Tributyltin and bisphenol A induce polycystic ovarian syndrome and its mechanisms involved

多囊卵巢综合征（polycysticovariansyndrome,PCOS）是以稀发排卵或无排卵、高雄激素或胰岛素抵抗、多囊卵巢为特征的内分泌紊乱的症候群，复杂且具有异质性，是婚育年龄妇女中最常见的内分泌紊乱疾病。PCOS的病因较为复杂，已有研究证明类雌激素化合物双酚A暴露（bisphenolA,BPA）与PCOS的发病有关，说明环境中的内分泌干扰物与PCOS发病存在一定的联系。 本研究以大鼠为实验动物模型，以三丁基锡（tributyltin,TBT）作为类雄激素化合物的典型代表，探究TBT（10ng/kg/d、100ng/kg/d）能否诱导PCOS相关症状，同时以BPA（50μg/kg/...Polycystic ovarian syndrome (PCOS) is the most common endocrine abnormality in reproductive-age females, characterized by hyperandrogenaemia, insulin resistance, chronic anovulation and cystic follicles. The potential influence of environmental endocrine disrupting chemicals on the development of PCOS has been suggested because some studies have revealed that bisphenol A (BPA) could induce PCOS. ...学位：理学硕士院系专业：生命科学学院_动物学学号：2162012115229

民众与遗产：以上海为重点的若干考察

報告レジュメ集補助事業　文部科学省私立大学学術研究高度化推進事業オープン・リサーチ・センター整備事業（平成17年度～平成21年度）なにわ・大阪文化遺産の総合人文学的研

Word-formation of “Heart” And Teaching Chinese As A Foreign Language

随着对外汉语的逐渐升温和在世界范围内的迅猛发展，对外汉语的研究视角也随之细化和深化。词汇作为对外汉语中的重要组成部分，既是学生进行语言学习和跨文化交际的要求，也是教师语言要素教学的主体。词汇中，单音节语素在古汉语时期多单独成词使用，随着汉语双音化的发展趋势和语言的经济性原则，这些单音节词逐渐作为重要的成分参与构词，构成的合成词词义也呈现出多样化的态势。从当前的研究来看，对语素义和词义的探索多为列举和表面分析，对义项的内部联系也多通过隐喻、转喻等引申手段加以说明，将之与文化相关联的研究也在逐步展开，但研究力度和深度有待加强。本文将“心”的研究置于文化视角下，分以下四大部分进行论述： 第一部分，...With the rise and rapid development of Chinese on a global scale, the research perspective of teaching Chinese as a second language is refining and deepening. As an important part of Chinese learning, vocabulary is not only the requirement of language learning and cross-cultural communication, but also the major part of teaching listening, speaking, reading and writing for the teachers. Mono polys...学位：文学硕士院系专业：海外教育学院_语言学及应用语言学学号：2652012115127

Design and Implementation of Mobile Tax Information Platform for Local Taxation bureau

国内信息化水平和3G/4G移动互联网的发展随着科技的进步不断的提高，而由于移动网络传输速度的提高，使得移动互联网市场逐渐开始了大的发展。移动终端设备由于各种电子器件的研发，也逐渐走向智能化，移动支付、移动办公等新兴应用层出不穷，移动终端的App已经无所不在地融入到了人们的日常生活当中。移动互联网和移动应用在社交、金融、交通等各领域的广泛应用，不断改变原有的工作和生活模式，为人们提供更加高效和便捷的服务。 本文根据构建现代化税收征管体系要求，针对当今人们移动办公的需求，以信息化为支撑，依托移动3G/4G网络，将传统的办税服务、业务办理和涉税事项查询等功能延伸到手机端，提供全新的服务模式。 在...With the increase of domestic information technology and the development of 3G/4G mobile Internet, the mobile Internet market has achieved significant growth. The mobile terminal device has become more intelligent, various new applications have been developed, such as mobile payment and mobile office, and the Apps at mobile terminal have been gradually integrated into people’s daily lives. The bro...学位：工程硕士院系专业：软件学院_工程硕士(软件工程)学号：X201323051

Mechanisms of neuroprotection by curcumin in acute epileptic rat

目的：通过腹腔注射大剂量戊四氮建立急性大鼠癫痫模型，运用姜黄素进行干预，观察姜黄素对癫痫大鼠行为的影响和神经元的保护作用及其机制研究。 方法：实验选用健康雄性SD大鼠48只，完全随机分为:姜黄素组、对照组、模型组、实验组，每组12只大鼠，造模前进行相应的预干预，然后通过腹腔注射戊四氮建立急性癫痫动物模型。观察造模后各组大鼠行为学表现；尼氏染色、HE染色观察各组大脑病理变化；Tunnel染色观察各组大脑皮质神经元的凋亡情况；免疫组织化学方法观察姜黄素对海马组织或皮质部分LC3-Ⅱ、Beclin1表达的影响。 结果：相对于模型组，实验组腹腔注射姜黄素可明显延长发作潜伏期；病理学显示，实验组相对...Objective：To discuss the antiepileptic and neuroprotective effects of curcumin in epilepsy modeled by PTZ intraperitoneal injection. Medthods: The 48 SD male rats were randomly divided into four groups: curcumin group,control group, model group and curcumin intervention group,12 rats in each group.To establishe acute animal model of epilepsy by PTZ intraperitoneal injection ,we observed the behav...学位：医学硕士院系专业：医学院_外科学学号：2452014115355

