Synthesis of Polyhydroxylated 2-Aminocyclohexanecarboxylic Acids Derivatives

多羟基环己基手性β-氨基酸及其衍生物具有重要的药物、生物和合成用途。其中，2-氨基环己基羧酸及其衍生物的寡聚体已经被发现具有与蛋白质相似的二级结构,成为扩展已知蛋白质结构和稳定性的有用工具。本文开辟了一种合成多羟基取代的、具有光学活性的多羟基2-氨基环己基羧酸的衍生物的方法。该合成法以内消旋的cis-1,2,3,6-四氢邻苯二甲酸酐I为起始原料，以奎宁为手性试剂，通过去对称化、Curtius重排、醇解以及分子内立体选择性碘内酯化和消除反应等五步反应,以近40%的总产率简捷地合成光学活性多羟基环己基β-氨基酸的关键中间体II(图1)。图1从中间体II出发，一方面经邻二羟基化、开环，以45.0%的...Chiral polyhydroxy β-amino cyclohexane carboxylic acid have important pharmaceutical, biological and synthetic applications. Among these, oligmeric 2- amino cyclohexane carboxylic acid and their derivatives have been found to form secondary structures similar to those of proteins and used useful tools for the study of the known structure and stability of proteins. This thesis describes a novel app...学位：理学硕士院系专业：化学化工学院化学系_有机化学学号：20032504

The Effects of High Frequency Signal Investigated in a Neuron Model

高频电磁辐射对神经系统有负面影响,并且此类生物实验特别是人体实验会引起潜在的健康危害,而在数学模型中的仿真研究则可以完全避免。通过随机龙格库塔算法求解含有白噪声的HOdgkIn-HuXlEy神经元模型,研究了高频信号对神经元的影响。实验结果表明神经元模型处于其最敏感频率环境中时,随着高频信号的幅频比的提高,模型会产生放电频率下降,随机共振消失等现象,噪声强度较强时还产生了振动共振现象,而且神经元的静息电位也将被高频振荡代替。放电现象消失与生理实验发现的高频电流信号可以阻断外周神经动作电位的传导结果一致,本研究还有助于非电离辐射引起的体内特别是神经系统的损伤的预防和治疗,以及神经系统的模型仿真及其信号处理机制的研究。We have investigated the effects of high frequency (HF) signal on firing activity in a biologically realistic system-the noisy Hodgkin-Huxley (HH) neuron model via numerical simulations.The results show that when the HF amplitude to frequency ratio (AFR) increases,the firing rate is diminished and stochastic resonance disappears,even the HH neuron model is processing a stimulus of its most sensitive frequency.When the noise intensity is strong,the vibration resonance can be observed.Moreover,the fluctuation around the resting potential will be replaced by an oscillation of the same high frequency with the increasing AFR.The inhibition of the firing activity is consistent with the results of experiment in vivo that HF current can stop the transmission of action potential in peripheral nerve.This study is of functional significance to the biomedical research on the damages caused by electro-pollution in vivo and signal processing

Enhancement of Digital Image by Pulse Coupled Neural Networks with Noise

神经系统中广泛存在着噪声,大量研究表明噪声有助于弱信号的检测和传输。脉冲耦合神经网络是建立在生物神经系统上的第三代人工神经网络,被广泛应用于图像处理。为了研究噪声对脉冲耦合神经网络图像处理的影响,通过在网络中引入加性噪声,用于图像增强。直观视觉效果和图像直方图均表明适当的噪声有助于图像增强,噪声过小或过强则减弱图像增强效果;图像的峰值信噪比随噪声强度增强呈现倒钟形,表明存在随机共振现象。本研究表明适当强度的噪声能够提高脉冲耦合神经网络图像处理的效果,并显示出随机共振,有助于开展基于生物神经系统的智能化图像处理方法的研究。Noise has been found in many kinds of neural systems and thought to be helpful in detecting and processing weak signals.The pulse coupled neural network(PCNN) is a kind of artificial neural network based on the biological experiments,and has been widely applied to image processing.To investigate the influence of noise on the image processing by PCNN,we added a noise to the net to realize image enhancement.The images and their histograms showed that noise of suitable intensity was helpful to the image enhancement,while the noise with smaller or stronger intensities produced harmful effects on the results.The curve of peak signal-to-noise ratio(PSNR) versus noise intensity was reversed-bell like,representing the characteristic of stochastic resonance.It was showed that noise could improve the image enhancement by PCNN through stochastic resonance,being beneficial to the neural system for realizing intelligent signal processing

韓国における「デジタル性犯罪」処罰規定の改正及び今後の課題 -「性暴力犯罪の処罰等に関する特例法」を中心に-

departmental bulletin pape

Changes in psychology and behavior that travel experience gave to hemiplegic people at home stroke

旅行経験が在宅脳卒中片麻痺者にもたらす心理的要因と行動の変化を明らかにすることを目的に男性3名,女性4名の片麻痺者を対象としたインタビューを実施した.半構造化面接によるインタビュー内容をKJ法に準じてデータ化し,最終的に10個の統合概念が抽出された.旅行前には「障害への負の感情と旅行環境への過重配慮」「介助者に対するジレンマ」「旅行の動機となる他者からの働きかけと環境への安心感」が,旅行中では「家族との絆を再び認識出来た喜び」「成功体験から育まれる自信と心のゆとり」「旅行で向き合う自分らしさ」「心揺さぶる体験から育まれる感受性と好奇心」が,旅行後は「死生観への気づき」「旅行で気づいた自分の現実課題と目標」「自分の旅行経験を他者に伝えたい承認欲求」が抽出された.片麻痺者において,旅行とは単純な内的構造による活動ではなく,複数の気づきや行動変容などを生じさせる複合的な活動であることが示された.The purpose is to clarify the psychological factors and behavioral changes that travel experiences bring to homed stroke hemiplegics. We conducted an interview for hemiplegic people with 3 men and 4 females. We interviewed by semi-structured interview. It was converted into data according to KJ method. Finally, 10 integrated concepts were extracted. Prior to the trip, concepts such as "negative emotions to the disability and excessive attention to the traveling environment", "dilemma for carers", "motivation from others to motivate travel and feeling of security to the environment" were extracted It was. While traveling, the concepts such as "joy of recognizing bonds with family", "self confidence brought up from experience of success" and "relaxation of mind" "self-facing to travel" "susceptibility and curiosity bred from a trembling experience" Has been extracted. After traveling, "awareness of life and death", "my real problems and targets I realized on my trip" and "desire to pass my travel experience to others" were extracted. In stroke hemiplegic persons, travel was not a simple internal structure activity, but it was regarded as a collective term for multiple activities that resulted in multiple awareness and behavioral changes.首都大学東京, 2018-09-30, 修士（作業療法学）首都大学東

Evaluation of students' achievement and attitudes in primary school mathematics

published_or_final_versionEducationMasterMaster of Educatio