通过发表OA论文来提高学术影响力

1、生物物理所OA论文发表及学术影响力分析；2、与科研相关的OA；3、如何发表OA论文；4、开放科技资源介

厦门地区非饱和残积土抗剪强度的试验研究

非饱和残积土是厦门地区诸多填方工程的工程用土,而岩土工程的强度与稳定性问题都涉及到非饱和土的抗剪强度及其指标.采用滤纸法测定非饱和残积土的基质吸力,通过一系列的直接剪切试验,测定不同初始含水量状态下土的抗剪强度及其强度指标.试验结果表明:基质吸力随着含水量、体积含水量或饱和度的增加而减小.当含水量小于16%,体积含水量大于35%或者饱和度大于70%时,基质吸力对含水量的变化非常敏感.在低基质吸力区,抗剪强度随着基质吸力的增加显著增加,表观粘聚力随基质吸力的增大而线性增加;在高基质吸力区,强度随基质吸力的增加变化不大,表观粘聚力的增长速率减小.表观内摩擦角仅在基质吸力较小时增加而后可近似为某一定值

Thermodynamic Studies on Mechanism of Chiral Resolution by Liquid Chromatography

手性识别是分子识别的一个重要组成部分。液相色谱手性拆分机理研究有助于色谱条件的优化和新型手性固定相的设计,也有助于理解手性识别机制。本文就线性色谱与非线性色谱条件下手性拆分过程对应热力学参数的推求方法进行了评述,阐述了相关热力学参数的涵义及其在色谱保留及手性拆分机理探讨中的应用,并展望了该领域的研究前景。Chiral recognition is an important part of molecular recognition.Studies of mechanistic aspects of chiral resolution by liquid chromatography are helpful to optimize chromatographic conditions,to design novel chiral stationary phases and to understand chiral recogniton mechanisms.In this paper,the methodologies for deriving corresponding thermodynamic parameters in the chiral resolution processes by linear or nonlinear chromatography are reviewed.The meaning of correlative parameters is explained.The applications of these parameters in the studies of mechanistic aspects of retentions and chiral resolutions by liquid chromatography are expatiated,and corresponding research prospects are put forward.福建省自然科学基金(No.C0540024);; 福建省教育厅课题(No.JA05301)资

Thermodynamic studies on mechanism of chiral resolution by liquid chromatography

Chiral recognition is an important part of molecular recognition. Studies of mechanistic aspects of chiral resolution by liquid chromatography are helpful to optimize chromatographic conditions, to design novel chiral stationary phases and to understand chiral recogniton mechanisms. In this paper, the methodologies for deriving corresponding thermodynamic parameters in the chiral resolution processes by linear or nonlinear chromatography are reviewed. The meaning of correlative parameters is explained. The applications of these parameters in the studies of mechanistic aspects of retentions and chiral resolutions by liquid chromatography are expatiated, and corresponding research prospects are put forward

[[alternative]]A study of Taiwan’s film music industry and business model : the case of Cincin Lee Production Ltd.

