Comparison of Jiawei Xiaoyao Pills in treating women with emotional disorder during perimenopause

目的:探讨加味逍遥丸治疗围绝经期情绪障碍的优势。方法:经筛选后具有抑郁或焦虑的围绝经期女性患者80例随机等分为帕罗西汀组、利维爱组、帕+利组和加味逍遥丸组,分别给予相应药物治疗8周。所有患者在治疗前后均进行1次围绝经期症状主诉量表(grEEnE)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMd)评定,并在观察期结束时进行副反应量表(TESS)评定。结果:grEEnE、HAMA评分:4种治疗方法均能改善,且相互间无统计学差异;HAMd评分:除利维爱组均有效改善(P<0.01),帕+利组和加味逍遥丸组优于帕罗西汀组(P<0.05),且帕+利组和加味逍遥丸组间无统计学意义;TESS评分:前3组与加味逍遥丸组比较均有统计学意义(P<0.01),评分均大于加味逍遥丸组,且前3组间无统计学差异。结论:考虑到帕罗西汀的毒副作用和利维爱潜在的、远期的危险性,治疗该病加味逍遥丸值得推荐。Objective: To explore the superiority of Jiawei Xiaoyao Pills in treating perimenopausal women with emotional disorder.Methods: 80 perimenopausal women with emotional disorder screened by SAS and SDS were randomly divided into 4 equal groups: Paroxetine group, Livial group, Paroxetine combined with Livial group, Jiawei Xiaoyao Pills group, 20 in each group.All of them accepted 8 weeks' therapy.Every patient accepted the assessment of these rating scales(including Greene, HAMA, HAMD) one time before and after treatment, and only one test for TESS after treatment.Results: All regimens improved the score of Greene and HAMA, and there was no statistical dif erence between dif erent regimens.Except Livial group, the other regimens ef ectively improved the score of HAMD(P<0.01).The score of HAMD in Paroxetine combined with Livial group and Jiawei Xiaoyao Pills group was increased, better than Paroxetine group(P<0.05), and there was no statistical dif erence between Paroxetine combined with Livial group and Jiawei Xiaoyao Pills group(P<0.05).There was no signii cant dif erence in TESS score between the i rst 3 groups, but they all had a higher score than Jiawei Xiaoyao Pills group, and the dif erences were statistically signii cant(P<0.01).Conclusion: Considering the side ef ects of paroxetine and latent, long-term risk of Livial, the regimen of Jiawei Xiaoyao Pills therapy deserved to be advocated in the clinical practice for the disease.国家自然科学青年基金项目(No.81302960)~

Evaluation on difference of therapeutic efficacy of Jiawei Xiaoyao Granules and Pills in treatment of emotional disorder during perimenopause based on Greene Climacteric Scale

目的:在前期加味逍遥丸治疗围绝经期情绪障碍具有比较优势的基础上,基于grEEnE量表探讨其颗粒剂和丸剂不同剂型间疗效差异。方法:经筛选后患有情绪障碍的围绝经期女性75例随机等分为A、b、C3组,分别对应采用帕罗西汀、加味逍遥丸和加味逍遥颗粒剂治疗8周。所有患者在治疗前后各进行1次grEEnE及其子因子评定,并在观察期结束时进行TESS评定。结果:grEEnE总分差及其焦虑、抑郁因子分差:3种治疗方法均能改善,且相互间无显著差异;grEEnE性因子和血管因子分差:后二组均优于A组(P<0.01);TESS评分:与A组比较,b、C组均有统计学意义(P<0.01),评分均小于A组,且后二组间无显著差异。结论:加味逍遥的2种剂型间疗效无显著差异,考虑到帕罗西汀的不良反应,治疗该病加味逍遥的2种剂型都值得推荐。Objective: To investigate the difference in therapeutic efficacy between Jiawei Xiaoyao Granules and pills based on the preliminary research of treating emotional disorder during perimenopause with Jiawei Xiaoyao Pills and Greene Climacteric Scale.Methods: 75 female patients with emotional disorder during perimenopause were slected and randomly divided into 3 groups as group A, B and C.Patients in the 3 groups were treated with paroxetine, Jiawei Xiaoyao Pills and Jiawei Xiaoyao Granules respectively for 8 weeks.Greene and Greene factors assessment were carried out in all the patients before and after treatment, and the TESS assessment was carried out at the end of the observation period.Results: The three therapies all could improve the gap in total score of Greene and its factors as anxiety and depressed, and the difference among these three groups was no significant.The factors of Greene and gap in score of vascular factors of group B and C was better than that of group A(P<0.01).The difference in TESS score between group A and group B and C was significant(P<0.01), while the difference between group B and group C was not significant.Conclusion: The difference in curative effect between the two formulations was not significant.Because of the adverse reactions of paroxetine, in the treatment of emotional disorder during perimenopause, the two formulations of Jiawei Xiaoyao Powder were worth to be recommended.国家自然科学青年基金项目(No.81302960)~

