Functional Analysis and Molecular Mechanisms of Osteopontinin the Progression of Human Gastric Carcinoma Cells

Osteopontin（OPN）是最早从骨基质中分离得到的一种分泌型、粘附性的钙结合磷酸化糖蛋白。OPN通过与其主要的受体整合素和CD44相互作用，参与多组织、多器官的生理病理过程。近年发现OPN还是一种与肿瘤发生发展密切相关的多功能细胞外基质蛋白。OPN在乳腺癌、前列腺癌、肝癌、结肠癌、食管癌、肺癌和神经胶质瘤等许多肿瘤组织中高表达，并提示OPN与肿瘤细胞存活、侵袭转移和血管生成密切相关。胃癌是中国最常见的发病率和死亡率很高的恶性肿瘤之一。胃癌的发生发展涉及到多基因的改变，包含抑癌基因失活，癌基因的扩增及肿瘤转移相关基因的异常表达等。前人研究发现OPNmRNA在胃癌组织中的表达较正常胃粘膜组...Osteopontin (OPN) is a secreted, adhesive and calcium-binding phosphoprotein. Previous research found that OPN was involved in physiological and pathological processes in variety of tissues and organs through bindinging with integrins and CD44 receptors. Recently, OPN has also been found that it is a multifunctional matrix protein, and it has been detected in a number of human tumor types, includi...学位：理学博士院系专业：生命科学学院生物学系_细胞生物学学号：B20032601

SD Enterprise Business Model Innovation Study

本文的研究对象是位于厦门市翔安火炬园区的一家中小型制造企业——SD公司，该公司主要向园区内的光电显示产品制造商提供包装缓冲材料。 企业经营环境变化日益加快，传统的战略管理由于对环境的认知偏向于静态化和孤立化，环境之间缺乏内在关联，已经受到了商业实践的严重挑战（Grant，2007）。尽管主流业务战略理论如波特的通用战略理论和Wernerfelt(1984)等人的基于资源的观点或能力理论都试图向动态化延伸，但仍然没有取得实质突破(Hof，Arndt，2006)。 鉴于此种情况，本文选用能够反映动态现实的经营环境的介观商务模式理论（翁君奕，2003）作为研究工具，对SD公司的现实状况进行分析，...The research object of this dissertation is SD Enterprise, one of the medium-manufacturing corporation locating at Xiamen Torch High-tech Zone Pioneering Park (Xiang’an), which supplies packing material to the Optical Display products producers. Enterprise business surroundings shift quicker and quicker. The traditional Strategic Management is challenged by business practices due to the cognitive...学位：管理学硕士院系专业：管理学院企业管理系_企业管理(含财务管理、市场营销、人力资源管理)学号：E2007000

Design and Implementation of Intelligent Digital Board System Based on Embedded Technology

数字标牌系统的广泛应用改变了传统的信息传播模式，精彩的屏幕显示带来 了一轮又一轮视觉盛宴。从单机到网络，从简单到智能，从标清到高清，数字标 牌的变化让我们应接不暇，也让互联网数字化环境离我们的生活越来越近。商场、 超市、地铁、车站、飞机、加油站、连锁店、剧院等等，数字标牌无处不在。对 数字标牌系统的研究变得越来越重要，怎么让数字标牌更加智能化、人性化、高 效化以及更加节能，是数字标牌系统的发展趋势。从硬件到软件，从芯片的选择 到软件的开发，每一步都试图解决以上问题。 本文介绍了基于嵌入式技术的智能化数字标牌系统设计与实现，数字标牌系 统主要有四部分组成，服务器、网络平台、播放器...Spread application of Digital Indicating Board has been changing the way of information communication; it changes significantly day by day. From single PC to network, from simple application to automation, from normal to high qualified, Digital Indicating Board makes the closer connection between people routine life and internet world. Shopping Mall, Super Market, Metro Station, Bus Station, A...学位：工程硕士院系专业：软件学院_工程硕士(软件工程)学号：X200923049

A Study on the Customer Service Strategy of T Company

T公司地处福建省厦门市。该公司自2006年成立以来，在“技术领先”的 战略驱动下，至今已经发展成为中国大陆触控屏幕行业的技术领先者，形成了较 为全面的产品体系，与世界各大手机厂商均达成全面合作。但随着公司业务的全 面拓展，以及该行业的不断发展，客户的要求也越来越全面、细致，对T公司“聚 焦客户＋技术领先”战略下的客户服务工作提出了更高的要求；同时，行业内的 竞争对手也在各自的客户服务方面不断发展，对T公司的业务拓展构成极大的挑 战。本文通过对分析T公司的客户服务部门所处的宏观环境和行业环境以及内部 资源状况，对该公司的客户服务战略进行研究，提出了将公司原有的混合模糊战 略逐渐清...T Touch Solutions (Xiamen) Inc. is located in Xiamen city, Fujian Province. It was leaded by Top Technical Strategy since foundation of 2006, has been became technical leader in touch panel industry of China mail land, formed a whole products system for customer, and being comprehensive cooperation with top mobile phone manufactures in the world. But customer requirement being more and stricte...学位：管理学硕士院系专业：管理学院工商管理教育中心（MBA中心）_工商管理硕士(MBA)学号：20041505

Influence of different blood Glu cose control programs on prognosis and blood Glu cose in patients with intracerebral hemorrhage after operation together with stress hyperglycemia