碩士[[abstract]]　　電影配樂是輔助電影的一大功臣，在電影中扮演重要的角色。隨著2008年電影《海角七號》在臺灣創下5.3億的刷新票房紀錄、2010年政府制定並頒佈《文化創意產業發展法》將電影產業納入文化創意產業之一，臺灣電影產業又再度受到各界高度的重視，電影配樂也漸漸開始受到注意。 　　本研究以臺灣電影配樂為主軸，從文獻資料與實務觀點瞭解電影配樂的發展與臺灣電影配樂產業的發展現況，透過本研究對象－李欣芸音樂公司進行深入訪談，以瞭解電影配樂的製作流程與該公司的營業概況等，進一步瞭解當今電影作曲家所面臨的市場現況。 　　臺灣大部分的電影配樂作曲家都是從流行音樂跨足來製作電影配樂，非音樂本科系出身，因電影配樂預算不多，故以個人工作室居多。許多作曲家與導演合作時，因礙於有限預算便接受低廉的酬勞，然而長期而言，仍需要有合理的制度與預算來激勵與輔助作曲家。 　　李欣芸音樂公司以電影配樂聞名，另從事跨界音樂演奏、流行音樂製作、廣告、偶像劇配樂與藝人經紀等營業項目。拓展業務的方式，則多以音樂界的既有人脈，及已經建立的知名度，以鞏固常態性的業務來源。在電影配樂的價值鏈中最重要的關鍵在於作曲、編曲者與音樂錄製部分。由於作曲家對作品品質的要求與堅持，製作時多採用成本較高的樂手真實聲音，故形成產品差異化的策略，並具備邁向國際化、拓展全球市場之條件。 　　最後根據結論，本研究提出對於電影配樂業者與李欣芸音樂公司之建議，及作為未來對臺灣電影配樂相關研究參考之用。[[abstract]]Film music, the essential element of the films, plays a very important role in the movies. Along with the success of the movie, Cape No. 7, breaking a historic box-office record of five hundred and thirty million NT in Taiwan in 2008, and in 2010, Taiwanese government enacting Law for the Development of the Cultural and Creative Industries and officially bringing film-making into the industry, motion picture industry in Taiwan again is highly valued in this society, bringing more attention to the importance of film music. This study mainly focuses on the film music in Taiwan to understand history of movie soundtracks and the current development of this industry based on the documentary data and business points of view. Through the object of the research, Cincin Lee Production Ltd., this study, with in-depth interviews, process of making film music, and the operation of company, provides current market situation that a contemporary film music composer faces. Most of film music composers in Taiwan started with making pop music then crossed over to produce movie soundtracks. With no official background of music and low budge on film music, most composers could only afford to establish personal studios instead of building film music companies. When working with movie directors, most composers have no choice but accept low payment because of the budget issue. However, from a long-term point of view, it is necessary to create a system and reasonable budget to motivate film music composers. Cincin Lee Production Ltd. is famous for movie soundtracks. She also provides the services of crossover music performing, pop-music producing, TV advertisements, TV drama music and talents management. She expands her business with current connections in the music industry and strengthens regular business income with long-built brand awareness. In the process of making movie soundtracks, the most essential parts are melody composer, arrangement and music recording. For the quality of their works, she insists on recording with real voice of musician. This results in higher cost yet a strategy of product differentiation for expanding the market overseas. In the end based on conclusion, this study offers suggestions for business sectors related to film music and Cincin Lee Production Ltd. for further research.[[tableofcontents]]第一章、 緒論 1 第一節 研究背景 1 第二節 研究動機 3 第三節 研究目的 5 第四節 研究流程 6 第二章、 文獻探討 7 第一節 電影配樂 7 第二節 電影配樂的發展 13 第三節 電影配樂類型與重要價值性 21 第三章、 研究方法 26 第一節 個案研究法 26 第二節 研究對象 27 第三節 研究變數 29 第四章、 電影配樂產業概況 30 第一節 電影配樂製作流程 30 第二節 電影配樂市場 40 第三節 電影配樂作曲者 50 第五章、 個案分析 69 第一節 李欣芸音樂公司介紹 69 第二節 李欣芸音樂公司經營模式與價值鏈 76 第三節 李欣芸音樂公司SWOT分析 85 第六章、 結論與建議 92 第一節 結論 92 第二節 建議 95 第三節 研究限制 97 參考文獻 98 附錄A(訪談同意書) 104 附錄B(訪談大綱) 105 附錄C(電影配樂cue list) 106 附錄D(主題音樂) 107 表目錄 表2-1 2005年美國電影協會(AFI)百年最佳電影配樂 25 表4-1 2008~2013年臺灣文化創意產業營業額及成長率－次產業別 44 表4-2 2005~2012年國片細部成本結構 48 表4-3 約翰．威廉斯經典配樂作品 51 表4-4 顔尼歐．莫利克奈經典配樂作品 53 表4-5 久石讓經典動畫電影配樂作品 56 表4-6 久石讓經典真人電影配樂作品 57 表4-7 國外知名作曲家經典配樂作品 58 表4-8 陳明章經典配樂作品 61 表4-9 林強經典配樂作品 62 表4-10 侯志堅經典配樂作品 64 表4-11 國內知名作曲家經典配樂作品 64 表4-12 金馬獎歷屆最佳音樂得獎名單 67 表5-1 創辦人李欣芸獲獎記錄 72 表5-2 創辦人李欣芸經歷與公司沿革 72 表5-3 李欣芸電影配樂作品 83 表5-4 臺灣電影製作業與整體電影產業SWOT分析 85 表5-5 臺灣電影配樂市場SWOT分析 86 表5-6 李欣芸音樂公司電影配樂SWOT分析 91  圖目錄 圖1-1 研究流程 6 圖2-1 電影配樂構成圖 10 圖2-2 電影風格和類型的分類 21 圖4-1 電影產業鏈 30 圖4-2 電影後製流程 32 圖4-3 電影配樂製作流程 39 圖4-4 全球電影娛樂市場地區別市場規模預測 41 圖4-5 2013~2017年全球電影娛樂地區別年複合成長率預測 41 圖4-6 美國歷年電影發行量 42 圖4-7 美國歷年電影平均製作成本與行銷費用 43 圖4-8 2008~2012年電影產業產值趨勢 45 圖4-9 1998~2014年臺灣國片歷年核定准演數量 46 圖4-10 2012年電影後製業者主要營業項目 47 圖5-1 李欣芸音樂公司組織圖 78 圖5-2 李欣芸音樂公司電影配樂價值鏈 79[[note]]學號: 701520115, 學年度: 10

