Regulation effect of exogenous nitric oxide on anti-oxidation system of Kandelia candel seedlings treated with NaCl

研究了外源一氧化氮(NO)供体硝普钠(SNP)对NaCl处理下红树植物秋茄(Kan-deliacandel)幼苗叶片中抗氧化酶活性、抗氧化物质及脯氨酸含量的影响。结果表明:NaCl处理下,秋茄幼苗叶片中超氧化物歧化酶(SOD)、过氧化物酶(POD)、过氧化氢酶(CAT)和抗坏血酸过氧化物酶(APX)等4种活性氧清除酶的活性均受到明显抑制(P<0.05),SNP可以不同程度地恢复SOD、POD、CAT的活性,但对APX活性影响不大;SNP提高谷胱甘肽(GSH)及类胡萝卜素(Car)的含量,促进脯氨酸含量的上升,显著降低叶片中过氧化氢(H2O2)和丙二醛(MDA)的累积。表明外源NO可以缓解NaCl处理诱导的秋茄幼苗叶片氧化损伤,降低膜脂过氧化水平,有利于秋茄适应盐生环境。By using sodium nitroprusside(SNP)as the donor of exogenous nitric oxide,this paper studied its effects on the antioxidant enzyme activities,anti-oxidation substances,and proline content in the leaves of Kandelia candel seedlings treated with NaCl.The results showed that after treated with NaCl,the activities of superoxide dismutase(SOD),peroxidase(POD),catalase(CAT)and ascorbate peroxidase(APX)in K.candel seedling leaves were depressed significantly(P<0.05),while SNP could recover the activities of SOD,POD and CAT to different degrees but showed little effect on APX.SNP increased the contents of glutathione(GSH)and carotenoid(Car),promoted the production of proline,and decreased the accumulation of H2O2 and malondialdehyde(MDA)significantly.It was indicated that SNP could relieve the oxidation damages induced by NaCl via decreasing the level of membrane lipid peroxidation in K.candel leaves,and facilitate K.candel to adapt to saline environment.国家自然科学基金项目(30670317和39970438);; 厦门大学新世纪优秀人才支持计划项目(0000-X07115)资

SYNTHESIS OF FULLERENE CRYSTALS SMALLER THAN C_( 60) BY ION BEAM IRRADIATION OF POLYETHYLENE

通过荷能离子 (包括团簇离子 )辐照聚乙烯首次合成了小于C6 0 的富勒烯———C2 0 和C2 6 分子晶体 .在此基础之上 ,进一步探索其他小富勒烯分子晶体 (如C32 ,C38和C2 4 )存在的确凿证据 .C 20 and C 26 fullerene crystals have been synthesized for the first time by irradiating polyethylene with energetic ions(including cluster ions).Based on this we are now trying to find evidence for the existence of other small fullerenes,such as C 24 ,C 32 ,and C 38 .中国科学院知识创新工程重要方向项目 (批准号 :2 60 10 0 3 1

Highly ionic-conductive crosslinked cardo poly(arylene ether sulfone)s as anion exchange membranes for alkaline fuel cells

通讯作者地址: Zhang, QGAnion exchange membrane fuel cells (AEMFCs) have become one of the most promising energy conversion devices due to the potential of adopting non-noble metal catalysts and faster oxygen reduction reaction kinetics in an alkaline operating environment. Here, a series of anion exchange membranes with high ionic-conductivity and low swelling ratio were prepared from imidazolium-functionalized crosslinked cardo poly(arylene ether sulfone)s for AEMFCs. Two oligomers, tertiary amine-containing poly(arylene ether sullone) (PES-DA) and bromomethyl-containing poly(arylene ether sullone) (BPES), are synthesized and then mixed at -40 degrees C. They are spontaneously inter-crosslinked at room temperature to form dense anion exchange membranes (AEMs), in which the tertiary amine groups of PES-DA rapidly react with the bromomethyl groups of BPES to form the crosslinked bonds. This avoids the use of crosslinking agents and the expense of functional groups. The resulting membranes show a high hydroxide conductivity up to 82.4 mS cm(-1) at 80 degrees C and a slight swelling low to traditional AEMs due to its crosslinked network structure. An open circuit voltage (OCV) of 0.82 V and a maximum power density of 92.1 mW cm(-2) are achieved in a H-2/O-2 single cell. The as-prepared membranes have a great potential for the application in AEMFCs.National Natural Science Foundation of China 21376194 Nature Science Foundation of Fujian Province of China 2014H0043 research fund for the Priority Areas of Development in Doctoral Program of Higher Education 2013012113000

