Design and Implementation of Remote Interrogation Command Procuratorate Management System

随着信息技术的不断发展以及各级检察院的相关规定，各地市检察院先后建立各种管理信息系统，虽然这些系统在功能上实现了基本信息的管理以及基本工作流程的管理，但是，系统在建设的过程中，都是由各相关分支机构进行控制的，所以各系统之间采用的开发标准、建设方式不一致，这就导致了系统数据格式的不一致，各分支结构内部数据不能得到有效的共享，达不到上级部门对远程审讯指挥系统的要求。因此，如何建立一个符合标准的、能最大限度使信息得到共享的、功能完善的、能稳定运行的远程审讯指挥系统是某市检察院急需解决的问题。 本文针对某市检察院现有远程审讯指挥系统存在的问题以及实际工作需求进行研发的，主要研究工作如下： 首先，本...Abstract With the continuous development of information technology-related provisions, and procuratorates at all levels around the City Procuratorate has established various management information systems, although these systems on the management functions to achieve the basic workflow management and basic information, however, the system construction The process is controlled by the relevant bra...学位：工程硕士院系专业：软件学院_工程硕士(软件工程)学号：X201323220

Response of antioxidase in viscera tissue of Pagrosomus major larvae to water-soluble fraction in No. 0 diesel oil

在实验生态条件下 ,研究了不同浓度 0 #柴油的水溶性成分 (watersolublefraction ,WSF)对真鲷幼体内脏组织抗氧化酶活性变化的影响 .结果表明 :不同浓度的WSF污染对抗氧化酶活性变化的影响表现为抛物线型剂量 效应作用形式 ;同一剂量组随着污染时间的延长 ,过氧化物歧化酶 (SOD)活力上升 ,硒谷胱甘肽过氧化物酶 (Se GPx)和过氧化氢酶 (Ca)的活力下降 ;受污染幼体在污染解除之后 ,其抗氧化酶活性得到不同程度的恢复 .Response of antioxidase (superoxide dismutase, SOD; catalase, Ca; sedium\|dependent glutathione peroxidase, Se\|Gpx) in viscera tissues of Pagrosomus Major larvae to water\|soluble fraction in No. 0 diesel oil were tested. Pagrosomus Majoe larvae were exposed to the solutions with the conc. at 0.017, 1.22, 8.82?mg(No.0 diesel oil)/L for 15 days. The results showed that the activity of antioxidase was statistically significant dose\|related effect in different WSF concentrations. Under same dosed\|concentration exposure, significant increases in SOD activity and decreases of Ca and Se\|Gpx activity were observed with the prolonged exposure time. The activity of antioxidase returned to corresponding control level after the recovery experiment.国家自然科学基金!资助项目 (项目批准号 :2 96 770 14) ;; 福建省自然科学基金!资助项目 (C9810 0 3

Modulations of cortical oscillatory activities by nociceptive pain

Nociception is the encoding and processing of noxious stimuli that is important as a protective mechanism to avoid potential or actual tissue damage. Previously, the neural basis of nociceptive processing was investigated by various neuroimaging techniques that measured neural activities in response to the experimental noxious stimuli. Such noxious stimuli can elicit sudden and short-lasting changes (event related potentials [ERPs], time-locked and phase-locked to the stimuli), and can trigger transient modulations of the ongoing oscillatory brain activity (appearing as event related desynchronization [ERD]/event related synchronization [ERS], time-locked but non-phase-locked to the stimuli). Most investigated pain-related ERPs have been shown to be correlated with subjective pain perception, reflecting the involuntary mechanism of attentional reorientation to a novel stimulus. In addition, pain induced α-ERD/ERS has been repeatedly associated with the administration of noxious stimuli, but their neural functions are still not fully understood. For a better understanding of the neural mechanism of α-ERD in pain perception, we comprehensively investigated changes in alpha oscillatory activities induced by transient and tonic experimental noxious stimuli. First, by applying oddball paradigms composed of auditory, visual, somatosensory, and pain modalities, we evaluated the characteristics of α-ERD and assessed the effective connectivity between P300 and α-ERD across the different sensory modalities. Second, we evaluated the specific neural functions of α-ERD in pain perception by comparing the temporal, spectral and spatial characteristics in response to frequent and infrequent painful stimuli. Third, we investigated changes in oscillatory activities induced by tonic heat by comparing the resting-state, innoxious-distracted, noxious-distracted, and noxious-attended conditions. We demonstrated that regardless of the sensory modalities, P300 and α-ERD were mainly generated from the posterior cingulate cortex and occipital lobe, respectively. The cortical information was consistently found to flow from α-ERD sources to P300 sources. This indicates that both α-ERD and the effective connectivity between the neural generators of P300 and α-ERD induced by the target stimuli were modality-independent, and that P300 was modulated by changes in α-ERD. These findings are useful for exploring the neural mechanism of cognitive information processing in the human brain. Moreover, α-ERD induced by painful stimuli reflected the summary effects of stimulus-related and task-related cortical processing, and could be greatly influenced by variations in the subject’s mental state. Our findings add to the understanding of the multiple neural functions of α-ERD, and could potentially help us more accurately interpret the possible modulation of physiological and/or psychological factors on α-ERD. Furthermore, the change of oscillatory activity in tonic heat pain perception was characterized by a stable and persistent decrease of contralateral-central alpha oscillation power and widespread increase of gamma oscillation power, which were significantly correlated with subjective pain intensity. The observed alpha suppression primarily reflected a top-down attention cognitive process, whereas the widespread gamma enhancement reflected the summary effects of bottom-up stimulus-related and top-down subject-driven cognitive processes. Finally, a theory model comprised of sensory, affective and cognitive modulations was proposed to explain the determinants of modulations of alpha oscillatory activity by pain.published_or_final_versionOrthopaedics and TraumatologyDoctoralDoctor of Philosoph