[[alternative]]The Study of the Knowledge, Attitude and Behavior of Drug Abuse among Junior High School Students in Taipei City

[[abstract]]The main purpose of this study was to research the knowledge, attitude and behavior of drug abuse among junior high school students in Taipei City In addition, we also to predict these results by their demography, achievement in school, peer drug abuse and attitude, and family factors. The sample was selected by the proportionate probability sampling method. Six schools were included, with the total number of valid question-naires being 640. The data were collected via a group self-administration in December 1993. The main findings of this study were as followings: 1. The correct rate in the test about knowledge was 75.5%. 2. The most common sourceuof knowledge was the televesion programs which was followed by newspapers and teachers. 3. The mean scoring about the attitude of drug abuse was 5.37 which revealed that most of students disapproved to use addivtive drugs. 4. The rate of students who has been taken addictive drug was 0.6% 5. There was a positive relationship between knowledge and attitude about the drug abuse. (r=.39，P<.001). The result showed that the higher the score about knowledge, the less they agreed to use addictive drug. 6. We could predict the knowledge and attitude of the students via their demography, achievement in school, peer drug abuse and peer attitude, and family factor. 7. The predictive rate for knowledge was 6.8%; for attitude was 11.5%. We suggested the authority of education to set a good program for drug education and start experimental study inevery school. We also have to emphasize the dangerous of the addictive drug to phisical body and calrify the punishment of abuse in these programs. Furture research need more samples, indepednt variables and fruther clinical observation, urianalysis and sincerly talking to make the study more perfect.

