An Asymptomatic Case of Strongyloides stercoralis Complicated with Gastric Cancer

We have reported a case of Strongyloides stercolaris complicated with gastric cancer. A 67-year-old man who had no clinical symptoms and signs of parasitic infection was admitted to Juzenkai Hospital in Nagasaki because of iron-deficient anemia. He had histories of diabetes mellitus, chronic atrial fibrillation and benign prostate hypertrophy. The radiological studies revealed the existence of gastric cancer (Bormann III) and the rhabditiform larvae were found in the stool after purgation unexpectedly. Subsequently characteristic filariform larvae were detected in the stool by means of filter paper culture technique. We performed the radiological and endoscopic examinations of the alimentary tract, and made a diagnosis of strongyloides infestation by the morphological and immunological (Ouchterlony\u27s method) studies. First of all we tried to exterminate the parasite because the influence of surgical operation in aggravation of infections was a troublesome problem. The treatment with pyrantel pamoate was not effective but a large dose of thiabendazol was very effective to get rid of rhabditiform larvae in the stool. He underwent a gastrojejunostomy with Billroth I methods under the diagnosis of gastric cancer with no evidence of metastasis. After operation, he received the twice of therapy with thiabendazol and the rhabditiform larvae in the stool disappeared completely. We could protect him against the manifestation of the strongyloides infestation. This case suggests that an asymptomatic case of the strongyloides infestation may be existent with or without other disease and we have to examine not only occult blood but also the existence of the parasite in the stool especially before surgical operation of the alimentary tract

Effect of perception of self-physical fitness, value and demand for regular sport participation of university students on the intention of Sport participation

The purpose of this study is to understand effect of perception of self-physical fitness, value and demand for regular sport participation of university students on the intention of sport participation. Three different characteristics were identified form factor analysis. One is that, the probability of having the intention to keep frequency of sport participation will be higher to level up satisfaction with self-physical fitness. And the probability of having the intention to increase frequency of sport participation will be higher to level down satisfaction with self-physical fitness. Two is, in case of sport-participants, who low frequently do sport or do not, the probability of having the intention to increase frequency of sport participation increases by objective of sports participation for health promotion. But in case of sport-participants, who do high frequently sport, the probability of having the intention to increase frequency of sport participation does not increase by objective of sports participation for health promotion. Three is, in case of sport participants, who high frequently do sports is not influenced by cost of sport participation

ジュツゼン ニ シテキ サレテ イナカッタ ソウボウベン ヘイサ フゼンショウ ニヨル シンフゼン デ ジュンカン ハタン シタ Aガタキュウセイ ダイドウミャク カイリ ノ イチ シュジュツ レイ

Acute type A aortic dissection is a life-threating disease, and preoperative congestive heart failure caused by newly developed aortic regurgitation is known as a risk factor for increased hospital mortality. Herein, we report didactic case of hemodynamic deterioration during surgical treatment of acute type A aortic dissection, which was induced by pre-existed but undiagnosed severe mitral regurgitation. Not only surgeons but also all members of surgical team should bear in mind the possibility of pre-existed mitral valvular disease, which possibly induce congestive heart failure in patients undergoing surgery of acute type A aortic dissection even in emergent setting

Potential amelioration of upregulated renal HIF-1alpha–endothelin-1 system by landiolol hydrochloride in a rat model of endotoxemia

AimsEndothelin (ET)-1 is the best known potent vasoconstrictor and has been implicated in pathogenesis of sepsis-associated acute kidney injury (AKI) in human or lipopolysaccharide (LPS)-induced AKI in animal models. We have previously shown that ET-1 is highly up-regulated in renal tissues and in plasma after LPS administration. Here, we investigated whether landiolol hydrochloride, an ultra-short-acting beta-blocker, can play an important role in ameliorating levels of LPS-induced up-regulation of renal HIF-1α–ET-1 system and inflammatory cytokines in a rat model of endotoxemia.Main methodsMale Wistar rats at 8 weeks of age were either administered with: a) lipopolysaccharide (LPS) only for three hours (3 h) or b) LPS, followed by continuous administration of landiolol for 3 h; c) third group was only treated with vehicle.Key findingsAt 3 h after LPS administration there was: a) minimal injury in kidney tissues; b) circulatory levels of creatinine, blood urea nitrogen and NGAL increased and c) expression of inflammatory cytokines, such as TNF-α, IL-6 and iNOS increased at the level of both circulatory and renal tissues. In addition, LPS significantly induced renal expression of ET-1 and HIF-1α compared to control. Finally, treatment of LPS-administered rats with landiolol for 3 h normalized elevated serum markers of renal injury and up-regulated levels of renal HIF-1α–ET-1 system with normalization of TNF-α.SignificanceTaken together, these data led us to conclude that landiolol ameliorates the up-regulation of HIF-1α–ET-1 system in minimally morphologically-injured kidney and normalizes biomarkers of renal injury in early hours of endotoxemia of a rat model