Electric Hot Assisted Turning and Its Process Monitoring

近年来，机械加工行业中出现了大量耐高温、强度高、硬度大的难加工材料。在这些材料的加工过程中，普遍存在着切削力大、刀具磨损严重、表面质量差等问题。用常规的刀具材料和加工方法很难进行切削加工，也达不到现代工业技术的要求。随着历史的发展，人们提出了许多针对这些难加工材料的加工思路和方法，加热切削就是比较好的思路，而导电加热切削则是其中一种行之有效的方法。 本文对现有导电加热切削技术做出了一些研究，提出了通电加热辅助车削的方法，意在探寻这种方法的可行性和效果。通电加热辅助车削是把低压大电流通入到由电源、加热电极和工件材料构成的回路中，利用电流流经电极—工件间接触电阻时产生的热量，使工件迅速升温从而软...Recently, lots of high temperature resistance, high strength and high hardness materials has appeared in machining industries. These materials have some problems in the process of machining because of these characteristics, such as high cutting force, serious tool weal and low surface quality. If we use traditional tool or machining methods, we may fail and it could not reach industrial request. W...学位：工程硕士院系专业：物理与机电工程学院_工程硕士(电子与通信工程)学号：3312012115267

The Principle of Electric Hot Milling and Its Experimental Verification

提出了一种通电加热铣削方法,介绍了其基本原理与实验装置。通过试验及分析用小波变换处理采集到的振动信号来证明这种方法能够大幅降低切削过程的振动,提高刀具寿命,降低表面粗糙度,并且成本低、实验装置简单实用。提出了一种基于通电加热的新型高温硬度测量方法,用该方法分析淬火钢在高温下的硬度变化情况,发现常温57HrC的淬火T10A工具钢在300℃左右,硬度就急剧降低至30HrC,这也证明了加热切削的有效性。A new electric hot milling method is proposed firstly,and then this paper has proposed the theory and the experimental device of the new method.It has been proved by experiment and analyzing the vibration signal processed by wavelet transform on the new method that it really can significantly reduce the vibration and increase the tool life in milling process.And it also can reduce the surface roughness of the material.Besides,the device is not only cheap but also simple and practical.A new high-temperature hardness measurement method based on electric hot technology is proposed.The change of hardness at high temperature of the hardened steel has been analyzed.The hardness of T10 A carbon tool steel which has been hardened is nearly 57 HRC in normal atmospheric temperature,but the hardness drastically reduce to hardness 30 HRC when the material is heated to 300 ℃.So the efficiency of the new electric hot milling method has also been proved.国家自然科学基金项目(50875120)资

Advance in research of water-proof liquid band-aid

创可贴是人们生活中最常用的外科用药。传统的创可贴即是一长形胶布,中间附以浸过药物的纱布,从而起保护伤口,暂时止血的作用。传统创可贴适合创伤较为表浅,伤口整齐干净、出血不多而又不需要缝合的小伤口使用。本文所要讲述的液体创可贴可用于大部分的外伤伤口,能够及时止血及防止病原微生物的感染。本文主要讲述了近些年刚刚出现的防水型液体创可贴,包括其主要的作用,材料组成及相关临床研究。Band-aid is the most commonly used surgical medication. The traditional band-aid is a longshaped adhesive,and the intermediate layer accompanied by soaking medicine gauze,thereby used for the wound and temporary hemostasis. The traditional band-aid is suitable for shallow trauma,small wound,clean and tidy wound,less bleeding and the wound that needs no suture. In this article we introduced a liquid band-aid that can be used for most of the traumatic wound,can timely stop bleeding and prevent microbial infection. We mainly described the waterproof liquid band-aid appeared in recent years,including its main effects,material composition and related clinical research

Advances in preparation of mesoporous silica nanoparticles and its use as different functional drug

近年来,有越来越多的文献报道关于介孔二氧化硅纳米粒（mesoporous silica nanoparticles,MSN）作药物载体的研究。本文结合近几年国内外的相关文献,介绍了由Mobli公司合成的M41S系列,圣巴巴拉大学合成的SBA系列,以及中空介孔二氧化硅纳米粒这3种最常见的MSN的特点及制备方法,并举例介绍了MSN作为药物速释载体的相关研究,同时从p H敏感型、热敏型、光响应型三方面介绍了MSN作为药物控释载体的研究。从相关研究结果可以看出,将MSN作为药物的载体,鉴于其独特的介孔孔径、可调节的纳米孔道结构、易于功能化修饰的表面等特点,可以实现对药物的速释、缓释及控释释放。由此可见,选择将MSN作为药物的载体具有广阔的应用前景。In the past a few years, mesoporous silica nanoparticles (MSN) have attracted more and more attention for their application in drug delivery. The recent relative literature was used for reference to introduce the characteristics and preparation of M41S series MSN (synthesized by Mobil Corporation), the SBA series MSN (synthesized by Santa Barbara University), and hollow mesoporous silica nanoparticles. Examples were presented to introduce the use of MSN as immediate drug delivery carrier. The use of MSN as controlled drug delivery carrier (CDDC) was illustrated via pH-responsive CDDC, temperature-sensitive CDDC, and light-triggered CDDC. MSN showed great properties in immediate/sustained/controlled drug delivery system, in view of their unique mesoporous pore diameter, adjustable nano-channel, and surface easily to be modified. The selection of MSN as drug carrier has a broad application prospect. ? 2017, Chinese Journal of New Drugs Co. Ltd. All right reserved.福建省科技计划重点项目（2013Y0074