Empathy: The genetics-environment-endocrine-brain mechanism

共情是指感知到他人的情感状态,&nbsp; 使得自己产生与之类似的情绪或感受的能力,&nbsp; 它包含情感共情和认知共情两种成分.&nbsp; 本文结合健康被试和脑损伤患者的神经影像学研究,&nbsp; 概述了共情两种成分的认知神经基础:&nbsp; 情感共情涉及的特异性脑区主要有额下回(IFG)、脑岛和前扣带回(ACC),&nbsp; 认知共情的特异性脑区主要有腹内侧前额叶皮层(vmPFC). 然后, 从内分泌、遗传和环境几个方面, 详细讨论了影响共情能力及其行为的复杂因素. 对共情的内分泌研究发现,&nbsp; 催产素能够促进个体的共情反应,&nbsp; 而睾丸素则会弱化个体的共情反应,&nbsp; 且产前睾丸素可能会影响个体共情能力的发育; 对共情的社会环境和遗传学研究发现, 家庭成员的特质、父母教养方式、学校教育和人际关系等环境因素与催产素受体、多巴胺受体、五羟色胺转运蛋白(5-HTTLPR)和锌指蛋白(ZNF804A)等基因的多态性都会影响共情反应和共情能力的发展.&nbsp; 在现有研究的基础上,&nbsp; 本文提出了共情的遗传-环境-内分泌-大脑理论框架,&nbsp; 揭示了影响共情的各个因素间的相互作用.&nbsp; 最后,&nbsp; 指出了当前共情研究中所存在的问题和局限,&nbsp; 未来有必要在大样本研究的基础上开展纵向研究,&nbsp; 综合考量多个因素(遗传、环境、内分泌和大脑)及其交互作用对共情的影响,&nbsp; 揭示共情能力提升的关键因素;&nbsp; 并在此基础上促进基础共情研究成果向社会生活和临床实践转化,&nbsp; 有效地改善个体的共情能力及其行为,&nbsp; 从而促进社会和谐与进步,&nbsp; 真正意义上实现&ldquo;老吾老,&nbsp; 以及人之老;&nbsp; 幼吾幼,&nbsp; 以及人之幼&rdquo;.</p

Neural mechanisms of pain-related fear and its reduction

&nbsp; &nbsp; 疼痛恐惧是疼痛基础和临床研究中的一个重要课题。个体对疼痛信息产生过度警觉,&nbsp; 诱发不恰当的回避行为,&nbsp; 扰乱机体的正常功能,&nbsp; 加剧疼痛的现象即为疼痛恐惧。 疼痛恐惧可影响个体的疼痛感知以及疼痛相关的注意和回避行为,&nbsp; 且在慢性疼痛(如慢性肌骨骼疼痛)的发展、 维持个体正常生理功能的丧失中起着重要作用。疼痛恐惧的形成与表达涉及杏仁核、海马、背侧前扣带回皮层、和前额叶皮层等脑区的参与。当前的疼痛恐惧消退的心理&minus;行为干预方法可在疼痛恐惧加工的不同阶段(巩固、再巩固和消退)消退个体的疼痛恐惧。然而,&nbsp; 由于恐惧记忆形成过程较为复杂并受多种因素影响,&nbsp; 疼痛恐惧记忆消退方法效果较不稳定,&nbsp; 其基础研究与临床应用之间仍存在较大的鸿沟。将来研究有必要考虑到疼痛恐惧形成环境的差异以及个体人格特质/心理状态的差异,&nbsp; 逐步完善相关消退方法并将其引入临床镇痛,&nbsp; 以期帮助患者弱化、 擦除甚至改写困扰他们的疼痛恐惧,&nbsp; 从而缓解甚至消除病患的疼痛。</p

