Novel fast magnetic resonance spectroscopy and imaging with their applications via spatiotemporally encoding

磁共振波谱和成像研究在化学，材料，生命科学领域都具有重要的应用价值。缩短实验时间和改善谱图分辨率一直是磁共振波谱学研究发展的重要挑战。另一方面，目前快速成像技术对磁场不均匀性非常的敏感，这也限制了许多快速成像的运用。本论文主要集中于发展磁共振波谱新技术用于加速NMR实验速度并改善谱图分辨率，和磁共振快速成像新技术用于增强抗拒磁场不均匀性能力获取图像。论文的主要内容可以归结如下： 1. 系统的回顾了磁共振实验中常用的快速波谱和成像技术，包括时空编码和脉冲相位编码技术。进一步总结了不均匀场下基于分子间多量子相干获取高分辨NMR谱的方法及运用。解释了快速实验技术与分子间多量子相干高分辨技术的结合难...Nuclear magnetic resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI) play numerous roles in contemporary research, including chemical, biological, and medical studies. Shortening the acquisition times and improving the spectral resolution are significant challenges in NMR research. And current fast imaging techniques are sensitivity to the field inhomogeneities. During the course of ...学位：工学博士院系专业：物理与机电工程学院_电磁场与微波技术学号：3312012015386

Mapping of Major QTL for Grain Shape and Weight Traits in Rice(Oryza sativa L.)

水稻特殊种质资源是解析水稻基因组功能的重要途径。水稻粒型（粒长、粒宽和长宽比）和千粒重性状与稻米外观、产量及市场价值密切相关，发掘控制水稻粒型和千粒重的主效基因是当前遗传学家和育种家们共同关注的焦点。本研究采用大粒种（JF171和JF178）和小粒种（JF222和Samba）做亲本，构建两个F2群体——JF171/Samba群体和JF222/JF178群体；应用微卫星标记（simplesequencerepeats,SSR），通过基于目标性状表现型的分离群体分组分析法（bulksergeantanalysis,BSA）构建遗传框架图；采用混合线形模型复合区间定位法（mixed-modelbas...Studying special germplasm resource is an important way to reveal rice genomic function. Grain shape traits including grain length(GL), grain width(GW) as well as length/width ratio(GS) and 1000-grain weight(KGW) are closely associated with rice appearance quality, yield and market value. In this study, we selected large grain parent(JF171 and JF178) and small grain parent(JF222 and Samba) to esta...学位：理学硕士院系专业：生命科学学院生物化学与生物技术系_生物化学与分子生物学学号：2005130210

High temperature micro pressure sensor based on model identification

高温压力传感器应用在很多领域,由于高温将使放大电路工作失效,因而采用将放大电路与传感器件分离的设计方案是解决高温测量的方法之一。介绍一种将放大电路与传感器件分离的基于模型识别技术的微型电容式压力传感器。传感器件由MEMS工艺来实现,信号激励与信号处理由计算机来完成。对电路的工作过程进行了计算机仿真和试验,并给出了微型高温压力传感器的MEMS工艺设计流程。High temperature pressure sensor is applied in many fields. However, the amplifying circuit may be invalidate at high temperature. One way to solve this problem is to separate the amplifying circuit and sensor. A kind of high temperature micro pressure sensor based on model identification using this method is introduced, which is realized by MEMS process. Signal stimulation and disposal are accomplished by computer. The circuit is simulated and tested. And the MEMS process of the high temperature micro pressure sensor is designed

Hige Temperature Pressure Microsensor Based on Model Identification

【中文文摘】高温测量是急需解决的测量问题之一。介绍一种将放大电路与信号传感器件分离的基于模型识别技术的高温微型电容式压力传感器。电阻电容信号滤波网络和信号的模型识别组成一个微型传感系统,在对滤波网络进行激励和模型识别后就可以得到变化的电容值。这种MEMS技术制作的硅玻璃键合的电容式压力传感器,可以在小于300℃环境下工作。此高温测量系统既满足高精度测量的要求,也避免了在高温环境中进行信号放大的难题。 【英文文摘】Measuring in high temperature is a problem in dire need of sloving.A kind of high temperature capacitive pressure microsensor based on model identification is introduced.The microsensor is made of RC signal filter and signal model identification.Can get a capacitor after inspiring the filter and model identification.It can work in a condition less than 300 ℃ .The high temperature measuring system with high precision avoids the trouble of amplifying signal in high temperature

锂离子电池正极材料第一原理计算研究

利用第一原理计算方法可分析和预测锂-金属氧化物电池正极材料在Li离子嵌入脱出过程中的电势和稳定性等性能。本文详细介绍了第一原理计算方法的理论背景以及目前LiCoO2正极材料计算研究的现状。利用此方法对LixNiO2及多组分材料掺杂进行研究是今后工作的重点