白念珠菌基因多态性与耐药性关系

【目的】探讨耐氟康唑白念珠菌基因多态性与其耐药性是否相关。【方法】收集48株敏感白念珠菌和10株耐氟康唑白念珠菌,其中包括2株体外诱导的耐氟康唑白念珠菌。选择1个随机引物(引物1251),采用任意引物PCR方法基因分型,将电泳图谱扫描入计算机后采用Labwork4.0软件转化为数值图表,利用SPSS11.5进行聚类分析。【结果】引物1251的PCR指纹图带型稳定,多态性丰富,可以作为分型引物。聚类分析结果提示8株临床耐药菌的PCR指纹图相似系数为71.7%,而其中7株的耐药菌相似系数高达86.7%,远高于58株菌的平均相似系数(47.3%)。2株体外诱导的耐药菌诱导前后基因型未发生变化。【结论】基因分型的结果未提示耐氟康唑白念珠菌存在一定的特殊电泳条带,但提示了特定的PCR指纹图可能与耐药性有一定相关性

Preparation of mesoporous silica nanoparticles in different pore size and its use in the solidification of sirolimus loaded self-microemulsifying drug delivery system

研究制备了不同孔径的介孔二氧化硅纳米粒及西罗莫司自微乳。使用扫描电镜、透射电镜、小角度X-射线衍射、氮气吸附-脱附表征制得的介孔二氧化硅纳米粒,发现其为有序的纳米孔道结构,孔径分别为6.3、8.1和10.8 nm,通过粒径测定仪测得西罗莫司自微乳粒径为20.6±1.3 nm。通过搅拌法制备载西罗莫司自微乳介孔二氧化硅纳米粒。研究发现,当西罗莫司自微乳与介孔二氧化硅纳米粒质量比2∶1时为最佳比例,载药量约为0.83%,且固体粉末流动性良好。采用差示扫描量热法表明,西罗莫司以非晶体或无定形存在于载体材料中,重分散性良好。孔径大小对于载西罗莫司自微乳介孔二氧化硅纳米粒在250 m L水中2 h的释放终点并没有显著影响,但对于最初40 min释放结果影响较大。综上,介孔二氧化硅纳米粒有望成为一种新型的自微乳吸附剂。The mesoporous silica nanoparticles (MSN) in different pore size and sirolimus (SRL) loaded self-microemulsifying drug delivery system (SMEDDS) were prepared. The results in morphology were collected by scanning electron microscope, transmission electron microscope, small-angle X-ray diffraction, and N2 adsorption-desorption. The results showed that the prepared MSN has ordered nanochannels with a pore size of 6.3, 8.1, 10.8 nm, respectively. The particle size of SRL-SMEDDS were measured by particle sizing system, which was 20.6 ± 1.3 nm. The stirring method was developed to prepare SRL-SMEDDS-MSN. It was found that the optimal ratio of SRL-SMEDDS to MSN was 2: 1, while the drug loading rate was near 0.83%, and the flow properties of SRL-SMEDDS-MSN were of good condition. The differential scanning calorimetry results proving a molecular or amorphous dispersed state of SRL in MSN while the suspension experiment has shown great reconstitution properties of SRL-SMEDDS-MSN. There is no significant influence on maximum drug release rate of different pore size of SRL-SMEDDS-MSN in 250 mL water within 2 h, while the results of the first 40 min have an obvious difference. Above all, MSN might provide a new strategy for the solidification of SMEDDS.福建省科技计划重点资助项目（2013Y0074

