EFFECT OF THE PROSTATIC EXTRACT (ROBAVERON) ON BLADDER FUNCTION : AN EXPERIMENTAL STUDY 3 －RESULT OF PHYSIOLOGICAL AND BIOCHEMICAL STUDY ON THE EXPERIMENTAL NEUROGENIC BLADDER -

Through the physiological and the biochemical study, the effects of prostatic extract (Robaveron) were investigated on the rabbits with experimental motor neuron lesion by the perfect transsection of the spinal cord. Experiments were carried out with two groups, in which one was transsected the spinal cord at the level of the twelfth dorsal vertebra and another was transsected at the level of the fifth lumbal vertebra after two weeks of operation. The pattern of neurogenic bladder was established within two weeks. From the physiological experiments, it became clear that the sphincter was important as the factor for the lower urinary tract obstruction in the case of upper motor neuron lesion, whereas the bladder neck was more dominant than sphincter in the case of lower motor neuron lesion and that in the lower motor neuron lesion, the acceleration of the vas deferens motility was observed by the stimulation on the urinary bladder, and the regular low voltage contraction in the case of lower motor neuron lesion was the rhythmical contraction of the detrusor muscle itself, moreover it was not influenced by the electrical stimulation of hypogastric nerve. Prostatic extract (Robaveron) increased the elasticity of detrusor muscle and the voiding pressure regardless of upper or lower motor neuron lesion, furthermore in the case of lower motor neuron lesion increased action potential to the rhythmical characteristic contraction of the urinary bladder. On the biochemical study, Robaveron increased permeability of organic acid of TCA cycle member to the mitochondria membrane and result in the elevation of the respiration of TCA cycle. The potent activity of Robaveron was found in the experiment under succinate or oxalacetate, on the comparison of the both, succinate was more efficiently utilized than oxalacetate, while citrate was hardly utilized. Futhermore the respiration of urinary bladder under succinate especially decreased in the case of lower motor neuron lesion, and the decreasing respiration was recovered by injection of Robaveron. From these physiological and biochemical experiments, it was concluded that the beneficial effect of Robaveron on the urinary bladder function was thoroughly myotropic and Robaveron was extensively useful for the improvement in the neurogenic bladder

Observation results by the TAMA300 detector on gravitational wave bursts from stellar-core collapses

We present data-analysis schemes and results of observations with the TAMA300 gravitational-wave detector, targeting burst signals from stellar-core collapse events. In analyses for burst gravitational waves, the detection and fake-reduction schemes are different from well-investigated ones for a chirp-wave analysis, because precise waveform templates are not available. We used an excess-power filter for the extraction of gravitational-wave candidates, and developed two methods for the reduction of fake events caused by non-stationary noises of the detector. These analysis schemes were applied to real data from the TAMA300 interferometric gravitational wave detector. As a result, fake events were reduced by a factor of about 1000 in the best cases. The resultant event candidates were interpreted from an astronomical viewpoint. We set an upper limit of 2.2x10^3 events/sec on the burst gravitational-wave event rate in our Galaxy with a confidence level of 90%. This work sets a milestone and prospects on the search for burst gravitational waves, by establishing an analysis scheme for the observation data from an interferometric gravitational wave detector