The Study of Computerized Bone Age Cluster Assessment System Based on Hand Radiographs

本論文提出了基於掌骨X光影像中骨骺/幹骺切割技術以及其對電腦化骨齡群集估測之相關研究。主要貢獻如下︰(1)基於X光片中複雜及不規則的背景及不論手掌在X光片中是否定位，提出一個全自動且有效的骨骺/幹骺特徵區域擷取方法。(2)提出一個以空間統計為基礎的distance approach adaptive two-means影像切割方法，其骨骺/幹骺區域的切割結果之準確度遠高於基於機率分佈的adaptive two-mean方法，同時亦大幅地降低了整個演算法的迭代次數及運算時間。(3)進一步地，我們考量不論是何種adaptive two-means的方法，其最終分類結果往往取決於初始分類的好壞，而初始分類又受到不同指節的特徵區域影像特性之影響。因此，為了更精進整個演算法對於的骨骺/幹骺區域切割的精準度及效率，我們針對不同指節提出兩個影像切割方法。針對遠端及中間指節，提出一個不考慮背景的影像切割方法，克服了在大部分影像切割分法如Sobel, two-means, Canny edge-detection 及 watershed中，因含背景導致所得到初始分類之精確度將嚴重影響最終切割結果的問題。針對近端指節，提出一個基於α-gamma equalization enhanced的影像切割方法，解決了在近端指節特徵區域影像中，因骨組織及軟組織之灰度階對比低而影響初始分類的問題。實驗結果顯示，上述我們提出的兩個方法，其最終得到之骨骺/幹骺區域切割的準確度均遠高於影像切割常用到之GVF的方法。(4)依據上述方法所得到的切割結果，萃取出各指節骨骺/幹骺區域之直徑比值作為特徵，提出一個基於模糊類神經網路系統之掌骨X光影像骨齡群集之估測系統，並重新定義出不同於傳統骨骼發展階段(前期及後期)的四個階段，以及建議各階段所對應的ROI處理及特徵選取方法。本系統最主要解決了以往骨齡估測必須依賴先驗知識(a priori knowledge)預先決定骨骼發展階段，據以作為選擇適當特徵項目及分類器的問題。實驗結果證明，我們提出的系統除了可以說明上述四個新定義骨骼發展階段之合理性之外，並可準確地估測掌骨X光影像之骨齡群集，使得整個電腦化骨齡估測系統更具彈性與可靠度。This dissertation is focused on the study of segmentation for epiphyseal/metaphyseal regions of interest (EMROI) and bone age cluster assessment system using fuzzy neural network (FNN) based on phalangeal image segmentation. The contributions are illustrated as follows. (1)An automated ROI extraction with normalization is proposed to automatically select ROIs no matter whether the hand position is in upright or not. (2)A distance approach adaptive two-means clustering scheme is proposed to get a more precise segmentation on ROI and greatly reduce the processing time by comparing the probability approach adaptive two-means clustering method. (3) Furthermore, the performance of any above-mentioned segmentation techniques relies on the precisian of a given initial segmentation. In general, the initial segmentation is given by random or manual choices. Thus, two modification methods for optimum reliability, robustness and computational efficiency according to the properties of phalangeal ROIs are presented. For the distal and middle phalange, an excluding background initial segmentation method is proposed to overcome the initial segmentation problem for the bony structure segmentation. Experimental results verify that using this method can provide a better initial segmentation than other methods, such as Sobel, two-means, Canny edge-detection and watershed. An α-gamma equalization enhanced image segmentation scheme for proximal phalange is given to solve the problem of poor intensity contrast between soft tissues and bony tissues. The comparative experimental results show that these two methods really promote the performance and achieve a more accurate and robust epiphyseal/metaphyseal segmentation against GVF snake. (4) A bone age cluster assessment system using fuzzy neural network (FNN) based on phalangeal image segmentation is presented. This could avoid taking an a priori knowledge for bone age stage and provide a more flexible and reliable BAA system. Experimental results reveal that the presented FNN system provides a very well ability to assign the hand radiograph to an appropriate bone age cluster. The rationality of our four new defined stages which are different from the traditional skeletal development stages (the early and later stage). Furthermore, the related feature clustering analysis for various stages is discussed to obtain an accurate quantitative evaluation of specific features for the final BAA. Finally, it can provide a more flexible and reliable BAA system.摘 要 I Abstract II List of Figures VI List of Tables IX Chapter 1 Introduction 1 1.1 Motivation 1 1.2 Review of Segmentation Methods for Epiphyseal/Metaphyseal Regions 3 1.3 Review of CABAA system 5 1.4 Dissertation Organization 7 Chapter 2 Preliminaries 8 2.1 Finding Maximum Connected Component 8 2.2 Bilinear Interpolation 9 2.3 Adaptive Lee Filter 10 2.4 Some Image Segmentation and Edge Detection Methods 11 2.5 Measure of Errors (MOE) for image Segmentation 19 2.6 Some Classification Methods 21 Chapter 3 26 Automated ROI Extraction with Normalization 26 3.1 Background Removal 27 3.2 Hand Object Extraction 28 3.3 Hand Normalization 30 3.4 Finger Normalization and EMROI Extraction 34 Chapter 4 38 Distance Approach Adaptive Two-means Clustering Scheme 38 4.1 The Image Preprocessing 39 4.2 The Distance Approach Adaptive Two-means Clustering Algorithm 41 4.3 The Comparison of Probability Approach and Distance Approach Scheme 47 4.4 Experimental Results 49 Chapter 5 57 Two Segmentation Schemes Based on the Property of Different EMROIs 57 5.1 Excluding Background Initial Segmentation Scheme 57 5.2 An α-Gamma Equalization Enhanced Image Segmentation Scheme 63 Chapter 6 74 Bone Age Cluster Assessment and Feature Clustering Analysis 74 6.1 Stage and Feature Analysis 76 6.2 The Bone Age Cluster Assessment Using the Fuzzy Neural Network 83 6.3 Performance Analysis 91 Chapter 7 96 Conclusions and Further Researches 96 7.1 Conclusions 96 7.2 Further Researches 99 Bibliography 10