深度学习的目标跟踪算法综述

目标跟踪是利用一个视频或图像序列的上下文信息,对目标的外观和运动信息进行建模,从而对目标运动状态进行预测并标定目标位置的一种技术,是计算机视觉的一个重要基础问题,具有重要的理论研究意义和应用价值,在智能视频监控系统、智能人机交互、智能交通和视觉导航系统等方面具有广泛应用。大数据时代的到来及深度学习方法的出现,为目标跟踪的研究提供了新的契机。本文首先阐述了目标跟踪的基本研究框架,从观测模型的角度对现有目标跟踪的历史进行回顾,指出深度学习为获得更为鲁棒的观测模型提供了可能;进而从深度判别模型、深度生成式模型等方面介绍了适用于目标跟踪的深度学习方法;从网络结构、功能划分和网络训练等几个角度对目前的深度目标跟踪方法进行分类并深入地阐述和分析了当前的深度目标跟踪方法;然后,补充介绍了其他一些深度目标跟踪方法,包括基于分类与回归融合的深度目标跟踪方法、基于强化学习的深度目标跟踪方法、基于集成学习的深度目标跟踪方法和基于元学习的深度目标跟踪方法等;之后,介绍了目前主要的适用于深度目标跟踪的数据库及其评测方法;接下来从移动端跟踪系统,基于检测与跟踪的系统等方面深入分析与总结了目标跟踪中的最新具体应用情况,最后对深度学习方法在目标跟踪中存在的训练数据不足、实时跟踪和长程跟踪等问题进行分析,并对未来的发展方向进行了展望。国家自然科学基金项目(U1605252,61872307,61773397)~

Thermodynamic Analysis of the Efficiency Improvement of a Photovoltaic-thermoelectric Hybrid System

太阳能电池和热电模块组成的复合系统有望获得较高的太阳能到电能的转换效率。本文利用热力学方法分析了由商业化太阳能电池构成的复合系统,并根据一维模型下能流输运特性计算了系统内各模块温度及其对转换效率的影响,发现低温度系数和低效率的太阳能电池可以通过构建复合系统获得更大的性能提升。同时,由于太阳辐照的有限性导致流经热电模块的热流受到限制,因此热电模块效率无法达到理想条件下的最优值。这表明复合系统的优化并非各个模块优化后结果的简单线性叠加,而需要考虑构成复合系统的各个模块间的约束条件进行整体计算和优化,即复合系统效率不仅与材料本征特性(如电导率、热导率等)有关,也和其工作状态(如入射太阳辐照强度、热电模块构成及几何尺寸、模块之间热学特性等)有关。上述模型与结果对于类似复合系统的设计有着指导作用。A hybrid system formed by a photovoltaic module and a thermoelectric module has a great potential to enhance the solar-to-electricity efficiency.A mathematical model based on the first law of thermodynamics and the heat transfer analyses of the hybrid system is built, where the overall efficiency of the system is enhanced by optimizing the system as a whole.The model is used to study hybrid systems formed by commercially available photovoltaic modules and thermoelectric modules.It is found that, due to a limited incoming heat flux for the thermoelectric module, the overall performance of the hybrid system depends not only on the intrinsic properties of the materials forming such a hybrid system, but also on their working conditions, such as incoming solar radiation, geometry of each module, and interfacial properties.The results indicate that only photovoltaic modules with low temperature coefficient and low efficiency can truly benefit from forming such hybrid system, and the optimization of a hybrid system must be done as a whole.教育部高等学校博士学科点专项科研基金新教师项目(20090121120028);教育部高等学校博士学科点专项科研基金博导类项目(20120121110021); 国家自然科学基金项目(U1232110

中药多组分缓释制剂体外释放评价体系的研究进展

目的：为找到更适合中药多组分的评价方法提供思路。方法：以＂中药多组分＂＂体外释放＂＂同步释药＂＂多指标＂＂Synchronized＂＂Release in vitro＂＂TCM multicomponent＂＂Multi-index＂等为关键词,组合查询2004年1月-2016年6月在PubMed、Elsevier、Springer Link、中国知网、万方、维普等数据库中的相关文献,对中药已知成分作为评价指标、中药指纹图谱在药物体外释放中的应用,以及中药化合物组、吸波面积法、质量权重系数法等方法在中药多组分缓释制剂体外释放中的应用进行综述。结果与结论：共检索到相关文献210篇,其中有效文献42篇。对于成分复杂的中药制剂,溶出度的测定选择其中某种已知的指标成分进行;选择中药组分制剂中的一种或几种药效成分的释放度作为评价指标,可反映中药组分制剂中特定成分的释放特征;以指纹图谱相关峰为指标,可更全面地评价中药多组分缓释制剂的体外释放行为;选择中药多组分制剂中的几种有效成分并结合中药制剂的指纹图谱进行评价中药多组分制剂的释药行为,既可反映多个成分的含量变化,又可反映中药复方整体的含量变化;基于中药化合物组的整体谱特征,采用卡尔曼滤波法,计算获得溶出介质中化合物的含量,能很好地反映中药多组分的释药行为;吸波面积法能考察中药所有成分的释放情况,对复方药物溶出度及体内药动学的研究有指导意义;质量权重法可为中药组分的整体性研究提供参考,但必须明确各成分在整体组分中所占的质量权重系数才能整合反映整体性质。福建省自然科学基金资助项目（No.2015J01491

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