Evaluation of PI Research Management Mode by Delphi Method

目的运用德尔菲法对PI制科研管理模式的影响因素进行分析,初步确定影响PI制科研管理模式的相关因素。方法采用德尔菲法问卷咨询法。结果两轮问卷调查,专家积极系数都为100%,专家权威系数分别为0.80和0.84。第一轮的变异系数为0.11,肯德尔和谐系数为0.78;第二轮变异系数为0.04,肯德尔变异系数为0.89,且两次的检验差异都有统计学意义（P〈0.01）。PI制管理模式影响因素的重要程度依次为PI自主权、稳定的科研经费来源、科研机构学术氛围。结论通过德尔菲法评价影响PI制科研管理相关影响因素,为PI制的高效率科研管理提供参考和帮助。Objective To evaluate and determine the factors affecting Principal Investigators（PI） research management mode by Delphi method.Methods Expert consultation was conducted in the form of questionnaire according to Delphi method.Results The positive coefficients of two rounds of expert consultation were both 100% and the authority coefficient was 0.80 and 0.84 in the two rounds.In the first round,coefficient of variation were 0.11 and coordination coefficient（Kendall W） was 0.78.In the second round,coefficient of variation was 0.04 and coordination coefficient（Kendall W） was 0.89,and the differences of the two rounds were statistically significant（P 0.001）.The factors affecting PI management mode was PI autonomy,stable source of research funding and academic environment in order of sigificance.Conclusion Evaluation of key factors by Delphi method can provide reference for more effective PI research management

Identification and Analysis of Differentially Expressed Genes in Haemocytes of Variously Colored Abalone (Haliotis diversicolor Reeve,1846) Challenged with Bacteria

鲍以其丰富的营养价值在民间一直被认为是与鱼翅、燕窝齐名的营养食品。养殖鲍市场价格高且稳定，销路畅通，利润空间大，深受水产养殖户的欢迎，是我国重要的海水养殖经济物种。杂色鲍(HaliotisdiversicolorReeve,1846)隶属于软体动物门，腹足纲，前鳃亚纲，原始腹足目，鲍科，是我国南方鲍种,因其生长迅速，一直在南方沿海海域得到广泛的养殖。但近年来由于养殖海域水质影响及养殖鲍种自身退化，使得人工养殖杂色鲍抗病力低，时有疫病发生，给养鲍业带来很大的经济损失。因此，寻求免疫防治是保障鲍养殖业健康发展的重要措施，但迄今有关鲍免疫机制的研究报道较少。本项研究应用抑制性差减杂交(SSH)技术筛...Abalones are one of the largest marine gastropod mollusks and they are a economically important seafood in aquaculture worldwide. However, bacterial epidemic infection has been reported in China and other countries in recent years and mass mortality in abalones causes significant economic losses. For this reason, a large scale screening of immune-related abalone genes is necessary. A better unders...学位：理学博士院系专业：海洋与环境学院环境科学与工程系_环境科学学号：B20043400

非公立医疗机构中高级医疗专业技术人才的保留机制研究

国家在政策层面不断激励社会各方资源组建非公立医疗机构,我国目前现有的非公立医疗机构已然成为公立医疗机构有力的补充,切实解决了部分老百姓的就医难的问题.但非公立医疗机构多在夹缝里生存和发展,其主要原因是人才问题.而在非公立医院的人才队伍中,最重要也最稀缺的是中高级医疗专业技术人才.本文研究分析了非公立医疗机构中高级医疗专业技术人才的流失原因,并提出相应的人才保留对策,如在学科人才梯队建设、学术氛围营造、薪酬制度建设等方面采取一系列措施,建立非公立医疗机构专属的中、高级医疗人才的保留机制等

The effect and mechanism of N-(Z)-9-octadecenyl-2-propanesulfonamide in treatment of insulin resistance in type 2 diabetic mice