目的 探讨不同血糖控制方案对脑出血术后应激性高血糖患者预后及血糖的影响。方法 采用回顾性研究方法将2015年6月~2016年5月入住我院重症医学科的52例脑出血术后应激性高血糖患者根据血糖控制方案的不同分为A组（n=25）和B组（n=27）,A组采用静脉单次推注,B组采用持续静脉泵注。比较两组的28 d生存率、格拉斯哥预后评分、血糖达标率、达标时间、血糖监测次数、低血糖发生率、血糖水平和血糖变异度指标的差异。结果 两组的28 d生存率、血糖达标率、达标时间、低血糖发生率比较,差异无统计学意义（P〉0.05）。A组的格拉斯哥预后评分显著高于B组,差异有统计学意义（P〈0.05）。A组的血糖监测次数显著少于B组,差异有统计学意义（P〈0.05）。A组的血糖最大值（Glu_（max））和血糖差值（Glu_（dif））均显著小于B组,差异有统计学意义（P〈0.05）。结论静脉单次推注胰岛素能够改善脑出血术后应激性高血糖患者的神经功能预后,可以降低入ICU后血糖最大值和血糖差异。Objective To investigate influence of different blood glucose control programs on prognosis and blood glucose in patients with intracerebral hemorrhage after operation together with stress hyperglycemia.Methods A retrospective study was conducted,and 52 patients with stress hyperglycemia after cerebral hemorrhage in our hospital from June 2015 to May 2016 were divided into group A （n=25） and group B （n=27） according to different blood glucose control programs.Group A was treated with intravenous bolus injection,and group B was treated with continuous intravenous pump.The 28 d survival rate,the Glasgow outcome score,the blood glucose compliance rate,the standard time,the fre- quency of blood glucose monitoring,the incidence rate of hypoglycemia,blood glucose levels and blood glucose variabili- ty indexes were compared between the two groups.Results There was no significant difference in 28 d survival rate,the blood glucose compliance rate,the standard time,the incidence rate of hypoglycemia between the two groups （P〉0.05）. The Glasgow outcome score in group A was significantly higher than that in group B,with significant difference （P〈 0.05）.The number of blood glucose monitoring in group A was significantly less than that in group B,with significant dif- ference （P〈0.05）.The Glu., and Glu~f in group A was significantly less than that in group B,with significant difference （P〈O.O5）.Conclusion Intravenous single bolus insulin injection can improve the prognosis of nervous function in pa- tients with intracerebral hemorrhage after operation together with stress hyperglycemia,and can reduce the maximum blood glucose and blood glucose difference after ICU.广东省东莞市医疗卫生类科技计划一般项目（2015105101220

Influence of Blood Samples Collection on the Results of Biochemical Detection in ICU Patients

目的:探讨血液标本采集对ICu住院患者生化检验结果的影响。方法:选择2014年1月-2015年1月本院ICu住院患者300例作为研究对象,分别从不同采血部位、不同采血时间及是否使用促凝管方面对检验指标进行对比分析。结果:输液同侧总胆红素、总蛋白、尿素氮、肌酐、总胆固醇、甘油三酯均显著低于输液另侧,比较差异有统计学意义(P0.05)。输液后2 H钾、钠浓度均显著高于输液后半小时(P0.05)。采用EdTA-k2抗凝管钙浓度显著低于采用促凝管检验结果,比较差异有统计学意义(P0.05)。结论:血液生化检验需注重采血部位、采血时间。除钙浓度外,采用EdTA-k2抗凝管不影响生化检验结果。Objective: To investigate the influence of blood samples collection on the results of biochemical detection in ICU patients.Method:300 patients in the ICU of our hospital from January 2014 to January 2015 were selected as the research objects.The laboratory test parameters of different blood collecting locations,different collection time and whether using procoagulation or not were compared and analyzed.Result:The TBil,TP,BUN,Cr,TC and TG of the same side with the infusion were significantly lower than those of the other side,the differences were statistically significant(P0.05).K+ and Na+ of two hours after infusion were significantly higher than those of half an hour after infusion,the differences were statistically significant(P0.05).Ca2+ of EDTA-K2 tube was significantly lower than that of pro-coagulation tube,the difference was statistically significant(P0.05).Conclusion:Blood collecting location and time have an effect on the results of biochemical detection.Using EDTA-K2 tubes for collecting blood samples has no effect on the results of biochemical detection except Ca2+.福建省科公益研院所专项基金(2014R1036-3

人参皂甙肠道细菌代谢物Compound K抗肿瘤研究进展

0引言Compound K(20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol,CK),又称为IH-901或M1,是二醇型人参皂甙如Rb1、Rb2、Rc等在肠道细菌作用下的最终代谢产物[1]。研究证实,口服人参

The Study on Effect of Deep Dyslexia through Cognitive Neuropsychology Rehabilitation

目的通过评价汉语深层失读患者进行针对性康复训练的康复效果,考查认知神经心理康复训练的有效性。方法应用纵向对比方法研究了1名深层失读患者的认知神经心理康复的训练效果,并采用横向对比法,通过与3名未采用该技术、自然康复的深层失读患者进行比较,分析了认知神经康复训练技术的康复效果。结果进行针对性认知神经心理康复训练的患者训练后阅读成绩提高了65.24%,语义错误和字形错误都有下降。而自然康复的3名患者阅读成绩提高了13.73%～30.47%。结论针对性的认知神经心理康复训练对汉语深层失读患者的康复有一定的效果,该方法有潜在的临床应用前景。</p

1976 Vol. 24 Number 11

https://engagedscholarship.csuohio.edu/lawpublications_gavel1970s/1100/thumbnail.jp

美国研究生负责任研究行为(RCR)教育计划及启示

介绍了美国负责任研究行为(rCr)教育的发展、教学内容、教育资源及作为美国rCr教育体系的重要组成部分的研究生rCr教育计划,并对美国rCr教育给我国研究生的科研诚信教育的启示进行了讨论