The Effect of Secretory 24p3 Protein on Endometrial Carcinoma Cell Line

在哺乳動物系統中，疏水性結合蛋白的生物功能與作用尚未完全清楚，由於小白鼠24p3蛋白與人類NGAL胺基酸序列、蛋白質結構相似性高，被認為是不同物種的相似性蛋白，為瞭解本實驗室由小白鼠子宮液純化所得之子宮分泌性24p3蛋白在生殖系統的功能，因此我們利用人類子宮內膜癌細胞株RL95-2作為體外 (In vitro) 實驗時的標的細胞研究24p3蛋白的生理功能。以0.75The biological functions and reaction pathways of lipocalins in mammalian system were sought. Mouse uterine 24p3 protein is a secreted lipocalin from mouse uterus and it was human NGAL homologus protein. To evaluate the effect of uterine 24p3 protein on the reproductive system, human endometrial carcinoma cell line (RL95-2) was an experimental target for achieving the in vitro study. The cells were treated with 0.75口試委員會審定書 I 謝辭 II 中文摘要 III ABSTRACT IV 縮寫表 6 第一章 緒論 9 一、 疏水性分子結合蛋白家族 (LIPOCALIN SUPERFAMILY) 9 二、 24P3蛋白 --- 源起 9 三、24P3蛋白 --- 急性反應蛋白 11 四、子宮動情週期與生殖系統 12 五、24P3蛋白與子宮動情週期 14 六、子宮內膜週期性變化與細胞凋亡 15 七、24P3蛋白與細胞凋亡 16 八、細胞內活性氧與細胞凋亡 18 九、本研究目的與方向 19 第二章 實驗材料與方法 21 一、材料 21 二、藥品、試劑組 21 三、儀器 23 四、實驗方法 24 1. 人類子宮內膜癌細胞株(ATCC CRL1671, RL95-2 )細胞培養 24 2. 小白鼠子宮液中24p3蛋白質純化 25 3. 蛋白質定量 -- BCA (Bicinchoninic acid Protein Assay) 28 4. 24p3蛋白標記 29 5. 24p3蛋白與RL95-2細胞株之結合 30 6. 24p3蛋白的內吞作用 (Endocytosis) 30 7. 十二酯硫酸鈉-聚丙烯醯胺膠體電泳 (SDS-Polyacrylamide Gel Electrophoresis) 31 8. 蛋白質染色 -- Coomassie BlueG250染色 33 9. RL95-2細胞總體蛋白萃取 (Total Protein Extraction) 33 10. 細胞總體核糖核酸 (Total RNA) 分析 34 11. 即時定量聚合酶連鎖反應 (Quantitative Real Time PCR) 37 12. Propidium iodide - Annexin V染色法判別細胞死亡 38 13. Caspase活性偵測 (PhiPhiLux/ CaspaLux kit) 39 14. 西方墨點法 (Western blot) 39 15. 細胞粒線體膜電位 (Mitochondrial membrane potential) 變化之偵測 40 16. 粒線體膜細胞色素c的釋放 42 17. 三明治免疫色法染細胞激素陣列膜 43 18. 錐蟲藍 (Trypan Blue) 染色法 43 19. 細胞內活性氧 (intracellular reactive oxygen species，ROS) 測定 43 20. NF