Asymmetric Total Synthesis of Verrupyrroloindoline and the Exploration of Efficient Synthesis of Loline Alkaloid

天然产物全合成是有机化学中最为活跃、最具原动力的研究方向之一。发展高效、高选择性合成方法以减少合成步骤、降低成本和提高合成效率是当前有机合成的主要目标之一。 酰胺作为稳定的合成中间体被广泛应用于有机合成和药物化学。因此，发展通用、化学选择性的酰胺直接转化的方法十分重要。同时，课题组发展了DMDO引发的吲哚氧化、环氧开环环化、酰胺化一锅串联反应构建喹唑啉酮，该方法具有步骤经济性、原子经济性和无保护基合成的优点。 本论文结合两种高效的合成方法完成了verrupyrroloindoline的不对称全合成研究及发展了铱催化硅烷还原α-酯基叔酰胺叔酰胺为重要合成中间体烯胺酯方法；另外，基于环状烯醇硅...The total synthesis of natural products is a principal driving force for new chemical and biological discovery. Total synthesis projects often require a variety of reactions and intermittent tedious purifications, thus, which push the synthetic chemist to develop and perform highly efficient and selective synthetic methods aiming at designing and executing an efficient synthesis. Amides are stabl...学位：理学硕士院系专业：化学化工学院_有机化学学号：2052014115155

Financial Flexibility,Product Market Competition and Capital Structure

以2001-2014年中国A股上市公司为样本,将财务灵活性价值和产品市场竞争状况纳入资本结构的分析框架进行研究。结果表明:在其他条件不变的情况下,财务灵活性价值越高,公司的财务杠杆越小;除了掠夺风险与市场杠杆之间的关系不显著之外,产品市场竞争与财务杠杆正相关;由于受到严格的监管,公司在中国资本市场上的股权融资难以实现,产品市场竞争所引致的融资需求会减弱财务灵活性价值对资本结构的负向作用。This paper uses the A shares of listed companies for the period 2001-2014 to estimate and compare the value of financial flexibility. We use three different measures of product market competition:predation risk, HHI and the number of listed companies,then we analyzes the effect of financial flexibility and product market competition on capital structure of Chinese listed companies. The conclusions show that, ceteris paribus, the capital structure negatively related to the value of financial flexibility. Subjected to the supervision of CSRC, except for predation risk shows no significant effect on market leverage,other results show that the leverage of listed companies increase with the strength of product market competition;the effect of the value of financial flexibility on the capital structure is weakened by product market competition.国家自然科学基金项目(71472160);; 教育部人文社会科学规划项目(20120121110041

Correspondence: YANG Zhilin to KONG Changan on Exhibition and Artistic Creation Mentality

This letter is addressed to Kong Chang-an, an art critic. The letter\u27s opening greeting was followed by a brief mention of Xu Lei\u27s exhibition. He then began to express his creative mindset in the 1990s, often known as the Apartment Art . Because there were few opportunities for exhibition, artists reverted back to underground. Yang Zhi-Lin, the artist and the writer of this letter, claimed that he encountered a bottleneck while creating. He continued to depict his hazy dreams in ink, eventually completing between fifty and sixty pieces. At that time, Duo Yun-Xuan, an art dealer and auction house, founded in Shanghai in 1900, sent him an invitation to an exhibition. He was putting everything together like a headless chicken because he did not ask for any media attention or financial gain. However, he also felt hassle-free. He said in his words why? I don\u27t know twice to state his mindset, once for the exhibition and creation; once for his teaching duties at the Industry Design of Nanjing University of Arts. (Zhuocheng Jiang \u2726)https://digital.kenyon.edu/zhoudocs/1363/thumbnail.jp

Ecosystem Health Assessment of Dongshan Bay

海洋作为地球生态系统的主要组成部分，在提供可再生资源、调节全球气候变化和维持生态平衡中起着举足轻重的作用。海湾是海洋生态系统中最具有重要意义的部分，它为人类提供优良的生存空间，为国民经济发展提供有利的自然资源和条件；同时，海湾生态系统又是受自然和人类活动影响剧烈的生态系统之一，是典型的敏感和脆弱生态系统。本文选择受影响剧烈且与人类生活密切相关的海湾生态系统进行评价具有重要的社会、经济和生态意义。 本文以海湾生态系统为研究对象，研究海湾生态系统与社会经济协调发展之间的关系，为海湾生态管理提供决策依据，为维持海湾生态系统健康以及海湾地区的可持续发展提供依据。在分析国内外生态系统评价概念和方法的基...The ocean, as a major component of terrestrial ecosystems, plays a decisive role in providing renewable resources, regulating climate and maintaining ecological balance. Bays are the most significant part in marine ecosystem. They provide good living spaces for human beings and superior natural conditions for national economic development. At the same time, bay ecosystem is susceptible and closely...学位：理学硕士院系专业：海洋与环境学院海洋学系_海岸带综合管理学号：2242007115086