疼痛恐惧的神经机制及其消退

&nbsp; &nbsp; 疼痛恐惧是疼痛基础和临床研究中的一个重要课题。个体对疼痛信息产生过度警觉,&nbsp; 诱发不恰当的回避行为,&nbsp; 扰乱机体的正常功能,&nbsp; 加剧疼痛的现象即为疼痛恐惧。 疼痛恐惧可影响个体的疼痛感知以及疼痛相关的注意和回避行为,&nbsp; 且在慢性疼痛(如慢性肌骨骼疼痛)的发展、 维持个体正常生理功能的丧失中起着重要作用。疼痛恐惧的形成与表达涉及杏仁核、海马、背侧前扣带回皮层、和前额叶皮层等脑区的参与。当前的疼痛恐惧消退的心理&minus;行为干预方法可在疼痛恐惧加工的不同阶段(巩固、再巩固和消退)消退个体的疼痛恐惧。然而,&nbsp; 由于恐惧记忆形成过程较为复杂并受多种因素影响,&nbsp; 疼痛恐惧记忆消退方法效果较不稳定,&nbsp; 其基础研究与临床应用之间仍存在较大的鸿沟。将来研究有必要考虑到疼痛恐惧形成环境的差异以及个体人格特质/心理状态的差异,&nbsp; 逐步完善相关消退方法并将其引入临床镇痛,&nbsp; 以期帮助患者弱化、 擦除甚至改写困扰他们的疼痛恐惧,&nbsp; 从而缓解甚至消除病患的疼痛

Placebo Effects： Psychological Mechanisms and Clinical Applications

安慰剂效应在临床治疗中发挥着重要作用,如缓解患者的疼痛及促进患者运动功能康复等。由于临床环境的复杂性,安慰剂效应的产生涉及到患者、医护人员和医疗环境等复杂的心理社会因素。为综合调节这些因素使得安慰剂效应最大化,有效提高整体治疗效果,本研究系统总结了安慰剂效应产生的心理机制,包括预期、条件化、社会观察学习和个体因素的作用;讨论了安慰剂在临床镇痛中的有效性;从患者、医护人员和治疗环境等方面探讨了影响临床中安慰剂效应的因素及相应的调节策略;最后,针对当前安慰剂相关的基础研究向临床转化中所面临的问题提出了可能的解决方案

经皮神经电刺激的镇痛机制及其临床应用

经皮神经电刺激(transcutaneous electrical nerve stimulation,TENS)是一种非侵入式的通过电流脉冲来激活外周神经纤维的镇痛疗法,具有非药理性、安全无创伤、费用低等多方面优点,已用于临床中多种疼痛的缓解。然而,TENS的临床镇痛效果存在较大的差异,这可能是由于不同刺激参数下的TENS涉及不同的镇痛机制。为推进TENS相关的基础研究与临床应用,本文首先综述了不同类型TENS镇痛的神经生理和生化机制,进而从刺激位置、脉冲参数(电流强度、频率与脉宽)以及使用时长和使用频度等多个方面讨论了影响TENS镇痛效果的因素,并总结了TENS在临床镇痛的相关应用,包括术后痛、慢性腰背痛、分娩痛等。最后,为实现更好的临床镇痛效果,本文提出在TENS相关的临床应用中,应充分考虑到不同刺激参数对TENS镇痛效果的影响以及患者个体间差异所导致的TENS镇痛效果的差别,优化TENS参数设置,建立基于患者疼痛评分与TENS刺激输入之间的动态关系模型,自适应地根据患者实时疼痛评分调整TENS刺激模式。 更多还原</p

Effect of benzo(a)pyrene on antioxidant enzyme activities in Boleophthalmus pectinirostris liver.

在实验条件下 ,研究了不同浓度苯并 (a)芘 (BaP)暴露对大弹涂鱼肝脏内抗氧化酶 超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶 (GPx)和过氧化氢酶 (CAT)活性的影响 .结果表明 ,不同浓度的BaP暴露对抗氧化酶活性产生不同程度的影响 .低浓度组 (3μg·L-1)BaP暴露 ,抗氧化酶活性未发生显著变化 .高浓度组 (30 μg·L-1)BaP暴露 ,随着污染时间的延长 ,SOD活性在第 3天显著升高 (α≤ 0 .0 5 ) ,随后逐渐降至对照组水平 ;GPx活性则在第 7天显著升高 (α≤ 0 .0 5 ) .在整个实验周期中 ,BaP暴露浓度的变化以及暴露时间的延长对CAT活性无显著影响 .The effect of different BaP concentrations on the activities of superoxide dismutase(SOD),glutathione peroxidase(GPx) and catalase(CAT) in Boleophthalmus pectinirostris liver was studied under experimental condition.The results showed that the activities of antioxidant enzymes did not change too much with BaP exposure in lower concentration,whereas the SOD and GPx activities were increased significantly with BaP exposure in higher concentration.No statistical changes were observed in the effect of BaP exposure in different concentrations on CAT activities throughout the experiment.高等学校博士学科点专项科研基金;; 国家自然科学基金!资助项目 (498760 2 9

Effect of oil pollution on gluthione and relative enzyme in oyster(Saccostrea cucullata)

福建省自然科学基金资助项目(D9910004)