On Produced and avoid of Science and technology risk

现代社会是一个以科学技术为基础的社会，在科学技术不断为人类创造物质财富、改变人类生活方式的同时，也加剧了人类对自然界的消极影响，加大了人类危害自身生存的可能性，比如：核辐射、转基因食品、农药污染等科学技术的负面效应问题。可以说，科学技术已经成为当今社会不可忽视的一个风险源。为了应对这一危机局面，学术界对科技风险的探讨早已提上日程。本文在总结中外学者研究成果基础上，对风险、科技风险及其特征进行界定，对科技风险的种类进行辨别，特别是对于科技风险产生的诸多不确定性因素，以及规避措施问题上进行重点阐述。风险是科学技术的内在属性，科技风险不可能完全消除，但我们希望通过政府以及社会各界多方面共同努力，将科...Modern society is a science –and- technology-oriented society. Creating material wellbeing for our human beings and changing our ways of life, science and technology at the same time has negative effects on us and nature and even threaten to our survival. The negative effects include nuclear radiation, genetically modified food, and agricultural chemical pollution etc. As it were, science and tech...学位：哲学硕士院系专业：人文学院哲学系_科学技术哲学学号：1042006115018

X射线像增强器及其应用

综述了X射线像增强器的结构、工作原理和性能，简要介绍了它的可能的应用

Ki-67与脑膜瘤分级及复发的相关性分析

目的分析Ki-67与脑膜瘤分级及复发的相关性。方法收集2005年1月—2013年5月的172例脑外科脑膜瘤初次手术治疗患者病理标本,采用免疫组化染色检测标本中Ki-67的阳性率,随访患者5年内复发情况,并分析Ki-67与脑膜瘤分级及复发的相关性。结果Ⅰ、Ⅱ、Ⅲ级脑膜瘤患者的Ki-67阳性率分别为(1.70±1.13)%、(4.81±3.63)%和(25.00±8.53)%,Ki-67阳性率逐渐增高,差异有统计学意义(Z=79.474,P <0.05)。随访5年,复发患者32例。复发患者Ki-67阳性率(10.94±12.25)%高于非复发患者(2.30±2.34)%,差异有统计学意义(Z=3.958,P <0.05)。结论 Ki-67与脑膜瘤分级及复发有关,具有重要的临床价值

MySQL密码认证算法的FPGA优化实现

My SQL数据库软件被广泛地应用于WEB项目中,因此它的安全性极为重要。本文针对My SQL密码认证算法的FPGA实现以及应用进行研究,利用并行化、流水线架构实现My SQL认证算法。提出一种基于BRAM的SHA-1算法流水线架构并对其流水线级数进行优化,从而实现高性能。同时利用多模块并行,多密码验证算法,以提高硬件运行速度和计算资源的利用效率。通过优化,高性能实现了基于FPGA硬件的My SQL认证算法,单块芯片的口令恢复速度为18亿个口令密码每秒,多个FPGA构成子板的认证速度为72亿/秒,比采用GPU GTX 690平台的速度提高了5倍。本研究项目获得集成电路设计与测试分析福建省高校重点实验室建设资金.厦门市科技局科技专项经费以及2017年厦门大学教学改革研究项目资金的支持

Photosynthetic capacity of three common species of macroalgae and the application in coral aquarium

利用水下饱和脉冲调制叶绿素荧光仪(dIVIng-PAM)测定了珊瑚养殖水处理中3种常见大型海藻石莼(ulVA lACTuCA)、条浒苔(EnTErOMOrPHA ClATHrATA)和羽状蕨藻(CAulErPA MEXICAnA)光能转化效率(fV/fM),快速光曲线(rlC)相关参数和非光化学淬灭(nPQ)。结果表明:石莼和条浒苔的fV/fM分别为0.808±0.004和0.816±0.009,显著高于羽状蕨藻。最大相对电子传递速率rETrMAX(17.52±2.92和19.59±4.43μMOl E·M-2·S-1)、半饱和光强Ik(53.41±8.18和59.71±13.52μMOl PHOTOnS·M-2·S-1)也明显高于羽状蕨藻(rETrMAX和Ik分别为13.72±5.41μMOl E·M-2·S-1和32.67±14.06μMOl PHOTOnS·M-2·S-1),表明石莼和条浒苔有着比羽状蕨藻更高的光合能力和对强光的耐受能力,光保护能力更强;羽状蕨藻较高的rlC初始斜率α表明其在弱光下拥有更强的光捕获能力,弱光下光合效率更高;随光照的增强(0~373μMOl PHOTOnS·M-2·S-1),羽状蕨藻nPQ的增幅有限(0~0.2),最大值仅为条浒苔和石莼的38.1%和62.5%,表明这种藻类更容易受到强光的抑制。因此,在珊瑚养殖的水处理中,可以根据不同的光照选择适宜的藻种或藻种组合并根据光梯度进行布局,反之也可以根据藻种来选择合适的光源,以达到最佳的处理效率。This study investigated the difference of photosynthetic capacity in three macroalgae species( Ulva lactuca,Enteromorpha clathrata,and Caulerpa mexicana) commonly used for nutrient removal in coral aquariums.The photochemical efficiency( Fv/Fm),parameters relevant to rapid light curve( RLC) and non-photochemical quenching( NPQ) in the macroalgae were measured by underwater saturation pulse modulated chlorophyll fluorometer( Diving-PAM).The results showed that Fv/Fmwas 0.808 ± 0.004 for U.lactuca and 0.816 ± 0.009 for E.clathrata,which were higher than that for C.mexicana.Higher maximum relative electron transfer rates( rETRmax)( 17.52 ±2.92 and 19.59 ±4.43 μmol e·m- 2·s- 1) and half-starved value of light intensities( Ik)( 53.41 ±8.18 and 59.71 ±13.52 μmol photons·m- 2·s- 1) were observed in U.lactuca and E.clathrata than that in C.mexicana( 13.72 ± 5.41 μmol e·m- 2·s- 1for rETRmaxand 32.67 ± 14.06 μmol photons·m- 2·s- 1for Ik),indicating that U.lactuca and E.clathrata have stronger photosynthetic capacities,photo-protection capacities and tolerance to higher intense light than C.mexicana.A significantly lower RLC initial slope α in C.mexicana implied that this algal species has a higher photosynthetic capacity under weak light condition.With increasing the light intensity( 0- 373 μmol photons·m- 2·s- 1),however,C.mexicana had a limited increase of NPQ( 0- 0.2),the maximum of which was equivalent to 38.1% of that in U.lactuca and 62.5% of that in E.clathrata.These results indicate that the photosynthesis of E.clathrata may be more easily limited by intense light.Our study suggests that the selection of algal species for nutrient removal in a coral aquarium should be adapted to the light intensity.Single species or the combination of different species of macroalgae can be selected according to the illumination of the coral aquarium in order to maximize the efficiency of nutrient removal.国家海洋局第三海洋研究所基本科研业务项目(海三科2011033); 厦门海洋研究开发院共建项目; 海洋公益性行业科研项目(201105012)资