水痘患児の隔離基準の再検討

Article信州大学医学部附属病院看護研究集録 1985: 93-98 (1985)departmental bulletin pape

骨髄移植患者の看護

Article信州大学医学部附属病院看護研究集録 1984: 96-114 (1984)departmental bulletin pape

白血病患児の感染予防についての一考察 : 肛門周囲膿瘍をひき起こした患児の看護を通して

Article信州大学医学部附属病院看護研究集録 1982: 93-104 (1982)departmental bulletin pape

Trisomy 21-induced Dysregulation of Microglial Homeostasis in Alzheimer’s Brains is Mediated by USP25

阿尔茨海默病（Alzheimer’s disease, AD）是一种最为常见的与记忆、认知能力退化相关的渐进性神经退行性疾病。唐氏综合征（Down’s syndrome, DS）是早发型阿尔茨海默病的一个重要风险因素，作为最常见的智力障碍遗传疾病，厦门大学医学院神经科学研究所王鑫教授团队揭示了治疗阿尔茨海默病和唐氏综合征新的治疗靶点，并且在小鼠模型上利用USP25小分子抑制剂成功地改善了阿尔茨海默病小鼠的认知功能，缓解了神经退行性病变的病理进程。该研究工作由王鑫教授指导完成，厦门大学医学院助理教授郑秋阳和博士生李桂林完成主要实验工作，王世华、朱琳、高月、邓青芳、张洪峰、张丽珊、吴美玲、狄安洁参与了部分研究工作。厦门大学医学院许华曦、赵颖俊和孙灏教授在研究过程中给予大力帮助和支持，清华大学董晨教授提供了Usp25基因敲除小鼠，厦门大学附属妇女儿童医院周裕林教授和郑良楷博士帮助收集了脑组织样品。Down syndrome (DS), caused by trisomy of chromosome 21, is the most significant risk factor for early-onset Alzheimer’s disease (AD); however, underlying mechanisms linking DS and AD remain unclear. Here, we show that triplication of homologous chromosome 21 genes aggravates neuroinflammation in combined murine DS-AD models. Overexpression of USP25, a deubiquitinating enzyme encoded by chromosome 21, results in microglial activation and induces synaptic and cognitive deficits, whereas genetic ablation of Usp25 reduces neuroinflammation and rescues synaptic and cognitive function in 5×FAD mice. Mechanistically, USP25 deficiency attenuates microglia-mediated proinflammatory cytokine overproduction and synapse elimination. Inhibition of USP25 reestablishes homeostatic microglial signatures and restores synaptic and cognitive function in 5×FAD mice. In summary, we demonstrate an unprecedented role for trisomy 21 and pathogenic effects associated with microgliosis as a result of the increased USP25 dosage, implicating USP25 as a therapeutic target for neuroinflammation in DS and AD.This work was supported by the National Natural Science Foundation of China (31871077, 81822014, and 81571176 to X.W.; 81701130 to Q.Z.), the National Key R&D Program of China (2016YFC1305900 to X.W.), the Natural Science Foundation of Fujian Province of China (2017J06021 to X.W.), the Fundamental Research Funds for the Chinese Central Universities (20720150061 to X.W.), and the BrightFocus Foundation (A2018214F to Yingjun Zhao). 该研究工作得到国家重点研发计划项目、国家自然科学基金、福建省自然科学基金、厦门大学校长基金的资助和支持

基于柔性销轴技术的风电齿轮箱行星轮轴装配工艺研究与分析

先对风电齿轮箱行星轮柔性销轴组件结构、配合关系进行了较深入的分析,再确认影响行星轮柔性销轴装配因素变量,通过实验提取变量数据,得出行星架上行星轮销轴孔温升与尺寸变量的关系曲线及函数关系,发现了柔性销轴套筒与定位环恢复常温后间隙和预调间隙、组合瞬间间隙3个变量之间规律,最后通过模拟实验及最终装配结果验证了前述行星轮柔性销轴组件装配工艺研究方案

The Library of Ethnic Minority Area Should Take the Road to Innovation for the Development of Western Regions

围绕民族地区图书馆信息服务存在的问题, 提出图书馆信息服务应遵循的原则, 从转变观念、加大基础设施投入、创新服务手段、方式与内容等方面阐明民族地区图书馆为西部大开发服务要走的创新之路。广西民族学院 2003年重点科研课题的研究成果之