锂离子电池正极材料第一原理计算研究

利用第一原理计算方法可分析和预测锂-金属氧化物电池正极材料在Li离子嵌入脱出过程中的电势和稳定性等性能。本文详细介绍了第一原理计算方法的理论背景以及目前LiCoO2正极材料计算研究的现状。利用此方法对LixNiO2及多组分材料掺杂进行研究是今后工作的重点

重组人血管内皮生长抑制因子对人肺腺癌裸鼠移植瘤的放射效应影响

目的:探讨重组人血管内皮抑制因子(recombinant human vascular endothelial growth inhiloitor-192,rhVEGI-192)对人肺腺癌裸鼠移植瘤的放射增敏作用。方法:采用原核表达rhVEGI-192,获得目的蛋白。通过肿瘤倍增时间,计算药物的增敏系数。通过建立人肺腺癌裸鼠移植瘤模型,荷瘤裸鼠随机分为4组:对照组、10Gy、rhVEGI-192、rhVEGI-192+10Gy。采用6MV-X线进行照射,照射剂量为10Gy。获得移植瘤标本,利用免疫印迹法检测移植瘤中VEGF(vascular endothelial growth factor)的表达变化。结果:SDS电泳结果显示,目的蛋白位于22k D左右。10Gy照射时,重组人血管内皮抑制因子的EF(enhancement factor)值为1.5。和空白对照组相比,rhVEGI-192组和10Gy组移植瘤的生长受到抑制(P<0.001),rhVEGI-192+10Gy组移植瘤生长显著抑制(P<0.001),rhVEGI-192+10Gy组移植瘤较10Gy组有明显生长抑制。和空白组相比,rhVEGI-192组VEGF表达减少,而10Gy组VEGF表达变化不明显,rhVEGI-192+10Gy组VEGF表达明显减少。rhVEGI-192+10Gy和rhVEGI-192组相比,VEGF表达减少。结论:rhVEGI-192联合照射能够减少VEGF的表达。这可能是rhVEGI-192的增敏机制之一。中国人民解放军南京军区医学科技创新项目(编号:No.12MA061

Anatomic and radiograph study of double-bundle anterior cruciate ligament reconstruction

目的测量并研究标准膝关节侧位X线片上前交叉韧带(ACl)股骨止点的相关骨性标志数据,为临床ACl重建提供参考。方法对10例成人膝关节标本进行解剖观察,标记ACl股骨止点前内侧束和后外侧束,摄标准膝关节正侧位X线片,利用图像分析软件测量两束止点中心(前内侧束为A点,后外侧束为b点)与股骨后髁弧形中心(I点)的距离,测量A点与过顶点、b点与过顶点的距离。结果解剖观察表明,ACl在中段根据其纤维走行及屈伸过程中的松紧变化,较易分为2束。A点与I点的距离为3.08~7.33(5.40±1.56)MM,b点与I点的距离为3.42~7.15(5.40±1.31)MM,A、b点与I点的距离差异无统计学意义(T=0.198,P=0.848)。A点与过顶点的距离为7.60~12.40(9.90±1.60)MM,b点与过顶点的距离为13.50~18.60(15.70±1.70)MM。结论股骨外髁弧形中心(单束重建等长点)与ACl前内侧束、后外侧束中心等距,支持单隧道双束重建ACl的理论要求。Objective To measure and study the distance relationship between femoral footprint ACL and femoral condylar landmarks on a standard knee joint lateral X-ray, in order to provide reference for clinical ACL reconstruction.Methods Ten human cadaveric knees disposaled in formalin were anatomized.A mark was made on the footprint of anterior cruciate attachment, ACL was divided into anteromedial bundle and posterlateral bundle, and a standard knee joint lateral X-ray was taken.The distance between the centre of two bundle(the anteromedial bundle was A point, the posterolateral bundle was B point) and the centre point of femoral condyle arc were measured by using the image analysis software.The distance between theover-the-topposition and point A, point B were measured.Results The anatomy observation showed that, in the middle of the ACL according to elastic change of the fiber and the flexion and extension process, it was easy to be divided into two bundles.The distance between point A and point i was 3.08-7.33(5.40 ±1.56) mm, the distance between point B and point i was 3.42-7.15(5.40±1.31)mm.There were no significant differences(t =0.198,P =0.848).The distance between point A and over-the-topposition was 7.60-12.40(9.90±1.60)mm, and the distance between point B and over-the-topposition was 13.50-18.60(15.70±1.70)mm.Conclusion The distance between the centre of AM, PL and the centre point of femoral condyle arc is equal, which supports the theory of the single tunnel double bundle reconstruction.厦门市科技计划项目(3502Z20114036