全球海洋次表层温度异常遥感反演的季节时空变化特征

卫星遥感反演海洋内部多时相、大尺度热力结构信息对于了解海洋内部复杂、多维的动力过程有重要意义。本文采用随机森林回归模型,利用卫星遥感观测的海表参量(海表高度异常(SSHA)、海表温度异常(SSTA)、海表盐度异常(SSSA)和海表风场异常(SSWA)),反演不同季节、不同深度层位(1000 m深度以上)的海洋次表层温度异常(STA),并用Argo实测数据作精度验证,采用均方根误差(RMSE)、归一化均方根误差(NRMSE)以及决定系数(R2)评价模型在全球及洋盆尺度上的反演精度。结果显示,全球海洋16个深度层位的平均R2在春、夏、秋、冬四季分别为0.53、0.60、0.54、0.66,NRMSE分别为0.051、0.031、0.043、0.044。随着季节的变化,模型反演性能有所波动。模型在印度洋的反演效果最佳,不同季节、不同深度层位上的平均R2和RMSE分别为0.71和0.18℃,而大西洋的反演精度最低,平均R2和RMSE分别为0.46和0.25℃。研究表明随机森林模型适用于全球不同季节的STA遥感反演,且在不同洋盆上均有较好的反演效果;不同季节上,上层STA有明显变化信号,空间异质性显著,但300 m以深,STA信号较弱且基本不随季节变化。本研究可为长时序、大尺度海洋内部参量信息遥感反演与重建提供依据,有助于进一步发展深海遥感方法。国家自然科学基金(编号:41971384,41601444,41630963)福建省高校杰出青年科研人才培育计划(编号:KJ2017-17)福建省自然科学基金(编号:2017J01657)海西政务大数据应用协同创新中心资助(编号:2015750401)中央引导地方科技发展专项(编号:2017L3012)~

Autophagy Inhibition by Chloroquine Sensitizes Cervical Cancer SiHa Cells to CPT Treatment

自噬诱导是肿瘤细胞对化疗药物抵抗性的原因之一,该研究探讨溶酶体抑制剂氯喹对喜树碱(camptothecin,CPT)诱导的宫颈癌细胞Si Ha死亡的增敏效果。CPT和/或氯喹处理宫颈癌Si Ha细胞,MTT法检测细胞增殖,DAPI和TUNEL染色观察细胞凋亡,Western blot和免疫荧光检测自噬及凋亡相关蛋白。结果发现,CPT处理后,Si Ha细胞MAP1LC3B荧光点和LC3II(microtubuleassociated protein light chain 3II)蛋白水平增加,p62荧光点和蛋白质水平则减少;而采用氯喹特异抑制自噬后,可明显提高CPT诱导的细胞凋亡、caspase-9的激活和PARP(poly ADP-ribose polymerase)的切割,而全长caspase-2水平显著下降。以上结果提示,氯喹可通过抑制细胞自噬而增强宫颈癌细胞株Si Ha对CPT诱导细胞凋亡的敏感性。The autophagy induction is one of the reasons for the resistance of tumor cells to chemotherapy drugs. In this study, the enhanced sensitivity of cervical cancer Si Ha cells to camptothecin(CPT)-induced cell death by chloroquine(a lysosome inhibitor) was investigated. The cell viability was detected by MTT assay, meanwhile, apoptosis was observed by DAPI and TUNEL, autophagy related proteins and apoptosis proteins were analyzed by immunofluorescence(IF) staining and Western blot in Si Ha cells after CPT treatment alone or combined with chloroquine. The results found that in Si Ha cells with CPT treatment the autophagy related protein LC3 foci and microtubule-associated protein light chain 3II(LC3II) protein level was increased, but p62 foci and protein level was decreased. When autophagy was inhibited by chloroquine, the CPT-induced apoptosis was obviously enhanced, and caspase-9 was activated and PARP was cleaved, but full length caspase-2 was decreased. Taken together, these results indicated that the inhibition of autophagy by chloroquine could sensitize cervical cancer Si Ha cells to CPT inducing cell apoptosis.山西省自然科学基金(批准号:2014021037-9);; 山西医科大学汾阳学院博士启动基金(批准号:1301);山西医科大学汾阳学院科研项目基金(批准号:1422)资助的课题~