包括：硅离子自注入和热退火。X射线双晶衍射和器件电学测量表明：多晶化的SOS薄膜固相外延生长导致硅外延层晶体质量改进和载流子迁移率提高。固相外延改进的薄层SOS薄膜材料能够应用于先进的CMOS电路

用环境毒物对草鱼组织ATPase的影响作为生态毒理学指标的初步研究

不同季节捕获的草鱼在实验室(16±4℃)驯化3—7天,其鳃ATPase活力在显著性水平为0.05时,不同批鱼无显著差异。离体实验条件下,汞、三氯联苯、直链烷基苯磺酸钠对草鱼组织ATPase的半抑制浓度分别为1.8ppM(肾),1.84ppM(鳃),3.9ppM(鳃);Hg~(2+)对肾的作用大于对鳃的作用。草鱼组织ATPase可作为一项指标用于毒理学研究

热退火γ-Al_2O_3/Si异质结构薄膜质量改进

采用高真空MOCVD外延技术，利用TMA（Al(CH_3)_3）和O_2作为反应源，在Si(100)衬底上外延生长γ－Al_2O_3绝缘膜形成γ-Al_2O_3/Si异质结构材料。同时，引入外延后退火工艺以便改善γ-Al_2O_3薄膜的晶体质量及电学性能。测试结果表明，通过在O_2常压下的退火工艺可以有效地消除γ－Al_2O_3外延层的残余热应力及孪晶缺陷，改善外延层的晶体质量，同时可以提高MOS电容的抗击穿能力，降低漏电电流