[[alternative]]A Research on the Relationship between Promoting Corporate Training and Employee Performance-A Case study of Company C

[[abstract]]隨著時代的進步公司的管理已經都朝向人資、行銷業務、生產、財務、研發和管理等各大部門平均發展的方向，尤其是人資單位已經不是90年代的人事產業，人力資源單位已經越來越被重視，因為人才是未來企業的資產。本研究在21世紀之後企業最重要的動態資源就是人力資源，人力資源不再是企業購買的商品，人力資源已經成為企業重要的資本、資產。且人力資源不只是會選人也必須要知道育才和用才及留才，人力資源管理把人變成有價值的人才再利用教育訓練把人才變成更有價值的公司資產，所以企業推動教育訓練過程不但可以把有用的人培訓成人才更可以變成公司重要之資產。但光是教育訓練是無法評斷出人才的高低標準，所以也必須搭配績效考核，但績效考核也必須要有其考核標準。 研究結果顯示，欲增加員工的績效就必須給予員工更多的教育訓練，因為現今社會的技術越來越高，要求員工要會的也越來越多，但是員工不可憑空就能擁有如此多的技術或技能，所以只能靠教育訓練來讓員工能跟得上公司要求的步伐，但不是訓練了員工就一定能掌握或是學會新的技術或是技能，所以必須依靠績效考核才能確定員工能學以致用達到公司所要求的績效，留任意願的結論應該是一個個人化的決策，基於對自己的了解和對未來的規劃。重要的是仔細考慮自己的長期目標、職業發展機會以及對留任意願的實際情況的評估，以做出最適合自己的決策。[[abstract]]With the progress of the times, the management of the company has been towards the direction of the average development of human resources, marketing business, production, finance, R&D and management. More and more attention is paid, because talents are the assets of future enterprises. In this study, after the 21st century, the most important dynamic resource of enterprises is human resources. Human resources are no longer a commodity purchased by enterprises. Human resources have become an important capital and asset of enterprises. And human resources are not only good at selecting people, but also must know how to cultivate, use and retain talents. Human resource management turns people into valuable talents, and then uses education and training to turn talents into more valuable company assets. Therefore, enterprises promote the education and training process. It can not only train useful people into talents, but also become an important asset of the company. However, education and training alone cannot judge the high and low standards of talents, so it must be accompanied by performance appraisal, but performance appraisal must also have its own assessment standards. The research results show that in order to increase the performance of employees, more education and training must be given to employees, because the technology in today's society is getting higher and higher, and employees are required to know more and more, but employees cannot have so many skills out of thin air. technology or skills, so we can only rely on education and training to enable employees to keep up with the pace required by the company, but it is not certain that employees will be able to master or learn new technologies or skills after training, so it is necessary to rely on performance appraisal to determine whether employees can Apply what you have learned to achieve the performance required by the company