2020年我国英文科技期刊发展回顾

收集2020年中国新批准CN号的英文科技期刊名录及卓越行动计划高起点新刊批准情况,整理2020年SCI和Scopus数据库新收录中国英文科技期刊情况,基于JCR数据库分析中国科技期刊学术影响力,回顾2020年影响中国英文科技期刊的重要政策和事件,并就预印本、载文量、引入社会资本等影响中国英文科技期刊发展的几个问题进行了讨论

Research of manufacturing execution system platform based on production model

分析了卷烟企业设备状态监测的技术现状,介绍了基于传感器网络的烟机在线监控与预防维护系统,结合先进的实时数据采集技术以及移动通信技术,构建了可配置的集成设备维护系统。阐述了系统涉及的关键技术,包括传感器网络、基于手持PDA的信息采集与处理、系统开发模式等

灭活病毒诱导牙鲆传代细胞差减cDNA文库的构建及分析

以灭活大鳞鲆弹状病毒诱导的牙鲆(Paralichthys olivaceus)传代细胞作为检测子(tester)，正常对照细胞作为驱赶子(driver)，分别提取mRNA，逆转录合成双链cDNA。经两轮差减杂交，两轮抑制性PCR扩增后，取正向差减的PCR产物与T载体连接，构建抑制差减cDNA文库，随机挑取7400余个克隆，对其中4200多个克隆进行PCR扩增鉴定，发现近4000个克隆中均含有插入片段，大小在250～1000bps之间，进一步对含有插入片段的近4000个克隆进行了斑点杂交筛选，得到近668个可能含有抗病毒或与免疫相关的阳性克隆。初步的结果表明所建立的差减cDNA文库适合进一步克隆鱼类抗病毒相关新基因

新型铁碳微电解填料制备与除磷性能评价

针对传统铁碳填料处理污水活性低的问题,通过均质化-碳化-成型工艺制备新型铁碳微电解填料,采用SEM-EDS、XRD等方法对制备填料进行了表征,探讨了新型填料除磷机理;同时,开展了填料制备条件优化及生活污水除磷性能评价研究。结果表明,新型填料(Fe-C)由于焦油经高温碳化处理可在海绵铁表面及内部孔道形成大量铁碳微原电池,提高了电化学反应速率,其磷脱除率显著高于传统填料(Fe/C);在焦油/铁比(Tar/Fe)为0.3、碳化温度为950℃、恒温时间为0 min、黏结剂质量分数为30%、900℃焙烧90 min条件下,制备的填料除磷性能最佳,除磷效率达98%,可实现含磷废水达标排放

新型铁碳微电解填料制备与除磷性能评价

针对传统铁碳填料处理污水活性低的问题,通过均质化-碳化-成型工艺制备新型铁碳微电解填料,采用SEM-EDS、XRD等方法对制备填料进行了表征,探讨了新型填料除磷机理;同时,开展了填料制备条件优化及生活污水除磷性能评价研究。结果表明,新型填料(Fe-C)由于焦油经高温碳化处理可在海绵铁表面及内部孔道形成大量铁碳微原电池,提高了电化学反应速率,其磷脱除率显著高于传统填料(Fe/C);在焦油/铁比(Tar/Fe)为0.3、碳化温度为950℃、恒温时间为0 min、黏结剂质量分数为30%、900℃焙烧90 min条件下,制备的填料除磷性能最佳,除磷效率达98%,可实现含磷废水达标排放

鄂尔多斯高原本氏针茅与油蒿群落过渡过程中的植被动态

灌木入侵对草原生态系统结构和功能产生了严重影响,了解其植被动态对草地灌丛化的控制和恢复具有重要意义.在鄂尔多斯高原选取本氏针茅向油蒿群落过渡过程中不同演替阶段的代表性群落类型,采用样方法、刈割法和根钻法,对不同群落的盖度、密度、生物量、凋落物、根系以及物种多样性进行调查和分析.结果表明:从本氏针茅向油蒿群落过渡的过程中,(1)演替阶段经历了本氏针茅群落、本氏针茅+糙隐子草群落、本氏针茅+油蒿群落、油蒿+糙隐子草群落、油蒿+达乌里胡枝子群落、油蒿群落6个群落类型.(2)群落盖度呈现先下降后上升,总密度先下降后升高再下降的趋势,地上、地下生物量及总生物量和凋落物干重在演替过程中总体呈上升趋势.(3)本氏针茅的盖度、密度、生物量和重要值逐渐下降,油蒿则相反.(4)随土层深度的增加,群落内植物根系干重总体上呈下降的趋势.根系干重在0-30 cm土层较为集中,整个演替阶段油蒿群落根系干重分布出现先升高后下降趋势,到第VI阶段根系分布深度可达80-90 cm.(5)物种丰富度指数、Simpson优势度指数、Shannon-Winner多样性指数和Pielou均匀度指数均呈现先升高后下降的趋势.因此,鄂尔多斯高原草地灌丛化较为严重,尽管中度灌丛化阶段群落的盖度、生物量和生物多样性较高,但由于灌木入侵后整个演替阶段盖度、密度、物种多样性等明显下降,草原生态系统的可利用性降低,应将灌丛化草地恢复为本氏针茅为主的草地