探索新化合物N-(Z)-9-十八烯基-2-丙磺酰胺(N15)对2型糖尿病(T2DM)胰岛素抵抗小鼠的影响并探讨其可能作用机制。采用链脲佐菌素(S; TZ)连续小剂量腹腔注射诱导T2DM小鼠模型, N15(50、100和200 mg·kg~(-1)·d~(-1))和吡格列酮(6; mg·kg~(-1)·d~(-1))连续灌胃给药6周,期间分别对小鼠空腹血糖(FBG)、胰岛素(FIns)和胰岛素抵抗指数(HOMA-IR)进行; 测定比较;并于末次给药后测定各组小鼠葡萄糖耐量(OGTT)和胰岛素耐量(IPITT);通过Western; blot对能量代谢关键蛋白Akt、AMPK和Glut4加以分析。结果表明, N15可显著降低模型小鼠FBG、Fins和HOMA-IR水平(P ; 0.05)。上述结果表明,新型化合物N15具有改善2型糖尿病胰岛素抵抗的功效,其机制可能与增加肝内胰岛素受体调节及促使磷脂酰肌醇3磷酸磷酸化相关; 。This study was designed to investigate the therapeutic effect and; mechanisms of action of novel compound; N-(Z)-9-octadecenyl-2-propanesulfonamide(N15) on type 2 diabetes(T2DM).; A mouse model of T2DM was established with multiple injection of; streptozotocin(STZ) at a low dose. N15 at different doses(50, 100 and; 200 mg·kg~(-1)·d~(-1)) and pioglitazone(6 mg·kg~(-1)·d~(-1)) were; administrated orally for 6 weeks. The level of fasting blood; glucose(FBG) and fasting insulin(FIns) were measured in the course of; the experiment for insulin resistance index(HOMA-IR). Oral glucose; tolerance test(OGTT) and intraperitoneal insulin tolerance test(IPITT); were determined in the treated mice. The expression of Akt, AMPK and; Glut4 in liver were analyzed by Western blot. N15 was found to reduce; the level of FBG, FIns and HOMA-IR(P 0.05). These results suggested that the novel compound; N15 can ameliorate insulin resistance and the potential mechanism may be; associated with increased insulin signaling in liver and promotion of; phosphatidyl inositol 3 phosphate phosphorylation.国家自然基金联合基金; 促进海峡两岸科技合作联合基金项目; 泉州市科技计划项目; 泉州市科技计划项

The Study on Improvement Strategies of Quality Management in BJFT Company

随着汽车工业快速发展成长起来的中国本土汽车零部件企业在成本增加、创新不足的压力下，如何加强质量管理理论的综合运用以提升竞争优势是目前很多企业所困惑的问题。本文以为汽车整车企业配套汽车安全玻璃的BJFT公司的质量管理提升活动为研究对象，探索企业如何围绕着自身特点开展质量管理提升活动，实现企业的高质量、低成本的发展战略，从而保持竞争优势、巩固并提高市场份额。本文先从质量管理发展概述开始，阐述了当前主流的全面质量管理理念、质量改进方法和质量管理实践的相关研究,然后剖析了BJFT公司是如何运用质量管理成熟度和朱兰三部曲的概念对自身的质量管理水平进行系统的评价和诊断，并根据诊断发现综合运用各种质量管理实...Local automotive parts manufacturers in China that have developed rapidly along with the automobile industry are facing urgent issues of increasing costs and shortage of innovation. Many of them are perplexed of how to promote application of quality management theories so as to enhance competitiveness.This thesis regards quality management improvement carried out by BJFT company, which supplies sa...学位：工商管理硕士院系专业：管理学院_工商管理硕士(MBA)学号：1792009115074

Retired Generals Exchanges and the Building of Cross-straits Military Mutual Trust

2008年以来，两岸关系呈现出“大交流、大合作、大发展”的新局面。然而，相较于两岸经济关系的突飞猛进以及两岸文化关系的日益密切，两岸军事领域方面的交流却相对有限。由于历史和政治方面的原因，两岸的信任积累还很不够，双方在军事领域的互动存在很多的障碍。在两岸尚未就军事互信议题开展官方正式对话的情况下，两岸退役将领交流活动已经成为两岸军事领域交流互动的主要内容，两岸退役将领通过多种形式的交流互动，已经为两岸军事领域的正式对话营造了很好的氛围，搭建了一系列可参照的研讨和对话平台，也对当前两岸军事领域交流存在的困难和障碍做出了分析，提出了不少具有建设性的建议，在两岸社会都产生了很大的影响。 本文首先介...Since 2008, a new situation in cross-straits relations have shown "great communication, great cooperation and great development". However, compared to the rapid development of cross-straits cultural relations and the increasing thermal envelope of cross-straits economic relations, cross-straits exchanges in the military field is relatively limited. Due to historical and political reasons , the acc...学位：公共管理硕士院系专业：公共事务学院_公共管理硕士(MPA)学号：1392011115041

间充质干细胞在恶性肿瘤生物学中作用的研究进展

过去近半个世纪的研究表明,间充质干细胞(MSCs)作为肿瘤微环境中细胞成份的重要成员之一,它在肿瘤细胞生长增殖、凋亡调控、侵袭性生长和转移、血管新生、能量代谢以及治疗抗性等诸多恶性生物学特性中均发挥重要的生物学作用,其相关的分子机制也逐步被揭示;相应地,基于这些发现的基因工程修饰和物理(化学)预处理的MSCs在特定肿瘤综合治疗中临床应用研究也取得了令人振奋的结果。本文就目前MSCs在恶性肿瘤发生发展中所起的生物学作用及其分子机制研究的相关进展作一综述,并就未来MSCs相关的新研究方向及其肿瘤综合治疗中可能的临床应用作一简单的展望。国家自然科学基金面上项目(81772848);;福建省自然科学基金面上项目(2016J01577

ICP-AESによる魚体と飼料中カドミウム定量に及ぼすマイクロ波分解条件の影響

東京海洋大学海洋科学部海洋環境学科東京海洋大学海洋科学部海洋環境学科東京海洋大学海洋科学部海洋生物資源学科東京海洋大学海洋科学部海洋環境学科東京海洋大学海洋科学部海洋環境学